Journal of Microbiology

Most-cited are based on citations from 2023 ~ 2025.

Reviews

Temperature Matters: Bacterial Response to Temperature Change: Seongjoon Moon , Soojeong Ham , Juwon Jeong , Heechan Ku , Hyunhee Kim , Changhan Lee; J. Microbiol. 2023;61(3):343-357. Published online April 3, 2023; DOI: https://doi.org/10.1007/s12275-023-00031-x

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Temperature is one of the most important factors in all living organisms for survival. Being a unicellular organism, bacterium requires sensitive sensing and defense mechanisms to tolerate changes in temperature. During a temperature shift, the structure and composition of various cellular molecules including nucleic acids, proteins, and membranes are affected. In addition, numerous genes are induced during heat or cold shocks to overcome the cellular stresses, which are known as heat- and cold-shock proteins. In this review, we describe the cellular phenomena that occur with temperature change and bacterial responses from a molecular perspective, mainly in Escherichia coli.

Citations

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Onion-like carbon based single-atom iron nanozyme for photothermal and catalytic synergistic antibacterial application
Yuchen Feng, Yuxi Shi, Qi Zhao, Guanyue Gao, Zhiqiang Wang, Jinfang Zhi
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Regulation and response of heterotrophic bacterial production to environmental changes in marginal seas of the Western Pacific Ocean
Qiao Liu, Jinyan Wang, Xiao-Jun Li, Ni Meng, Gui-Peng Yang, Guiling Zhang, Guang-Chao Zhuang
Global and Planetary Change.2025; 245: 104678. CrossRef
Quality effects of sodium alginate coating cross-linked with CaCl2 on Mugil liza fillets during storage
Márcio Vargas-Ramella, Débora da Silva, Guilherme Dilarri, Antonella Valentina Lazzari Zortea, Carolina Rosai Mendes, Gabriel de Souza Laurentino, Paulo Cezar Bastianello Campagnol, Aline Fernandes de Oliveira, Cristian Berto da Silveira
Food Control.2025; 170: 111048. CrossRef
Decoding bacterial communication: Intracellular signal transduction, quorum sensing, and cross-kingdom interactions
Shuxun Liu, Xujie Feng, Hangjia Zhang, Ping Li, Baoru Yang, Qing Gu
Microbiological Research.2025; 292: 127995. CrossRef
Seasonal variations in physicochemical properties, volatile compounds, and microbial community structure of Dajiang fermented using a semi-controlled method
Xiaojing Zhang, Qiqi Xiao, Xin Wang, Zhehao Zhang, Tao Guo, Bin Wang, Yanshun Xu
Food Bioscience.2025; 63: 105791. CrossRef
Microalgal-bacterial consortia for the treatment of livestock wastewater: Removal of pollutants, interaction mechanisms, influencing factors, and prospects for application
KhinKhin Phyu, Suli Zhi, Junfeng Liang, Chein-Chi Chang, Jiahua Liu, Yuang Cao, Han Wang, Keqiang Zhang
Environmental Pollution.2024; 349: 123864. CrossRef
Laser NIR Irradiation Enhances Antimicrobial Photodynamic Inactivation of Biofilms of Staphylococcus aureus
Leandro Mamone, Roberto Tomás, Gabriela Di Venosa, Lautaro Gándara, Edgardo Durantini, Fernanda Buzzola, Adriana Casas
Lasers in Surgery and Medicine.2024; 56(9): 783. CrossRef
Comparison of Incubation Conditions for Microbial Contaminant Isolation in Microbiological Environmental Monitoring
O. V. Gunar, N. G. Sakhno, O. S. Tyncherova
Regulatory Research and Medicine Evaluation.2024; 14(4): 483. CrossRef
Molecular insights and functional analysis of isocitrate dehydrogenase in two gram-negative pathogenic bacteria
Wei Xiong, Rui Su, Xueyang Han, Mengxiao Zhu, Hongyiru Tang, Shiping Huang, Peng Wang, Guoping Zhu
World Journal of Microbiology and Biotechnology.2024;[Epub] CrossRef
The transcriptional response to low temperature is weakly conserved across the Enterobacteriaceae
Johnson Hoang, Daniel M. Stoebel, Sarah L. Svensson
mSystems.2024;[Epub] CrossRef
The bacterial assemblage in the plumage of the Violet-crowned Hummingbird (Ramosomyia violiceps) varies with contrasting environments in Central-Western Mexico
Lizeth Raygoza-Alcantar, Verónica Rosas-Espinoza, Fabián Rodríguez-Zaragoza, María E. Macías-Rodríguez, Flor Rodríguez-Gómez
Journal of Ornithology.2024;[Epub] CrossRef
A newly isolated strain for poly(3-hydroxybutyrate) production under anaerobic conditions and the key enzyme analysis
Rui Ma, Ji Li, R.D. Tyagi, Xiaolei Zhang
Chemical Engineering Journal.2024; 496: 154200. CrossRef
Construction of a tertiary model and uncertainty analysis for the effect of time, temperature, available chlorine concentration of slightly acidic electrolyzed water on salmonella enteritidis and background total bacteria counts on chicken
Yao Zang, Yitian Zang, Qiang Zhang, Guosheng Zhang, Jie Hu, Renxin Liu, Mingming Tu, Wenduo Qiao, Mengzhen Hu, Boya Fu, Dengqun Shu, Yanjiao Li, Xianghui Zhao
LWT.2024; 214: 117166. CrossRef
Assimilatory sulphate reduction by acidogenesis: The key to prevent H2S formation during food and green waste composting for sustainable urbanization
Xingzu Gao, Zhicheng Xu, Lanxia Zhang, Guoxue Li, Long D. Nghiem, Wenhai Luo
Chemical Engineering Journal.2024; 499: 156149. CrossRef
A riboswitch-controlled TerC family transporter Alx tunes intracellular manganese concentration in Escherichia coli at alkaline pH
Ravish Sharma, Tatiana V. Mishanina, Conrad W. Mullineaux
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Assessing the health of climate-sensitive trees in a subalpine ecosystem through microbial community dynamics
Bo Ram Kang, Soo Bin Kim, Jin-Kyung Hong, Seok Hyun Ahn, Jinwon Kim, Nayeon Lee, Tae Kwon Lee
Science of The Total Environment.2024; 957: 177724. CrossRef
Enhancing polycyclic aromatic hydrocarbon soil remediation in cold climates using immobilized low-temperature-resistant mixed microorganisms
Dan Su, YiHan Liu, FengFei Liu, YuShan Dong, Yu Pu
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Investigating Escherichia coli habitat transition from sediments to water in tropical urban lakes
Boyu Liu, Choon Weng Lee, Chui Wei Bong, Ai-Jun Wang
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Bacterial bioaugmentation for paracetamol removal from water and sewage sludge. Genomic approaches to elucidate biodegradation pathway
A. Lara-Moreno, A. Vargas-Ordóñez, J. Villaverde, F. Madrid, J.D. Carlier, J.L. Santos, E. Alonso, E. Morillo
Journal of Hazardous Materials.2024; 480: 136128. CrossRef
Dietary supplementation with host-associated low-temperature potential probiotics improves the growth, immunity, digestive enzyme activity, and intestinal microbial population of olive flounder (Paralichthys olivaceus)
Su-Jeong Lee, Young-Sun Lee, Da-In Noh, Md Tawheed Hasan, Sang Woo Hur, Seunghan Lee, Seong-Mok Jeong, Kang-Woong Kim, Jong Min Lee, Eun-Woo Lee, Won Je Jang
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Soil Organic Matter and Total Nitrogen Reshaped Root-Associated Bacteria Community and Synergistic Change the Stress Resistance of Codonopsis pilosula
Xiaokang Huo, Yumeng Zhou, Ning Zhu, Xiaopeng Guo, Wen Luo, Yan Zhuang, Feifan Leng, Yonggang Wang
Molecular Biotechnology.2024;[Epub] CrossRef
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Volha Akulava, Valeria Tafintseva, Uladzislau Blazhko, Achim Kohler, Uladzislau Miamin, Leonid Valentovich, Volha Shapaval, Marcos Pileggi
PLOS ONE.2024; 19(6): e0303298. CrossRef
Phyletic patterns of bacterial growth temperature in Pseudomonas and Paenibacillus reveal gradual and sporadic evolution towards cold adaptation
Kihyun Lee, Seong-Hyeon Kim, Seongjoon Moon, Sangha Kim, Changhan Lee
ISME Communications.2024;[Epub] CrossRef
Bacterial Regulatory Mechanisms for the Control of Cellular Processes: Simple Organisms’ Complex Regulation
Jin-Won Lee
Journal of Microbiology.2023; 61(3): 273. CrossRef

