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Most-cited are based on citations from 2024 ~ 2025.
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- Understanding the Diversity and Roles of the Ruminal Microbiome
- Gi Beom Keum, Sriniwas Pandey, Eun Sol Kim, Hyunok Doo, Jinok Kwak, Sumin Ryu, Yejin Choi, Juyoun Kang, Sheena Kim, Hyeun Bum Kim
- J. Microbiol. 2024;62(3):217-230. Published online April 25, 2024
- DOI: https://doi.org/10.1007/s12275-024-00121-4
- 904 View
- 58 Download
- 30 Web of Science
- 31 Crossref
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Abstract
PDF - The importance of ruminal microbiota in ruminants is emphasized, not only as a special symbiotic relationship with ruminants but also as an interactive and dynamic ecosystem established by the metabolites of various rumen microorganisms. Rumen microbial community is essential for life maintenance and production as they help decompose and utilize fber that is difcult to digest, supplying about 70% of the energy needed by the host and 60–85% of the amino acids that reach the small intestine. Bacteria are the most abundant in the rumen, but protozoa, which are relatively large, account for 40–50% of the total microorganisms. However, the composition of these ruminal microbiota is not conserved or constant throughout life and is greatly infuenced by the host. It is known that the initial colonization of calves immediately after birth is mainly infuenced by the mother, and later changes depending on various factors such as diet, age, gender and breed. The initial rumen microbial community contains aerobic and facultative anaerobic bacteria due to the presence of oxygen, but as age increases, a hypoxic environment is created inside the rumen, and anaerobic bacteria become dominant in the rumen microbial community. As calves grow, taxonomic diversity increases, especially as they begin to consume solid food. Understanding the factors afecting the rumen microbial community and their efects and changes can lead to the early development and stabilization of the microbial community through the control of rumen microorganisms, and is expected to ultimately help improve host productivity and efciency.
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Citations
Citations to this article as recorded by
- The microbiome’s influence on obesity: mechanisms and therapeutic potential
Dawit Adisu Tadese, James Mwangi, Lei Luo, Hao Zhang, Xiaoshan Huang, Brenda B. Michira, Shengwen Zhou, Peter Muiruri Kamau, Qiumin Lu, Ren Lai
Science China Life Sciences.2025; 68(3): 657. CrossRef - Mitigating enteric methane emissions: An overview of methanogenesis, inhibitors and future prospects
Xin Xie, Yurong Cao, Qiushuang Li, Qi Li, Xingze Yang, Rong Wang, Xiumin Zhang, Zhiliang Tan, Bo Lin, Min Wang
Animal Nutrition.2025; 21: 84. CrossRef - International Symposium on Ruminant Physiology: Stochastic and deterministic factors that shape the rumen microbiome
Samodha C. Fernando, Seidu Adams, Andrew Lakamp, Matthew L. Spangler
Journal of Dairy Science.2025; 108(7): 7576. CrossRef - Genome analysis of Lactococcus taiwanensis strain
K_LL001 with potential cellulose degrading functions
Eun Sol Kim, Jin Ho Cho, Minho Song, Sheena Kim, Gi Beom Keum, Hyunok Doo, Jinok Kwak, Sriniwas Pandey, Sumin Ryu, Yejin Choi, Juyoun Kang, Hyeun Bum Kim, Ju-Hoon Lee
Journal of Animal Science and Technology.2025; 67(1): 273. CrossRef - Dynamic Changes in Rumen Microbial Diversity and Community Composition Within Rumen Fluid in Response to Various Storage Temperatures and Preservation Times
Chang Liu, Jin Cheng, Yunong Xie, Kehui Ouyang, Mingren Qu, Ke Pan, Qinghua Qiu
Veterinary Sciences.2025; 12(3): 234. CrossRef - Integrated multi-omics to elucidate the interplay between rumen microorganisms and host metabolism in Hu sheep supplemented with herbal preparations
Chunhui Wang, Qiao Li, Xingcai Qi, Huihui Wang, Yi Wu, Keyan Ma, Juanjuan Song, Zilong Liu, Youji Ma, Garret Suen
mSphere.2025;[Epub] CrossRef - Investigation on the action mechanisms of taurine on rumen microbial crude protein synthesis and nitrogen metabolism in beef steers using sodium sulfate as a contrast
Manman Fan, Jinming Hu, Cheng Liu, Shuo Zhang, Yufeng Liu, Guangyong Zhao
Animal Nutrition.2025; 22: 1. CrossRef - Sex-specific microbiota associations with backfat thickness, eye muscle area, and rumen fermentation in Qinchuan cattle
Yueting Pan, Gege Sun, Guo Li, Shuaicheng Chen, Haibing Liu, Huaxuan Li, Chugang Mei, Wucai Yang, Linsen Zan
BMC Microbiology.2025;[Epub] CrossRef - Growth performance, meat quality, rumen morphometrics and microbiota of finishing bulls fed diets supplemented with oregano essential oils
Stella Dokou, Ilias Giannenas, Ioanna Stylianaki, Eleftherios Bonos, Vangelis Economou, Georgios Arsenos
Animal Feed Science and Technology.2025; 327: 116405. CrossRef - Evaluation of kefir consumption on gut microbial diversity in a healthy young population using full-length 16S rRNA sequencing
Yejin Choi, Gi Beom Keum, Juyoun Kang, Hyunok Doo, Jinok Kwak, Haram Kim, Yeongjae Chae, Suyoung Lee, Hyunjin Yang, Sheena Kim, Xingmin Sun, Hyeun Bum Kim, Soo Jin Yoo
Frontiers in Microbiology.2025;[Epub] CrossRef - The interaction between rumen microbiota and neurotransmitters plays an important role in the adaptation of phenological changes in Tibetan sheep
Wei Huang, Yuzhu Sha, Qianling Chen, Xiaowei Chen, Min Gao, Xiu Liu, Yapeng He, Xu Gao, Jiang Hu, Jiqing Wang, Shaobin Li, Zhiyun Hao, Yanyu He
BMC Veterinary Research.2025;[Epub] CrossRef - Effects of Grazing in a Low Deciduous Forest on Rumen Microbiota and Volatile Fatty Acid Production in Lambs
Raúl Ávila-Cervantes, Pedro González-Pech, Carlos Sandoval-Castro, Felipe Torres-Acosta, José Ramos-Zapata, Mónica Galicia-Jiménez, Ramón Pacheco-Arjona
Animals.2025; 15(11): 1565. CrossRef - Metagenomic sequencing reveals the taxonomic and functional characteristics of rumen microorganisms in Dongliu buffalo
Wenwen Lu, Jinling Hua, Min Zhang, Longfei Yan, Huwei Zhao, Xiaokang Lv
Scientific Reports.2025;[Epub] CrossRef - The Effect of Sodium Humate on Sheep In Vitro Fermentation Characteristics and Rumen Bacterial Community
Na Yin, Yuchao Hu, Xiangting Cai, Long Gao, Wenwen Wang, Yuan Wang, Jingwei Qi
Microorganisms.2025; 13(6): 1266. CrossRef - A refined comparative mouse model of acute and chronic atopic dermatitis
Jinok Kwak, Hyunok Doo, Eun Sol Kim, Gi Beom Keum, Sumin Ryu, Yejin Choi, Juyoun Kang, Haram Kim, Yeongjae Chae, Sheena Kim, Ju-Hoon Lee, Hyeun Bum Kim
Journal of Animal Science and Technology.2025; 67(3): 636. CrossRef - Effect of Diet and Lifestyle Changes on Gut Microbial Diversity in Healthy Adolescents
Juyoun Kang, Yejin Choi, Gi Beom Keum, Hyunok Doo, Jinok Kwak, Haram Kim, Yeongjae Chae, Suyoung Lee, Hyunjin Yang, Sheena Kim, Xingmin Sun, Hyeun Bum Kim, Soo Jin Yoo
Journal of Microbiology and Biotechnology.2025;[Epub] CrossRef - Understanding the diversity and roles of the canine gut microbiome
Haram Kim, Yeongjae Chae, Jin Ho Cho, Minho Song, Jinok Kwak, Hyunok Doo, Yejin Choi, Juyoun Kang, Hyunjin Yang, Suyoung Lee, Gi Beom Keum, Suphot Wattanaphansak, Sheena Kim, Hyeun Bum Kim
Journal of Animal Science and Biotechnology.2025;[Epub] CrossRef - The ins and outs of integrative digestive biology
Carol Bucking, John S. Terblanche, Matthew D. Regan
Journal of Experimental Biology.2025;[Epub] CrossRef - Analysis of the Microbiota of Milk from Holstein–Friesian Dairy Cows Fed a Microbial Supplement
Bronwyn E. Campbell, Mohammad Mahmudul Hassan, Timothy Olchowy, Shahab Ranjbar, Martin Soust, Orlando Ramirez-Garzon, Rafat Al Jassim, Robert J. Moore, John I. Alawneh
Animals.2025; 15(14): 2124. CrossRef - Complete genome sequence of Lactiplantibacillus
plantarum strain GA_C_14 with potential characteristics applicable
in the swine industry
Sumin Ryu, Hyunok Doo, Eun Sol Kim, Gi Beom Keum, Jinok Kwak, Sriniwas Pandey, Yejin Choi, Juyoun Kang, Sheena Kim, Hyeun Bum Kim, Ju-Hoon Lee
Journal of Animal Science and Technology.2025; 67(4): 944. CrossRef - Heated drinking water in winter improves growth performance of male Hu sheep by modulating rumen quorum sensing and metabolites, and enhancing serum antioxidant capacity
Chang Liu, Lingyan Li, Jiaqi Dai, Mingren Qu, Kehui Ouyang, Qinghua Qiu
Animal Bioscience.2025; 38(10): 2280. CrossRef - Artificial Intelligence in Microbiome Research and Beyond: Connecting Human Health, Animal Husbandry, and Aquaculture
Silvio Rizzi, Giulio Saroglia, Violeta Kalemi, Simona Rimoldi, Genciana Terova
Applied Sciences.2025; 15(17): 9781. CrossRef - Bovine Lymphocyte Intestinal Retention Defect (BLIRD): a novel recessive immunogenetic disorder in Holstein cattle
Lucie Dutheil, Blandine Gausseres, Florian Besnard, Laurence Guzylack-Piriou, Yanad Abou Monsef, Nicolas Gaide, Lisa Arnalot, Fabien Corbiere, Marie Gaborit, Frédéric Launay, Agnès Poujade, Aurélien Capitan, Gilles Foucras
Veterinary Quarterly.2025;[Epub] CrossRef - Self-reported hopefulness and cognitive function: the moderating effect of physical activity in older adults without cognitive impairment
Boung Chul Lee, Young Min Choe, Ji-Hyun Kim, Hye Ji Choi, Guk-Hee Suh, Shin Gyeom Kim, Hyun Soo Kim, Jaeuk Hwang, Dahyun Yi, Jee Wook Kim
Frontiers in Aging Neuroscience.2025;[Epub] CrossRef - Effects of Oregano Essential Oil and/or Yeast Cultures on the Rumen Microbiota of Crossbred Simmental Calves
Ting Liu, Zhihao Luo, Tao Zhang, Huan Chen, Xuejiao Yi, Jiang Hu, Bingang Shi, Yuxi An, Changze Cui, Xiangyan Wang
Animals.2024; 14(24): 3710. CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef - GnRH Immunocastration in Male Xizang Sheep: Impacts on Rumen Microbiome and Metabolite Profiles for Enhanced Health and Productivity
Xiaoming Zhang, Tianzeng Song, Guiqiong Liu, Jing Wu, Yangzong Zhaxi, Shehr Bano Mustafa, Khuram Shahzad, Xiaoying Chen, Wangsheng Zhao, Xunping Jiang
Animals.2024; 14(20): 2942. CrossRef - Gut Akkermansia muciniphila, Prevotellaceae, and Enterobacteriaceae spp. as Possible Markers in Women-Related Nutritional and Clinical Trials: Familial Mediterranean Fever Disease
Astghik Pepoyan
Women's Health Reports.2024; 5(1): 785. CrossRef - Exploring the Spatial Variation in the Microbiota and Bile Acid Metabolism of the Compound Stomach in Intensively Farmed Yaks
Shichun He, Zaimei Yuan, Sifan Dai, Zibei Wang, Shusheng Zhao, Bin Zhang, Huaming Mao, Dongwang Wu
Microorganisms.2024; 12(10): 1968. CrossRef - Investigation of the impact of multi-strain probiotics containing
Saccharomyces cerevisiae on porcine
production
Sheena Kim, Jinho Cho, Gi Beom Keum, Jinok Kwak, Hyunok Doo, Yejin Choi, Juyoun Kang, Haram Kim, Yeongjae Chae, Eun Sol Kim, Minho Song, Hyeun Bum Kim
Journal of Animal Science and Technology.2024; 66(5): 876. CrossRef - The Effects of Mixed Inoculum Storage Time on In Vitro Rumen Fermentation Characteristics, Microbial Diversity, and Community Composition
Chang Liu, Jing Ge, Jiaqi Dai, Mingren Qu, Kehui Ouyang, Qinghua Qiu
Animals.2024; 15(1): 5. CrossRef
- The microbiome’s influence on obesity: mechanisms and therapeutic potential
- Skin Deep: The Potential of Microbiome Cosmetics
- Ju Hee Han, Hei Sung Kim
- J. Microbiol. 2024;62(3):181-199. Published online April 16, 2024
- DOI: https://doi.org/10.1007/s12275-024-00128-x
- 2,080 View
- 59 Download
- 18 Web of Science
- 21 Crossref
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Abstract
PDF
- The interplay between the skin microbiome and its host is a complex facet of dermatological health and has become a critical focus in the development of microbiome cosmetics. The skin microbiome, comprising various microorganisms, is essential from birth, develops over the lifespan, and performs vital roles in protecting our body against pathogens, training the immune system, and facilitating the breakdown of organic matter. Dysbiosis, an imbalance of these microorganisms, has been implicated in a number of skin conditions such as acne, atopic dermatitis, and skin cancer. Recent scientific findings have spurred cosmetic companies to develop products that preserve and enhance the skin's microbial diversity balance. These products may incorporate elements like prebiotics, probiotics, and postbiotics, which are beneficial for the skin microbiome. Beyond topical products, there's increasing interest in ingestible beauty supplements (i.e. oral probiotics), highlighting the connection between the gut and skin. This review examines the influence of the microbiome on skin health and the emerging trends of microbiome skincare products.
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Citations
Citations to this article as recorded by- Influence of Cosmetic Skincare Products with pH < 5 on the Skin Microbiome: A Randomized Clinical Evaluation
Ciska Janssens-Böcker, Claudia Doberenz, Marta Monteiro, Marta de Oliveira Ferreira
Dermatology and Therapy.2025; 15(1): 141. CrossRef - Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers
Ulya Badilli, Ozge Inal
Polymers.2025; 17(6): 798. CrossRef - Cytoprotective effects of the fermented milk by Streptococcus thermophilus CGMCC 24468 against ROS damage in HaCaT cells
Tingting Zhang, Yan Li, Chunying Yuan, Xiaoce Zhu, Mingyu Wang, Suzhen Yang, Jian Kong
Journal of Functional Foods.2025; 128: 106829. CrossRef - Frontiers in Topical Photoprotection
Margaret Sullivan, Constancio Gonzalez Obezo, Zachary Lipsky, Abhishek Panchal, Jaide Jensen
Cosmetics.2025; 12(3): 96. CrossRef - Skin Lipids and Their Influence on Skin Microbiome and Skin Care
Raquel Allen Garcia Barbeto Siqueira, Iveta Hradkova, Vânia Rodrigues Leite-Silva, Newton Andréo-Filho, Patricia Santos Lopes
ACS Omega.2025; 10(27): 28534. CrossRef - Skin microbiota in atopic dermatitis: victim or executioner?
Chiara Maria Teresa Boggio, Federica Veronese, Marta Armari, Elisa Zavattaro, Elia Esposto, Paola Savoia, Barbara Azzimonti, Christopher Staley, Eman Adel Elmansoury, Yunhua Tu
Clinical Microbiology Reviews.2025;[Epub] CrossRef - Prebiotic Oligosaccharides in Skin Health: Benefits, Mechanisms, and Cosmetic Applications
Meijun Zeng, Yang Li, Jie Cheng, Jingyu Wang, Qiyu Liu
Antioxidants.2025; 14(6): 754. CrossRef - The Transformative Impact of Extracellular Vesicles on the Cosmetics Industry: A Comprehensive Review
Valéria Dal Col, Fábio Fernandes Ribas, Rodrigo Pinheiro Araldi
Cosmetics.2025; 12(5): 191. CrossRef - Hydroponic cultivation technique in Populus nigra (L.) for the sustainable production of root metabolites with antimicrobial and prebiotic potential for skin microbiota
Sonia Malik, Maria Michela Salvatore, Laura Bauchet, Margot Bruat, Benoît Roubinet, Sabine Carpin, Anna Andolfi, Alessio Cimmino, Ludovic Landemarre, Marco Masi, Frédéric Lamblin
Industrial Crops and Products.2025; 235: 121717. CrossRef - Efficacy and Safety of a Novel Anhydrous 0.1% Retinal-Based Concentrate with Hydrophilic Actives for Photoaged Skin: A Six-Week Prospective Study
Ulf Åkerström, Chloé Gaudicheau, Blandine Locret, Johanna Maria Gillbro
Cosmetics.2025; 12(6): 235. CrossRef - Selective Regulatory Effects of Lactobacillus Plantarum Fermented Milk: Enhancing the Growth of Staphylococcus Epidermidis and Inhibiting Staphylococcus aureus and Escherichia coli
Yajuan Sun, Ying Wang, Zixia Ren, Shasha Wang, Yun Ding, Nan Liu, Cheng Yang, Bingtian Zhao
Cosmetics.2025; 12(5): 232. CrossRef - Case Study on Shifts in Human Skin Microbiome During Antarctica Expeditions
Kyu-Chan Lee, Hanbyul Lee, Ok-Sun Kim, Woo Jun Sul, Hyeonah Lee, Hye-Jin Kim
Microorganisms.2025; 13(11): 2491. CrossRef - The Skin Microbiome and Bioactive Compounds: Mechanisms of Modulation, Dysbiosis, and Dermatological Implications
Katarzyna Wojciechowska, Katarzyna Dos Santos Szewczyk
Molecules.2025; 30(22): 4363. CrossRef - Efficacy of the Combination Therapy of Intense Pulsed Light and Microneedling With a Postbiotic Formulation for Melasma
Zhanhong Li, Yiyuan Xiang, Juan Meng, Huiying Wang, Hao Wu, Ting Li, Xiaoling Jiang, Tao Wu, Yan Zhang, Xuehua Xiao, Xiufen Ma, Mei Yang, Han Zhu, Yan Bi, Yurong Chen, Hong Lei, Jing Hu, Guiyun Huang, Lin Cong, Jing Wang, Lei Yan, Han Zhou, Chunqing Li, X
Journal of Cosmetic Dermatology.2025;[Epub] CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef - Skin Microbiome and Acne: Microbial Imbalances and Impact – Interview with Three Key Opinion Leaders
Brigitte Scott
EMJ Dermatology.2024; : 83. CrossRef - Cosmeceuticals: A Review of Clinical Studies Claiming to Contain Specific, Well-Characterized Strains of Probiotics or Postbiotics
Ioannis M. Theodorou, Dorothea Kapoukranidou, Markos Theodorou, Joulia K. Tsetis, Alexandra Eleftheria Menni, Georgios Tzikos, Stella Bareka, Anne Shrewsbury, George Stavrou, Katerina Kotzampassi
Nutrients.2024; 16(15): 2526. CrossRef - Effect of Staphylococcus aureus colonization and immune defects on the pathogenesis of atopic dermatitis
Evrim Özdemіr, Lütfiye Öksüz
Archives of Microbiology.2024;[Epub] CrossRef - A New Generation of Postbiotics for Skin and Scalp: In Situ Production of Lipid Metabolites by Malassezia
Martin Patrick Pagac, Mathias Gempeler, Remo Campiche
Microorganisms.2024; 12(8): 1711. CrossRef - Antimelanogenic and Antioxidant Effects of Postbioics of Lactobacillus Strains in α-MSH-Induced B16F10 Melanoma Cells via CREB/MITF and MAPKs Signaling Pathway
Hye-Won Lee, Yu-Rim Lee, Kyung-Min Park, Na-Kyoung Lee, Hyun-Dong Paik
Journal of Microbiology and Biotechnology.2024; 34(11): 2279. CrossRef - Evaluation of the Effects of Age, Sex, and Dexpanthenol-Containing Skin Care on the Facial and Body Skin Microbiome
Zainab Qaizar, Raffaella de Salvo, Gregor Bieri, Katrin Unbereit, Shannon Montgomery, Erwan Peltier
Cosmetics.2024; 11(6): 213. CrossRef
- Influence of Cosmetic Skincare Products with pH < 5 on the Skin Microbiome: A Randomized Clinical Evaluation
- Balancing Act of the Intestinal Antimicrobial Proteins on Gut Microbiota and Health
- Ye Eun Ra, Ye‑Ji Bang
- J. Microbiol. 2024;62(3):167-179. Published online April 17, 2024
- DOI: https://doi.org/10.1007/s12275-024-00122-3
- 585 View
- 15 Download
- 14 Web of Science
- 16 Crossref
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Abstract
PDF
- The human gut houses a diverse and dynamic microbiome critical for digestion, metabolism, and immune development, exerting profound efects on human health. However, these microorganisms pose a potential threat by breaching the gut barrier, entering host tissues, and triggering infections, uncontrolled infammation, and even sepsis. The intestinal epithelial cells form the primary defense, acting as a frontline barrier against microbial invasion. Antimicrobial proteins (AMPs), produced by these cells, serve as innate immune efectors that regulate the gut microbiome by directly killing or inhibiting microbes. Abnormal AMP production, whether insufcient or excessive, can disturb the microbiome equilibrium, contributing to various intestinal diseases. This review delves into the complex interactions between AMPs and the gut microbiota and sheds light on the role of AMPs in governing host-microbiota interactions. We discuss the function and mechanisms of action of AMPs, their regulation by the gut microbiota, microbial evasion strategies, and the consequences of AMP dysregulation in disease. Understanding these complex interactions between AMPs and the gut microbiota is crucial for developing strategies to enhance immune responses and combat infections within the gut microbiota. Ongoing research continues to uncover novel aspects of this intricate relationship, deepening our understanding of the factors shaping gut health. This knowledge has the potential to revolutionize therapeutic interventions, ofering enhanced treatments for a wide range of gut-related diseases.
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Citations
Citations to this article as recorded by- Host-directed therapies modulating innate immunity against infection in hematologic malignancies
Qiong Wang, Kristján Hermannsson, Egill Másson, Peter Bergman, Guðmundur Hrafn Guðmundsson
Blood Reviews.2025; 70: 101255. CrossRef - Progress in the Identification and Design of Novel Antimicrobial Peptides Against Pathogenic Microorganisms
Shengwei Sun
Probiotics and Antimicrobial Proteins.2025; 17(2): 918. CrossRef - Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience
Henriette Arnesen, Signe Birkeland, Harriet Stendahl, Klaus Neuhaus, David Masopust, Preben Boysen, Harald Carlsen
Discovery Immunology.2025;[Epub] CrossRef - Oral administration of LEAP2 enhances immunity against Edwardsiella tarda through regulation of gut bacterial community and metabolite in mudskipper
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Fish & Shellfish Immunology.2025; 158: 110128. CrossRef - Pharmacology of Intestinal Inflammation and Repair
Céline Deraison, Nathalie Vergnolle
Annual Review of Pharmacology and Toxicology .2025; 65(1): 301. CrossRef - Microbiome dysbiosis in SARS-CoV-2 infection: implication for pathophysiology and management strategies of COVID-19
Shukur Wasman Smail, Niaz Albarzinji, Rebaz Hamza Salih, Kalthum Othman Taha, Sarah Mousa Hirmiz, Hero M. Ismael, Marwa Fateh Noori, Sarkar Sardar Azeez, Christer Janson
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Veterinary Sciences.2025; 12(11): 1100. CrossRef - Macrophages and Gut Barrier Function: Guardians of Gastrointestinal Health in Post-Inflammatory and Post-Infection Responses
Edward Xiangtai Meng, George Nicholas Verne, Qiqi Zhou
International Journal of Molecular Sciences.2024; 25(17): 9422. CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef - Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease
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Biomedicines.2024; 13(1): 74. CrossRef
- Host-directed therapies modulating innate immunity against infection in hematologic malignancies
- Biological and Chemical Approaches for Controlling Harmful Microcystis Blooms
- Wonjae Kim, Yerim Park, Jaejoon Jung, Che Ok Jeon, Masanori Toyofuku, Jiyoung Lee, Woojun Park
- J. Microbiol. 2024;62(3):249-260. Published online April 8, 2024
- DOI: https://doi.org/10.1007/s12275-024-00115-2
- 712 View
- 22 Download
- 14 Web of Science
- 14 Crossref
-
Abstract
PDF
- The proliferation of harmful cyanobacterial blooms dominated by Microcystis aeruginosa has become an increasingly serious problem in freshwater ecosystems due to climate change and eutrophication. Microcystis-blooms in freshwater generate compounds with unpleasant odors, reduce the levels of dissolved O2, and excrete microcystins into aquatic ecosystems, potentially harming various organisms, including humans. Various chemical and biological approaches have thus been developed to mitigate the impact of the blooms, though issues such as secondary pollution and high economic costs have not been adequately addressed. Red clays and H2O2 are conventional treatment methods that have been employed worldwide for the mitigation of the blooms, while novel approaches, such as the use of plant or microbial metabolites and antagonistic bacteria, have also recently been proposed. Many of these methods rely on the generation of reactive oxygen species, the inhibition of photosynthesis, and/or the disruption of cellular membranes as their mechanisms of action, which may also negatively impact other freshwater microbiota. Nevertheless, the underlying molecular mechanisms of anticyanobacterial chemicals and antagonistic bacteria remain unclear. This review thus discusses both conventional and innovative approaches for the management of M. aeruginosa in freshwater bodies.
