Journal of Microbiology

Association of a Provisional New emm Type Opacity Factor-Negative Group A Streptococci Strain ST4529 with Septicemia: R.R. Rantty , M. Eshaghi , A.M. Ali , F. Jamal , K. Yusoff; J. Microbiol. 2001;39(3):236-239.

Abstract: Group A Streptococcus strain ST4529 is a provisional new emm type which has been recently reported in Malaysia (Jomal, et al. 1999. Energ. Infect . Dis. 5, 10-14). This strain was found to be opacity factor (OF) negative with a T1 phenotype. Usually, OF negative strains with T1 phenotypes are associated with acute rheumatic fever. However, strain ST4529 was isolated from the blood of a patient with septicemia. Comparison of the deduced amino acid sequence of the mature hypervariable N-terminus of ST4529 showed only 43% identity with that of M5, the closest matched OF negative strain with a T1 phenotype. Thus, ST4529 most probably encodes a new serospecifically unique M protein which is associated with septicemia rather than pharyngitis infections. The strains with these phenotypes are very important because their sequences should be considered for developing any anti-streptococcal vaccines.

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