Recent Advances in CRISPR‑Cas Technologies for Synthetic Biology: Song Hee Jeong , Ho Joung Lee , Sang Jun Lee; J. Microbiol. 2023;61(1):13-36. Published online February 1, 2023; DOI: https://doi.org/10.1007/s12275-022-00005-5

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Abstract

With developments in synthetic biology, “engineering biology” has emerged through standardization and platformization based on hierarchical, orthogonal, and modularized biological systems. Genome engineering is necessary to manufacture and design synthetic cells with desired functions by using bioparts obtained from sequence databases. Among various tools, the CRISPR-Cas system is modularly composed of guide RNA and Cas nuclease; therefore, it is convenient for editing the genome freely. Recently, various strategies have been developed to accurately edit the genome at a single nucleotide level. Furthermore, CRISPR-Cas technology has been extended to molecular diagnostics for nucleic acids and detection of pathogens, including disease-causing viruses. Moreover, CRISPR technology, which can precisely control the expression of specific genes in cells, is evolving to find the target of metabolic biotechnology. In this review, we summarize the status of various CRISPR technologies that can be applied to synthetic biology and discuss the development of synthetic biology combined with CRISPR technology in microbiology.

Citations

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Irkham, Abdullahi Umar Ibrahim, Chidi Wilson Nwekwo, Pwadubashiyi Coston Pwavodi, Salma Nur Zakiyyah, Mehmet Ozsoz, Yeni Wahyuni Hartati
Microchemical Journal.2025; 208: 112577. CrossRef
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Mohd Afaque Ansari, Damini Verma, Mohd-Akmal Hamizan, Maumita Das Mukherjee, Noor Faizah Mohd-Naim, Minhaz Uddin Ahmed
ACS Synthetic Biology.2025;[Epub] CrossRef
Comprehensive approaches to heavy metal bioremediation: Integrating microbial insights and genetic innovations
Mehran khan, Mir Muhammad Nizamani, Muhammad Asif, Ali Kamran, Guandi He, Xiangyang Li, Sanwei Yang, Xin Xie
Journal of Environmental Management.2025; 374: 123969. CrossRef
AlPaCas: allele-specific CRISPR gene editing through a protospacer-adjacent-motif (PAM) approach
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Nucleic Acids Research.2024; 52(W1): W29. CrossRef
Use of paired Cas9-NG nickase and truncated sgRNAs for single-nucleotide microbial genome editing
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Journal Article

Effects of Continuous Straw Returning on Soil Functional Microorganisms and Microbial Communities: Yunpeng Guan , Meikang Wu , Songhao Che , Shuai Yuan , Xue Yang , Siyuan Li , Ping Tian , Lei Wu , Meiying Yang , Zhihai Wu; J. Microbiol. 2023;61(1):49-62. Published online January 26, 2023; DOI: https://doi.org/10.1007/s12275-022-00004-6

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Abstract

This study examined the changes in soil enzymatic activity, microbial carbon source metabolic diversity, and straw decomposition rates in paddy fields treated with 1, 2, or 3 years of straw returning (SR1–SR3). The soil’s ability to decompose straw and cellulolytic bacteria increased with the number of treatment years (1: 31.9% vs. 2: 43.9% vs. 3: 51.9%, P < 0.05). The numbers of Azotobacter, Nitrobacteria, cellulolytic bacteria, and inorganic phosphate bacteria increased progressively with the numbers of straw returning years. Cellulolytic bacteria and inorganic phosphate bacteria were significantly positively correlated with the decomposition rate (r = 0.783 and r = 0.375, P < 0.05). Based on 16S sequencing results, straw returning improved the microbial diversity of paddy soils by increasing unclassified bacteria and keeping dominant soil microorganism populations unchanged. The relative importance of individual microbial taxa was compared using random forest models. Proteobacteria, ammoniating bacteria, and potassium dissolving bacteria contributed to peroxidase activity. The significant contributors to phosphate monoesterase were Acidobacteriota, Desulfobacterota, ammoniating bacteria, cellulolytic bacteria, and potassium-dissolving bacteria. Proteobacteria, ammoniating bacteria, cellulolytic bacteria, and potassium-dissolving bacteria contributed to urease activity. Desulfobacterota, ammoniating bacteria, cellulolytic bacteria, and potassium-dissolving bacteria contributed to the neutral invertase activity. In conclusion, soil microbial community structure and function were affected within 2 years of straw returning, which was driven by the combined effects of soil organic carbon, available nitrogen, available potassium, and pH. With elapsing straw returning years, soil properties interacted with soil microbial communities, and a healthier soil micro-ecological environment would form.