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Citations
Citations to this article as recorded by- Rapid and selective disruption of photosystem I in toxic cyanobacteria protects aquatic ecosystem health
Wonjae Kim, Yerim Park, Yongjun Son, Nayeon Yoo, Eui-Hwan Chung, Woojun Park
Journal of Hazardous Materials.2026; 501: 140736. CrossRef - Strong inhibitory effects of Desmodesmus sp. on Microcystis blooms: Potential as a biological control agent in aquaculture
Bo Yang, Yuhua Li, Zihan Wang, Zhiguang Yue, Junqi Wen, Xueqin Zhao, Hu Zhang, Xianfeng Wang, Xiufen Wang, Man Zhang
Aquaculture Reports.2025; 40: 102579. CrossRef - Field-scale artificial floating islands reduces cyanotoxin from residential raw sewage treatment basin
Zhaozhe Chen, Jiyoung Lee, Molly Mills, Abigail Volk, Ozeas S. Costa
Ecological Engineering.2025; 212: 107543. CrossRef - HABS-BLOCKS© Inhibited Microcystis and Planktothrix and Reduced Microcystin Concentrations in a Lake Water Mesocosm Study
Cameron Gastaldo, Stephen Vesper
Microorganisms.2025; 13(5): 1074. CrossRef - Synergistic radical-mediated algal inactivation via FeMoS2/ZnO-persulfate visible-light photocatalysis
Yingjian Ma, Yuxuan Tian, Ning Ding, Hong Liu
Composites Part B: Engineering.2025; 305: 112740. CrossRef - Isolation of a Novel Streptomyces sp. TH05 with Potent Cyanocidal Effects on Microcystis aeruginosa
Xuhan Wang, Siqi Zhu, Shenchen Tao, Shaoyong Zhang, Ruijun Wang, Liqin Zhang
Toxins.2025; 17(7): 354. CrossRef - Public goods-mediated bacterial interplay in aquatic ecosystems
Yerim Park, Wonjae Kim, Jihye Bae, Woojun Park
Water Research.2025; 287: 124310. CrossRef - Molecular mechanisms underlying the bloom-forming cyanobacterium Microcystis defence against predation by flagellates
Yan Chen, Xiao Zhang, Xinyang Bai, Yonglan Xu, Hangzhou Xu, Li Li
Journal of Water Process Engineering.2025; 77: 108611. CrossRef - Utilizing allelopathy from the invasive plant Solidago canadensis to control Microcystis aeruginosa blooms: An integrated metabolomic and bioassay approach
Miao Wu, Huiyuan Liu, Jiaxin Shen, Zhaohui Xie, Siyuan Yang, Jiahui Guo, Yijiang Liu, Huiting Lian, Dingli Wang
Journal of Hazardous Materials.2025; 499: 140043. CrossRef - Artificial Intelligence-Based Microfluidic Platform for Detecting Contaminants in Water: A Review
Yihao Zhang, Jiaxuan Li, Yu Zhou, Xu Zhang, Xianhua Liu
Sensors.2024; 24(13): 4350. CrossRef - Alleviation of H2O2 toxicity by extracellular catalases in the phycosphere of Microcystis aeruginosa
Yerim Park, Wonjae Kim, Yeji Cha, Minkyung Kim, Woojun Park
Harmful Algae.2024; 137: 102680. CrossRef - Extensive Genomic Rearrangement of Catalase-Less Cyanobloom-Forming Microcystis aeruginosa in Freshwater Ecosystems
Minkyung Kim, Jaejoon Jung, Wonjae Kim, Yerim Park, Che Ok Jeon, Woojun Park
Journal of Microbiology.2024; 62(11): 933. CrossRef - Laboratory-Simulated Inhibitory Effects of the Floating-Bed Plants on Microcystis aeruginosa and Their Microbial Communities’ Responses to Microcystins
Shuwen Zhang, Yuanpu Sha, Yuanyuan Tang, Longjie Li, Feihu Wang, Jing Dong, Xuejun Li, Yunni Gao, Xiaofei Gao, Huatao Yuan, Jingxiao Zhang
Microorganisms.2024; 12(10): 2035. CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
- Rapid and selective disruption of photosystem I in toxic cyanobacteria protects aquatic ecosystem health
- Progress and challenges in CRISPR/Cas applications in microalgae
- Quynh-Giao Tran, Trang Thi Le, Dong-Yun Choi, Dae-Hyun Cho, Jin-Ho Yun, Hong Il Choi, Hee-Sik Kim, Yong Jae Lee
- J. Microbiol. 2025;63(3):e2501028. Published online March 28, 2025
- DOI: https://doi.org/10.71150/jm.2501028
- 3,410 View
- 171 Download
- 7 Web of Science
- 13 Crossref
-
Abstract
PDF
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Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technologies have emerged as powerful tools for precise genome editing, leading to a revolution in genetic research and biotechnology across diverse organisms including microalgae. Since the 1950s, microalgal production has evolved from initial cultivation under controlled conditions to advanced metabolic engineering to meet industrial demands. However, effective genetic modification in microalgae has faced significant challenges, including issues with transformation efficiency, limited target selection, and genetic differences between species, as interspecies genetic variation limits the use of genetic tools from one species to another. This review summarized recent advancements in CRISPR systems applied to microalgae, with a focus on improving gene editing precision and efficiency, while addressing organism-specific challenges. We also discuss notable successes in utilizing the class 2 CRISPR-associated (Cas) proteins, including Cas9 and Cas12a, as well as emerging CRISPR-based approaches tailored to overcome microalgal cellular barriers. Additionally, we propose future perspectives for utilizing CRISPR/Cas strategies in microalgal biotechnology.
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Citations
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Ling Wang, Mingjing Zhang, Jialin Wang, Chen Hu, Zhanyou Chi, Lei Li, Wenjun Luo, Chengze Li, Chenba Zhu
Algal Research.2026; 93: 104455. CrossRef - Advancing microbial engineering through synthetic biology
Ki Jun Jeong
Journal of Microbiology.2025; 63(3): e2503100. CrossRef - Progress and prospects in metabolic engineering approaches for isoprenoid biosynthesis in microalgae
Sonia Mohamadnia, Borja Valverde-Pérez, Omid Tavakoli, Irini Angelidaki
Biotechnology for Biofuels and Bioproducts.2025;[Epub] CrossRef - Beyond Biomass: Reimagining Microalgae as Living Environmental Nano-Factories
Thinesh Selvaratnam, Shaseevarajan Sivanantharajah, Kirusha Sriram
Environments.2025; 12(7): 221. CrossRef - Harnessing MicroRNAs and CRISPR to enhance biofuel production in microalgae
Dariga K. Kirbayeva, Altynay Y. Shayakhmetova, Bekzhan D. Kossalbayev, Assemgul K. Sadvakasova, Meruyert O. Bauenova
International Journal of Hydrogen Energy.2025; 157: 150399. CrossRef - Beyond Cutting: CRISPR-Driven Synthetic Biology Toolkit for Next-Generation Microalgal Metabolic Engineering
Limin Yang, Qian Lu
International Journal of Molecular Sciences.2025; 26(15): 7470. CrossRef - Mechanistic Role of Heavy Metals in Driving Antimicrobial Resistance: From Rhizosphere to Phyllosphere
Rahul Kumar, Tanja P. Vasić, Sanja P. Živković, Periyasamy Panneerselvam, Gustavo Santoyo, Sergio de los Santos Villalobos, Adeyemi Nurudeen Olatunbosun, Aditi Pandit, Leonard Koolman, Debasis Mitra, Pankaj Gautam
Applied Microbiology.2025; 5(3): 79. CrossRef - Strain Improvement Through Genetic Engineering and Synthetic Biology for the Creation of Microalgae with Enhanced Lipid Accumulation, Stress Tolerance, and Production of High-value
Alebachew Molla, Gedif Meseret
Science Frontiers.2025; 6(3): 80. CrossRef - The Role of Molecular Tools in Microalgal Strain Improvement: Current Status and Future Perspectives
Alebachew Molla, Gedif Meseret
Advances in Bioscience and Bioengineering.2025; 13(3): 51. CrossRef - CRISPR-Cas9 genome editing in microalgae for improved high-value products (HVP) production
Fazleen Haslinda Mohd Hatta, Nurin Nisa’ Ahmad Zamri, Norazlina Ahmad
Asia Pacific Journal of Molecular Biology and Biotechnology.2025; : 245. CrossRef - Advances in Algae-Based Bioplastics: From Strain Engineering and Fermentation to Commercialization and Sustainability
Nilay Kumar Sarker, Prasad Kaparaju
Fermentation.2025; 11(10): 574. CrossRef - Exploring the nutritional and bioactive potential of microalgal sulfated polysaccharides for functional food applications
Fajar Sofyantoro, Eka Sunarwidhi Prasedya, Fahrul Nurkolis, Andri Frediansyah
Food Science and Biotechnology.2025;[Epub] CrossRef - Harnessing microalgae for bioproducts: innovations in synthetic biology
Zheng Li, Yuhui Cheng, Chengcheng Li, Qianyi Wu, Yi Xin
World Journal of Microbiology and Biotechnology.2025;[Epub] CrossRef
- Active and targeted micro/nanoplastics remediation via engineered microalgae co-displaying polymer-binding peptides and plastic-degrading enzymes: A critical review and perspectives
- MAPK Cascades in Plant Microbiota Structure and Functioning
- Thijs Van Gerrewey, Hoo Sun Chung
- J. Microbiol. 2024;62(3):231-248. Published online April 8, 2024
- DOI: https://doi.org/10.1007/s12275-024-00114-3
- 589 View
- 7 Download
- 14 Web of Science
- 12 Crossref
-
Abstract
PDF
- Mitogen-activated protein kinase (MAPK) cascades are highly conserved signaling modules that coordinate diverse biological processes such as plant innate immunity and development. Recently, MAPK cascades have emerged as pivotal regulators of the plant holobiont, infuencing the assembly of normal plant microbiota, essential for maintaining optimal plant growth and health. In this review, we provide an overview of current knowledge on MAPK cascades, from upstream perception of microbial stimuli to downstream host responses. Synthesizing recent fndings, we explore the intricate connections between MAPK signaling and the assembly and functioning of plant microbiota. Additionally, the role of MAPK activation in orchestrating dynamic changes in root exudation to shape microbiota composition is discussed. Finally, our review concludes by emphasizing the necessity for more sophisticated techniques to accurately decipher the role of MAPK signaling in establishing the plant holobiont relationship.
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Citations
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Evgenios Agathokleous, Edward J. Calabrese, Stavros D. Veresoglou
Trends in Plant Science.2025; 30(5): 515. CrossRef - Lipid transfer protein VAS inhibits the hypersensitive response via reactive oxygen species signaling in Nicotiana benthamiana
Rina Koyama, Akira Suzuki, Kouhei Ohnishi, Yasufumi Hikichi, Akinori Kiba, Stefanie Ranf
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Baoyun Feng, Erxing Wang, Yating Zhang, Lurong Xu, Yanwen Xue, Yunpeng Chen
Microorganisms.2025; 13(3): 506. CrossRef - Genome-wide identification and unveiling the role of MAP kinase cascade genes involved in sugarcane response to abiotic stressors
Ahmad Ali, Xue-Ting Zhao, Ji-Shan Lin, Ting-Ting Zhao, Cui-Lian Feng, Ling Li, Rui-Jie Wu, Qi-Xing Huang, Hong-Bo Liu, Jun-Gang Wang
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Meiqiang Yin, Mengyao An, Yuxin Gao, Jianjun Guo, Chongyue Wang, Yanjie Wen, Mingjing Huang, Juan Zhao, Yinyuan Wen
Environmental and Experimental Botany.2025; 234: 106144. CrossRef - Comparative transcriptomic analysis and genome-wide identification provide insights into the potential role of fungal-responsive MAPK cascade genes in tanshinone accumulation in Salvia miltiorrohiza
Ann Abozeid, Xinru Du, Lan Zhang, Furui Yang, Jianxiong Wu, Lin Zhang, Qi Cui, Zongqi Yang, Dongfeng Yang
Frontiers in Plant Science.2025;[Epub] CrossRef - Characteristics of the MAPK gene family in Zizania latifolia and MAPK3 role in response to fungal pathogen infection
Lijun Xu, Pengfei Guo, Yong Kuang, Ke Su, Keling Hu, Defang Gan
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Jing Shi, Lele Li, Hao Zhou, Jialian Su, Song Bai, Miao Li, Jianta Wang, Lei Tang
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Hassan Etesami, Umarov Otabek, Bafayeva Zahro, To'rayeva Nargiza, Ochilova Muyassar
Physiological and Molecular Plant Pathology.2025; 139: 102841. CrossRef - Pharmacological effects and the related mechanism of scutellarin on inflammation-related diseases: a review
Yang Zhou, Chenlin Gu, Yan Zhu, Yuting Zhu, Yutong Chen, Li Shi, Yang Yang, Xin Lu, Hanqing Pang
Frontiers in Pharmacology.2024;[Epub] CrossRef - Rice E3 ubiquitin ligases: From key modulators of host immunity to potential breeding applications
Yuqing Yan, Hui Wang, Yan Bi, Fengming Song
Plant Communications.2024; 5(12): 101128. CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
- The microbiome orchestrates contaminant low-dose phytostimulation
Journal Articles
- Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model
- Woon-ki Kim , You Jin Jang , SungJun Park , Sung-gyu Min , Heeun Kwon , Min Jung Jo , GwangPyo Ko
- J. Microbiol. 2024;62(2):91-99. Published online February 22, 2024
- DOI: https://doi.org/10.1007/s12275-024-00104-5
- 674 View
- 24 Download
- 13 Web of Science
- 12 Crossref
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Abstract
PDF
- Atopic dermatitis (AD) is a chronic inflammatory skin disease with repeated exacerbations of eczema and pruritus. Probiotics can prevent or treat AD appropriately via modulation of immune responses and gut microbiota. In this study, we evaluated effects of Lactobacillus acidophilus (L. acidophilus) KBL409 using a house dust mite (Dermatophagoides farinae)-induced in vivo AD model. Oral administration of L. acidophilus KBL409 significantly reduced dermatitis scores and decreased infiltration of immune cells in skin tissues. L. acidophilus KBL409 reduced in serum immunoglobulin E and mRNA levels of T helper (Th)1 (Interferon-γ), Th2 (Interleukin [IL]-4, IL-5, IL-13, and IL-31), and Th17 (IL-17A) cytokines in skin tissues. The anti-inflammatory cytokine IL-10 was increased and Foxp3 expression was up-regulated in AD-induced mice with L. acidophilus KBL409. Furthermore, L. acidophilus KBL409 significantly modulated gut microbiota and concentrations of short-chain fatty acids and amino acids, which could explain its effects on AD. Our results suggest that L. acidophilus KBL409 is the potential probiotic for AD treatment by modulating of immune responses and gut microbiota of host.
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Citations
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Sung Jae Jang, Eun Jung Jo, Cheonghoon Lee, Bo-Ram Cho, Yun Jeong Shin, Jun Soo Song, Woon-Ki Kim, Nanhee Lee, Hyungjin Lee, SungJun Park, GwangPyo Ko
Probiotics and Antimicrobial Proteins.2025; 17(6): 4580. CrossRef - The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential
Maira Jimenez-Sanchez, Larissa S. Celiberto, Hyungjun Yang, Ho Pan Sham, Bruce A. Vallance
Gut Microbes.2025;[Epub] CrossRef - Probiotics ameliorate atopic dermatitis by modulating the dysbiosis of the gut microbiota in dogs
Hyokeun Song, Seung-Hyun Mun, Dae-Woong Han, Jung-Hun Kang, Jae-Uk An, Cheol-Yong Hwang, Seongbeom Cho
BMC Microbiology.2025;[Epub] CrossRef - The effect of daily oral probiotic and postbiotic supplementation on the canine skin microbiota: Insights from culture‐dependent and long‐read 16S rRNA gene sequencing methods
Letitia Grant, Manijeh Mohammadi Dehcheshmeh, Esmaeil Ebrahimie, Aliakbar Khabiri, Tania Veltman, Michael Shipstone, Darren J. Trott
Veterinary Dermatology.2025; 36(5): 581. CrossRef - The efficacy of Akkermansia muciniphila YGMCC2602-derived postbiotics in skin repair
Zhili He, Wenfang Song, Shichang Zhang, Minlei Zhao, Fan Wang, Shanshan He, Xiaochi Jie, Qi Gao, Jianguo Chen
Journal of Functional Foods.2025; 131: 106950. CrossRef -
Differential modulation of post-antibiotic colonization resistance to
Clostridioides difficile
by two probiotic
Lactobacillus
strains
Matthew H. Foley, Arthur S. McMillan, Sarah O'Flaherty, Rajani Thanissery, Molly E. Vanhoy, Mary Gracen Fuller, Rodolphe Barrangou, Casey M. Theriot, Jacques Ravel
mBio.2025;[Epub] CrossRef - Innovative microbial strategies in atopic dermatitis
Jingtai Ma, Yiting Fang, Jinxing Hu, Shiqi Li, Lilian Zeng, Siyi Chen, Zhifeng Li, Ruiling Meng, Xingfen Yang, Fenglin Zhang, Guiyuan Ji, Peihua Liao, Liang Chen, Wei Wu
Frontiers in Immunology.2025;[Epub] CrossRef - Nanoencapsulation of Biotics: Feasibility to Enhance Stability and Delivery for Improved Gut Health
Pedro Brivaldo Viana da Silva, Thiécla Katiane Osvaldt Rosales, João Paulo Fabi
Pharmaceutics.2025; 17(9): 1180. CrossRef - Microbiota Modulation as an Approach to Prevent the Use of Antimicrobials Associated with Canine Atopic Dermatitis
Tânia Lagoa, Luís Martins, Maria Cristina Queiroga
Biomedicines.2025; 13(10): 2372. CrossRef - Lactobacillus crispatus KBL693 alleviates atopic dermatitis symptoms through immune modulation
Seokcheon Song, Jun-Hyeong Kim, Sung Jae Jang, Eun Jung Jo, Sang Kyun Lim, GwangPyo Ko
Journal of Microbiology.2025; 63(10): e2509005. CrossRef - Oral Administration of Lactiplantibacillus plantarum KBL396 Regulates Serum 5-Hydroxytryptamine and Gut Microbiota: Evidence from a Preclinical Mouse Model and a Randomized Controlled Human Trial
Woojae Myung, Sung Jae Jang, Giljae Lee, Cheonghoon Lee, Kiuk Lee, Sung Hyun Moon, Yunsun Jeong, Woon-Ki Kim, SungJun Park, Hyungjin Lee, Yun Seong Park, Sangah Shin, Tae-Wook Nam, Hong Jin Jeon, GwangPyo Ko
Probiotics and Antimicrobial Proteins.2025;[Epub] CrossRef - The Skin Histopathology of Pro- and Parabiotics in a Mouse Model of Atopic Dermatitis
Hun Hwan Kim, Se Hyo Jeong, Min Yeong Park, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Jeong Doo Heo, Hyun Wook Kim, Je Kyung Seong, Tae Yang Kim, Jeong Woo Park, Byeong Soo Kim, Gon Sup Kim
Nutrients.2024; 16(17): 2903. CrossRef
- Limosilactobacillus fermentum KBL674 Alleviates Vaginal Candidiasis
- Furan-based Chalcone Annihilates the Multi-Drug-Resistant Pseudomonas aeruginosa and Protects Zebra Fish Against its Infection
- Santosh Pushpa Ramya Ranjan Nayak , Catharine Basty , Seenivasan Boopathi , Loganathan Sumathi Dhivya , Khaloud Mohammed Alarjani , Mohamed Ragab Abdel Gawwad , Raghda Hager , Muthu Kumaradoss Kathiravan , Jesu Arockiaraj
- J. Microbiol. 2024;62(2):75-89. Published online February 21, 2024
- DOI: https://doi.org/10.1007/s12275-024-00103-6
- 626 View
- 9 Download
- 11 Web of Science
- 12 Crossref
-
Abstract
PDF
- The emergence of carbapenem-resistant Pseudomonas aeruginosa, a multi-drug-resistant bacteria, is becoming a serious public health concern. This bacterium infects immunocompromised patients and has a high fatality rate. Both naturally and synthetically produced chalcones are known to have a wide array of biological activities. The antibacterial properties of synthetically produced chalcone were studied against P. aeruginosa. In vitro, study of the compound (chalcone derivative named DKO1), also known as (2E)-1-(5-methylfuran-2-yl)-3-(4-nitrophenyl) prop-2-en-1-one, had substantial antibacterial and biofilm disruptive action. DKO1 effectively shielded against P. aeruginosa-induced inflammation, oxidative stress, lipid peroxidation, and apoptosis in zebrafish larvae. In adult zebrafish, the treatment enhanced the chances of survivability and reduced the sickness-like behaviors. Gene expression, biochemical analysis, and histopathology studies found that proinflammatory cytokines (TNF-α, IL-1β, IL-6, iNOS) were down regulated; antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) levels increased, and histoarchitecture was restored in zebrafish. The data indicate that DKO1 is an effective antibacterial agent against P. aeruginosa demonstrated both in vitro and in vivo.
