Warning: mkdir(): Permission denied in /home/virtual/lib/view_data.php on line 81

Warning: fopen(upload/ip_log/ip_log_2024-09.txt): failed to open stream: No such file or directory in /home/virtual/lib/view_data.php on line 83

Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84
Characterization and Cytotoxic Activities of Nonadecanoic Acid Produced by Streptomyces scabiei subsp. chosunensis M0137 (KCTC 9927)
Skip Navigation
Skip to contents

Journal of Microbiology : Journal of Microbiology

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > J. Microbiol > Volume 40(4); 2002 > Article
Characterization and Cytotoxic Activities of Nonadecanoic Acid Produced by Streptomyces scabiei subsp. chosunensis M0137 (KCTC 9927)
Jin-Cheol Yoo 1, Ji-Man Han 1, Seung-Kwan Nam 1, Ok-Hyun Ko 1, Cheol-Hee Choi 2, Keun-Hong Kee 3, Jae-Kyung Sohng 4, Jung-Sun Jo , Chi-Nam Seong
Journal of Microbiology 2002;40(4):331-334

Department of Biological Science, Sunchon National University, Sunchon 540-742, Korea; 1 Department of Pharmacy, 2 Department of Pharmacology and 3 Department of Pathology, Chosun University, Gwangju 501-759, Korea; 4 Department of Chemistry, Sunmoon University, Asan 337-840, KoreaDepartment of Biological Science, Sunchon National University, Sunchon 540-742, Korea; 1 Department of Pharmacy, 2 Department of Pharmacology and 3 Department of Pathology, Chosun University, Gwangju 501-759, Korea; 4 Department of Chemistry, Sunmoon University, Asan 337-840, Korea
Corresponding author:  Chi-Nam Seong , Tel: 82-61-750-3613, 
prev next
  • 3 Views
  • 0 Download
  • 0 Crossref
  • 0 Scopus
Full Article

Abstract

The substance 0116p, which exhibits cytotoxicity against human macrophage cell line THP-1, was isolated from a mycelial extract of Streptomyces scabiei subsp. chosunensis M0137. The cytotoxic substance was purified by Diaion-HP20 adsorption, solvent extraction, Sephadex LH-20 column chromatography, and silica-gel column chromatography. The molecular formula is C_19 H_38 O_2 (MW 301.10) based on elemental and spectrometric analysis. It was identified as nonadecanoic acid by NMR spectral data. It exhibits cytotoxic activities in various human cancer cell lines, including A549, SK-OV-3, SK-MEL-2 and HCT-15. In addition, 0116p also inhibits IL-12 production in lipopolysaccharide-activated macrophages.

  • Cite this Article
    Cite this Article
    export Copy Download
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Characterization and Cytotoxic Activities of Nonadecanoic Acid Produced by Streptomyces scabiei subsp. chosunensis M0137 (KCTC 9927)
    J. Microbiol. 2002;40(4):331-334.
    Close
Related articles
Journal of Microbiology : Journal of Microbiology
© The Microbiological Society of Korea.
TOP