Citations

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Synergistic Effects of Rice Straw Return and Nitrogen Fertilizer on Rhizosphere Bacterial Communities and Soil Fertility
Nasita Rahman Borny, Golam Mohammod Mostakim, Asif Raihan, Md Shoaibur Rahman
Journal of Soil, Plant and Environment.2024; : 41. CrossRef
Vertical differences in carbon metabolic diversity and dominant flora of soil bacterial communities in farmlands
Bufan Zheng, Zhipeng Xiao, Jiaqi Liu, Yi Zhu, Kaifeng Shuai, Xiaye Chen, Yongjun Liu, Ruiwen Hu, Guangjue Peng, Junlin Li, Yichao Hu, Zan Su, Ming Fang, Juan Li
Scientific Reports.2024;[Epub] CrossRef
Microbial Network Complexity Helps to Reduce the Deep Migration of Chemical Fertilizer Nitrogen Under the Combined Application of Varying Irrigation Amounts and Multiple Nitrogen Sources
Taotao Chen, Erping Cui, Yanbo Zhang, Ge Gao, Hao You, Yurun Tian, Chao Hu, Yuan Liu, Tao Fan, Xiangyang Fan
Agriculture.2024; 14(12): 2311. CrossRef
Effects of Combined Peanut Shell and Biochar Application on Soil Nutrient Content, CO2 Emission, and Bacterial Community in Dryland Red Soil of Southern China
Xinyi Yu, Qian Wei, Meng Na, Chunjie Tian, Shangqi Xu, Jihai Zhou
Journal of Soil Science and Plant Nutrition.2024; 24(1): 219. CrossRef
Long-term in situ straw returning increased soil aggregation and aggregate associated organic carbon fractions in a paddy soil
Jiaren Liu, Xuehai Wang, Hu Zhang, Yifei Lu, Yusef Kianpoor Kalkhajeh, Hongxiang Hu, Jieying Huang
Heliyon.2024; 10(11): e32392. CrossRef
The role of tillage practices in wheat straw decomposition and shaping the associated microbial communities in Endocalcaric– Epigleyic Cambisol soil
Arman Shamshitov, Gražina Kadžienė, Francesco Pini, Skaidrė Supronienė
Biology and Fertility of Soils.2024;[Epub] CrossRef
Agricultural ecosystems rather than fertilization strategies drives structure and composition of the ureolytic microbial functional guilds
Na Lv, Ping Gong, Hao Sun, Xiangxin Sun, Zhiguang Liu, Xueshi Xie, Yan Xue, Yuchao Song, Kaikuo Wu, Tingting Wang, Zhijie Wu, Lili Zhang
Journal of Environmental Management.2024; 372: 123148. CrossRef
Effects of Burial Furrow Parameters on Soil Water Movement under Subsurface Stalk Composite Pipe Irrigation
Feng Wu, Xuefang Feng, Xuemei Liu, Di Wu, Songmei Zai, Linbao Liu
Agriculture.2024; 14(2): 287. CrossRef
Improving Soil Quality and Crop Yields Using Enhancing Sustainable Rice Straw Management Through Microbial Enzyme Treatments
Van-Phuc Dinh, Hoai-An Tran-Vu, Thanh Tran, Bich-Ngoc Duong, Ngoc-Mai Dang-Thi, Hoai-Luan Phan-Van, Tuan-Kiet Tran, Van-Hieu Huynh, Thi-Phuong-Tu Nguyen, Thanh Q Nguyen
Environmental Health Insights.2024;[Epub] CrossRef
Improvement of Saline–Alkali Soil and Straw Degradation Efficiency in Cold and Arid Areas Using Klebsiella sp. and Pseudomonas sp.
Xiaoyu Zhao, Xiaofang Yu, Julin Gao, Jiawei Qu, Qinggeer Borjigin, Tiantian Meng, Dongbo Li
Agronomy.2024; 14(11): 2499. CrossRef
Successive Years of Rice Straw Return Increased the Rice Yield and Soil Nutrients While Decreasing the Greenhouse Gas Intensity
Meikang Wu, Min Nuo, Zixian Jiang, Ruiyao Xu, Hongcheng Zhang, Xiao Lu, Liqun Yao, Man Dou, Xu Xing, Xin Meng, Dongchao Wang, Xiaoshuang Wei, Ping Tian, Guan Wang, Zhihai Wu, Meiying Yang
Plants.2024; 13(17): 2446. CrossRef
The effects of straw return on soil bacterial diversity and functional profiles: A meta-analysis
Miaomiao Zhang, Pengfei Dang, Bart Haegeman, Xiaoqing Han, Xiaofan Wang, Xuan Pu, Xiaoliang Qin, Kadambot H.M. Siddique
Soil Biology and Biochemistry.2024; 195: 109484. CrossRef
Dissolved Organic Matters, an Intermediary of the Microbial Community and Potassium Fertilizers in A. carmichaeli rhizosphere Soil
Fei Xia, Meng Fu, Chen Liu, Yulong Li, Yi Qiang, Ding He, Guoyan Zhang, Langjun Cui
Journal of Soil Science and Plant Nutrition.2024; 24(3): 5472. CrossRef
Effects of Straw and Nitrogenous Fertilizers on the Soil Aggregate Stability and Quality in Subtropical Regions of China
Jia Yi Yang, Shahbaz Atta Tung, Jin Ting Xu, Yan Qiong Pan, Li Yang, Xun Bo Zhou
Journal of Soil Science and Plant Nutrition.2024; 24(3): 5988. CrossRef
Improved Straw Decomposition Products Promote Peanut Growth by Changing Soil Chemical Properties and Microbial Diversity
Yaxin Liu, Meng Wu, Jia Liu, Daming Li, Xiaoli Liu, Ling Chen, Xi Guo, Ming Liu
Sustainability.2024; 16(16): 7096. CrossRef
Straw Returning Measures Enhance Soil Moisture and Nutrients and Promote Cotton Growth
Min Tang, Rui Liu, Zhenhai Luo, Chao Zhang, Jiying Kong, Shaoyuan Feng
Agronomy.2023; 13(7): 1850. CrossRef