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Citations
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S. Madesh, Mukil Srivasan, Karthikeyan Ramamurthy, Sanjay Gopi, B. Aswinanand, Santhanam Sanjai Dharshan, Bader O. Almutairi, Ki Choon Choi, Jesu Arockiaraj
Journal of Hazardous Materials.2026; 501: 140692. CrossRef - Chalcone derivative enhance poultry meat preservation through quorum sensing inhibition against Salmonella (Salmonella enterica serovar Typhi) contamination
S.P. Ramya Ranjan Nayak, Pratik Pohokar, Anamika Das, L.S. Dhivya, Mukesh Pasupuleti, Ilavenil Soundharrajan, Bader O. Almutairi, Kathiravan Muthu Kumaradoss, Jesu Arockiaraj
Food Control.2025; 171: 111155. CrossRef - Harnessing Cyclic di-GMP Signaling: A Strategic Approach to Combat Bacterial Biofilm-Associated Chronic Infections
P. Snega Priya, Ramu Meenatchi, Mukesh Pasupuleti, S. Karthick Raja Namasivayam, Jesu Arockiaraj
Current Microbiology.2025;[Epub] CrossRef - Targeted inhibition of PqsR in Pseudomonas aeruginosa PAO1 quorum-sensing network by chalcones as promising antibacterial compounds
Negin Arami, Amineh Sadat Tajani, Maryam Hashemi, Tahoura Rezaei, Razieh Ghodsi, Vahid Soheili, Bibi Sedigheh Fazly Bazzaz
Molecular Biology Reports.2025;[Epub] CrossRef - Exposure to bisphenol A and sodium nitrate found in processed meat induces endocrine disruption and dyslipidemia through PI3K/AKT/SREBP pathway in zebrafish larvae
Santosh Pushpa Ramya Ranjan Nayak, Anamika Das, Karthikeyan Ramamurthy, Mukesh Pasupuleti, Rajakrishnan Rajagopal, Jesu Arockiaraj
The Journal of Nutritional Biochemistry.2025; 140: 109887. CrossRef - Starch films with triethanolamine and chalcone derivative for improved durability and antimicrobial properties in poultry packaging
S.P. Ramya Ranjan Nayak, Pratik Pohokar, L.S. Dhivya, Aveeda Herold, V. Chitra, Mansour K. Gatasheh, Selvaraj Arokiyaraj, Kathiravan Muthu Kumaradoss, Jesu Arockiaraj
International Journal of Biological Macromolecules.2025; 316: 144627. CrossRef - Efficacy of 6-nitrobenzo[d]thiazol-2 Amine Derivative (N3) in Mitigating PTZ-Induced Epileptic Conditions Via Modulation of Inflammatory and Neuroprotective Pathways in-vivo Zebrafish
Karthikeyan Ramamurthy, S. P. Ramya Ranjan Nayak, S. Madesh, Siva Prasad Panda, K. Manikandan, Rajakrishnan Rajagopal, Ahmed Alfarhan, Senthilkumar Palaniappan, Ajay Guru, M. K. Kathiravan, Jesu Arockiaraj
Journal of Neuroimmune Pharmacology.2025;[Epub] CrossRef - Testing of Anti-EMT, Anti-Inflammatory and Antibacterial Activities of 2′,4′-Dimethoxychalcone
Peiling Zhao, Mengzhen Xu, Kai Gong, Kaihui Lu, Chen Ruan, Xin Yu, Jiang Zhu, Haixing Guan, Qingjun Zhu
Pharmaceuticals.2024; 17(5): 653. CrossRef - Furan-based chalcone protects β-cell damage and improves glucose uptake in alloxan-induced zebrafish diabetic model via influencing Peroxisome Proliferator-Activated Receptor agonists (PPAR-γ) signaling
S.P. Ramya Ranjan Nayak, B. Haridevamuthu, Raghul Murugan, L.S. Dhivya, S. Venkatesan, Mikhlid H. Almutairi, Bader O. Almutairi, M.K. Kathiravan, S. Karthick Raja Namasivayam, Jesu Arockiaraj
Process Biochemistry.2024; 142: 149. CrossRef - Protective role of 2-aminothiazole derivative against ethanol-induced teratogenic effects in-vivo zebrafish
S. Madesh, Gokul Sudhakaran, Karthikeyan Ramamurthy, Avra Sau, Kathiravan Muthu Kumaradoss, Mikhlid H. Almutairi, Bader O. Almutairi, Senthilkumar Palaniappan, Jesu Arockiaraj
Biochemical Pharmacology.2024; 230: 116601. CrossRef - Tissue damage alleviation and mucin inhibition by P5 in a respiratory infection mouse model with multidrug-resistant Acinetobacter baumannii
Jun Hee Oh, Jonggwan Park, Hee Kyoung Kang, Hee Joo Park, Yoonkyung Park
Biomedicine & Pharmacotherapy.2024; 181: 117724. CrossRef - Toxicity and therapeutic property of dioxopiperidin derivative SKT40 demonstrated in-vivo zebrafish model due to inflammatory bowel disease
B. Aswinanand, S.P. Ramya Ranjan Nayak, S. Madesh, Suthi Subbarayudu, S. Kaliraj, Rajakrishnan Rajagopal, Ahmed Alfarhan, Muthu Kumaradoss Kathiravan, Jesu Arockiaraj
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology.2024; 284: 109990. CrossRef
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Reviews
- Adenoviral Vector System: A Comprehensive Overview of Constructions, Therapeutic Applications and Host Responses
- Anyeseu Park, Jeong Yoon Lee
- J. Microbiol. 2024;62(7):491-509. Published online July 22, 2024
- DOI: https://doi.org/10.1007/s12275-024-00159-4
- 774 View
- 10 Download
- 12 Web of Science
- 11 Crossref
-
Abstract
PDF
- Adenoviral vectors are crucial for gene therapy and vaccine development, offering a platform for gene delivery into host cells. Since the discovery of adenoviruses, first-generation vectors with limited capacity have evolved to third-generation vectors flacking viral coding sequences, balancing safety and gene-carrying capacity. The applications of adenoviral vectors for gene therapy and anti-viral treatments have expanded through the use of in vitro ligation and homologous recombination, along with gene editing advancements such as CRISPR-Cas9. Current research aims to maintain the efficacy and safety of adenoviral vectors by addressing challenges such as pre-existing immunity against adenoviral vectors and developing new adenoviral vectors from rare adenovirus types and non-human species. In summary, adenoviral vectors have great potential in gene therapy and vaccine development. Through continuous research and technological advancements, these vectors are expected to lead to the development of safer and more effective treatments.
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International Journal of Pharmaceutics.2025; 668: 124941. CrossRef - Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology
Emile Youssef, Brandon Fletcher, Dannelle Palmer
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Lisha Ou, Mekedlawit T. Setegne, Jeandele Elliot, Fangfang Shen, Laura M. K. Dassama
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Duo Ning, Yuqing Deng, Simon Zhongyuan Tian
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Ke-Ke Feng, Cheng-Lei Li, Yi-Fan Tu, Shi-Cheng Tian, Rui Xiong, Bai-Sheng Sa, Jing-Wei Shao
Chemical Engineering Journal.2025; 515: 163429. CrossRef - Genetically modified cell membrane proteins in tissue engineering and regenerative medicine
Yilin Bao, Yue Hu, Mengxuan Hao, Qinmeng Zhang, Guoli Yang, Zhiwei Jiang
Biofabrication.2025; 17(3): 032004. CrossRef - Surgical treatment of otogenic vertigo
Tian Yu, Xiaohong Chen
European Archives of Oto-Rhino-Laryngology.2025;[Epub] CrossRef - Chimeric Element-Regulated MRI Reporter System for Mediation of Glioma Theranostics
Qian Hu, Jie Huang, Xiangmin Zhang, Haoru Wang, Xiaoying Ni, Huiru Zhu, Jinhua Cai
Cancers.2025; 17(14): 2349. CrossRef - Molecular Engineering of Virus Tropism
Bo He, Belinda Wilson, Shih-Heng Chen, Kedar Sharma, Erica Scappini, Molly Cook, Robert Petrovich, Negin P. Martin
International Journal of Molecular Sciences.2024; 25(20): 11094. CrossRef - Antisolvent 3D Printing of Gene-Activated Scaffolds for Bone Regeneration
Andrey Vyacheslavovich Vasilyev, Irina Alekseevna Nedorubova, Viktoria Olegovna Chernomyrdina, Anastasiia Yurevna Meglei, Viktoriia Pavlovna Basina, Anton Vladimirovich Mironov, Valeriya Sergeevna Kuznetsova, Victoria Alexandrovna Sinelnikova, Olga Anatol
International Journal of Molecular Sciences.2024; 25(24): 13300. CrossRef
- Engineering an oncolytic adenoviral platform for precise delivery of antisense peptide nucleic acid to modulate PD-L1 overexpression in cancer cells
- Fecal Microbiota Transplantation: Indications, Methods, and Challenges.
- Jee Young Lee, Yehwon Kim, Jiyoun Kim, Jiyeun Kate Kim
- J. Microbiol. 2024;62(12):1057-1074. Published online November 18, 2024
- DOI: https://doi.org/10.1007/s12275-024-00184-3
- 558 View
- 10 Download
- 7 Web of Science
- 10 Crossref
-
Abstract
PDF
- Over the past two decades, as the importance of gut microbiota to human health has become widely known, attempts have been made to treat diseases by correcting dysbiosis of gut microbiota through fecal microbiota transplantation (FMT). Apart from current knowledge of gut microbiota, FMT to treat disease has a long history, from the treatment of food poisoning in the fourth century to the treatment of Clostridioides difficile infections in the twentieth century. In 2013, FMT was recognized as a standard treatment for recurrent C. difficile because it consistently showed high efficacy. Though recurrent C. difficile is the only disease internationally recognized for FMT efficacy, FMT has been tested for other diseases and shown some promising preliminary results. Different FMT methods have been developed using various formulations and administration routes. Despite advances in FMT, some issues remain to be resolved, such as donor screening, manufacturing protocols, and unknown components in the fecal microbiota. In this review, we discuss the mechanisms, clinical indications, methods, and challenges of current FMT. We also discuss the development of alternative therapies to overcome the challenges of FMT.
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Citations
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Liang Feng, Jianting Feng, Li He, Fu Chen, Xin Feng, Suwen Wang
Applied Microbiology.2025; 5(1): 29. CrossRef - Management of refractory checkpoint inhibitor-induced colitis
Anas Zaher, Maria Julia Moura Nascimento Santos, Hassan Elsaygh, Stephen J. Peterson, Carolina Colli Cruz, Anusha Shirwaikar Thomas, Yinghong Wang
Expert Opinion on Drug Safety.2025; : 1. CrossRef - Fecal Microbiota Transplantation (FMT) in Clostridium difficile Infection: A Paradigm Shift in Gastrointestinal Microbiome Modulation
Muhammad Hamza Saeed, Sundas Qamar, Ayesha Ishtiaq, Qudsia Umaira khan, Asma Atta, Maryam Atta, Hifza Ishtiaq, Marriam Khan, Muhammad Rawal Saeed, Ayesha Iqbal
Cureus.2025;[Epub] CrossRef - Exploring the gut microbiome’s influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies
Ayrton Bangolo, Behzad Amoozgar, Maryam Habibi, Elizabeth Simms, Vignesh K Nagesh, Shruti Wadhwani, Nikita Wadhwani, Auda Auda, Daniel Elias, Charlene Mansour, Robert Abbott, Nisrene Jebara, Lili Zhang, Sarvarinder Gill, Kareem Ahmed, Andrew Ip, Andre Goy
World Journal of Gastrointestinal Pharmacology and Therapeutics.2025;[Epub] CrossRef - Microbiome Therapeutics for Clostridioides difficile Infection
Christine W. Lucky, Rachel L. Medernach, Brendan J. Kelly, Jennie H. Kwon, Michael H. Woodworth
Infectious Disease Clinics of North America.2025; 39(4): 663. CrossRef - Laboratory preparation methods for human-derived fecal microbial suspensions for fecal microbiota transplantation: a review and standardization perspectives
Jinhua Gong, Yuchi Liu, Liuye Huang
Frontiers in Microbiology.2025;[Epub] CrossRef - Improving fecal transplantation precision for enhanced maturation of intestinal function in germ-free mice through microencapsulation and probiotic intervention
Furong Ba, Wei Wang, Yilun Huang, Shuobo Zhang, Bo Qiu, Siyuan Xie, Lvwan Xu, Wang Gao, Xiaoqin Zhang, Zhenyu Wen, Qifan Wang, Hainv Gao, Guoping Sheng, Björn Berglund, Ping Li, Lanjuan Li, Mingfei Yao
Microbiome.2025;[Epub] CrossRef - Fecal microbiota transplantation as salvage therapy for disseminated strongyloidiasis in an immunosuppressed patient: a case report
Wei Fu, Na Peng, Yan Geng
Frontiers in Immunology.2025;[Epub] CrossRef - Research progress in the construction and application of immunotherapy resistance models
Huiling Li, Shenzhan Wang, Xiaoxi Li, Chao Wu, Yingnan Feng, Xin Hu, Lan Zhang, Xianzhe Dong
Cancer Immunology, Immunotherapy.2025;[Epub] CrossRef - The microbiome’s hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis
Briana M. Peterson, Ina Rudloff, Nadia S. Deen, Sara K. Di Simone, Ramesh M. Nataraja, Gergely Toldi, Maurizio Pacilli, Steven P. Garrick, Steven X. Cho, Marcel F. Nold, Samuel C. Forster, Claudia A. Nold-Petry
Seminars in Immunopathology.2025;[Epub] CrossRef
- Transplantation of Fecal Flora from Patients with Atherosclerosis to Mice Can Increase Serum Low-Density Lipoprotein Cholesterol and Affect Intestinal Flora and Its Metabolites
Journal Article
- Mammaliicoccus sciuri's Pan-Immune System and the Dynamics of Horizontal Gene Transfer Among Staphylococcaceae: a One-Health CRISPR Tale
- Allan de Carvalho, Marcia Giambiagi-deMarval, Ciro César Rossi
- J. Microbiol. 2024;62(9):775-784. Published online July 22, 2024
- DOI: https://doi.org/10.1007/s12275-024-00156-7
- 509 View
- 8 Download
- 9 Web of Science
- 10 Crossref
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Abstract
PDF
- Recently emancipated from the Staphylococcus genus due to genomic differences, Mammaliicoccus sciuri, previously classified as an occasional pathogen, emerges as a significant player in the landscape of resistance gene dissemination among Staphylococcaceae. Despite its classification, its role remained enigmatic. In this study, we delved into the genomic repertoire of M. sciuri to unravel its contribution to resistance and virulence gene transfer in the context of One Health. Through comprehensive analysis of publicly available genomes, we unveiled a diverse pan-immune system adept at defending against exogenous genetic elements, yet concurrently fostering horizontal gene transfer (HGT). Specifically, exploration of CRISPR-Cas systems, with spacer sequences as molecular signatures, elucidated a global dissemination pattern spanning environmental, animal, and human hosts. Notably, we identified the integration of CRISPR-Cas systems within SCCmecs (Staphylococcal Cassette Chromosome mec), harboring key genes associated with pathogenicity and resistance, especially the methicillin resistance gene mecA, suggesting a strategic adaptation to outcompete other mobile genetic elements. Our findings underscored M. sciuri's active engagement in HGT dynamics and evolutionary trajectories within Staphylococcaceae, emphasizing its central role in shaping microbial communities and highlighting the significance of understanding its implications in the One Health framework, an interdisciplinary approach that recognizes the interconnectedness of human, animal, and environmental health to address global health challenges.
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Citations
Citations to this article as recorded by- From Farm to Community: Dispersal of Potentially Pathogenic Staphylococcus and Mammaliicoccus Species and Antimicrobial Resistance Across Shared Environments
Faizan Ahmad, Samuel Sathler Martuchelle, Ana Luisa Andrade-Oliveira, Vitor Emanuel Lanes Viana, Maria Antônia Silva Melo Sousa, Felipe Sicchierolli da Silveira, Marisa Alves Nogueira-Diaz, Monalessa Fábia Pereira, Marcia Giambiagi-deMarval, Ciro César Ro
Current Microbiology.2025;[Epub] CrossRef - Genomic insights into multidrug and heavy metal resistance in Chryseobacterium sp. BI5 isolated from sewage sludge
Mrinmoy Patra, Anand Kumar Pandey, Suresh Kumar Dubey
Total Environment Microbiology.2025; 1(1): 100005. CrossRef - The Arms Race Between Actinobacillus pleuropneumoniae and Its Genetic Environment: A Comprehensive Analysis of Its Defensome and Mobile Genetic Elements
Giarlã Cunha da Silva, Ciro César Rossi
Molecular Microbiology.2025; 124(1): 40. CrossRef - Defense systems and mobile elements in Staphylococcus haemolyticus: a genomic view of resistance dissemination
Giarlã Cunha da Silva, Ciro César Rossi
Microbial Pathogenesis.2025; 206: 107808. CrossRef - Frequency, Distribution, and Antimicrobial Resistance of Methicillin-Resistant Staphylococci and Mammaliicoccus sciuri Isolated from Dogs and Their Owners in Rio de Janeiro
Fernanda Cruz Bonnard, Luciana Guimarães, Izabel Mello Teixeira, Sandryelle Mercês Freire, Alessandra Maia, Patrícia Câmara de Castro Abreu Pinto, Thais Veiga Blanchart, Bruno Penna
Antibiotics.2025; 14(4): 409. CrossRef - From farm effluent to biotechnological potential: pGLS, a novel and resilient temperate bacteriophage with synergistic activity and broad antibiofilm properties against Staphylococcus and Mammaliicoccus
Vitor Emanuel Lanes Viana, Faizan Ahmad, Samuel Sathler Martuchelle, Sandy de Almada Estanislau, Nohman Rasheed, Marinella Silva Laport, Monalessa Fábia Pereira, Marcia Giambiagi-deMarval, Ciro César Rossi
Journal of Applied Microbiology.2025;[Epub] CrossRef - Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods
Ju Hye Baek, Dong Min Han, Dae Gyu Choi, Chae Yeong Moon, Jae Kyeong Lee, Chul-Hong Kim, Jung-Woong Kim, Che Ok Jeon
Journal of Microbiology.2025; 63(8): e2503003. CrossRef - Discovery of phage CSF, a novel generalist bacteriophage targeting multidrug-resistant and potentially pathogenic Staphylococcus spp. and Mammaliicoccus spp.
Faizan Ahmad, Vitor Emanuel Lanes Viana, Rafael Reis de Rezende, Samuel Sathler Martuchelle, Anderson Souza Cabral, Ana Luisa Andrade-Oliveira, Isabella Monteiro Carvalho, Sandy de Almada Estanislau, Nohman Rasheed, Poliane Alfenas Zerbini, Monalessa Fábi
Archives of Virology.2025;[Epub] CrossRef - Characterization of Phylogenetically Distinct Temperate Phages from Kenyan Mammaliicoccus sciuri
Jérémy D.R. Cherbuin, Jaime Llodrá, Loïc Borcard, Sabine Kaessmeyer, Alban Ramette, Javier Eduardo Fernandez, Theresa Maria Wagner, Sergi Torres-Puig, Peter Kuhnert, Dann Turner, Fabien Labroussaa, Jörg Jores
PHAGE.2025; 6(4): 259. CrossRef - Human Pathogenic Bacteria Within the Nasal and Rectal Microbiome of Macropus giganteus
David Arroyo, Amy Peart, Brian Vesely, Andrew Trudgian, Jessica Chellappah
Tropical Medicine and Infectious Disease.2025; 10(11): 322. CrossRef
- From Farm to Community: Dispersal of Potentially Pathogenic Staphylococcus and Mammaliicoccus Species and Antimicrobial Resistance Across Shared Environments
Review
- Metabolic Interaction Between Host and the Gut Microbiota During High‑Fat Diet‑Induced Colorectal Cancer
- Chaeeun Lee, Seungrin Lee, Woongjae Yoo
- J. Microbiol. 2024;62(3):153-165. Published online April 16, 2024
- DOI: https://doi.org/10.1007/s12275-024-00123-2
- 604 View
- 17 Download
- 11 Web of Science
- 10 Crossref
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Abstract
PDF
- Colorectal cancer (CRC) is the second-highest cause of cancer-associated mortality among both men and women worldwide. One of the risk factors for CRC is obesity, which is correlated with a high-fat diet prevalent in Western dietary habits. The association between an obesogenic high-fat diet and CRC has been established for several decades; however, the mechanisms by which a high-fat diet increases the risk of CRC remain unclear. Recent studies indicate that gut microbiota strongly infuence the pathogenesis of both high-fat diet-induced obesity and CRC. The gut microbiota is composed of hundreds of bacterial species, some of which are implicated in CRC. In particular, the expansion of facultative anaerobic Enterobacteriaceae, which is considered a microbial signature of intestinal microbiota functional imbalance (dysbiosis), is associated with both high-fat diet-induced obesity and CRC. Here, we review the interaction between the gut microbiome and its metabolic byproducts in the context of colorectal cancer (CRC) during high-fat diet-induced obesity. In addition, we will cover how a high-fat diet can drive the expansion of genotoxin-producing Escherichia coli by altering intestinal epithelial cell metabolism during gut infammation conditions.
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Citations
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Min Li, Qingshan Wang, Xiuwei Zhang, Kaikai Li, Meng Niu, Siming Zhao
International Journal of Biological Macromolecules.2025; 288: 138754. CrossRef - Microbial Metabolites-induced Epigenetic Modifications for Inhibition of Colorectal Cancer: Current Status and Future Perspectives
Vaibhav Singh, Ekta Shirbhate, Rakesh Kore, Subham Vishwakarma, Shadiya Parveen, Ravichandran Veerasamy, Amit K Tiwari, Harish Rajak
Mini-Reviews in Medicinal Chemistry.2025; 25(1): 76. CrossRef - Deciphering the impact of dietary habits and behavioral patterns on colorectal cancer
Qihang Yuan, Jiahua Liu, Xinyu Wang, Chunchun Du, Yao Zhang, Lin Lin, Chengfang Wang, Zhijun Hong
International Journal of Surgery.2025; 111(3): 2603. CrossRef - Integrating single-cell with transcriptome-proteome Mendelian randomization reveals colorectal cancer targets
Song Wang, Xin Yao, Shenshen Li, Shanshan Wang, Xuyu Huang, Jing Zhou, Xiao Li, Jieying Wen, Weixuan Lan, Yunsi Huang, Hao Li, Yunlong Sun, Xiaoqian Zhao, Qiaoling Chen, Xuedong Han, Ziming Zhu, Xinyue Zhang, Tao Zhang
Discover Oncology.2025;[Epub] CrossRef - Parabacteroides johnsonii inhibits the onset and progression of colorectal cancer by modulating the gut microbiota
Jing Liu, Yong Zhang, Linxiang Xu, Guoli Gu, Zhiwei Dong
Journal of Translational Medicine.2025;[Epub] CrossRef - Differences in the faecal microbiome of obese and non-obese pregnant women: a matched cohort study in Sweden
Evangelos Patavoukas, Bangzhuo Tong, Unnur Guðnadóttir, Kyriakos Charalampous, Nele Brusselaers, Ina Schuppe-Koistinen, Lars Engstrand, Emma Fransson, Eva Wiberg-Itzel, Luisa Hugerth
BMC Microbiology.2025;[Epub] CrossRef - High-Fat Diet: A Paradoxical Factor in the Setting of Type 1 Diabetes
Wan-Ying Lu, Shan-Jie Rong, Shi-Wei Liu, Chun-Liang Yang, Yue-Chen Liu, Heba H Al-Siddiqi, Fei Sun, Cong-Yi Wang
Nutrition Reviews.2025;[Epub] CrossRef - Molecular Mechanisms of Skatole-Induced Inflammatory Responses in Intestinal Epithelial Caco-2 Cells: Implications for Colorectal Cancer and Inflammatory Bowel Disease
Katsunori Ishii, Kazuma Naito, Dai Tanaka, Yoshihito Koto, Koichi Kurata, Hidehisa Shimizu
Cells.2024; 13(20): 1730. CrossRef - Research Progress on the Relationship between Intestinal Flora and Gastrointestinal Malignancy
军 陈
Advances in Clinical Medicine.2024; 14(11): 262. CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
- Wheat β-glucan reduces obesity and hyperlipidemia in mice with high-fat and high-salt diet by regulating intestinal flora
Journal Articles
- miR-135b Aggravates Fusobacterium nucleatum-Induced Cisplatin Resistance in Colorectal Cancer by Targeting KLF13
- Wei Zeng , Jia Pan , Guannan Ye
- J. Microbiol. 2024;62(2):63-73. Published online February 24, 2024
- DOI: https://doi.org/10.1007/s12275-023-00100-1
- 447 View
- 8 Download
- 9 Web of Science
- 9 Crossref
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Abstract
PDF
- Cisplatin resistance is the main cause of colorectal cancer (CRC) treatment failure, and the cause has been reported to be related to Fusobacterium nucleatum (Fn) infection. In this study, we explored the role of Fn in regulating cisplatin resistance of CRC cells and its underlying mechanism involved. The mRNA and protein expressions were examined by qRT-PCR and western blot. Cell proliferation and cell apoptosis were assessed using CCK8 and flow cytometry assays, respectively. Dual-luciferase reporter gene assay was adopted to analyze the molecular interactions. Herein, our results revealed that Fn abundance and miR-135b expression were markedly elevated in CRC tissues, with a favorable association between the two. Moreover, Fn infection could increase miR-135b expression via a concentration-dependent manner, and it also enhanced cell proliferation but reduced apoptosis and cisplatin sensitivity by upregulating miR-135b. Moreover, KLF13 was proved as a downstream target of miR-135b, of which overexpression greatly diminished the promoting effect of miR-135b or Fn-mediated cisplatin resistance in CRC cells. In addition, it was observed that upstream 2.5 kb fragment of miR-135b promoter could be interacted by β-catenin/TCF4 complex, which was proved as an effector signaling of Fn. LF3, a blocker of β-catenin/TCF4 complex, was confirmed to diminish the promoting role of Fn on miR-135b expression. Thus, it could be concluded that Fn activated miR-135b expression through TCF4/β-catenin complex, thereby inhibiting KLF13 expression and promoting cisplatin resistance in CRC.