Review

Influence of Microbiota on Vaccine Effectiveness: “Is the Microbiota the Key to Vaccine‑induced Responses?”: So-Hee Hong; J. Microbiol. 2023;61(5):483-494. Published online April 13, 2023; DOI: https://doi.org/10.1007/s12275-023-00044-6

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Abstract

Vaccines are one of the most powerful tools for preventing infectious diseases. To effectively fight pathogens, vaccines should induce potent and long-lasting immune responses that are specific to the pathogens. However, not all vaccines can induce effective immune responses, and the responses vary greatly among individuals and populations. Although several factors, such as age, host genetics, nutritional status, and region, affect the effectiveness of vaccines, increasing data have suggested that the gut microbiota is critically associated with vaccine-induced immune responses. In this review, I discuss how gut microbiota affects vaccine effectiveness based on the clinical and preclinical data, and summarize possible underlying mechanisms related to the adjuvant effects of microbiota. A better understanding of the link between vaccine-induced immune responses and the gut microbiota using high-throughput technology and sophisticated system vaccinology approaches could provide crucial insights for designing effective personalized preventive and therapeutic vaccination strategies.

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Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways
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Frontiers in Immunology.2025;[Epub] CrossRef
Intestinal Microbiota and Its Effect on Vaccine-Induced Immune Amplification and Tolerance
Yixin Liu, Jianfeng Zhou, Yushang Yang, Xiangzheng Chen, Longqi Chen, Yangping Wu
Vaccines.2024; 12(8): 868. CrossRef
Immune Cells, Gut Microbiota, and Vaccines: A Gender Perspective
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Parasite-microbiota interactions: a pathway to innovative interventions for Chagas disease, leishmaniasis, and ascariasis
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Ruhao Dashi granules exert therapeutic effects on H1N1 influenza virus infection by altering intestinal microflora composition
Wei Pan, Rui Wu, Qianyun Zhang, Yuan Ma, Jinxiang Xiang, Jingbo Wang, Jing Chen
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When inflammatory stressors dramatically change, disease phenotypes may transform between autoimmune hematopoietic failure and myeloid neoplasms
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Vaccines.2024; 12(6): 587. CrossRef
Baseline Gut Microbiota Was Associated with Long-Term Immune Response at One Year Following Three Doses of BNT162b2
Li-Na Zhang, Jing-Tong Tan, Ho-Yu Ng, Yun-Shi Liao, Rui-Qi Zhang, Kwok-Hung Chan, Ivan Fan-Ngai Hung, Tommy Tsan-Yuk Lam, Ka-Shing Cheung
Vaccines.2024; 12(8): 916. CrossRef
Immunologische Konsequenzen bei frühgeborenen Kindern
Josina M. Hofer, Dimitra E. Zazara, Anke Diemert, Petra Clara Arck
Gynäkologische Endokrinologie.2023; 21(4): 261. CrossRef
Ginsenoside Rb1 enhanced immunity and altered the gut microflora in mice immunized by H1N1 influenza vaccine
Chuanqi Wan, Rufeng Lu, Chen Zhu, Haibo Wu, Guannan Shen, Yang Yang, Xiaowei Wu, Bangjiang Fang, Yuzhou He
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Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go
Francesca Romana Ponziani, Gaetano Coppola, Pierluigi Rio, Mario Caldarelli, Raffaele Borriello, Giovanni Gambassi, Antonio Gasbarrini, Rossella Cianci
Vaccines.2023; 11(10): 1609. CrossRef

Journal Article

Silver Nanoparticles Modified with Polygonatum sibiricum Polysaccharide Improve Biocompatibility and Infected Wound Bacteriostasis: Ruonan Wang , Rongyu Li , Peng Zheng , Zicheng Yang , Cheng Qian , Zhou Wang , Senhe Qian; J. Microbiol. 2023;61(5):543-558. Published online April 13, 2023; DOI: https://doi.org/10.1007/s12275-023-00042-8

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Abstract

Silver nanoparticles (AgNPs) exhibit strong antibacterial activity and do not easily induce drug resistance; however, the poor stability and biocompatibility in solution limit their widespread application. In this study, AgNPs were modified with Polygonatum sibiricum Polysaccharide (PSP) to synthesize PSP@AgNPs with good stability, biocompatibility, and antibacterial activity. When PSP@AgNP synthesis was performed under a reaction time of 70 min, a reaction temperature of 35 °C, and an AgNO3- to-PSP volume ratio of 1:1, the synthesized PSP@AgNPs were more regular and uniform than AgNPs, and their particle size was around 10 nm. PSP@AgNPs exhibited lower cytotoxicity and hemolysis, and stronger bacteriostatic activity. PSP@AgNPs damage the integrity and internal structure of cells, resulting in the leakage of intracellular nucleic acids and proteins. The rate of cell membrane damage in Escherichia coli and Staphylococcus aureus treated with PSP@ AgNPs increased by 38.52% and 43.75%, respectively, compared with that of AgNPs. PSP@AgNPs inhibit the activities of key enzymes related to antioxidant, energy and substance metabolism in cells. The inhibitory effects on the activities of superoxide dismutase (SOD), catalase (CAT), adenosine triphosphate enzyme (ATPase), malate dehydrogenase (MDH), and succinate dehydrogenase (SDH) in E. coli and S. aureus cells were significantly higher than those of AgNPs. In addition, compared with AgNPs, PSP@AgNPs promote faster healing of infected wounds. Therefore, PSP@AgNPs represent potential antibacterial agents against wound infections.

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Improving the biocompatibility and antibacterial efficacy of silver nanoparticles functionalized with (LLRR)3 antimicrobial peptide
Rongyu Li, Jiaqing Mao, Peng Zheng, Ruonan Wang, Zicheng Yang, Senhe Qian
World Journal of Microbiology and Biotechnology.2024;[Epub] CrossRef
Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles
J. Nandhini, E. Karthikeyan, E. Elizabeth Rani, V.S. Karthikha, D. Sakthi Sanjana, H. Jeevitha, S. Rajeshkumar, Vijayan Venugopal, A. Priyadharshan
Engineered Regeneration.2024; 5(3): 306. CrossRef
Effect of Polygonatum sibiricum on biological toxicity of zinc oxide nanoparticles during respiratory exposure
Jingjing Yao, Wanqing Yang, Liang Tang, Dicheng Yang, Yan Xu, Shenmin Zhu, Jun Zhu
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Reviews

Envelope‑Stress Sensing Mechanism of Rcs and Cpx Signaling Pathways in Gram‑Negative Bacteria: Seung-Hyun Cho , Kilian Dekoninck , Jean-Francois Collet; J. Microbiol. 2023;61(3):317-329. Published online March 9, 2023; DOI: https://doi.org/10.1007/s12275-023-00030-y

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Abstract

The global public health burden of bacterial antimicrobial resistance (AMR) is intensified by Gram-negative bacteria, which have an additional membrane, the outer membrane (OM), outside of the peptidoglycan (PG) cell wall. Bacterial twocomponent systems (TCSs) aid in maintaining envelope integrity through a phosphorylation cascade by controlling gene expression through sensor kinases and response regulators. In Escherichia coli, the major TCSs defending cells from envelope stress and adaptation are Rcs and Cpx, which are aided by OM lipoproteins RcsF and NlpE as sensors, respectively. In this review, we focus on these two OM sensors. β-Barrel assembly machinery (BAM) inserts transmembrane OM proteins (OMPs) into the OM. BAM co-assembles RcsF, the Rcs sensor, with OMPs, forming the RcsF-OMP complex. Researchers have presented two models for stress sensing in the Rcs pathway. The first model suggests that LPS perturbation stress disassembles the RcsF-OMP complex, freeing RcsF to activate Rcs. The second model proposes that BAM cannot assemble RcsF into OMPs when the OM or PG is under specific stresses, and thus, the unassembled RcsF activates Rcs. These two models may not be mutually exclusive. Here, we evaluate these two models critically in order to elucidate the stress sensing mechanism. NlpE, the Cpx sensor, has an N-terminal (NTD) and a C-terminal domain (CTD). A defect in lipoprotein trafficking
results
in NlpE retention in the inner membrane, provoking the Cpx response. Signaling requires the NlpE NTD, but not the NlpE CTD; however, OM-anchored NlpE senses adherence to a hydrophobic surface, with the NlpE CTD playing a key role in this function.

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Transcriptome reveals the role of the htpG gene in mediating antibiotic resistance through cell envelope modulation in Vibrio mimicus SCCF01
Zhenyang Qin, Kun Peng, Yang Feng, Yilin Wang, Bowen Huang, Ziqi Tian, Ping Ouyang, Xiaoli Huang, Defang Chen, Weimin Lai, Yi Geng
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Rcs signal transduction system in Escherichia coli: Composition, related functions, regulatory mechanism, and applications
Zeyu Li, Yingying Zhu, Wenli Zhang, Wanmeng Mu
Microbiological Research.2024; 285: 127783. CrossRef
Identification of genes used by Escherichia coli to mitigate climatic stress conditions
Styliani Roufou, Sholeem Griffin, Lydia Katsini, Monika Polańska, Jan F.M. Van Impe, Panagiotis Alexiou, Vasilis P. Valdramidis
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The Role of Propionate-Induced Rearrangement of Membrane Proteins in the Formation of the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli
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International Journal of Molecular Sciences.2024; 25(18): 10118. CrossRef
CpxAR two-component system contributes to virulence properties of Cronobacter sakazakii
Tong Jin, Xiangjun Zhan, Liuxin Pang, Bo Peng, Xinpeng Zhang, Wenxiu Zhu, Baowei Yang, Xiaodong Xia
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Breaking Barriers: Exploiting Envelope Biogenesis and Stress Responses to Develop Novel Antimicrobial Strategies in Gram-Negative Bacteria
Renu Bisht, Pierre D. Charlesworth, Paola Sperandeo, Alessandra Polissi
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Jian Wang, Yaping Wang, Shouquan Lu, Haibo Lou, XiaoBing Wang, Wei Wang
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Understanding the Diversity and Roles of the Ruminal Microbiome: Gi Beom Keum, Sriniwas Pandey, Eun Sol Kim, Hyunok Doo, Jinok Kwak, Sumin Ryu, Yejin Choi, Juyoun Kang, Sheena Kim, Hyeun Bum Kim; J. Microbiol. 2024;62(3):217-230. Published online April 25, 2024; DOI: https://doi.org/10.1007/s12275-024-00121-4

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Abstract

The importance of ruminal microbiota in ruminants is emphasized, not only as a special symbiotic relationship with ruminants but also as an interactive and dynamic ecosystem established by the metabolites of various rumen microorganisms. Rumen microbial community is essential for life maintenance and production as they help decompose and utilize fber that is difcult to digest, supplying about 70% of the energy needed by the host and 60–85% of the amino acids that reach the small intestine. Bacteria are the most abundant in the rumen, but protozoa, which are relatively large, account for 40–50% of the total microorganisms. However, the composition of these ruminal microbiota is not conserved or constant throughout life and is greatly infuenced by the host. It is known that the initial colonization of calves immediately after birth is mainly infuenced by the mother, and later changes depending on various factors such as diet, age, gender and breed. The initial rumen microbial community contains aerobic and facultative anaerobic bacteria due to the presence of oxygen, but as age increases, a hypoxic environment is created inside the rumen, and anaerobic bacteria become dominant in the rumen microbial community. As calves grow, taxonomic diversity increases, especially as they begin to consume solid food. Understanding the factors afecting the rumen microbial community and their efects and changes can lead to the early development and stabilization of the microbial community through the control of rumen microorganisms, and is expected to ultimately help improve host productivity and efciency.

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Effects of Oregano Essential Oil and/or Yeast Cultures on the Rumen Microbiota of Crossbred Simmental Calves
Ting Liu, Zhihao Luo, Tao Zhang, Huan Chen, Xuejiao Yi, Jiang Hu, Bingang Shi, Yuxi An, Changze Cui, Xiangyan Wang
Animals.2024; 14(24): 3710. CrossRef
Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
GnRH Immunocastration in Male Xizang Sheep: Impacts on Rumen Microbiome and Metabolite Profiles for Enhanced Health and Productivity
Xiaoming Zhang, Tianzeng Song, Guiqiong Liu, Jing Wu, Yangzong Zhaxi, Shehr Bano Mustafa, Khuram Shahzad, Xiaoying Chen, Wangsheng Zhao, Xunping Jiang
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Astghik Pepoyan
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Shichun He, Zaimei Yuan, Sifan Dai, Zibei Wang, Shusheng Zhao, Bin Zhang, Huaming Mao, Dongwang Wu
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Sheena Kim, Jinho Cho, Gi Beom Keum, Jinok Kwak, Hyunok Doo, Yejin Choi, Juyoun Kang, Haram Kim, Yeongjae Chae, Eun Sol Kim, Minho Song, Hyeun Bum Kim
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Chang Liu, Jing Ge, Jiaqi Dai, Mingren Qu, Kehui Ouyang, Qinghua Qiu
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Dawit Adisu Tadese, James Mwangi, Lei Luo, Hao Zhang, Xiaoshan Huang, Brenda B. Michira, Shengwen Zhou, Peter Muiruri Kamau, Qiumin Lu, Ren Lai
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Skin Deep: The Potential of Microbiome Cosmetics: Ju Hee Han, Hei Sung Kim; J. Microbiol. 2024;62(3):181-199. Published online April 16, 2024; DOI: https://doi.org/10.1007/s12275-024-00128-x