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Citations
Citations to this article as recorded by- miR-135b: A key role in cancer biology and therapeutic targets
Yingchun Shao, Shuangshuang Zhang, Yuxin Pan, Zhan Peng, Yinying Dong
Non-coding RNA Research.2025; 12: 67. CrossRef - miR‐135b: A Potential Biomarker for Pathological Diagnosis and Biological Therapy
Dezhi Yan, Qingliu He, Chunjian Wang, Tian Li, Xueping Yi, Haisheng Yu, Wenfei Wu, Hanyun Yang, Wenzhao Wang, Liang Ma
WIREs RNA.2025;[Epub] CrossRef - Effects of the Intestinal Microbiome and Metabolites on Neoadjuvant Chemotherapy Efficacy in Breast Cancer
Jingyue Fu, Hongxin Lin, Shuaikang Li, Xingying Yu, Yufan Jin, Jie Mei, Yichao Zhu, Tiansong Xia
BIO Integration.2025;[Epub] CrossRef - Fusobacterium nucleatum and non-coding RNAs: orchestrating oncogenic pathways in colorectal cancer
Zahra Sadeghloo, Sara Ebrahimi, Mojdeh Hakemi-Vala, Mehdi Totonchi, Amir Sadeghi, Nayeralsadat Fatemi
Gut Pathogens.2025;[Epub] CrossRef - Regulatory mechanisms and emerging diagnostic and therapeutic opportunities of non-coding RNAs in tumorigenesis: a pan-cancer perspective
Doblin Sandai, Zengkan Du, Haoling Zhang, Qi Sun
Critical Reviews in Clinical Laboratory Sciences.2025; : 1. CrossRef - Emerging roles of intratumor microbiota in cancer: tumorigenesis and management strategies
Zhuangzhuang Shi, Zhaoming Li, Mingzhi Zhang
Journal of Translational Medicine.2024;[Epub] CrossRef - Fusobacterium nucleatum: a novel regulator of antitumor immune checkpoint blockade therapy in colorectal cancer
Mengjie Luo
American Journal of Cancer Research.2024; 14(8): 3962. CrossRef - Antioxidant Role of Probiotics in Inflammation-Induced Colorectal Cancer
Sevag Hamamah, Andrei Lobiuc, Mihai Covasa
International Journal of Molecular Sciences.2024; 25(16): 9026. CrossRef - Identification of Penexanthone A as a Novel Chemosensitizer to Induce Ferroptosis by Targeting Nrf2 in Human Colorectal Cancer Cells
Genshi Zhao, Yanying Liu, Xia Wei, Chunxia Yang, Junfei Lu, Shihuan Yan, Xiaolin Ma, Xue Cheng, Zhengliang You, Yue Ding, Hongwei Guo, Zhiheng Su, Shangping Xing, Dan Zhu
Marine Drugs.2024; 22(8): 357. CrossRef
- miR-135b: A key role in cancer biology and therapeutic targets
- Rhodobacteraceae are Prevalent and Ecologically Crucial Bacterial Members in Marine Biofloc Aquaculture
- Meora Rajeev, Jang-Cheon Cho
- J. Microbiol. 2024;62(11):985-997. Published online November 15, 2024
- DOI: https://doi.org/10.1007/s12275-024-00187-0
- 445 View
- 7 Download
- 11 Web of Science
- 8 Crossref
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Abstract
PDF
- Bioflocs are microbial aggregates primarily composed of heterotrophic bacteria that play essential ecological roles in maintaining animal health, gut microbiota, and water quality in biofloc aquaculture systems. Despite the global adoption of biofloc aquaculture for shrimp and fish cultivation, our understanding of biofloc microbiota-particularly the dominant bacterial members and their ecological functions-remains limited. In this study, we employed integrated metataxonomic and metagenomic approaches to demonstrate that the family Rhodobacteraceae of Alphaproteobacteria consistently dominates the biofloc microbiota and plays essential ecological roles. We first analyzed a comprehensive metataxonomic dataset consisting of 200 16S rRNA gene amplicons collected across three Asian countries: South Korea, China, and Vietnam. Taxonomic investigation identified Rhodobacteraceae as the dominant and consistent bacterial members across the datasets. The predominance of this taxon was further validated through metagenomics approaches, including read taxonomy and read recruitment analyses. To explore the ecological roles of Rhodobacteraceae, we applied genome-centric metagenomics, reconstructing 45 metagenome-assembled genomes. Functional annotation of these genomes revealed that dominant Rhodobacteraceae genera, such as Marivita, Ruegeria, Dinoroseobacter, and Aliiroseovarius, are involved in vital ecological processes, including complex carbohydrate degradation, aerobic denitrification, assimilatory nitrate reduction, ammonium assimilation, and sulfur oxidation. Overall, our study reveals that the common practice of carbohydrate addition in biofloc aquaculture systems fosters the growth of specific heterotrophic bacterial communities, particularly Rhodobacteraceae. These bacteria contribute to maintaining water quality by removing toxic nitrogen and sulfur compounds and enhance animal health by colonizing gut microbiota and exerting probiotic effects.
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Citations
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Xusheng Jiang, Xuehong Zhang, Xijun Liu, Hui Qiu, Mengting Lin, Guo Yu, Shouhui Zhang, Jie Liu
Resources, Conservation and Recycling.2025; 218: 108259. CrossRef - Variation of Microorganisms and Water Quality, and Their Impacts on the Production of Penaeus vannamei in Small-Scale Greenhouse Ponds
Siyu Wu, Haochang Su, Lei Su, Yucheng Cao, Guoliang Wen, Yu Xu, Bin Shen, Shanshan Wu, Yuting Su, Xiaojuan Hu
Microorganisms.2025; 13(3): 546. CrossRef - Effect of hydraulic retention time of sponge-based trickling filter for shrimp culture recirculating tank
Penpicha Satanwat, Mami Nagai, Tharin Boonprasertsakul, Akihiro Nagano, Tsutomu Okubo, Nur Adlin, Takahiro Watari, Masashi Hatamoto, Takashi Yamaguchi, Sitthakarn Sitthi, Wiboonluk Pungrasmi, Rapeepun Vanichviriyakit, Sorawit Powtongsook
Process Safety and Environmental Protection.2025; 198: 107154. CrossRef - Divergence patterns of bacterial communities between larviculture systems of two Penaeus vannamei strains with distinct culture traits
Heng Chen, Fengdie Zhang, Junqi Yu, Rudan Chen, Demin Zhang, Chen Chen, Kai Wang
Aquaculture.2025; 606: 742572. CrossRef - Influence of Polyester and Denim Microfibers on the Treatment and Formation of Aerobic Granules in Sequencing Batch Reactors
Victoria Okhade Onyedibe, Hassan Waseem, Hussain Aqeel, Steven N. Liss, Kimberley A. Gilbride, Roxana Sühring, Rania Hamza
Processes.2025; 13(7): 2272. CrossRef - Where Have You Been? Backtracking Microplastic to Its Source Using the Biomolecular Composition of the Ecocorona
Amanda L. Dawson, Utpal Bose, Sophia Escobar-Correas, Kuok Yap, David J. Craik, Cassandra L. Pegg
Environmental Science & Technology.2025; 59(41): 22227. CrossRef - Effects of butyric acid on the inhibition of Vibrio parahaemolyticus and its impacts on growth performance, intestinal microbiota, and water microbiota in Litopenaeus vannamei
Minghan Yin, Zhangyi Zheng, Ruiyan Xing, Lefei Jiao, Moussa Gouife, Tinghong Ming, Fei Kong, Shuang Qiu, Jiajie Xu
Aquaculture Reports.2025; 45: 103078. CrossRef - Evaluating the potential of Rhodopseudomonas faecalis PA2 as a probiotic and biofloc supplement for Nile tilapia (Oreochromis niloticus)
Wipavee Thaimuangphol, Ranumas Sukkum, Zhongliang Wang, Chewapat Saejung
Aquaculture Reports.2025; 45: 103201. CrossRef
- Ecological disposal of bauxite tailings and red mud: A sustainable strategy for bauxite industrial waste reuse
- CA‑CAS‑01‑A: A Permissive Cell Line for Isolation and Live Attenuated Vaccine Development Against African Swine Fever Virus
- Seung-Chul Lee , Yongkwan Kim , Ji-Won Cha , Kiramage Chathuranga , Niranjan Dodantenna , Hyeok-Il Kwon , Min Ho Kim , Weonhwa Jheong , In-Joong Yoon , Joo Young Lee , Sung-Sik Yoo , Jong-Soo Lee
- J. Microbiol. 2024;62(2):125-134. Published online March 13, 2024
- DOI: https://doi.org/10.1007/s12275-024-00116-1
- 520 View
- 5 Download
- 7 Web of Science
- 8 Crossref
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Abstract
PDF
- African swine fever virus (ASFV) is the causative agent of the highly lethal African swine fever disease that affects domestic pigs and wild boars. In spite of the rapid spread of the virus worldwide, there is no licensed vaccine available. The lack of a suitable cell line for ASFV propagation hinders the development of a safe and effective vaccine. For ASFV propagation, primary swine macrophages and monocytes have been widely studied. However, obtaining these cells can be time-consuming and expensive, making them unsuitable for mass vaccine production. The goal of this study was to validate the suitability of novel CA-CAS-01-A (CAS-01) cells, which was identified as a highly permissive cell clone for ASFV replication in the MA-104 parental cell line for live attenuated vaccine development. Through a screening experiment, maximum ASFV replication was observed in the CAS-01 cell compared to other sub-clones of MA-104 with 14.89 and log10 7.5 ± 0.15 Ct value and TCID50/ ml value respectively. When CAS-01 cells are inoculated with ASFV, replication of ASFV was confirmed by Ct value for ASFV DNA, HAD50/ ml assay, TCID50/ ml assay, and cytopathic effects and hemadsoption were observed similar to those in primary porcine alveolar macrophages after 5th passage. Additionally, we demonstrated stable replication and adaptation of ASFV over the serial passage. These results suggest that CAS-01 cells will be a valuable and promising cell line for ASFV isolation, replication, and development of live attenuated vaccines.
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Citations
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Xiangwan Lu, Xiadan Gong, Yingshuo Sun, Lang Gong, Yan Zhang
In Vitro Cellular & Developmental Biology - Animal.2025; 61(4): 425. CrossRef - Genetic and Pathogenic Characteristic of High Pathogenic Korean NADC34‐Like Porcine Reproductive and Respiratory Syndrome Virus
Sehyeong Ham, Chanhee Chae, Nan-hua Chen
Transboundary and Emerging Diseases.2025;[Epub] CrossRef - Efficient and modular reverse genetics system for rapid generation of recombinant severe acute respiratory syndrome coronavirus 2
Sojung Bae, Jinjong Myoung
Journal of Microbiology.2025; 63(7): e2504015. CrossRef - Progress in the in vitro propagation of African swine fever virus and implications for vaccine development
Thanathom Chailangkarn, Theeradej Thaweerattanasinp, Asawin Wanitchang, Janya Saenboonrueng, Challika Kaewborisuth, Anan Jongkaewwattana
Animal Diseases.2025;[Epub] CrossRef - Analysis of novel African swine fever variants circulating in wild boars in South Korea isolated in 2021 by deep sequencing
Van Dam Lai, Yong-kwan Kim, Min-Ho Kim, Yeeun Moon, Hyeok-Il Kwon, Weon-hwa Jheong, Jong-Soo Lee, Sung-Sik Yoo, In Pil Mo
Infection, Genetics and Evolution.2025; 135: 105833. CrossRef - Domain-Specific Impacts of Spike Protein Mutations on Infectivity and Antibody Escape in SARS-CoV-2 Omicron BA.1
Tae-Hun Kim, Sojung Bae, Jinjong Myoung
Journal of Microbiology and Biotechnology.2025;[Epub] CrossRef - Current status of African swine fevervaccine research and thoughts
Jiarong Yu, Shengbin Gao, Jiao Xu, Yonggang Zhao, Linlin Fang, Xiaozhen Wang, Yingli Wang, Jingyue Bao, Zhiliang Wang
Journal of Integrative Agriculture.2025;[Epub] CrossRef - Development and characterization of high-efficiency cell-adapted live attenuated vaccine candidate against African swine fever
Min Ho Kim, Ashan Subasinghe, Yongkwan Kim, Hyeok-Il Kwon, Yehjin Cho, Kiramage Chathuranga, Ji-Won Cha, Ji-Yoon Moon, Ji-Hyeon Hong, Jin Kim, Seung-Chul Lee, Niranjan Dodantenna, Nuwan Gamage, W. A. Gayan Chathuranga, Yeonji Kim, In-Joong Yoon, Joo Young
Emerging Microbes & Infections.2024;[Epub] CrossRef
- Establishment of a highly sensitive porcine alveolar macrophage cell line for African swine fever virus
Review
- Advancements in dengue vaccines: A historical overview and pro-spects for following next-generation candidates
- Kai Yan, Lingjing Mao, Jiaming Lan, Zhongdang Xiao
- J. Microbiol. 2025;63(2):e2410018. Published online February 27, 2025
- DOI: https://doi.org/10.71150/jm.2410018
- 13,104 View
- 437 Download
- 5 Web of Science
- 7 Crossref
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Abstract
PDF
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Dengue, caused by four serotypes of dengue viruses (DENV-1 to DENV-4), is the most prevalent and widely mosquito-borne viral disease affecting humans. Dengue virus (DENV) infection has been reported in over 100 countries, and approximately half of the world's population is now at risk. The paucity of universally licensed DENV vaccines highlights the urgent need to address this public health concern. Action and attention to antibody-dependent enhancement increase the difficulty of vaccine development. With the worsening dengue fever epidemic, Dengvaxia® (CYD-TDV) and Qdenga® (TAK-003) have been approved for use in specific populations in affected areas. However, these vaccines do not provide a balanced immune response to all four DENV serotypes and the vaccination cannot cover all populations. There is still a need to develop a safe, broad-spectrum, and effective vaccine to address the increasing number of dengue cases worldwide. This review provides an overview of the existing DENV vaccines, as well as potential candidates for future studies on DENV vaccine development, and discusses the challenges and possible solutions in the field.
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Grace Paola Carreño-Flórez, Alexandra Milena Cuartas-López, Ryan L. Boudreau, Miguel Vicente-Manzanares, Juan Carlos Gallego-Gómez
International Journal of Molecular Sciences.2025; 26(9): 4206. CrossRef - Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals
Manisha Saini, Jasmin C. Aschenbrenner, Francesc Xavier Ruiz, Ashima Chopra, Anu V. Chandran, Peter G. Marples, Blake H. Balcomb, Daren Fearon, Frank von Delft, Eddy Arnold
Journal of Medicinal Chemistry.2025; 68(17): 18356. CrossRef - Understanding the Diversity of Dengue Serotypes: Impacts on Public Health and Disease Control
Gopinath Ramalingam, Madhumitha Patchaiyappan, M. Arundadhi, Krishnapriya Subramani, A. Dhanasezhian, Sucila Thangam Ganesan
The Journal of Medical Research.2025; 11(4): 69. CrossRef - Dengue Fever Resurgence in Iran: An Integrative Review of Causative Factors and Control Strategies
Seyed Hassan Nikookar, Saeedeh Hoseini, Omid Dehghan, Mahmoud Fazelidinan, Ahmadali Enayati
Tropical Medicine and Infectious Disease.2025; 10(11): 309. CrossRef - Enhancement of viral infection by antibodies and consequences
Corentin Morvan, Magloire Pandoua Nekoua, Cyril Debuysschere, Enagnon Kazali Alidjinou, Didier Hober, Sebla Bulent Kutluay
Microbiology and Molecular Biology Reviews.2025;[Epub] CrossRef - Microbial Volatiles from Human Skin and Floral Nectar: Insufficiently Understood Adult Feeding Cues To Improve Odor-Based Traps for Aedes Vector Control
Simon Malassigné, Claire Valiente Moro, Patricia Luis
Journal of Chemical Ecology.2025;[Epub] CrossRef - An interpretable machine learning model for dengue detection with clinical hematological data
Izaz Ahmmed Tuhin, A.K.M.Fazlul Kobir Siam, Md Mahfuzur Rahman Shanto, Md Rajib Mia, Imran Mahmud, Apurba Ghosh
Healthcare Analytics.2025; 8: 100430. CrossRef
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Journal Article
- Quorum Quenching Potential of Reyranella sp. Isolated from Riverside Soil and Description of Reyranella humidisoli sp. nov.
- Dong Hyeon Lee, Seung Bum Kim
- J. Microbiol. 2024;62(6):449-461. Published online May 30, 2024
- DOI: https://doi.org/10.1007/s12275-024-00131-2
- 446 View
- 9 Download
- 7 Web of Science
- 7 Crossref
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Abstract
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- Quorum quenching refers to any mechanism that inhibits quorum sensing processes. In this study, quorum quenching activity among bacteria inhabiting riverside soil was screened, and a novel Gram-stain-negative, rod shaped bacterial strain designated MMS21-HV4-11(T), which showed the highest level of quorum quenching activity, was isolated and subjected to further analysis. Strain MMS21-HV4-11(T) could be assigned to the genus Reyranella of Alphaproteobacteria based on the 16S rRNA gene sequence, as the strain shared 98.74% sequence similarity with Reyranella aquatilis seoho-37(T), and then 97.87% and 97.80% sequence similarity with Reyranella soli KIS14-15(T) and Reyranella massiliensis 521(T), respectively. The decomposed N-acyl homoserine lactone was restored at high concentrations under acidic conditions, implying that lactonase and other enzyme(s) are responsible for quorum quenching. The genome analysis indicated that strain MMS21-HV4-11(T) had two candidate genes for lactonase and one for acylase, and expected protein structures were confirmed. In the quorum sensing inhibition assay using a plant pathogen Pectobacterium carotovorum KACC 14888, development of soft rot was significantly inhibited by strain MMS21-HV4-11(T). Besides, the swarming motility by Pseudomonas aeruginosa PA14 was significantly inhibited in the presence of strain MMS21-HV4-11(T). Since the isolate did not display direct antibacterial activity against either of these species, the inhibition was certainly due to quorum quenching activity. In an extended study with the type strains of all known species of Reyranella, all strains were capable of degrading N-acyl homoserine lactones (AHLs), thus showing quorum quenching potential at the genus level. This is the first study on the quorum quenching potential and enzymes responsible in Reyranella. In addition, MMS21-HV4-11(T) could be recognized as a new species through taxonomic characterization, for which the name Reyranella humidisoli sp. nov. is proposed (type strain = MMS21-HV4-11( T) = KCTC 82780( T) = LMG 32365(T)).
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Citations
Citations to this article as recorded by- Study of N-acyl homoserine lactone (AHL) degradation potential of bacteria isolated from environmental samples and their impact on quorum sensing regulated biofilm formation of Pseudomonas aeruginosa
Anju Tomy, Rakesh Yasarla
Journal of Environmental Chemical Engineering.2025; 13(2): 115974. CrossRef - Hepatotoxicity of imidacloprid in zebrafish and the alleviating role of 10-hydroxy-2-decenoi acid: Insights into oxidative stress, inflammation, and gut microbiota
Yujing Tang, Yandong Zhan, Shuangshuang Gao, Ting Li, Hongzhuan Xuan
Journal of Hazardous Materials.2025; 494: 138695. CrossRef - Description of Humidisolicoccus flavus gen. nov., sp. nov., a novel actinobacterium isolated from riverside soil
Da Chan Kim, Seung Bum Kim
International Journal of Systematic and Evolutionary Microbiology .2025;[Epub] CrossRef - The Causative Agent of Soft Rot in Plants, the Phytopathogenic Bacterium Pectobacterium carotovorum subsp. carotovorum: A Brief Description and an Overview of Methods to Control It
Alla I. Perfileva, Elena I. Strekalovskaya, Nadezhda V. Klushina, Igor V. Gorbenko, Konstantin V. Krutovsky
Agronomy.2025; 15(7): 1578. CrossRef - SynCom‐mediated herbicide degradation activates microbial carbon metabolism in soils
Yuxiao Zhang, Jack A. Gilbert, Xuan Liu, Li Nie, Xiyuan Xu, Guifeng Gao, Lihui Lyu, Yuying Ma, Kunkun Fan, Teng Yang, Yumeng Zhang, Jiabao Zhang, Haiyan Chu
iMeta.2025;[Epub] CrossRef - Research progress of bacterial quorum sensing systems in synthetic biology applications
Boyu Luo, Tuoyu Liu, Zhi Sun, Yue Teng
Chinese Science Bulletin.2024; 69(36): 5213. CrossRef - Validation List no. 220. Valid publication of new names and new combinations effectively published outside the IJSEM
Aharon Oren, Markus Göker
International Journal of Systematic and Evolutionary Microbiology .2024;[Epub] CrossRef
- Study of N-acyl homoserine lactone (AHL) degradation potential of bacteria isolated from environmental samples and their impact on quorum sensing regulated biofilm formation of Pseudomonas aeruginosa
Review
- The Microbiome Matters: Its Impact on Cancer Development and Therapeutic Responses
- In‑Young Chung, Jihyun Kim, Ara Koh
- J. Microbiol. 2024;62(3):137-152. Published online April 8, 2024
- DOI: https://doi.org/10.1007/s12275-024-00110-7
- 633 View
- 27 Download
- 6 Web of Science
- 7 Crossref
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Abstract
PDF
- In the evolving landscape of cancer research, the human microbiome emerges as a pivotal determinant reshaping our understanding of tumorigenesis and therapeutic responses. Advanced sequencing technologies have uncovered a vibrant microbial community not confned to the gut but thriving within tumor tissues. Comprising bacteria, viruses, and fungi, this diverse microbiota displays distinct signatures across various cancers, with most research primarily focusing on bacteria. The correlations between specifc microbial taxa within diferent cancer types underscore their pivotal roles in driving tumorigenesis and infuencing therapeutic responses, particularly in chemotherapy and immunotherapy. This review amalgamates recent discoveries, emphasizing the translocation of the oral microbiome to the gut as a potential marker for microbiome dysbiosis across diverse cancer types and delves into potential mechanisms contributing to cancer promotion. Furthermore, it highlights the adverse efects of the microbiome on cancer development while exploring its potential in fortifying strategies for cancer prevention and treatment.
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Citations
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Jamie Rossjohn, Luigi Nezi, Julianne S. Walz, Maria Tagliamonte, Luigi Buonaguro
Trends in Immunology.2025; 46(11): 741. CrossRef - A Comprehensive Oncological Biomarker Framework Guiding Precision Medicine
Reza Bayat Mokhtari, Manpreet Sambi, Faezeh Shekari, Kosar Satari, Roya Ghafoury, Neda Ashayeri, Paige Eversole, Narges Baluch, William W. Harless, Lucia Anna Muscarella, Herman Yeger, Bikul Das, Myron R. Szewczuk, Sayan Chakraborty
Biomolecules.2025; 15(9): 1304. CrossRef - Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer
Kaoru Fujikawa, Takuro Saito, Atsunari Kawashima, Kentaro Jingushi, Daisuke Motooka, Shigeto Nakai, Takaomi Hagi, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa, Kazutake Tsujikawa, Hisashi Wada, Hidetoshi
Cancer Immunology, Immunotherapy.2025;[Epub] CrossRef - COVID-19, Long COVID, and Gastrointestinal Neoplasms: Exploring the Impact of Gut Microbiota and Oncogenic Interactions
do Rêgo Amália Cinthia Meneses, Araújo-Filho Irami
Archives of Cancer Science and Therapy.2024; 8(1): 054. CrossRef - Glycans in the oral bacteria and fungi: Shaping host-microbe interactions and human health
Xiameng Ren, Min Wang, Jiabao Du, Yu Dai, Liuyi Dang, Zheng Li, Jian Shu
International Journal of Biological Macromolecules.2024; 282: 136932. CrossRef - A Review of the Relationship between Tumors of the Biliary System and Intestinal Microorganisms
勇利 李
Advances in Clinical Medicine.2024; 14(07): 833. CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
- Molecular mimicry as a driver of T cell-mediated tumour immunity
Journal Article
- Exploring the Therapeutic Potential of Scorpion‑Derived Css54 Peptide Against Candida albicans
- Jonggwan Park , Hyeongsun Kim , Da Dam Kang , Yoonkyung Park
- J. Microbiol. 2024;62(2):101-112. Published online April 8, 2024
- DOI: https://doi.org/10.1007/s12275-024-00113-4
- 514 View
- 14 Download
- 7 Web of Science
- 7 Crossref
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Abstract
PDF
- Candida albicans (C. albicans) is one of the most common opportunistic fungi worldwide, which is associated with a high mortality rate. Despite treatment, C. albicans remains the leading cause of life-threatening invasive infections. Consequently, antimicrobial peptides (AMPs) are potential alternatives as antifungal agents with excellent antifungal activity. We previously reported that Css54, found in the venom of Centrurodies suffusus suffusus (C. s. suffusus) showed antibacterial activity against zoonotic bacteria. However, the antifungal activity of Css54 has not yet been elucidated. The obj!ective of this study was to identify the antifungal activity of Css54 against C. albicans and analyze its mechanism. Css54 showed high antifungal activity against C. albicans. Css54 also inhibited biofilm formation in fluconazole-resistant fungi. The antifungal mechanism of action of Css54 was investigated using membrane-related assays, including the membrane depolarization assay and analysis of the membrane integrity of C. albicans after treatment with Css54. Css54 induced reactive oxygen species (ROS) production in C. albicans, which affected its antifungal activity. Our results indicate that Css54 causes membrane damage in C. albicans, highlighting its value as a potential therapeutic agent against C. albicans infection.
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Citations
Citations to this article as recorded by- Natural product-derived antifungals against Candida albicans: Chemical diversity and mechanisms of action
Runchu Li, Xiaoxu Yang, Wenjia Dan, Jiangkun Dai
Bioorganic & Medicinal Chemistry.2026; 132: 118435. CrossRef - Animal-derived peptides from Traditional Chinese medicines: medicinal potential, mechanisms, and prospects
Jiahui Zhang, Siyi Li, Yueyi Qi, Jieyu Shen, Aijing Leng, Jialin Qu
Journal of Ethnopharmacology.2025; 349: 119872. CrossRef - Scorpion venom as a natural peptide source for innovative therapeutic solutions: A comprehensive review of its potential in emerging medical frontiers
Radwa Abdallnasser Amen, Rawan Atef Essmat, Alyaa Farid, Mohamed A. Abdel-Rahman, Ahmed A. El-Sherif, Yonghong Zhang
Toxicon.2025; 268: 108603. CrossRef - Design and Characterization of Antibacterial Peptide Nanofibrils as Components of Composites for Biomaterial Applications
Justyna Sawicka, Piotr Bollin, Anna Sylla, Miroslawa Panasiuk, Michalina Wilkowska, Lidia Ciolek, Mateusz Leśniewski, Aleksandra Konopka, Karol Struniawski, Gabriela Calka-Kuc, Adam Liwo, Piotr Hanczyc, Maciej Kozak, Beata Gromadzka, Monika Biernat, Sylwi
Current Protein & Peptide Science.2025; 26(10): 875. CrossRef - Properties and Pharmacology of Scorpion Toxins and Their Biotechnological Potential in Agriculture and Medicine
Cháriston André Dal Belo, Stephen Hyslop, Célia Regina Carlini
Toxins.2025; 17(10): 497. CrossRef - Antimicrobial Potential of Scorpion-Venom-Derived Peptides
Zhiqiang Xia, Lixia Xie, Bing Li, Xiangyun Lv, Hongzhou Zhang, Zhijian Cao
Molecules.2024; 29(21): 5080. CrossRef - Synthetic Short Cryptic Antimicrobial Peptides as Templates for the Development of Novel Biotherapeutics Against WHO Priority Pathogen
Manjul Lata, Vrushti Telang, Pooja Gupta, Garima Pant, Mitra Kalyan, Jesu Arockiaraj, Mukesh Pasupuleti
International Journal of Peptide Research and Therapeutics.2024;[Epub] CrossRef
- Natural product-derived antifungals against Candida albicans: Chemical diversity and mechanisms of action
Review
- Application of Microbiome‑Based Therapies in Chronic Respiratory Diseases
- Se Hee Lee, Jang Ho Lee, Sei Won Lee
- J. Microbiol. 2024;62(3):201-216. Published online April 18, 2024
- DOI: https://doi.org/10.1007/s12275-024-00124-1
- 568 View
- 10 Download
- 4 Web of Science
- 6 Crossref
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Abstract
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- The application of microbiome-based therapies in various areas of human disease has recently increased. In chronic respiratory disease, microbiome-based clinical applications are considered compelling options due to the limitations of current treatments. The lung microbiome is ecologically dynamic and afected by various conditions, and dysbiosis is associated with disease severity, exacerbation, and phenotype as well as with chronic respiratory disease endotype. However, it is not easy to directly modulate the lung microbiome. Additionally, studies have shown that chronic respiratory diseases can be improved by modulating gut microbiome and administrating metabolites. Although the composition, diversity, and abundance of the microbiome between the gut and lung are considerably diferent, modulation of the gut microbiome could improve lung dysbiosis. The gut microbiome infuences that of the lung via bacterial-derived components and metabolic degradation products, including short-chain fatty acids. This phenomenon might be associated with the cross-talk between the gut microbiome and lung, called gut-lung axis. There are multiple alternatives to modulate the gut microbiome, such as prebiotics, probiotics, and postbiotics ingestion and fecal material transplantation. Several studies have shown that high-fber diets, for example, present benefcial efects through the production of short-chain fatty acids. Additionally, genetically modifed probiotics to secrete some benefcial molecules might also be utilized to treat chronic respiratory diseases. Further studies on microbial modulation to regulate immunity and potentiate conventional pharmacotherapy will improve microbiome modulation techniques, which will develop as a new therapeutic area in chronic respiratory diseases.
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Citations
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Yue Zhu, Rui-Dong Ding
Molecular Medicine Reports.2025; 32(6): 1. CrossRef - Postbiotics in Respiratory Health: Functional Components, Innovative Application, and Emerging Challenges
Jianqiang Lan, Shimin Wu, Hong Li, Junfang Wang, Min Li
The Journal of Nutrition.2025; 155(11): 3676. CrossRef - Association between live microbe intake and depression in COPD aged 40 years and older: evidence from NHANES 2005–2018
Wei Gao, Xin Ling, Yan Wang, Xiaoxia Zhao, Yushan Shi
Frontiers in Nutrition.2025;[Epub] CrossRef - Bacteria and Allergic Diseases
Svetlana V. Guryanova
International Journal of Molecular Sciences.2024; 25(19): 10298. CrossRef - The emerging roles of microbiome and short-chain fatty acids in the pathogenesis of bronchopulmonary dysplasia
Yuan Gao, Kaixuan Wang, Zupan Lin, Shujing Cai, Aohui Peng, Le He, Hui Qi, Zhigang Jin, Xubo Qian
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
- Role of the gut‑lung axis in bronchopulmonary dysplasia: Physiological basis, pathogenesis and immunological modulation (Review)
Minireview
- Advances in functional analysis of the microbiome: Integrating metabolic modeling, metabolite prediction, and pathway inference with Next-Generation Sequencing data
- Sungwon Jung
- J. Microbiol. 2025;63(1):e.2411006. Published online January 24, 2025
- DOI: https://doi.org/10.71150/jm.2411006
- 3,967 View
- 177 Download
- 4 Web of Science
- 5 Crossref
-
Abstract
PDF
-
This review explores current advancements in microbiome functional analysis enabled by next-generation sequencing technologies, which have transformed our understanding of microbial communities from mere taxonomic composition to their functional potential. We examine approaches that move beyond species identification to characterize microbial activities, interactions, and their roles in host health and disease. Genome-scale metabolic models allow for in-depth simulations of metabolic networks, enabling researchers to predict microbial metabolism, growth, and interspecies interactions in diverse environments. Additionally, computational methods for predicting metabolite profiles offer indirect insights into microbial metabolic outputs, which is crucial for identifying biomarkers and potential therapeutic targets. Functional pathway analysis tools further reveal microbial contributions to metabolic pathways, highlighting alterations in response to environmental changes and disease states. Together, these methods offer a powerful framework for understanding the complex metabolic interactions within microbial communities and their impact on host physiology. While significant progress has been made, challenges remain in the accuracy of predictive models and the completeness of reference databases, which limit the applicability of these methods in under-characterized ecosystems. The integration of these computational tools with multi-omic data holds promise for personalized approaches in precision medicine, allowing for targeted interventions that modulate the microbiome to improve health outcomes. This review highlights recent advances in microbiome functional analysis, providing a roadmap for future research and translational applications in human health and environmental microbiology.
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Huan Zhang, Bing Jun Yang Lee, Tong Wang, Xuesong Xiang, Yafang Tan, Yanping Han, Yujing Bi, Fachao Zhi, Xin Wang, Fang He, Seppo J. Salminen, Baoli Zhu, Ruifu Yang
hLife.2025; 3(7): 307. CrossRef - Study on the Rhizosphere Soil Microbial Diversity of Five Common Orchidaceae Species in the Transitional Zone Between Warm Temperate and Subtropical Regions
Jingjing Du, Shengqian Guo, Xiaohang Li, Zhonghu Geng, Zhiliang Yuan, Xiqiang Song
Diversity.2025; 17(9): 605. CrossRef - Bioengineered Skin Microbiome: The Next Frontier in Personalized Cosmetics
Cherelle Atallah, Ayline El Abiad, Marita El Abiad, Mantoura Nakad, Jean Claude Assaf
Cosmetics.2025; 12(5): 205. CrossRef - Computational Metagenomics: State of the Art
Marco Antonio Pita-Galeana, Martin Ruhle, Lucía López-Vázquez, Guillermo de Anda-Jáuregui, Enrique Hernández-Lemus
International Journal of Molecular Sciences.2025; 26(18): 9206. CrossRef - Rotation of Corydalis yanhusuo with different crops enhances its quality and soil nutrients: a multi-dimensional analysis of rhizosphere microecology
Jia Liu, Qiang Yuan, Kejie Zhang, Xiaoxiao Sheng, Zixuan Zhu, Ning Sui, Hui Wang
BMC Plant Biology.2025;[Epub] CrossRef
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Research Article
- Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus
- Jueun Oh, Hayeon Kim, Jihye Lee, Suhyun Kim, Seyun Shin, Young-Eui Kim, Sehee Park, SangJoon Lee
- J. Microbiol. 2025;63(1):e.2409007. Published online January 24, 2025
- DOI: https://doi.org/10.71150/jm.2409007
- 1,777 View
- 107 Download
- 4 Web of Science
- 5 Crossref
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Abstract
PDF
Supplementary Material -
Korean Red ginseng has emerged as a potent candidate in the fight against various viral infections, demonstrating significant efficacy both in vitro and in vivo, particularly against influenza A viruses. Despite substantial evidence of its antiviral properties, the detailed molecular mechanisms through which it reduces viral lethality remain insufficiently understood. Our investigations have highlighted the superior effectiveness of Korean Red ginseng against influenza viruses, outperforming its effects on numerous other viral strains. We aim to uncover the specific mechanisms by which Korean Red ginseng exerts its antiviral effects, focusing on influenza A viruses. Our prior studies have identified the role of Z-DNA-binding protein 1 (ZBP1), a signaling complex involved in inducing programmed cell death in response to influenza virus infection. Given the critical role of ZBP1 as a sensor for viral nucleic acid, we hypothesize that Korean Red ginseng may modulate the ZBP1-derived cell death pathway. This interaction is anticipated to enhance cell death while concurrently suppressing viral protein expression, offering novel insights into the antiviral mechanism of Korean Red ginseng against influenza A viruses.
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Citations
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SuHyeon Oh, Young Ki Choi, SangJoon Lee
Molecules and Cells.2025; 48(8): 100239. CrossRef - Targeting innate immune sensors for therapeutic strategies in infectious diseases
Seyun Shin, Young Ki Choi, SangJoon Lee
Journal of Microbiology.2025; 63(6): e2503009. CrossRef - Formation and biological implications of Z-DNA
Yonghang Run, Mahmoud Tavakoli, Yuxuan Zhang, Karen M. Vasquez, Wenli Zhang
Trends in Genetics.2025;[Epub] CrossRef - mGem: Noncanonical nucleic acid structures—powerful but neglected antiviral targets
Václav Brázda, Richard P. Bowater, Petr Pečinka, Martin Bartas, Vinayaka R. Prasad
mBio.2025;[Epub] CrossRef - AIM2 drives inflammatory cell death and monkeypox pathogenesis
Jueun Oh, Yun-Ho Hwang, Jihye Lee, Cheong Seok, SuHyeon Oh, Hye Yoon Kim, Nabukenya Mariam, Jaeyoung Ahn, GyeongJu Yu, Jaewoo Park, Hayeon Kim, Suhyun Kim, Seyun Shin, Min-Chul Jung, Jinwoo Gil, Joo Sang Lee, Young Ki Choi, Dokeun Kim, Daesik Kim, You-Jin
Cellular & Molecular Immunology.2025; 22(12): 1615. CrossRef
- Pattern recognition receptors and inflammasome: Now and beyond
Review
- Microbiome-Mucosal Immunity Nexus: Driving Forces in Respiratory Disease Progression
- Young Chae Park, Soo Yeon Choi, Yunah Cha, Hyeong Won Yoon, Young Min Son
- J. Microbiol. 2024;62(9):709-725. Published online September 6, 2024
- DOI: https://doi.org/10.1007/s12275-024-00167-4
- 501 View
- 6 Download
- 4 Web of Science
- 5 Crossref
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Abstract
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- The importance of the complex interplay between the microbiome and mucosal immunity, particularly within the respiratory tract, has gained significant attention due to its potential implications for the severity and progression of lung diseases. Therefore, this review summarizes the specific interactions through which the respiratory tract-specific microbiome influences mucosal immunity and ultimately impacts respiratory health. Furthermore, we discuss how the microbiome affects mucosal immunity, considering tissue-specific variations, and its capacity in respiratory diseases containing asthma, chronic obstructive pulmonary disease, and lung cancer. Additionally, we investigate the external factors which affect the relationship between respiratory microbiome and mucosal immune responses. By exploring these intricate interactions, this review provides valuable insights into the potential for microbiome-based interventions to modulate mucosal immunity and alleviate the severity of respiratory diseases.
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Citations
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Yutao Ge, Guo Tang, Yawen Fu, Peng Deng, Rong Yao
European Journal of Medical Research.2025;[Epub] CrossRef - Meta-transcriptomics Reveals Dysbiosis of the Respiratory Microbiome in Older Adults with Long COVID
Meng’en Liao, Jianpeng Cai, Feng Zhu, Yuanbo Lan, Tianqi Xu, Jingxin Guo, Quanlin Xue, Yilong Wen, Fan Zou, Yu Zhang, Shiliang Zhang, Yan Yan, Jingwen Ai, Jie Cui, Wenhong Zhang
Research.2025;[Epub] CrossRef - Lactobacillus salivarius HHuMin-U attenuates vulvovaginal candidiasis via vaginal epithelial immune enhancement mediated by NF-κB activation
Juwon Choi, Jay-Young Jo, Ji Su Lee, Joe Eun Son, Sun Young Kim, Hye Eun Lee, Yeong-Je Seong, Keon Heo, Yongbaek Kim, Myeong Soo Park, Sanguine Byun
New Biotechnology.2025; 90: 36. CrossRef - Immune system - can it be boosted/influenced?
Jiřina Bartůňková
Medicína pro praxi.2025; 22(5): 319. CrossRef - Bacteria and fungi of the lung: allies or enemies?
Enrico Garaci, Marilena Pariano, Emilia Nunzi, Claudio Costantini, Marina Maria Bellet, Cinzia Antognelli, Matteo Antonio Russo, Luigina Romani
Frontiers in Pharmacology.2024;[Epub] CrossRef
- The impact of environmental factors on respiratory tract microbiome and respiratory system diseases
Journal Article
- Congregibacter variabilis sp. nov. and Congregibacter brevis sp. nov. Within the OM60/NOR5 Clade, Isolated from Seawater, and Emended Description of the Genus Congregibacter
- Hyeonsu Tak, Miri S Park, Hyerim Cho, Yeonjung Lim, Jang-Cheon Cho
- J. Microbiol. 2024;62(9):739-748. Published online July 18, 2024
- DOI: https://doi.org/10.1007/s12275-024-00158-5
- 583 View
- 9 Download
- 5 Web of Science
- 5 Crossref
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Abstract
PDF
- Two Gram-stain-negative, aerobic, motile by means of flagella, short rod-shaped bacterial strains, designated IMCC43200(T) and IMCC45268(T), were isolated from coastal seawater samples collected from the South Sea of Korea. Strains IMCC43200(T) and IMCC45268(T) shared 98.6% 16S rRNA gene sequence similarity and were closely related to Congregibacter litoralis KT71(T) (98.8% and 98.7%, respectively). Complete whole-genome sequences of IMCC43200(T) and IMCC45268(T) were 3.93 and 3.86 Mb in size with DNA G + C contents of 54.8% and 54.2%, respectively. Average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between the two strains were 74.5% and 23.4%, respectively, revealing that they are independent species. The two strains showed ANI values of ≤ 75.8% and dDDH values of ≤ 23.0% to the type and only species of the genus Congregibacter (C. litoralis), indicating that each strain represents a novel species. Both strains contained summed feature 3 (comprising C(16:1) ω6c and/or C(16:1) ω7c) and summed feature 8 (comprising C(18:1) ω6c and/or C(18:1) ω7c) as major fatty acid constituents. The predominant isoprenoid quinone detected in both strains was ubiquinone-8 (Q-8). The major polar lipids of the two strains were phosphatidylethanolamine, phosphatidylglycerol, phospholipids, and aminolipids. Based on the phylogenetic, genomic, and phenotypic characterization, strains IMCC43200(T) and IMCC45268(T) were considered to represent two novel species within the genus Congregibacter, for which the names Congregibacter variabilis sp. nov. and Congregibacter brevis sp. nov. are proposed with IMCC43200(T) (= KCTC 8133(T) = NBRC 116295(T) = CCTCC AB 2023139(T)) and IMCC45268(T) (= KCTC 92921(T) = NBRC 116135(T)) as the type strains, respectively.
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Citations
Citations to this article as recorded by- Validation List no. 223. Valid publication of new names and new combinations effectively published outside the IJSEM
Aharon Oren, Markus Göker
International Journal of Systematic and Evolutionary Microbiology .2025;[Epub] CrossRef - Phycobium rhodophyticola gen. nov., sp. nov. and Aliiphycobium algicola gen. nov., sp. nov., isolated from the phycosphere of marine red algae
Jeong Min Kim, Woonhee Baek, Byeong Jun Choi, Hülya Bayburt, Jae Kyeong Lee, Sung Chul Lee, Che Ok Jeon
Journal of Microbiology.2025; 63(6): e2503014. CrossRef - Notification of changes in taxonomic opinion previously published outside the IJSEM. List of Changes in Taxonomic Opinion no. 42
Aharon Oren, Markus Göker
International Journal of Systematic and Evolutionary Microbiology .2025;[Epub] CrossRef - Rubrivirga aquatilis sp. nov. and Rubrivirga halophila sp. nov., isolated from Korean coastal surface seawater
Jisoo Han, Yeonjung Lim, Mirae Kim, Jang-Cheon Cho
Journal of Microbiology.2025; 63(8): e2504017. CrossRef - Leuconostoc aquikimchii sp. nov., a Lactic Acid Bacterium Isolated from Cabbage Watery Kimchi
Subin Kim, Se Hee Lee, Ki Hyun Kim, Misun Yun
Journal of Microbiology.2024; 62(12): 1089. CrossRef
- Validation List no. 223. Valid publication of new names and new combinations effectively published outside the IJSEM
Review
- Reverse Zoonotic Transmission of SARS-CoV-2 and Monkeypox Virus: A Comprehensive Review
- Chiranjib Chakraborty, Manojit Bhattacharya, Md Aminul Islam, Hatem Zayed, Elijah Ige Ohimain, Sang-Soo Lee, Prosun Bhattacharya, Kuldeep Dhama
- J. Microbiol. 2024;62(5):337-354. Published online May 23, 2024
- DOI: https://doi.org/10.1007/s12275-024-00138-9
- 506 View
- 5 Download
- 5 Web of Science
- 5 Crossref
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Abstract
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- Reverse zoonosis reveals the process of transmission of a pathogen through the human-animal interface and the spillback of the zoonotic pathogen. In this article, we methodically demonstrate various aspects of reverse zoonosis, with a comprehensive discussion of SARS-CoV-2 and MPXV reverse zoonosis. First, different components of reverse zoonosis, such as humans, different pathogens, and numerous animals (poultry, livestock, pets, wild animals, and zoo animals), have been demonstrated. Second, it explains the present status of reverse zoonosis with different pathogens during previous occurrences of various outbreaks, epidemics, and pandemics. Here, we present 25 examples from literature. Third, using several examples, we comprehensively illustrate the present status of the reverse zoonosis of SARS-CoV-2 and MPXV. Here, we have provided 17 examples of SARS-CoV-2 reverse zoonosis and two examples of MPXV reverse zoonosis. Fourth, we have described two significant aspects of reverse zoonosis: understanding the fundamental aspects of spillback and awareness. These two aspects are required to prevent reverse zoonosis from the current infection with two significant viruses. Finally, the One Health approach was discussed vividly, where we urge scientists from different areas to work collaboratively to solve the issue of reverse zoonosis.
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Citations
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Chiranjib Chakraborty, Manojit Bhattacharya, Arpita Das, Ali S. Abdelhameed
Virus Genes.2025; 61(3): 265. CrossRef - Efficient and modular reverse genetics system for rapid generation of recombinant severe acute respiratory syndrome coronavirus 2
Sojung Bae, Jinjong Myoung
Journal of Microbiology.2025; 63(7): e2504015. CrossRef - Real-time malaria detection in the Amazon rainforest via drone-collected eDNA and portable qPCR
Yin Cheong Aden Ip, Luca Montemartini, Jia Jin Marc Chang, Andrea Desiderato, Nicolás D. Franco-Sierra, Christian Geckeler, Mailyn Adriana Gonzalez Herrera, Michele Gregorini, Meret Jucker, Steffen Kirchgeorg, Martina Lüthi, Elvira Mächler, Frederik Bendi
One Health.2025; 21: 101167. CrossRef - Development of a multiplex real-time PCR for the simultaneous detection of monkeypox virus clades I, II, and goatpox virus
Yongqiang Lin, Zijing Guo, Jinsong Chen, Xianwen Zhang, Long Zhou, Yanmin Li, Zhidong Zhang
Frontiers in Veterinary Science.2024;[Epub] CrossRef - Differential Impact of Spike Protein Mutations on SARS-CoV-2 Infectivity and Immune Evasion: Insights from Delta and Kappa Variants
Tae-Hun Kim, Sojung Bae, Jinjong Myoung
Journal of Microbiology and Biotechnology.2024; 34(12): 2506. CrossRef
- Phylogenetic analyses of the spread of Clade I MPOX in African and non-African nations
Journal Article
- Flavivirga spongiicola sp. nov. and Flavivirga abyssicola sp. nov., Isolated from Marine Environments
- Sung-Hyun Yang , Mi-Jeong Park , Hyun-Myung Oh , Yeong-Jun Park , Kae Kyoung Kwon
- J. Microbiol. 2024;62(1):11-19. Published online February 6, 2024
- DOI: https://doi.org/10.1007/s12275-023-00102-z
- 609 View
- 17 Download
- 5 Web of Science
- 5 Crossref
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Abstract
PDF
- Two novel Gram-stain-negative, strictly-aerobic, rod-shaped (1.2 ± 3.4 μm × 0.3 ± 0.7 μm), and non-motile marine bacterial species, designated MEBiC05379T and MEBiC07777T, were isolated from a marine sponge Pseudaxinella sp. in Gangneung City and deep-sea sediments of the Ulleung basin in the East Sea of Korea, respectively. The 16S rRNA gene sequence analysis revealed high levels of similarities between these strains and members of the genus Flavivirga (97.0–98.4% sequence identities). Both novel strains revealed as mesophilic, neutrophilic in pH and slightly halophilic. Similar to those of other Flavivirga members, the primary cellular fatty acids of both strains were iso-C15:0, iso-C15:1 G, iso-C15:03-OH, and iso-C17:0 3-OH, with MEBiC05379T and MEBiC07777T containing relatively higher proportions of C12: 0 and summed feature 3 ( C16:1ω7c and/or C16: 1ω6c). In both taxa, the major isoprenoid quinone was MK-6. The DNA G + C contents of MEBiC05379T and MEBiC07777T genomes were 32.62 and 32.46 mol%, respectively. Compared to other members of Flavivirga, both strains exhibited similar DNA G + C ratio and fatty acids pattern, yet enzyme expression and carbon sources utilization pattern were different. Genomes of the genus Flavivirga showed enzyme preferences to fucoidan and sulfated galactans. Considering the monophyly rule, AAI values delineate the genus Flavivirga from adjacent genera calculated to be 76.0–78.7%. Based on the phenotypic, genomic and biochemical data, strains for MEBiC05379T and MEBiC07777T thus represent two novel species in the genus Flavivirga, for which the names Flavivirga spongiicola sp. nov. ( MEBiC05379T [= KCTC 92527 T = JCM 16662 T]), and Flavivirga abyssicola sp. nov. ( MEBiC07777T [= KCTC 92563 T = JCM 36477 T]) are proposed.