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Abstract

The interplay between the skin microbiome and its host is a complex facet of dermatological health and has become a critical focus in the development of microbiome cosmetics. The skin microbiome, comprising various microorganisms, is essential from birth, develops over the lifespan, and performs vital roles in protecting our body against pathogens, training the immune system, and facilitating the breakdown of organic matter. Dysbiosis, an imbalance of these microorganisms, has been implicated in a number of skin conditions such as acne, atopic dermatitis, and skin cancer. Recent scientific findings have spurred cosmetic companies to develop products that preserve and enhance the skin's microbial diversity balance. These products may incorporate elements like prebiotics, probiotics, and postbiotics, which are beneficial for the skin microbiome. Beyond topical products, there's increasing interest in ingestible beauty supplements (i.e. oral probiotics), highlighting the connection between the gut and skin. This review examines the influence of the microbiome on skin health and the emerging trends of microbiome skincare products.

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Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
Skin Microbiome and Acne: Microbial Imbalances and Impact – Interview with Three Key Opinion Leaders
Brigitte Scott
EMJ Dermatology.2024; : 83. CrossRef
Cosmeceuticals: A Review of Clinical Studies Claiming to Contain Specific, Well-Characterized Strains of Probiotics or Postbiotics
Ioannis M. Theodorou, Dorothea Kapoukranidou, Markos Theodorou, Joulia K. Tsetis, Alexandra Eleftheria Menni, Georgios Tzikos, Stella Bareka, Anne Shrewsbury, George Stavrou, Katerina Kotzampassi
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Influence of Cosmetic Skincare Products with pH < 5 on the Skin Microbiome: A Randomized Clinical Evaluation
Ciska Janssens-Böcker, Claudia Doberenz, Marta Monteiro, Marta de Oliveira Ferreira
Dermatology and Therapy.2024;[Epub] CrossRef
Effect of Staphylococcus aureus colonization and immune defects on the pathogenesis of atopic dermatitis
Evrim Özdemіr, Lütfiye Öksüz
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A New Generation of Postbiotics for Skin and Scalp: In Situ Production of Lipid Metabolites by Malassezia
Martin Patrick Pagac, Mathias Gempeler, Remo Campiche
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Antimelanogenic and Antioxidant Effects of Postbioics of Lactobacillus Strains in α-MSH-Induced B16F10 Melanoma Cells via CREB/MITF and MAPKs Signaling Pathway
Hye-Won Lee, Yu-Rim Lee, Kyung-Min Park, Na-Kyoung Lee, Hyun-Dong Paik
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Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium: Nakyeong Ha , Eun-Jin Lee; J. Microbiol. 2023;61(3):289-296. Published online March 2, 2023; DOI: https://doi.org/10.1007/s12275-023-00027-7

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Abstract

The metal cofactors are essential for the function of many enzymes. The host restricts the metal acquisition of pathogens for their immunity and the pathogens have evolved many ways to obtain metal ions for their survival and growth. Salmonella enterica serovar Typhimurium also needs several metal cofactors for its survival, and manganese has been found to contribute to Salmonella pathogenesis. Manganese helps Salmonella withstand oxidative and nitrosative stresses. In addition, manganese affects glycolysis and the reductive TCA, which leads to the inhibition of energetic and biosynthetic metabolism. Therefore, manganese homeostasis is crucial for full virulence of Salmonella. Here, we summarize the current information about three importers and two exporters of manganese that have been identified in Salmonella. MntH, SitABCD, and ZupT have been shown to participate in manganese uptake. mntH and sitABCD are upregulated by low manganese concentration, oxidative stress, and host NRAMP1 level. mntH also contains a Mn2+- dependent riboswitch in its 5′ UTR. Regulation of zupT expression requires further investigation. MntP and YiiP have been identified as manganese efflux proteins. mntP is transcr!ptionally activated by MntR at high manganese levels and repressed its activity by MntS at low manganese levels. Regulation of yiiP requires further analysis, but it has been shown that yiiP expression is not dependent on MntS. Besides these five transporters, there might be additional transporters that need to be identified.

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Functional characterization of a TerC family protein of Riemerella anatipestifer in manganese detoxification and virulence
Qinyuan Chen, Fang Guo, Li Huang, Mengying Wang, Chunfeng Shi, Shutong Zhang, Yizhou Yao, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Bin Tian, Juan Huang, Xumin Ou, Qun Gao, Di Sun, Ling Zhang, Yanling
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Gut Lactobacillus and Probiotics Lactobacillus lactis/rhamnosis Ameliorate Liver Fibrosis in Prevention and Treatment: Sung Min Won , Na Young Lee , Ki&# , Haripriya Gupta , Satya Priya Sharma , Kyung Hwan Kim , Byoung Kook Kim , Hyun Chae Joung , Jin Ju Jeong , Raja Ganesan , Sang Hak Han , Sang Jun Yoon , Dong Joon Kim , Ki Tae Suk; J. Microbiol. 2023;61(2):245-257. Published online February 6, 2023; DOI: https://doi.org/10.1007/s12275-023-00014-y

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Abstract

The progression and exacerbation of liver fibrosis are closely related to the gut microbiome. It is hypothesized that some probiotics may slow the progression of liver fibrosis. In human stool analysis [healthy group (n = 44) and cirrhosis group (n = 18)], difference in Lactobacillus genus between healthy group and cirrhosis group was observed. Based on human data, preventive and therapeutic effect of probiotics Lactobacillus lactis and L. rhamnosus was evaluated by using four mice fibrosis models. L. lactis and L. rhamnosus were supplied to 3,5-diethoxycarbonyl-1,4-dihydrocollidine or carbon tetrachloride-induced liver fibrosis C57BL/6 mouse model. Serum biochemical measurements, tissue staining, and mRNA expression in the liver were evaluated. The microbiome was analyzed in mouse cecal contents. In the mouse model, the effects of Lactobacillus in preventing and treating liver fibrosis were different for each microbe species. In case of L. lactis, all models showed preventive and therapeutic effects against liver fibrosis. In microbiome analysis in mouse models administered Lactobacillus, migration and changes in the ratio and composition of the gut microbial community were confirmed. L. lactis and L. rhamnosus showed preventive and therapeutic effects on the progression of liver fibrosis, suggesting that Lactobacillus intake may be a useful strategy for prevention and treatment.