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Citations
Citations to this article as recorded by- Phycobium rhodophyticola gen. nov., sp. nov. and Aliiphycobium algicola gen. nov., sp. nov., isolated from the phycosphere of marine red algae
Jeong Min Kim, Woonhee Baek, Byeong Jun Choi, Hülya Bayburt, Jae Kyeong Lee, Sung Chul Lee, Che Ok Jeon
Journal of Microbiology.2025; 63(6): e2503014. CrossRef - Rubrivirga aquatilis sp. nov. and Rubrivirga halophila sp. nov., isolated from Korean coastal surface seawater
Jisoo Han, Yeonjung Lim, Mirae Kim, Jang-Cheon Cho
Journal of Microbiology.2025; 63(8): e2504017. CrossRef - Rhodobacteraceae are Prevalent and Ecologically Crucial Bacterial Members in Marine Biofloc Aquaculture
Meora Rajeev, Jang-Cheon Cho
Journal of Microbiology.2024; 62(11): 985. CrossRef - Validation List no. 220. Valid publication of new names and new combinations effectively published outside the IJSEM
Aharon Oren, Markus Göker
International Journal of Systematic and Evolutionary Microbiology .2024;[Epub] CrossRef - Optimization of Culture Medium for the Production of an Exopolysaccharide (p-CY02) with Cryoprotective Activity by Pseudoalteromonas sp. RosPo-2 from the Antarctic Sea
Pilsung Kang, Sung Jin Kim, Ha Ju Park, Il Chan Kim, Se Jong Han, Joung Han Yim
Journal of Microbiology and Biotechnology.2024; 34(5): 1135. CrossRef
- Phycobium rhodophyticola gen. nov., sp. nov. and Aliiphycobium algicola gen. nov., sp. nov., isolated from the phycosphere of marine red algae
Review
- Recent advances in the Design-Build-Test-Learn (DBTL) cycle for systems metabolic engineering of Corynebacterium glutamicum
- Subeen Jeon, Yu Jung Sohn, Haeyoung Lee, Ji Young Park, Dojin Kim, Eun Seo Lee, Si Jae Park
- J. Microbiol. 2025;63(3):e2501021. Published online March 28, 2025
- DOI: https://doi.org/10.71150/jm.2501021
- 1,888 View
- 153 Download
- 1 Web of Science
- 4 Crossref
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Abstract
PDF
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Existing microbial engineering strategies—encompassing metabolic engineering, systems biology, and systems metabolic engineering—have significantly enhanced the potential of microbial cell factories as sustainable alternatives to the petrochemical industry by optimizing metabolic pathways. Recently, systems metabolic engineering, which integrates tools from synthetic biology, enzyme engineering, omics technology, and evolutionary engineering, has been successfully developed. By leveraging modern engineering strategies within the Design-Build-Test-Learn (DBTL) cycle framework, these advancements have revolutionized the biosynthesis of valuable compounds. This review highlights recent progress in the metabolic engineering of Corynebacterium glutamicum, a versatile microbial platform, achieved through various approaches from traditional metabolic engineering to advanced systems metabolic engineering, all within the DBTL cycle. A particular focus is placed C5 platform chemicals derived from L-lysine, one of the key amino acid production pathways of C. glutamicum. The development of DBTL cycle-based metabolic engineering strategies for this process is discussed.
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Citations
Citations to this article as recorded by- Advancing microbial engineering through synthetic biology
Ki Jun Jeong
Journal of Microbiology.2025; 63(3): e2503100. CrossRef - Time-Series Metabolome and Transcriptome Analyses Reveal the Genetic Basis of Vanillin Biosynthesis in Vanilla
Zeyu Dong, Shaoguan Zhao, Yizhang Xing, Fan Su, Fei Xu, Lei Fang, Zhiyuan Zhang, Qingyun Zhao, Fenglin Gu
Plants.2025; 14(13): 1922. CrossRef - Systems and Synthetic Biology Approaches for Optimizing Microbial Cell Factories
Jongoh Shin, Myung Hyun Noh, Seung-Ho Baek, Jonghyeok Shin, Jung Ho Ahn, Sung Sun Yim, Sungho Jang, Hyun Gyu Lim
KSBB Journal.2025; 40(3): 214. CrossRef - Digital to Biological Translation: How the Algorithmic Data-Driven Design Reshapes Synthetic Biology
Abdul Manan, Nabila Qayyum, Rajath Ramachandran, Naila Qayyum, Sidra Ilyas
SynBio.2025; 3(4): 17. CrossRef
- Advancing microbial engineering through synthetic biology
Research Article
- Dissimilatory nitrate reductions in soil Neobacillus and Bacillus strains under aerobic condition
- Seohyun Ahn, Min Cho, Michael J. Sadowsky, Jeonghwan Jang
- J. Microbiol. 2025;63(2):e2411019. Published online February 27, 2025
- DOI: https://doi.org/10.71150/jm.2411019
- 1,874 View
- 83 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDFSupplementary Material
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Denitrification and dissimilatory nitrate reduction to ammonium (DNRA) were thought to be carried-out by anaerobic bacteria constrained to anoxic conditions as they use nitrate (NO3-) as a terminal electron acceptor instead of molecular O2. Three soil bacilli, Neobacillus spp. strains PS2-9 and PS3-12 and Bacillus salipaludis PS3-36, were isolated from rice paddy field soil in Korea. The bacterial strains were selected as possible candidates performing aerobic denitrification and DNRA as they were observed to reduce NO3- and produce extracellular NH4+ regardless of oxygen presence at the initial screening. Whole genome sequencing revealed that these strains possessed all the denitrification and DNRA functional genes in their genomes, including the nirK, nosZ, nirB, and nrfA genes, which were simultaneously cotranscribed under aerobic condition. The ratio between the assimilatory and dissimilatory NO3- reduction pathways depended on the availability of a nitrogen source for cell growth, other than NO3-. Based on the phenotypic and transcriptional analyses of the NO3- reductions, all three of the facultative anaerobic strains reduced NO3- likely in both assimilatory and dissimilatory pathways under both aerobic and anoxic conditions. To our knowledge, this is the first report that describes coexistence of NO3- assimilation, denitrification, and DNRA in a Bacillus or Neobacillus strain under aerobic condition. These strains may play a pivotal role in the soil nitrogen cycle.
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Citations
Citations to this article as recorded by- Biofertilizers Enhance Soil Fertility and Crop Yields Through Microbial Community Modulation
Xu Zhang, Lei Zhang, Junjie Liu, Zongzuan Shen, Zhuxiu Liu, Haidong Gu, Xiaojing Hu, Zhenhua Yu, Yansheng Li, Jian Jin, Guanghua Wang
Agronomy.2025; 15(7): 1572. CrossRef - Strategy of nitrate-enhanced natural attenuation for remediation of PAHs-contaminated subsoil
Xuyang Jiang, Zhen Mao, Zhenqi Hu, Tao Jin, Licun Zhong, Jinbiao Yu
Journal of Environmental Chemical Engineering.2025; 13(5): 118037. CrossRef - Leveraging iron-rich recovered waste as a co-electron donor in sulfur autotrophic denitrification for simultaneous nitrate and phosphate removal from low C/N hydroponic wastewater
Sandesh Pandey, Anup Gurung, Choe Earn Choong, Suleman Shahzad, Fida Hussain, Woochang Kang, Syed Ejaz Hussain Mehdi, Aparna Sharma, Min Jang, Sang-Eun Oh
Journal of Water Process Engineering.2025; 79: 108948. CrossRef - narG, rather than napA, mediates aerobic nitrate reduction process in Pseudomonas putida Y-9
Yuwen Luo, Luo Luo, Xuejiao Huang, Daihua Jiang, Zhenlun Li
Water Research X.2025; 29: 100437. CrossRef
- Biofertilizers Enhance Soil Fertility and Crop Yields Through Microbial Community Modulation
Journal Articles
- CalR Inhibits the Swimming Motility and Polar Flagellar Gene Expression in Vibrio parahaemolyticus
- Jingyang Chang, Yining Zhou, Miaomiao Zhang, Xue Li, Nan Zhang, Xi Luo, Bin Ni, Haisheng Wu, Renfei Lu, Yiquan Zhang
- J. Microbiol. 2024;62(12):1125-1132. Published online December 6, 2024
- DOI: https://doi.org/10.1007/s12275-024-00179-0
- 408 View
- 12 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDF
- Vibrio parahaemolyticus has two flagellar systems, the polar flagellum and lateral flagella, which are both intricately regulated by a multitude of factors. CalR, a LysR-type transcriptional regulator, is sensitive to calcium (Ca) and plays a crucial role in regulating the virulence and swarming motility of V. parahaemolyticus. In this study, we have demonstrated that the deletion of calR significantly enhances the swimming motility of V. parahaemolyticus under low Ca conditions but not under high Ca conditions or in the absence of Ca. CalR binds to the regulatory DNA regions of flgM, flgA, and flgB, which are located within the polar flagellar gene loci, with the purpose of repressing their transcription. Additionally, it exerts an indirect negative control over the transcription of flgK. The overexpression of CalR in Escherichia coli resulted in a reduction in the expression levels of flgM, flgA, and flgB, while having no impact on the expression of flgK. In summary, this research demonstrates that the negative regulation of V. parahaemolyticus swimming motility by CalR under low Ca conditions is achieved through its regulation on the transcription of polar flagellar genes.
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Citations
Citations to this article as recorded by- A DHH/DHHA1 family 3′-phosphoadenosine 5′-monophosphate (pAp) phosphoesterase Vp2835 is essential for regulating motility, biofilm formation and type III secretion system 1 in Vibrio parahaemolyticus
Chenzhi Zhuhuang, Chenxi Wang, Yu Sun, Min Chu, Menghua Yang, Guangzhi Xu
Food Bioscience.2025; 69: 106836. CrossRef - Chlorogenic Acid Targets Cell Integrity and Virulence to Combat Vibrio parahaemolyticus
Huan Liu, Jie Zhao, Yile Shi, Juanjuan Cao, Yanni Zhao
Foods.2025; 14(19): 3416. CrossRef -
CalR is an activator of biofilm formation in
Vibrio parahaemolyticus
Jingyang Chang, Yining Zhou, Miaomiao Zhang, Xue Li, Nan Zhang, Xi Luo, Bin Ni, Renfei Lu, Yiquan Zhang, Sophie Roussel
Applied and Environmental Microbiology.2025;[Epub] CrossRef - LtrA is critical for biofilm formation and colonization of Vibrio parahaemolyticus on food-related surfaces
Shuhui Xiong, Nan Zhang, Hui Sun, Miaomiao Zhang, Xue Li, Xi Luo, Yiquan Zhang, Renfei Lu
International Journal of Food Microbiology.2025; 441: 111327. CrossRef
- A DHH/DHHA1 family 3′-phosphoadenosine 5′-monophosphate (pAp) phosphoesterase Vp2835 is essential for regulating motility, biofilm formation and type III secretion system 1 in Vibrio parahaemolyticus
- The Gut Microbiota Mediates the Protective Effects of Spironolactone on Myocardial Infarction
- Lu Li, Jian-Yong Sun, Yu-Lin Li, Shi-Wei Zhu, Sheng-Zhong Duan
- J. Microbiol. 2024;62(10):883-895. Published online September 3, 2024
- DOI: https://doi.org/10.1007/s12275-024-00164-7
- 435 View
- 6 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDF
- Myocardial infarction (MI) is a type of cardiovascular disease that influences millions of human beings worldwide and has a great rate of mortality and morbidity. Spironolactone has been used as a critical drug for the treatment of cardiac failure and it ameliorates cardiac dysfunction post-MI. Despite these findings, whether there is a relationship between the therapeutic effects of spironolactone and the gut microorganism after MI has not been determined. In our research, we used male C57BL/6 J mice to explore whether the gut microbiota mediates the beneficial function of spironolactone after myocardial infarction. We demonstrated that deletion of the gut microbiota eliminated the beneficial function of spironolactone in MI mice, displaying exacerbated cardiac dysfunction, cardiac infarct size. In addition, the gut microbiota was altered by spironolactone after sham or MI operation in mice. We also used male C57BL/6 J mice to investigate the function of a probiotic in the myocardial infarction. In summary, our findings reveal a precious role of the gut flora in the therapeutic function of spironolactone on MI.
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Citations
Citations to this article as recorded by- Probiotics and Prebiotics in Post-Myocardial Infarction Rehabilitation: Mechanisms, Benefits, and Future Directions
Georgy Leonov, Elena Livantsova, Yurgita Varaeva, Antonina Starodubova
Current Nutrition Reports.2025;[Epub] CrossRef - Research Trends and Hotspots of Gut Microbiota and Its Metabolites in Cardiovascular Diseases: A Bibliometric Analysis
Kaixuan Zhang, Yajun Shi, Lirong Peng, Xiaofei Zhang, Nanbo Zheng, Jiajing Xin, Junbo Zou, Fei Luan
Journal of Multidisciplinary Healthcare.2025; Volume 18: 5125. CrossRef - Insights into the role of gut microbiota modulation in the management of various cardiovascular diseases: A new approach for improving the efficacy of current cardiovascular medications
Lamiaa A. Ahmed, Khaled F. Al-Massri
European Journal of Pharmacology.2025; 1007: 178210. CrossRef - The role of the gut microbiota in the onset and progression of heart failure: insights into epigenetic mechanisms and aging
Giulia Matacchione, Francesco Piacenza, Lorenzo Pimpini, Yuri Rosati, Serena Marcozzi
Clinical Epigenetics.2024;[Epub] CrossRef
- Probiotics and Prebiotics in Post-Myocardial Infarction Rehabilitation: Mechanisms, Benefits, and Future Directions
- Enhanced Poly-γ-Glutamic Acid Production by a Newly Isolated Bacillus halotolerans F29
- Xiaorong Sun, Yaoyu Cai, Dexin Wang
- J. Microbiol. 2024;62(8):695-707. Published online August 20, 2024
- DOI: https://doi.org/10.1007/s12275-024-00153-w
- 580 View
- 11 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDF
- Poly-γ-glutamic acid (γ-PGA) is a promising biopolymer for various applications. In this study, we isolated a novel γ-PGA-producing strain, Bacillus halotolerans F29. The one-factor-at-a-time method was used to investigate the influence of carbon sources, nitrogen sources, and culture parameters on γ-PGA production. The optimal carbon and nitrogen sources were sucrose and (NH4)2SO4, respectively. The optimal culture conditions for γ-PGA production were determined to be 37 °C and a pH of 5.5. Response surface methodology was used to determine the optimum medium components: 77.6 g/L sucrose, 43.0 g/L monosodium glutamate, and 2.2 g/L K2HPO4. The γ-PGA titer increased significantly from 8.5 ± 0.3 g/L to 20.7 ± 0.7 g/L when strain F29 was cultivated in the optimized medium. Furthermore, the γ-PGA titer reached 50.9 ± 1.5 g/L with a productivity of 1.33 g/L/h and a yield of 2.23 g of γ-PGA/g of L-glutamic acid with the optimized medium in fed-batch fermentation. The maximum γ-PGA titer reached 45.3 ± 1.1 g/L, with a productivity of 1.06 g/L/h when molasses was used as a carbon source. It should be noted that the γ-PGA yield in this study was the highest of all reported studies, indicating great potential for the industrial production of γ-PGA.
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Citations
Citations to this article as recorded by- Investigation of glutamic acid production capacity of Stenotrophomonas sp. strain CG2 isolated from soil
Cihat Guner, Ertan Ermis, Kubra Ozkan Guner
Biocatalysis and Agricultural Biotechnology.2025; 67: 103665. CrossRef - Metabolic engineering of microorganisms for tailor-made biopolymer production: A review
Mădălina Lorena Medeleanu, Lavinia-Florina Călinoiu, Gheorghe-Adrian Martău, Dan-Cristian Vodnar
International Journal of Biological Macromolecules.2025; 330: 147922. CrossRef - Poly-γ-glutamic acid production from untreated sugarcane molasses by non-sterilized repeated-batch fermentation with Bacillus subtilis GLS-8
Yu Lin, Lin Shu, Huizhen Chen, Xiaoqun Duan, Wei Zeng
Chemical Engineering Journal Advances.2025; 24: 100900. CrossRef - Transcriptomics-guided rational engineering in Bacillus licheniformis for enhancing poly-γ-glutamic acid biosynthesis using untreated molasses
Rui Han, Qian Zhong, Yifan Yan, Juan Wang, Yifan Zhu, Sha Li, Peng Lei, Rui Wang, Yibin Qiu, Zhengshan Luo, Hong Xu
International Journal of Biological Macromolecules.2024; 282: 137514. CrossRef
- Investigation of glutamic acid production capacity of Stenotrophomonas sp. strain CG2 isolated from soil
- Cultivation of Diverse Novel Marine Bacteria from Deep Ocean Sediment Using Spent Culture Supernatant of Ca. Bathyarchaeia Enrichment
- Sidra Erum Ishaq, Tariq Ahmad, Lewen Liang, Ruize Xie, Tiantian Yu, Yinzhao Wang, Fengping Wang
- J. Microbiol. 2024;62(8):611-625. Published online July 10, 2024
- DOI: https://doi.org/10.1007/s12275-024-00145-w
- 523 View
- 10 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDF
- Most microorganisms resist pure cultivation under conventional laboratory conditions. One of the primary issues for this un-culturability is the absence of biologically produced growth-promoting factors in traditionally defined growth media. However, whether cultivating microbes by providing spent culture supernatant of pivotal microbes in the growth medium can be an effective approach to overcome this limitation is still an under-explored area of research. Here, we used the spent culture medium (SCM) method to isolate previously uncultivated marine bacteria and compared the efficiency of this method with the traditional cultivation (TC) method. In the SCM method, Ca. Bathyarchaeia-enriched supernatant (10%) was used along with recalcitrant organic substrates such as lignin, humic acid, and organic carbon mixture. Ca. Bathyarchaeia, a ubiquitous class of archaea, have the capacity to produce metabolites, making their spent culture supernatant a key source to recover new bacterial stains. Both cultivation methods resulted in the recovery of bacterial species from the phyla Pseudomonadota, Bacteroidota, Actinomycetota, and Bacillota. However, our SCM approach also led to the recovery of species from rarely cultivated groups, such as Planctomycetota, Deinococcota, and Balneolota. In terms of the isolation of new taxa, the SCM method resulted in the cultivation of 80 potential new strains, including one at the family, 16 at the genus, and 63 at the species level, with a novelty ratio of ~ 35% (80/219). In contrast, the TC method allowed the isolation of ~ 10% (19/171) novel strains at species level only. These findings suggest that the SCM approach improved the cultivation of novel and diverse bacteria.
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Citations
Citations to this article as recorded by- Engineering the phycosphere: fundamental concepts and tools for the bottom-up design of microalgal-bacterial consortia
Austin Semple, Jagroop Pandhal
Applied Phycology.2025; 6(1): 21. CrossRef - Darkness to Discovery: A Comprehensive Mini-Review on Culturable and Non-Culturable Microbial Diversity from Deep Sea
Abhay B. Fulke, Nilkanth Sharma, Jayshree Nadekar
Microbial Ecology.2025;[Epub] CrossRef - The bacterial community of the freshwater bryozoan Cristatella mucedo and its secondary metabolites production potential
Inmaculada Tocino-Márquez, Martin Zehl, Joana Séneca, Petra Pjevac, Manuel Felkl, Christian F. W. Becker, Alexander Loy, Thomas Rattei, Andrew N. Ostrovsky, Sergey B. Zotchev
Scientific Reports.2025;[Epub] CrossRef - Uncertainty Analysis of Biogas Generation and Gas Hydrate Accumulations in the Baiyun Sag, South China Sea
Pibo Su, Jinqiang Liang, Huai Cheng, Yaoyao Lv, Wei Zhang, Zuofei Zhu
Microorganisms.2024; 13(1): 5. CrossRef
- Engineering the phycosphere: fundamental concepts and tools for the bottom-up design of microalgal-bacterial consortia
Review
- Structural Insights into the Lipopolysaccharide Transport (Lpt) System as a Novel Antibiotic Target
- Yurim Yoon, Saemee Song
- J. Microbiol. 2024;62(4):261-275. Published online May 31, 2024
- DOI: https://doi.org/10.1007/s12275-024-00137-w
- 368 View
- 9 Download
- 3 Web of Science
- 4 Crossref
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Abstract
PDF
- Lipopolysaccharide (LPS) is a critical component of the extracellular leaflet within the bacterial outer membrane, forming an effective physical barrier against environmental threats in Gram-negative bacteria. After LPS is synthesized and matured in the bacterial cytoplasm and the inner membrane (IM), LPS is inserted into the outer membrane (OM) through the ATP-driven LPS transport (Lpt) pathway, which is an energy-intensive process. A trans-envelope complex that contains seven Lpt proteins (LptA-LptG) is crucial for extracting LPS from the IM and transporting it across the periplasm to the OM. The last step in LPS transport involves the mediation of the LptDE complex, facilitating the insertion of LPS into the outer leaflet of the OM. As the Lpt system plays an essential role in maintaining the impermeability of the OM via LPS decoration, the interactions between these interconnected subunits, which are meticulously regulated, may be potential targets for the development of new antibiotics to combat multidrug-resistant Gram-negative bacteria. In this review, we aimed to provide an overview of current research concerning the structural interactions within the Lpt system and their implications to clarify the function and regulation of LPS transport in the overall process of OM biogenesis. Additionally, we explored studies on the development of therapeutic inhibitors of LPS transport, the factors that limit success, and future prospects.
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Citations
Citations to this article as recorded by- Boosting the Antimicrobial Activity of Quaternary Ammonium Photosensitizers by Janus‐Type AIE Luminogens
Dongyang Fan, Meng Li, Zipeng Shen, Ying Li, Jingjing Guo, Dong Wang, Ting Han, Ben Zhong Tang
Aggregate.2025;[Epub] CrossRef - Functional Versatility of Vibrio cholerae Outer Membrane Proteins
Annabelle Mathieu-Denoncourt, Marylise Duperthuy
Applied Microbiology.2025; 5(3): 64. CrossRef - Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101
Emmanuel Tope Oluwabusola, Stephen A. Jackson, Cristina Brunati, Stefanie Gackstatter, Hannah Vedder, Marianna Iorio, Gargee Chawande, Lekha Menon Margassery, Giang-Son Nguyen, David J. Clarke, Rainer Ebel, Marcel Jaspars, Alan D. W. Dobson
Marine Drugs.2025; 23(9): 362. CrossRef - Protein–Protein Interactions as Promising Molecular Targets for Novel Antimicrobials Aimed at Gram-Negative Bacteria
Piotr Maj, Joanna Trylska
International Journal of Molecular Sciences.2025; 26(22): 10861. CrossRef
- Boosting the Antimicrobial Activity of Quaternary Ammonium Photosensitizers by Janus‐Type AIE Luminogens
Journal Articles
- Medium Chain Length Polyhydroxyalkanoate Production by Engineered Pseudomonas gessardii Using Acetate-formate as Carbon Sources
- Woo Young Kim, Seung-Jin Kim, Hye-Rin Seo, Yoonyong Yang, Jong Seok Lee, Moonsuk Hur, Byoung-Hee Lee, Jong-Geol Kim, Min-Kyu Oh
- J. Microbiol. 2024;62(7):569-579. Published online May 3, 2024
- DOI: https://doi.org/10.1007/s12275-024-00136-x
- 432 View
- 7 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDF
- Production of medium chain length polyhydroxyalkanoate (mcl-PHA) was attempted using Pseudomonas gessardii NIBRBAC000509957, which was isolated from Sunchang, Jeollabuk-do, Republic of Korea (35°24'27.7"N, 127°09'13.0"E) and effectively utilized acetate and formate as carbon sources. We first evaluated the utilization of acetate as a carbon source, revealing optimal growth at 5 g/L acetate. Then, formate was supplied to the acetate minimal medium as a carbon source to enhance cell growth. After overexpressing the acetate and formate assimilation pathway enzymes, this strain grew at a significantly higher rate in the medium. As this strain naturally produces PHA, it was further engineered metabolically to enhance mcl-PHA production. The engineered strain produced 0.40 g/L of mcl-PHA with a biomass content of 30.43% in fed-batch fermentation. Overall, this strain can be further developed to convert acetate and formate into valuable products.