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Dingkang Wang, Ruijie Xu, Sha Liu, Xiaomin Sun, Tianxiao Zhang, Lin Shi, Youfa Wang
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Yu Mi Jo, Yoon Ji Son, Seul-Ah Kim, Gyu Min Lee, Chang Won Ahn, Han-Oh Park, Ji-Hyun Yun
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Xiaofei Zhu, Ziyuan Zhou, Xiaxia Pan
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Xue Li, Xinyi Xu, Sian Tao, Yue Su, Li Wen, Dong Wang, Jibin Liu, Quansheng Feng
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Lin Cheng, Jianyou Shi, Haoyuan Peng, Rongsheng Tong, Yonghe Hu, Dongke Yu
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The β‑Lactamase Activity at the Community Level Confers β‑Lactam Resistance to Bloom‑Forming Microcystis aeruginosa Ce: Yerim Park , Wonjae Kim , Minkyung Kim , Woojun Park; J. Microbiol. 2023;61(9):807-820. Published online October 18, 2023; DOI: https://doi.org/10.1007/s12275-023-00082-0

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Abstract

Many freshwater cyanobacteria, including Microcystis aeruginosa, lack several known antibiotic resistance genes; however, both axenic and xenic M. aeruginosa strains exhibited high antibiotic resistance against many antibiotics under our tested concentrations, including colistin, trimethoprim, and kanamycin. Interestingly, axenic PCC7806, although not the xenic NIBR18 and NIBR452 strains, displayed susceptibility to ampicillin and amoxicillin, indicating that the associated bacteria in the phycosphere could confer such antibiotic resistance to xenic strains. Fluorescence and scanning electron microscopic observations revealed their tight association, leading to possible community-level β-lactamase activity. Combinatory treatment of ampicillin with a β-lactamase inhibitor, sulbactam, abolished the ampicillin resistance in the xenic stains. The nitrocefin-based assay confirmed the presence of significant community-level β-lactamase activity. Our tested low ampicillin concentration and high β-lactamase activity could potentially balance the competitive advantage of these dominant species and provide opportunities for the less competitive species, thereby resulting in higher bacterial diversity under ampicillin treatment conditions. Non-PCR-based metagenome data from xenic NIBR18 cultures revealed the dominance of blaOXArelated antibiotic resistance genes followed by other class A β-lactamase genes (AST-1 and FAR-1). Alleviation of ampicillin toxicity could be observed only in axenic PCC7806, which had been cocultured with β-lactamase from other freshwater bacteria. Our study suggested M. aeruginosa develops resistance to old-class β-lactam antibiotics through altruism, where associated bacteria protect axenic M. aeruginosa cells.

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Sustainable control of Microcystis aeruginosa, a harmful cyanobacterium, using Selaginella tamariscina extracts
Wonjae Kim, Yerim Park, Minkyung Kim, Yeji Cha, Jaejoon Jung, Che Ok Jeon, Woojun Park
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Mingyeong Kang, Dong-Kyun Kim, Ve Van Le, So-Ra Ko, Jay Jung Lee, In-Chan Choi, Yuna Shin, Kyunghyun Kim, Chi-Yong Ahn
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Aabir Banerji, Nichole E. Brinkman, Benjamin Davis, Alison Franklin, Michael Jahne, Scott P. Keely
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Extensive Genomic Rearrangement of Catalase-Less Cyanobloom-Forming Microcystis aeruginosa in Freshwater Ecosystems
Minkyung Kim, Jaejoon Jung, Wonjae Kim, Yerim Park, Che Ok Jeon, Woojun Park
Journal of Microbiology.2024; 62(11): 933. CrossRef
Biological and Chemical Approaches for Controlling Harmful Microcystis Blooms
Wonjae Kim, Yerim Park, Jaejoon Jung, Che Ok Jeon, Masanori Toyofuku, Jiyoung Lee, Woojun Park
Journal of Microbiology.2024; 62(3): 249. CrossRef
Alleviation of H2O2 toxicity by extracellular catalases in the phycosphere of Microcystis aeruginosa
Yerim Park, Wonjae Kim, Yeji Cha, Minkyung Kim, Woojun Park
Harmful Algae.2024; 137: 102680. CrossRef

Review

Biological and Chemical Approaches for Controlling Harmful Microcystis Blooms: Wonjae Kim, Yerim Park, Jaejoon Jung, Che Ok Jeon, Masanori Toyofuku, Jiyoung Lee, Woojun Park; J. Microbiol. 2024;62(3):249-260. Published online April 8, 2024; DOI: https://doi.org/10.1007/s12275-024-00115-2

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Abstract

The proliferation of harmful cyanobacterial blooms dominated by Microcystis aeruginosa has become an increasingly serious problem in freshwater ecosystems due to climate change and eutrophication. Microcystis-blooms in freshwater generate compounds with unpleasant odors, reduce the levels of dissolved O₂, and excrete microcystins into aquatic ecosystems, potentially harming various organisms, including humans. Various chemical and biological approaches have thus been developed to mitigate the impact of the blooms, though issues such as secondary pollution and high economic costs have not been adequately addressed. Red clays and H₂O₂ are conventional treatment methods that have been employed worldwide for the mitigation of the blooms, while novel approaches, such as the use of plant or microbial metabolites and antagonistic bacteria, have also recently been proposed. Many of these methods rely on the generation of reactive oxygen species, the inhibition of photosynthesis, and/or the disruption of cellular membranes as their mechanisms of action, which may also negatively impact other freshwater microbiota. Nevertheless, the underlying molecular mechanisms of anticyanobacterial chemicals and antagonistic bacteria remain unclear. This review thus discusses both conventional and innovative approaches for the management of M. aeruginosa in freshwater bodies.