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Citations
Citations to this article as recorded by- Formate-driven photoautotrophic growth and biopolymer storage in anaerobic purple bacteria
Mohammad Adib Ghazali Abdul Rahman, Bronwyn Laycock, Steven Pratt, Damien J. Batstone
Bioresource Technology.2025; 434: 132753. CrossRef - Sulphide and oleic acid synergism in accelerating mcl-PHA biopolymer production in Pseudomonas aeruginosa MCC 5300 by modulating electron transport system
Raghavendra Paduvari, Divyashree Somashekara
Biochemistry and Biophysics Reports.2025; 44: 102286. CrossRef - Unlocking efficient polyhydroxyalkanoate production by Gram-positive Priestia megaterium using waste-derived feedstocks
Xinyi Bai, Libo Xu, Kang Li, Guangbao Zhang, Mengjun Zhang, Yi Huang
Microbial Cell Factories.2025;[Epub] CrossRef - Selective utilization of formic acid and acetic acid in succinic acid fermentation broth to produce single-cell protein using Rhodotorula glutinis
Fuqiang Liu, Pengfei Wu, Lin Yu, Zitu Lü, Xinying Sun, Jiaxin Li, Lei Liu, Jing Wu, Jianan Zhang
Bioprocess and Biosystems Engineering.2025;[Epub] CrossRef
- Formate-driven photoautotrophic growth and biopolymer storage in anaerobic purple bacteria
- Genetically Engineered CLDN18.2 CAR-T Cells Expressing Synthetic PD1/CD28 Fusion Receptors Produced Using a Lentiviral Vector
- Heon Ju Lee, Seo Jin Hwang, Eun Hee Jeong, Mi Hee Chang
- J. Microbiol. 2024;62(7):555-568. Published online May 3, 2024
- DOI: https://doi.org/10.1007/s12275-024-00133-0
- 510 View
- 11 Download
- 3 Web of Science
- 4 Crossref
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Abstract
PDF
- This study aimed to develop synthetic Claudin18.2 (CLDN18.2) chimeric antigen receptor (CAR)-T (CAR-T) cells as a treatment for advanced gastric cancer using lentiviral vector genetic engineering technology that targets the CLDN18.2 antigen and simultaneously overcomes the immunosuppressive environment caused by programmed cell death protein 1 (PD-1). Synthetic CAR T cells are a promising approach in cancer immunotherapy but face many challenges in solid tumors. One of the major problems is immunosuppression caused by PD-1. CLDN18.2, a gastric-specific membrane protein, is considered a potential therapeutic target for gastric and other cancers. In our study, CLDN18.2 CAR was a second-generation CAR with inducible T-cell costimulatory (CD278), and CLDN18.2-PD1/CD28 CAR was a third-generation CAR, wherein the synthetic PD1/CD28 chimeric-switch receptor (CSR) was added to the second-generation CAR. In vitro, we detected the secretion levels of different cytokines and the killing ability of CAR-T cells. We found that the secretion of cytokines such as interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) secreted by three types of CAR-T cells was increased, and the killing ability against CLDN18.2-positive GC cells was enhanced. In vivo, we established a xenograft GC model and observed the antitumor effects and off-target toxicity of CAR-T cells. These results support that synthetic anti-CLDN18.2 CAR-T cells have antitumor effect and anti-CLDN18.2-PD1/CD28 CAR could provide a promising design strategy to improve the efficacy of CAR-T cells in advanced gastric cancer.
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Citations
Citations to this article as recorded by- Enhancing the antitumor activity of CD19/BCMA CAR-T cells in vitro with a PD1IL7R chimeric switch receptor
Kai Yan, Zhongdang Xiao
Cellular Immunology.2025; 415-416: 105001. CrossRef - Research progress on mechanisms of tumor immune microenvironment and gastrointestinal resistance to immunotherapy: mini review
Zheng Zhang, Yangping Wu
Frontiers in Immunology.2025;[Epub] CrossRef - On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models
Filippo Birocchi, Antonio J. Almazan, Aiyana Parker, Amanda A. Bouffard, Sadie Goncalves, Christopher Kelly, Jessica Frank, Mark B. Leick, Nicholas J. Haradhvala, Shaw Kagawa, Gad Getz, Giulia Escobar, Diego Salas-Benito, Adele Mucci, Trisha R. Berger, Ma
Nature Communications.2025;[Epub] CrossRef - Innovative CAR-T approaches targeting Claudin 18.2 to counteract drug resistance in gastric cancer
Giovanni Calice, Carlo Calabrese, Tiziana Notarangelo
Biomedicine & Pharmacotherapy.2025; 193: 118863. CrossRef
- Enhancing the antitumor activity of CD19/BCMA CAR-T cells in vitro with a PD1IL7R chimeric switch receptor
- Vaccine Development for Severe Fever with Thrombocytopenia Syndrome Virus in Dogs
- Seok-Chan Park, Da-Eun Jeong, Sun-Woo Han, Joon-Seok Chae, Joo-Yong Lee, Hyun-Sook Kim, Bumseok Kim, Jun-Gu Kang
- J. Microbiol. 2024;62(4):327-335. Published online April 18, 2024
- DOI: https://doi.org/10.1007/s12275-024-00119-y
- 538 View
- 8 Download
- 5 Web of Science
- 4 Crossref
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Abstract
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- Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening viral zoonosis. The causative agent of this disease is the Dabie bandavirus, which is usually known as the SFTS virus (SFTSV). Although the role of vertebrates in SFTSV transmission to humans remains uncertain, some reports have suggested that dogs could potentially transmit SFTSV to humans. Consequently, preventive measures against SFTSV in dogs are urgently needed. In the present study, dogs were immunized three times at two-week intervals with formaldehyde-inactivated SFTSV with two types of adjuvants. SFTSV (KCD46) was injected into all dogs two weeks after the final immunization. Control dogs showed viremia from 2 to 4 days post infection (dpi), and displayed white pulp atrophy in the spleen, along with a high level of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling assay (TUNEL) positive area. However, the inactivated SFTSV vaccine groups exhibited rare pathological changes and significantly reduced TUNEL positive areas in the spleen. Furthermore, SFTSV viral loads were not detected at any of the tested dpi. Our results indicate that both adjuvants can be safely used in combination with an inactivated SFTSV formulation to induce strong neutralizing antibodies. Inactivated SFTSV vaccines effectively prevent pathogenicity and viremia in dogs infected with SFTSV. In conclusion, our study highlighted the potential of inactivated SFTSV vaccination for SFTSV control in dogs.
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Citations
Citations to this article as recorded by- The immunogenicity and protection efficacy evaluation of mRNA vaccine candidate for severe fever with thrombocytopenia syndrome in mice
Da-Eun Jeong, Jack Yoon, Baek Kim, Jun-Gu Kang, Abdallah M. Samy
PLOS Neglected Tropical Diseases.2025; 19(4): e0012999. CrossRef - Efficient and modular reverse genetics system for rapid generation of recombinant severe acute respiratory syndrome coronavirus 2
Sojung Bae, Jinjong Myoung
Journal of Microbiology.2025; 63(7): e2504015. CrossRef - Current status of severe fever with thrombocytopenia syndrome in China (Review)
Hao Sun, Quanman Hu, Saiwei Lu, Yanyan Yang, Li Zhang, Jinzhao Long, Yuefei Jin, Haiyan Yang, Shuaiyin Chen, Guangcai Duan
International Journal of Molecular Medicine.2025; 56(5): 1. CrossRef - Domain-Specific Impacts of Spike Protein Mutations on Infectivity and Antibody Escape in SARS-CoV-2 Omicron BA.1
Tae-Hun Kim, Sojung Bae, Jinjong Myoung
Journal of Microbiology and Biotechnology.2025;[Epub] CrossRef
- The immunogenicity and protection efficacy evaluation of mRNA vaccine candidate for severe fever with thrombocytopenia syndrome in mice
- Sporosarcina jeotgali sp. nov., Sporosarcina oncorhynchi sp. nov., and Sporosarcina trichiuri sp. nov., Isolated from Jeotgal, a Traditional Korean Fermented Seafood
- Ah-In Yang, Bora Kim, Sung-Hong Joe, Hae-In Joe, Hanna Choe, Ki Hyun Kim, Min Ok Jun, Na-Ri Shin
- J. Microbiol. 2024;62(4):285-296. Published online April 8, 2024
- DOI: https://doi.org/10.1007/s12275-024-00106-3
- 507 View
- 12 Download
- 3 Web of Science
- 4 Crossref
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Abstract
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- Three novel, Gram-stain-positive, obligate aerobic, catalase- and oxidase-positive bacterial strains, designated B2O-1(T), T2O-4(T), and 0.2-SM1T-5(T), were isolated from jeotgal, a traditional Korean fermented seafood. Strains B2O-1(T), T2O-4(T), and 0.2-SM1T-5(T) exhibited distinct colony colors, characterized by pink, yellow, and red opaque circular colonies, respectively. Phylogenetic analysis revealed that three strains formed a paraphyletic clade within the genus Sporosarcina and shared < 99.0% similarity with Sporosarcina aquimarina KCTC 3840(T) and Sporosarcina saromensis KCTC 13119(T) in their 16S rRNA gene sequences. The three strains exhibiting Orthologous Average Nucleotide Identity values < 79.3% and digital DNA-DNA hybridization values < 23.1% within the genus Sporosarcina affirmed their distinctiveness. Strains B2O-1(T), T2O-4(T), and 0.2-SM1T-5(T) contained MK-7 as a sole respiratory menaquinone and A4α type peptidoglycan based on lysine with alanine, glutamic acid, and aspartic acid. The common polar lipids include diphosphatidylglycerol, phosphatidylglycerol, and phosphatidylethanolamine. Strain T2O-4(T) contained one unidentified phospholipid, whereas strain 0.2-SM1T-5(T) contained two unidentified phospholipids. Cellular fatty acid profiles, with C(15:0) anteiso as the major fatty acid, supported the affiliation of the three strains to the genus Sporosarcina. Based on the polyphasic characteristics, strains B2O-1(T) (= KCTC 43506(T) = JCM 36032(T)), T2O-4(T) (= KCTC 43489(T) = JCM 36031(T)), and 0.2-SM1T-5(T) (= KCTC 43519(T) = JCM 36034(T)) represent three novel species within the genus Sporosarcina, named Sporosarcina jeotgali sp. nov., Sporosarcina oncorhynchi sp. nov., and Sporosarcina trichiuri sp. nov., respectively.
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Citations
Citations to this article as recorded by- Notification of changes in taxonomic opinion previously published outside the IJSEM. List of Changes in Taxonomic Opinion no. 41
Aharon Oren, Markus Göker
International Journal of Systematic and Evolutionary Microbiology .2025;[Epub] CrossRef -
Brevibacterium koreense sp. nov., a moderately halophilic bacterium isolated from jogae-jeotgal, a Korean fermented seafood
Sohee Nam, Yujin Kim, Min Ji Lee, Yeon Bee Kim, Jeong Ui Yun, Mi-Ja Jung, Hye Seon Song, Se Hee Lee, Seok-Jun Kim, Tae Woong Whon
International Journal of Systematic and Evolutionary Microbiology .2025;[Epub] CrossRef - Bacteroides celer sp. nov. and Bacteroides mucinivorans sp. nov., isolated from human feces, and the reclassification of Bacteroides koreensis Shin et al. 2017 and Bacteroides kribbi Shin et al. 2017 as later heterotypic synonyms of Bacteroides ovatus Egg
Ah-In Yang, Bora Kim, Woorim Kang, Hae-In Joe, Na-Ri Shin
Journal of Microbiology.2025; 63(6): e2502006. CrossRef - Validation List no. 220. Valid publication of new names and new combinations effectively published outside the IJSEM
Aharon Oren, Markus Göker
International Journal of Systematic and Evolutionary Microbiology .2024;[Epub] CrossRef
- Notification of changes in taxonomic opinion previously published outside the IJSEM. List of Changes in Taxonomic Opinion no. 41
- Mycobacterium tuberculosis PE_PGRS45 (Rv2615c) Promotes Recombinant Mycobacteria Intracellular Survival via Regulation of Innate Immunity, and Inhibition of Cell Apoptosis
- Tao Xu , Chutong Wang , Minying Li , Jing Wei , Zixuan He , Zhongqing Qian , Xiaojing Wang , Hongtao Wang
- J. Microbiol. 2024;62(1):49-62. Published online February 9, 2024
- DOI: https://doi.org/10.1007/s12275-023-00101-0
- 444 View
- 21 Download
- 4 Web of Science
- 4 Crossref
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Abstract
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- Tuberculosis (TB), a bacterial infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis), is a significant global public health problem. Mycobacterium tuberculosis expresses a unique family of PE_PGRS proteins that have been implicated in pathogenesis. Despite numerous studies, the functions of most PE_PGRS proteins in the pathogenesis of mycobacterium infections remain unclear. PE_PGRS45 (Rv2615c) is only found in pathogenic mycobacteria. In this study, we successfully constructed a recombinant Mycobacterium smegmatis (M. smegmatis) strain which heterologously expresses the PE_PGRS45 protein. We found that overexpression of this cell wall-associated protein enhanced bacterial viability under stress in vitro and cell survival in macrophages. MS_PE_PGRS45 decreased the secretion of pro-inflammatory cytokines such as IL-1β, IL-6, IL-12p40, and TNF-α. We also found that MS_PE_PGRS45 increased the expression of the anti-inflammatory cytokine IL-10 and altered macrophage-mediated immune responses. Furthermore, PE_PGRS45 enhanced the survival rate of M. smegmatis in macrophages by inhibiting cell apoptosis. Collectively, our findings show that PE_PGRS45 is a virulent factor actively involved in the interaction with the host macrophage.
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Citations
Citations to this article as recorded by- Evolution of the PE_PGRS Proteins of Mycobacteria: Are All Equal or Are Some More Equal than Others?
Bei Chen, Belmin Bajramović, Bastienne Vriesendorp, Herman Pieter Spaink
Biology.2025; 14(3): 247. CrossRef - Recent advances in research on Mycobacterium tuberculosis virulence factors and their role in pathogenesis
Ming-Rui Sun, Jia-Yin Xing, Xiao-Tian Li, Ren Fang, Yang Zhang, Zhao-Li Li, Ning-Ning Song
Journal of Microbiology, Immunology and Infection.2025; 58(5): 497. CrossRef - Rv2741 Promotes Mycobacterium Survival by Modulating Macrophage Function via the IL-1α-MAPK Axis
Xintong He, Yonglin He, Xichuan Deng, Nan Lu, Anlong Li, Sijia Gao, Shiyan He, Yuran Wang, Nanzhe Fu, Zijie Wang, Yuxin Nie, Lei Xu
ACS Infectious Diseases.2025; 11(3): 676. CrossRef - The PE/PPE family proteins of Mycobacterium tuberculosis: evolution, function, and prospects for tuberculosis control
Zhijing Zhang, Le Dong, Xin Li, Taibing Deng, Qinglan Wang
Frontiers in Immunology.2025;[Epub] CrossRef
- Evolution of the PE_PGRS Proteins of Mycobacteria: Are All Equal or Are Some More Equal than Others?
- [Protocol] Use of Cas9 Targeting and Red Recombination for Designer Phage Engineering
- Shin-Yae Choi , Danitza Xiomara Romero-Calle , Han-Gyu Cho , Hee-Won Bae , You-Hee Cho
- J. Microbiol. 2024;62(1):1-10. Published online February 1, 2024
- DOI: https://doi.org/10.1007/s12275-024-00107-2
- 574 View
- 21 Download
- 2 Web of Science
- 4 Crossref
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Abstract
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- Bacteriophages (phages) are natural antibiotics and biological nanoparticles, whose application is significantly boosted by recent advances of synthetic biology tools. Designer phages are synthetic phages created by genome engineering in a way to increase the benefits or decrease the drawbacks of natural phages. Here we report the development of a straightforward genome engineering method to efficiently obtain engineered phages in a model bacterial pathogen, Pseudomonas aeruginosa. This was achieved by eliminating the wild type phages based on the Streptococcus pyogenes Cas9 (SpCas9) and facilitating the recombinant generation based on the Red recombination system of the coliphage λ (λRed). The producer (PD) cells of P. aeruginosa strain PAO1 was created by miniTn7-based chromosomal integration of the genes for SpCas9 and λRed under an inducible promoter. To validate the efficiency of the recombinant generation, we created the fluorescent phages from a temperate phage MP29. A plasmid bearing the single guide RNA (sgRNA) gene for selectively targeting the wild type gp35 gene and the editing template for tagging the Gp35 with superfolder green fluorescent protein (sfGFP) was introduced into the PD cells by electroporation. We found that the targeting efficiency was affected by the position and number of sgRNA. The fluorescent phage particles were efficiently recovered from the culture of the PD cells expressing dual sgRNA molecules. This protocol can be used to create designer phages in P. aeruginosa for both application and research purposes.
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Citations
Citations to this article as recorded by-
Pilin regions that select for the small RNA phages in
Pseudomonas aeruginosa
type IV pilus
Hee-Won Bae, Hyeong-Jun Ki, Shin-Yae Choi, You-Hee Cho, Kristin N. Parent
Journal of Virology.2025;[Epub] CrossRef - Synthetic and Functional Engineering of Bacteriophages: Approaches for Tailored Bactericidal, Diagnostic, and Delivery Platforms
Ola Alessa, Yoshifumi Aiba, Mahmoud Arbaah, Yuya Hidaka, Shinya Watanabe, Kazuhiko Miyanaga, Dhammika Leshan Wannigama, Longzhu Cui
Molecules.2025; 30(15): 3132. CrossRef - Characteristics of bioaerosols under high-ozone periods, haze episodes, dust storms, and normal days in Xi’an, China
Yiming Yang, Liu Yang, Xiaoyan Hu, Zhenxing Shen
Particuology.2024; 90: 140. CrossRef - Airborne desert dust and aeromicrobiology over the Turkish Mediterranean coastline
Dale W. Griffin, Nilgün Kubilay, Mustafa Koçak, Mike A. Gray, Timothy C. Borden, Eugene A. Shinn
Atmospheric Environment.2007; 41(19): 4050. CrossRef
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Pilin regions that select for the small RNA phages in
Pseudomonas aeruginosa
type IV pilus
Review
- Targeting innate immune sensors for therapeutic strategies in infectious diseases
- Seyun Shin, Young Ki Choi, SangJoon Lee
- J. Microbiol. 2025;63(6):e2503009. Published online June 30, 2025
- DOI: https://doi.org/10.71150/jm.2503009
- 3,025 View
- 89 Download
- 3 Web of Science
- 3 Crossref
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Abstract
PDF
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The innate immune system relies on innate immune sensors, such as pattern recognition receptors (PRRs), to detect pathogens and initiate immune responses, crucial for controlling infections but also implicated in inflammatory diseases. These innate immune sensors, including Toll-like receptors (TLRs), nod-like receptors (NLRs), RIG-I-like receptors (RLRs), absent in melanoma 2 (AIM2), and Z-DNA binding protein 1 (ZBP1) trigger signaling pathways that produce cytokines, modulating inflammation and cell death. Traditional therapies focus on directly targeting pathogens; however, host-targeting therapeutic strategies have emerged as innovative approaches to modulate innate immune sensor activity. These strategies aim to fine-tune the immune response, either enhancing antiviral defenses or mitigating hyperinflammation to prevent tissue damage. This review explores innate immune sensor-based therapeutic approaches, including inhibitors, agonists, and antagonists, that enhance antiviral defense or suppress harmful inflammation, highlighting innate immune sensors as promising targets in infectious and inflammatory disease treatment.
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Citations
Citations to this article as recorded by- A new fucosylated glucuronoxylomannan from the fruit bodies of Tremella aurantia: structural characterization and immunoenhancing activity on seasonal influenza mRNA vaccine
Jing Chen, Yuan Ma, Zhi-Min Rao, Song-Lin Jiang, Ying-Jun Lou, Karim Malik, Arman Chowdhury, Hua-Zhong Ying, Chen-Huan Yu
Carbohydrate Polymers.2026; 373: 124660. CrossRef - Z-DNA interaction proteins - insights from ChIP-seq data
Michaela Dobrovolná, Václav Brázda
Biochemical and Biophysical Research Communications.2025; 790: 152910. CrossRef - AIM2 drives inflammatory cell death and monkeypox pathogenesis
Jueun Oh, Yun-Ho Hwang, Jihye Lee, Cheong Seok, SuHyeon Oh, Hye Yoon Kim, Nabukenya Mariam, Jaeyoung Ahn, GyeongJu Yu, Jaewoo Park, Hayeon Kim, Suhyun Kim, Seyun Shin, Min-Chul Jung, Jinwoo Gil, Joo Sang Lee, Young Ki Choi, Dokeun Kim, Daesik Kim, You-Jin
Cellular & Molecular Immunology.2025; 22(12): 1615. CrossRef
- A new fucosylated glucuronoxylomannan from the fruit bodies of Tremella aurantia: structural characterization and immunoenhancing activity on seasonal influenza mRNA vaccine
Full article
- FunVIP: Fungal Validation and Identification Pipeline based on phylogenetic analysis
- Chang Wan Seo, Shinnam Yoo, Yoonhee Cho, Ji Seon Kim, Martin Steinegger, Young Woon Lim
- J. Microbiol. 2025;63(4):e2411017. Published online April 29, 2025
- DOI: https://doi.org/10.71150/jm.2411017
- 4,017 View
- 163 Download
- 3 Web of Science
- 3 Crossref
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Abstract
PDFSupplementary Material
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The increase of sequence data in public nucleotide databases has made DNA sequence-based identification an indispensable tool for fungal identification. However, the large proportion of mislabeled sequence data in public databases leads to frequent misidentifications. Inaccurate identification is causing severe problems, especially for industrial and clinical fungi, and edible mushrooms. Existing species identification pipelines require separate validation of a dataset obtained from public databases containing mislabeled taxonomic identifications. To address this issue, we developed FunVIP, a fully automated phylogeny-based fungal validation and identification pipeline (
https://github.com/Changwanseo/FunVIP ). FunVIP employs phylogeny-based identification with validation, where the result is achievable only with a query, database, and a single command. FunVIP command comprises nine steps within a workflow: input management, sequence-set organization, alignment, trimming, concatenation, model selection, tree inference, tree interpretation, and report generation. Users may acquire identification results, phylogenetic tree evidence, and reports of conflicts and issues detected in multiple checkpoints during the analysis. The conflicting sample validation performance of FunVIP was demonstrated by re-iterating the manual revision of a fungal genus with a database with mislabeled sequences, Fuscoporia. We also compared the identification performance of FunVIP with BLAST and q2-feature-classifier with two mass double-revised fungal datasets, Sanghuangporus and Aspergillus section Terrei. Therefore, with its automatic validation ability and high identification performance, FunVIP proves to be a highly promising tool for achieving easy and accurate fungal identification. -
Citations
Citations to this article as recorded by- Exploring Macrofungal Biodiversity and Distribution on Kyodong Island, Republic of Korea
Hannah Suh, Abel Severin Lupala, Hae Jin Cho, Sumin Jo, Jiyun Choi, Young Woon Lim
Mycobiology.2025; 53(4): 466. CrossRef -
Expanding the Inventory of Seven Unrecorded Marine
Penicillium
with Morphological Descriptions and Phenotypic Variability
Wonjun Lee, Ji Seon Kim, Sumin Jo, Young Woon Lim
Mycobiology.2025; 53(5): 648. CrossRef -
Exploring Fungal Diversity in Marine Plastic (PET) Wastes and Seafoam in Udo Island, South Korea, with Reports of Two New Species (
Leptospora conidiifera
and
Neodevriesia oceanoplastica
)
Wonjun Lee, Sumin Jo, Soo Hyun Maeng, Ji Seon Kim, Myung Kyum Kim, Young Woon Lim
Mycobiology.2025; 53(6): 770. CrossRef
- Exploring Macrofungal Biodiversity and Distribution on Kyodong Island, Republic of Korea
Review
- Harnessing organelle engineering to facilitate biofuels and biochemicals production in yeast
- Phuong Hoang Nguyen Tran, Taek Soon Lee
- J. Microbiol. 2025;63(3):e2501006. Published online March 28, 2025
- DOI: https://doi.org/10.71150/jm.2501006
- 2,038 View
- 105 Download
- 2 Web of Science
- 3 Crossref
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Abstract
PDF
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Microbial biosynthesis using yeast species offers numerous advantages to produce industrially relevant biofuels and biochemicals. Conventional metabolic engineering approaches in yeast focus on biosynthetic pathways in the cytoplasm, but these approaches are disturbed by various undesired factors including metabolic crosstalk, competing pathways and insufficient precursors. Given that eukaryotic cells contain subcellular organelles with distinct physicochemical properties, an emerging strategy to overcome cytosolic pathway engineering bottlenecks is through repurposing these organelles as specialized microbial cell factories for enhanced production of valuable chemicals. Here, we review recent progress and significant outcomes of harnessing organelle engineering for biofuels and biochemicals production in both conventional and non-conventional yeasts. We highlight key engineering strategies for the compartmentalization of biosynthetic pathways within specific organelles such as mitochondria, peroxisomes, and endoplasmic reticulum; involved in engineering of signal peptide, cofactor and energy enhancement, organelle biogenesis and dual subcellular engineering. Finally, we discuss the potential and challenges of organelle engineering for future studies and propose an automated pipeline to fully exploit this approach.