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Yerim Park, Wonjae Kim, Yeji Cha, Minkyung Kim, Woojun Park
Harmful Algae.2024; 137: 102680. CrossRef
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Minkyung Kim, Jaejoon Jung, Wonjae Kim, Yerim Park, Che Ok Jeon, Woojun Park
Journal of Microbiology.2024; 62(11): 933. CrossRef
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Ten Novel Species Belonging to the Genus Flavobacterium, Isolated from Freshwater Environments: F. praedii sp. nov., F. marginilacus sp. nov., F. aestivum sp. nov., F. flavigenum sp. nov., F. luteolum sp. nov., F. gelatinilyticum sp. nov., F. aquiphilum sp. nov., F. limnophilum sp. nov., F. lacustre: Hyunyoung Jo , Miri S. Park , Yeonjung Lim , Ilnam Kang , Jang-Cheon Cho; J. Microbiol. 2023;61(5):495-510. Published online May 23, 2023; DOI: https://doi.org/10.1007/s12275-023-00054-4

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Abstract

Eleven bacterial strains were isolated from freshwater environments and identified as Flavobacterium based on 16S rRNA gene sequence analyses. Complete genome sequences of the 11 strains ranged from 3.45 to 5.83 Mb with G + C contents of 33.41–37.31%. The average nucleotide identity (ANI) values showed that strains IMCC34515T and IMCC34518 belonged to the same species, while the other nine strains represented each separate species. The ANI values between the strains and their closest Flavobacterium species exhibited ≤ 91.76%, indicating they represent each novel species. All strains had similar characteristics such as being Gram-stain-negative, rod-shaped, and contained iso-C15:0 as the predominant fatty acid, menaquinone-6 as the respiratory quinone, and phosphatidylethanolamine and aminolipids as major polar lipids. Genomic, phylogenetic, and phenotypic characterization confirmed that the 11 strains were distinct from previously recognized Flavobacterium species. Therefore, Flavobacterium praedii sp. nov. (IMCC34515T = KACC 22282T = NBRC 114937T), Flavobacterium marginilacus sp. nov. (IMCC34673T = KACC 22284T = NBRC 114940T), Flavobacterium aestivum sp. nov. (IMCC34774T = KACC 22285T = NBRC 114941T), Flavobacterium flavigenum sp. nov. (IMCC34775T = KACC22286T = NBRC 114942T), Flavobacterium luteolum sp. nov. (IMCC34776T = KACC 22287T = NBRC 114943T), Flavobacterium gelatinilyticum sp. nov. (IMCC34777T = KACC 22288T = NBRC 114944T), Flavobacterium aquiphilum sp.nov. (IMCC34779T = KACC 22289T = NBRC 114945T), Flavobacterium limnophilum sp. nov. (IMCC36791T = KACC22290T = NBRC 114947T), Flavobacterium lacustre sp. nov. (IMCC36792T = KACC 22291T = NBRC 114948T), and Flavobacterium eburneipallidum sp. nov. (IMCC36793T = KACC 22292T = NBRC 114949T) are proposed as novel species.

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Comprehensive genome analysis of five novel flavobacteria: Flavobacterium piscisymbiosum sp. nov., Flavobacterium pisciphilum sp. nov., Flavobacterium flavipigmentatum sp. nov., Flavobacterium lipolyticum sp. nov. and Flavobacterium cupriresistens sp. nov
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CXCL12/CXCR4 Axis is Involved in the Recruitment of NK Cells by HMGB1 Contributing to Persistent Airway Inflammation and AHR During the Late Stage of RSV Infection: Sisi Chen , Wei Tang , Guangyuan Yu , Zhengzhen Tang , Enmei Liu; J. Microbiol. 2023;61(4):461-469. Published online February 13, 2023; DOI: https://doi.org/10.1007/s12275-023-00018-8

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Abstract

We previously showed that both high-mobility group box-1 (HMGB1) and natural killer (NK) cells contribute to respiratory syncytial virus (RSV)-induced persistent airway inflammation and airway hyperresponsiveness (AHR). Meanwhile, Chemokine (C-X-C motif) ligand 12 (CXCL12) and its specific receptor (chemokine receptor 4, CXCR4) play important roles in recruitment of immune cells. CXCL12 has been reported to form a complex with HMGB1 that binds to CXCR4 and increases inflammatory cell migration. The relationship between HMGB1, NK cells and chemokines in RSV-infected model remains unclear. An anti-HMGB1 neutralizing antibody and inhibitor of CXCR4 (AMD3100) was administered to observe changes of NK cells and airway disorders in nude mice and BALB/c mice. Results showed that the mRNA expression and protein levels of HMGB1 were elevated in late stage of RSV infection and persistent airway inflammation and AHR were diminished after administration of anti-HMGB1 antibodies, with an associated significant decrease in CXCR4+ NK cells. In addition, CXCL12 and CXCR4 were reduced after HMGB1 blockade. Treatment with AMD3100 significantly suppressed the recruitment of NK cells and alleviated the airway disorders. Thus, CXCL12/CXCR4 axis is involved in the recruitment of NK cells by HMGB1, contributing to persistent airway inflammation and AHR during the late stage of RSV infection.

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Review

Metabolic Interaction Between Host and the Gut Microbiota During High‑Fat Diet‑Induced Colorectal Cancer: Chaeeun Lee, Seungrin Lee, Woongjae Yoo; J. Microbiol. 2024;62(3):153-165. Published online April 16, 2024; DOI: https://doi.org/10.1007/s12275-024-00123-2

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Abstract

Colorectal cancer (CRC) is the second-highest cause of cancer-associated mortality among both men and women worldwide. One of the risk factors for CRC is obesity, which is correlated with a high-fat diet prevalent in Western dietary habits. The association between an obesogenic high-fat diet and CRC has been established for several decades; however, the mechanisms by which a high-fat diet increases the risk of CRC remain unclear. Recent studies indicate that gut microbiota strongly infuence the pathogenesis of both high-fat diet-induced obesity and CRC. The gut microbiota is composed of hundreds of bacterial species, some of which are implicated in CRC. In particular, the expansion of facultative anaerobic Enterobacteriaceae, which is considered a microbial signature of intestinal microbiota functional imbalance (dysbiosis), is associated with both high-fat diet-induced obesity and CRC. Here, we review the interaction between the gut microbiome and its metabolic byproducts in the context of colorectal cancer (CRC) during high-fat diet-induced obesity. In addition, we will cover how a high-fat diet can drive the expansion of genotoxin-producing Escherichia coli by altering intestinal epithelial cell metabolism during gut infammation conditions.

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