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Citations
Citations to this article as recorded by- Peroxisome engineering in yeast: Advances, challenges, and prospects
Cuifang Ye, Xiaoqian Li, Tao Liu, Shiyu Li, Mengyu Zhang, Yao Zhao, Jintao Cheng, Guiling Yang, Peiwu Li
Biotechnology Advances.2026; 86: 108747. CrossRef - Advancing microbial engineering through synthetic biology
Ki Jun Jeong
Journal of Microbiology.2025; 63(3): e2503100. CrossRef - Metabolic engineering strategies for constructing methylotrophic cell factories
Pei Zhou, Yang Sun, Yinbiao Xu, Yupeng Liu, Hua Li
Systems Microbiology and Biomanufacturing.2025; 5(4): 1371. CrossRef
- Peroxisome engineering in yeast: Advances, challenges, and prospects
Research Articles
- Synbiotic combination of fructooligosaccharides and probiotics ameliorates the metabolic dysfunction-associated steatotic liver disease
- Sang Yoon Lee, Su-Been Lee, Goo-Hyun Kwon, Seol Hee Song, Jeong Ha Park, Min Ju Kim, Jung A Eom, Kyeong Jin Lee, Sang Jun Yoon, Hyunjoon Park, Sung-Min Won, Jin-Ju Jeong, Ki-Kwang Oh, Young Lim Ham, Gwang Ho Baik, Dong Joon Kim, Satya Priya Sharma, Ki Tae Suk
- J. Microbiol. 2025;63(2):e2411002. Published online February 27, 2025
- DOI: https://doi.org/10.71150/jm.2411002
- 2,358 View
- 103 Download
- 2 Web of Science
- 3 Crossref
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Abstract
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Synbiotics have become a new-age treatment tool for limiting the progression of metabolic dysfunction-associated steatotic liver disease; however, inclusive comparisons of various synbiotic treatments are still lacking. Here, we have explored and evaluated multiple synbiotic combinations incorporating three distinctive prebiotics, lactitol, lactulose and fructooligosaccharides. Of the synbiotic treatments evaluated, a combination of fructooligosaccharides and probiotics (FOS+Pro) exhibited superior protection against western diet-induced liver degeneration. This synbiotic (FOS+Pro) combination resulted in the lowest body weight gains, liver weights and liver/body weight ratios. The FOS+Pro synbiotic combination substantially alleviated liver histopathological markers and reduced serum AST and cholesterol levels. FOS+Pro ameliorated hepatic inflammation by lowering expression of proinflammatory markers including TNF-α, IL-1β, IL-6, and CCL2. FOS+Pro significantly improved steatosis by restricting the expression of lipid metabolic regulators (ACC1, FAS) and lipid transporters (CD36) in the liver. These findings are critical in suggesting that synbiotic treatments are capable of restraining western diet-induced metabolic dysfunction in the liver. Additionally, this study demonstrated that adding probiotic strains amplified the effectiveness of fructooligosaccharides but not all prebiotics.
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Citations
Citations to this article as recorded by- Therapeutic Potential of Probiotics in Metabolic Dysfunction-Associated Steatohepatitis: A Comprehensive Review
Xueying Wang, Zhiying Wei, Qing Xiang, Lijie Tang, Weichun Xie
Microorganisms.2025; 13(8): 1894. CrossRef - Profiling oligosaccharide components in Polygonatum kingianum with potential anti-NAFLD activity using UPLC-Orbitrap-MS/MS technology
Hong Guo, Rui Yao, Jing Fan, Ying Wang, Lingzhi Zhang, Hua Sun, Xiaohan Guo, Jianbo Yang, Jingzhe Pu, Yazhong Zhang, Baozhong Duan, Jia Chen, Wenguang Jing, Xianlong Cheng, Feng Wei
Food Hydrocolloids for Health.2025; 8: 100248. CrossRef - Probiotics and cholesterol metabolism: new frontiers in science from intestinal microecology to cardiovascular health
Yue Li, Dayong Ren
Food Science of Animal Products.2025; 4(1): 9240146. CrossRef
- Therapeutic Potential of Probiotics in Metabolic Dysfunction-Associated Steatohepatitis: A Comprehensive Review
- Characteristics of skin microbiome associated with disease severity in systemic sclerosis
- Kyung-Ann Lee, Asad Ul-Haq, Hoonhee Seo, Sujin Jo, Sukyung Kim, Ho-Yeon Song, Hyun-Sook Kim
- J. Microbiol. 2025;63(1):e.2409018. Published online January 24, 2025
- DOI: https://doi.org/10.71150/jm.2409018
- 2,470 View
- 107 Download
- 1 Web of Science
- 3 Crossref
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Abstract
PDFSupplementary Material
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Systemic sclerosis (SSc) is a chronic autoimmune disorder characterised by skin fibrosis and internal organ involvement. Disruptions in the microbial communities on the skin may contribute to the onset of autoimmune diseases that affect the skin. However, current research on the skin microbiome in SSc is lacking. This study aimed to investigate skin microbiome associated with disease severity in SSc. Skin swabs were collected from the upper limbs of 46 healthy controls (HCs) and 36 patients with SSc. Metagenomic analysis based on the 16S rRNA gene was conducted and stratified by cutaneous subtype and modified Rodnan skin score (mRSS) severity. Significant differences in skin bacterial communities were observed between the HCs and patients with SSc, with further significant variations based on subtype and mRSS severity. The identified biomarkers were Bacteroides and Faecalibacterium for patients with diffuse cutaneous SSc with high mRSS (≥ 10) and Mycobacterium and Parabacteroides for those with low mRSS (< 10). Gardnerella, Abies, Lactobacillus, and Roseburia were the biomarkers in patients with limited cutaneous SSc (lcSS) and high mRSS, whereas Coprococcus predominated in patients with lcSS and low mRSS. Cutaneous subtype analysis identified Pediococcus as a biomarker in the HCs, whereas mRSS analysis revealed the presence of Pseudomonas in conjunction with Pediococcus. In conclusion, patients with SSc exhibit distinct skin microbiota compared with healthy controls. Bacterial composition varies by systemic sclerosis cutaneous subtype and skin thickness.
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Citations
Citations to this article as recorded by- Microbiome therapeutic PMC72 through reverse translational research in gout
Mohammed Solayman Hossain, Hoonhee Seo, Kyung-Ann Lee, Asad ul-Haq, Sukyung Kim, Sujin Jo, Md Abdur Rahim, Hanieh Tajdozian, Fatemeh Ghorbanian, Youjin Yoon, Indrajeet Barman, Md Sarower Hossen Shuvo, Hyun-Sook Kim, Ho-Yeon Song
Journal of Microbiology.2025; 63(5): e2501002. CrossRef - Alterations of the skin microbiome in multiple system atrophy: a pilot study
Daji Chen, Lang Sun, Linlin Wan, Zhao Chen, LinLiu Peng, Jinzi Peng, Riwei Ouyang, Xiafei Long, Kefang Du, Xiao Dong, Xiaokang Wu, Xinying Xiao, Ruqing He, Rong Qiu, Beisha Tang, Hong Jiang
npj Parkinson's Disease.2025;[Epub] CrossRef - Analysis of skin mycobiota associated with alopecia in captive cynomolgus macaques (Macaca fascicularis) based on Oxford Nanopore Technologies
Natthanit Phokkhasub, Suthida Visedthorn, Pavit Klomkliew, Prangwalai Chanchaem, Kittima Phutthawong, Taratorn Kemthong, Vorthon Sawaswong, Ariya Khamwut, Suchinda Malaivijitnond, Sunchai Payungporn
F1000Research.2025; 14: 1228. CrossRef
- Microbiome therapeutic PMC72 through reverse translational research in gout
- Simultaneous gene editing of both nuclei in a dikaryotic strain of Ganoderma lucidum using Cas9-gRNA ribonucleoprotein
- Yeon-Jae Choi, Hyerang Eom, Rutuja Nandre, Minseek Kim, Youn-Lee Oh, Sinil Kim, Hyeon-Su Ro
- J. Microbiol. 2025;63(1):e.2409006. Published online January 24, 2025
- DOI: https://doi.org/10.71150/jm.2409006
- 1,611 View
- 88 Download
- 3 Web of Science
- 3 Crossref
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Abstract
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The presence of multiple nuclei in a common cytoplasm poses a significant challenge to genetic modification in mushrooms. Here, we demonstrate successful gene editing in both nuclei of a dikaryotic strain of Ganoderma lucidum using the Cas9-gRNA ribonucleoprotein complex (RNP). The RNP targeting the pyrG gene was introduced into dikaryotic protoplasts of G. lucidum, resulting in the isolation of 31 mycelial colonies resistant to 5-fluoroorotic acid (5-FOA). Twenty-six of these isolates were confirmed as dikaryotic strains by the presence of two distinct A mating type markers, denoted as A1 and A2. All dikaryons exhibited clamp connections on their mycelial hyphae, while the remaining 5 transformants were monokaryotic. Subsequent sequence analysis of PCR amplicons targeting pyrG revealed that two dikaryons harbored disrupted pyrG in both nuclei (pyrG-/pyrG-), while 10 and 14 displayed pyrG+/pyrG- (A1/A2) and pyrG-/pyrG+ (A1/A2) configurations, respectively. The disruption was achieved through non-homologous end joining repair, involving deletion or insertion of DNA fragments at the site of the double-strand break induced by RNP. Importantly, the nuclei were stable throughout 10 serial transfers over a period of 6 months. These findings highlight the capability of RNP to target genes across multiple nuclei within the same cytoplasm.
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Citations
Citations to this article as recorded by- Gene Editing in Ganoderma lucidum: Development, Challenges, and Future Prospects
Shiqi He, Yuanchao Liu, Zhi Zhang, Manjun Cai, Yufan Hao, Huiping Hu
Journal of Fungi.2025; 11(4): 310. CrossRef - Development of a CRISPR/Cas9 RNP-mediated genetic engineering system in Paecilomyces variotii
Hui-Gang Han, Rutuja Nandre, Hyerang Eom, Yeon-Jae Choi, Hyeon-Su Ro
Journal of Microbiology.2025; 63(6): e2502011. CrossRef - CRISPR/Cas9-mediated gene editing in filamentous fungi, focusing on mushrooms and plant-pathogenic fungi
Rutuja Nandre, Hyerang Eom, Yeon-Jae Choi, Yanjiao Zhang, Hyeon-Su Ro
Fungal Biology Reviews.2025; 54: 100446. CrossRef
- Gene Editing in Ganoderma lucidum: Development, Challenges, and Future Prospects
Journal Articles
- Different Adaption Strategies of Abundant and Rare Microbial Communities in Sediment and Water of East Dongting Lake
- Yabing Gu, Junsheng Li, Zhenghua Liu, Min Zhang, Zhaoyue Yang, Huaqun Yin, Liyuan Chai, Delong Meng, Nengwen Xiao
- J. Microbiol. 2024;62(10):829-843. Published online October 22, 2024
- DOI: https://doi.org/10.1007/s12275-024-00171-8
- 767 View
- 13 Download
- 2 Web of Science
- 3 Crossref
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Abstract
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- The dynamics of aquatic microbes is of great importance for comprehending the acclimatisation and evolution of microorganisms in lake ecology. However, little is known about the adaption strategies of microbial communities in East Dongting Lake, which had special and complexity geographical characteristics. A semi-enclosed lake area (A) and a waterway connected to Yangtze River (B) both existed in the lake zone. Here, we investigated bacterial and fungal community diversity, community network and community assembly processes in sediment and water. The results indicated that the proportion of OTU numbers and their relative abundance for rare and abundant taxa were different obviously between sediment and water, but not between bacteria and fungi. However, abundant subcommunities dominated the shifts of bacterial community diversity and structure in A region, while rare subcommunities for fungal community diversity. Compared to fungal community, bacterial network was more compact and more key stones were identified as rare taxa. In addition, stochastic processes (dispersal limitation) drove the community assembly of abundant and rare subcommunities, but the effects of deterministic processes (including variable and heterogeneous selections) affected more on rare rather than abundant taxa. Partial Mantel test further indicated that the effect of environmental factors was a stronger force in shaping abundant bacterial subcommunities (TOC, NH4+-N, TN, and ORP) and rare fungal subcommunities (ORP). Environmental factors explained more of the variation in bacterial community structure than that in fungal community structure, although they had additional effects on fungal community diversity and community assembly. Moreover, bacterial community affected the fungal community as a biotic factor in water. This research provided new insights into better understanding of microbial communities in the complex environment of the East Dongting Lake.
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Citations
Citations to this article as recorded by- Bacterial and environmental factors had alternatively dominant effects on ecosystem multifunctionality of river–lake continuum: A rate-focused study
Xiujun Wang, Caixia Peng, Mengyuan Li, Junxiang Cheng, Ligang Xu, Qinglong L. Wu, Jin Zeng
Ecological Indicators.2026; 182: 114416. CrossRef - Diversity patterns and community assembly of the microbial community of periphyton in an urban Fenhe River under seasonal changes
Kangxu Zhao, Hanjie Huang, Wei Wang, Xudong Liu, Junping Lv, Zhengyu Hu, Ying Shi, Shulian Xie, Jia Feng
Journal of Environmental Chemical Engineering.2025; 13(5): 118148. CrossRef - The assembly processes and network characteristics of bacterial, fungal and archaeal communities in the middle Yangtze River and river-connected lakes
Fenglin Wang, Si Li, Pinjian Li, Chuanzhe Feng, Zhijie Zhao, Yulong Yang, Fulei Han, An Xue, Zhenshan Li, Peng Han
Frontiers in Microbiology.2025;[Epub] CrossRef
- Bacterial and environmental factors had alternatively dominant effects on ecosystem multifunctionality of river–lake continuum: A rate-focused study
- The Impact of Makgeolli Consumption on Gut Microbiota: An Enterotype-Based Preliminary Study
- Gyungcheon Kim, Seongok Kim, Hayan Jung, Seohyun Kang, Gwoncheol Park, Hakdong Shin
- J. Microbiol. 2024;62(11):965-972. Published online October 16, 2024
- DOI: https://doi.org/10.1007/s12275-024-00176-3
- 565 View
- 9 Download
- 3 Web of Science
- 3 Crossref
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Abstract
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- Makgeolli, a traditional Korean liquor, contains components such as lactic acid bacteria and dietary fiber, which can induce changes in the gut microbiome. Since variations in microbiome responses may exist between enterotypes-classifications based on the dominant bacterial populations in the gut-we hypothesized that the consumption of makgeolli leads to enterotype-dependent differences in gut microbial structures among healthy participants. This study aimed to determine the effect of makgeolli consumption on gut microbial structures by stratifying all participants into two enterotype groups: Bacteroides-dominant type (B-type, n = 7) and Prevotella-dominant type (P-type, n = 4). The B-type showed an increase in alpha diversity, while no significant difference was observed in the P-type following makgeolli consumption. The composition of gut microbiota significantly changed in the B-type, whereas no noticeable alteration was observed in the P-type after makgeolli consumption. Notably, Prevotella exhibited the most significant changes only in the P-type. In line with the increased abundance of Prevotella, the genes associated with carbohydrate metabolism, including pentose/glucuronate interconversions, fructose/mannose metabolism, starch/sucrose metabolism and amino sugar/nucleotide sugar metabolism were significantly enriched following makgeolli consumption in the P-type. These findings suggest that makgeolli consumption induces enterotype-dependent alterations in gut microbial composition and metabolic pathways, highlighting the potential for personalized dietary interventions.
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Citations
Citations to this article as recorded by- The prebiotic potential of dietary onion extracts: shaping gut microbial structures and promoting beneficial metabolites
Yebeen Yoo, Seongok Kim, WonJune Lee, Jinwoo Kim, Bokyung Son, Kwang Jun Lee, Hakdong Shin, Aviâja Lyberth Hauptmann
mSystems.2025;[Epub] CrossRef - Dietary Fiber Intake Improves Osteoporosis Caused by Chronic Lead Exposure by Restoring the Gut–Bone Axis
Ruijian Wang, Jin Shen, Chunqing Han, Xiaodong Shi, Yan Gong, Xiping Hu, Zhongtang Jia, Miaomiao Wang, Yu Wu
Nutrients.2025; 17(9): 1513. CrossRef - Modulation of Gut Microbiota by Cacao: Insights from an In Vitro Model
Jinshil Kim, Sunil Jung, Gyungcheon Kim, Jinwoo Kim, Bokyung Son, Hakdong Shin
Current Issues in Molecular Biology.2025; 47(6): 414. CrossRef
- The prebiotic potential of dietary onion extracts: shaping gut microbial structures and promoting beneficial metabolites
Review
- Extensive Genomic Rearrangement of Catalase-Less Cyanobloom-Forming Microcystis aeruginosa in Freshwater Ecosystems
- Minkyung Kim, Jaejoon Jung, Wonjae Kim, Yerim Park, Che Ok Jeon, Woojun Park
- J. Microbiol. 2024;62(11):933-950. Published online October 8, 2024
- DOI: https://doi.org/10.1007/s12275-024-00172-7
- 500 View
- 10 Download
- 3 Web of Science
- 3 Crossref
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Abstract
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- Many of the world's freshwater ecosystems suffer from cyanobacteria-mediated blooms and their toxins. However, a mechanistic understanding of why and how Microcystis aeruginosa dominates over other freshwater cyanobacteria during warmer summers is lacking. This paper utilizes comparative genomics with other cyanobacteria and literature reviews to predict the gene functions and genomic architectures of M. aeruginosa based on complete genomes. The primary aim is to understand this species' survival and competitive strategies in warmer freshwater environments. M. aeruginosa strains exhibiting a high proportion of insertion sequences (~ 11%) possess genomic structures with low synteny across different strains. This indicates the occurrence of extensive genomic rearrangements and the presence of many possible diverse genotypes that result in greater population heterogeneities than those in other cyanobacteria in order to increase survivability during rapidly changing and threatening environmental challenges. Catalase-less M. aeruginosa strains are even vulnerable to low light intensity in freshwater environments with strong ultraviolet radiation. However, they can continuously grow with the help of various defense genes (e.g., egtBD, cruA, and mysABCD) and associated bacteria. The strong defense strategies against biological threats (e.g., antagonistic bacteria, protozoa, and cyanophages) are attributed to dense exopolysaccharide (EPS)-mediated aggregate formation with efficient buoyancy and the secondary metabolites of M. aeruginosa cells. Our review with extensive genome analysis suggests that the ecological vulnerability of M. aeruginosa cells can be overcome by diverse genotypes, secondary defense metabolites, reinforced EPS, and associated bacteria.
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Citations
Citations to this article as recorded by- Cyanophage Infections in a Sponge Intracellular Cyanobacterial Symbiont
Tzipora Peretz, Esther Cattan‐Tsaushu, Chiara Conti, Benyamin Rosental, Laura Steindler, Sarit Avrani
Environmental Microbiology.2025;[Epub] CrossRef - Public goods-mediated bacterial interplay in aquatic ecosystems
Yerim Park, Wonjae Kim, Jihye Bae, Woojun Park
Water Research.2025; 287: 124310. CrossRef - Horizontal Gene Transfer and Recombination in Cyanobacteriota
Devaki Bhaya, Gabriel Birzu, Eduardo P.C. Rocha
Annual Review of Microbiology .2025; 79(1): 685. CrossRef
- Cyanophage Infections in a Sponge Intracellular Cyanobacterial Symbiont
Journal Article
- Upgrading Isoquercitrin Concentration via Submerge Fermentation of Mulberry Fruit Extract with Edible Probiotics to Suppress Gene Targets for Controlling Kidney Cancer and Inflammation
- Md Rezaul Karim, Safia Iqbal, Shahnawaz Mohammad, Jong-Hoon Kim, Li Ling, Changbao Chen, Abdus Samad, Md Anwarul Haque, Deok-Chun Yang, Yeon Ju Kim, Dong Uk Yang
- J. Microbiol. 2024;62(10):919-927. Published online October 8, 2024
- DOI: https://doi.org/10.1007/s12275-024-00163-8
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- 10 Download
- 4 Web of Science
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Abstract
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- In recent years, kidney cancer has become one of the most serious medical issues. Kidney cancer is treated with a variety of active compounds that trigger genes that cause cancer. We identified in our earlier research that isoquercitrin (IQ) can activate PIK3CA, IGF1R, and PTGS2. However, it has a very low bioavailability because of its lower solubility in water. So, we utilized sub-merge fermentation technology with two well-known probiotics, Lactobacillus acidophilus and Bacillus subtilis, as a microbial source and mulberry fruit extract as a substrate, which has a high IQ level to improve IQ yield. Furthermore, we compared the total phenolic, flavonoid, and antioxidant contents of fermented and non-fermented samples, and we found that the fermented samples had greater levels than non-fermented sample. In addition, the high-performance liquid chromatography (HPLC) results showed that the fermented mulberry fruit extract from B. subtilis and L. acidophilus showed higher IQ values (190.73 ± 0.004 μg/ml and 220.54 ± 0.007 μg/ml, respectively), compared to the non-fermented samples, which had IQ values (80.12 ± 0.002 μg/ml). Additionally, at 62.5 µg/ml doses of each sample, a normal kidney cell line (HEK 293) showed higher cell viability for fermented and non-fermented samples. Conversely, at the same doses, the fermented samples of L. acidophilus and B. subtilis in a kidney cancer cell line (A498) showed an inhibition of cell growth around 36% and 31%, respectively. Finally, we performed RT and qRT PCR assay, and we found a significant reduction in the expression of the PTGS2, PIK3CA, and IGF1R genes. We therefore can conclude that the fermented samples have a higher concentration of isoquercitrin, and also can inhibit the expression of the genes PTGS2, PIK3CA, and IGF1R, which in turn regulates kidney cancer and inflammation.
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Citations
Citations to this article as recorded by- Recent research on the bioactivity of polyphenols derived from edible fungi and their potential in chronic disease prevention
Wenbin Yu, Yufei Zhang, Yi Lu, Zhiwei Ouyang, Jiahua Peng, Yayi Tu, Bin He
Journal of Functional Foods.2025; 124: 106627. CrossRef - Protective roles of genistein and icaritin in skin barrier integrity and hydration in an atopic dermatitis model
Shahnawaz Mohammad, Anjali Kariyarath Valappil, Md. Rezaul Karim, Safia Iqbal, Deok Chun Yang, Changbao Chen, Li Ling, Dong Uk Yang
European Journal of Integrative Medicine.2025; 76: 102483. CrossRef - Isoquercitrin Improves Insulin Resistance by Inhibiting PTP1B-Regulated IRS/PI3K/AKT Signaling Pathway
Si-yu Liu, Lu-jing Yu, Sheng-nan Zhang, Jia-kui Yue, Guo-jun Jiang, Si-hua Lu, Ying-jia Li, Jun-yu Meng, Gui-hong Huang
Chinese Journal of Integrative Medicine.2025;[Epub] CrossRef
- Recent research on the bioactivity of polyphenols derived from edible fungi and their potential in chronic disease prevention
Review
- Recent Advances of Nipah Virus Disease: Pathobiology to Treatment and Vaccine Advancement
- Sagnik Saha, Manojit Bhattacharya, Sang-Soo Lee, Chiranjib Chakraborty
- J. Microbiol. 2024;62(10):811-828. Published online September 18, 2024
- DOI: https://doi.org/10.1007/s12275-024-00168-3
- 375 View
- 7 Download
- 2 Web of Science
- 3 Crossref
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Abstract
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- The zoonotic infection of the Nipah virus (NiV) has yet again appeared in 2023 in Kerala state, India. The virus, which has a mortality rate ranging from about 40 to 70%, has already infected India five times, the first being in 2001. The current infection is the sixth virus outbreak in the Indian population. In 1998, the first NiV infection was noted in one village in Malaysia. After that, outbreaks from other South and Southeast Asian countries have been reported periodically. It can spread between humans through contact with body fluids. Therefore, it is unlikely to generate a new pandemic. However, there is a considerable knowledge gap in the different areas of NiV. To date, no approved vaccines or treatments have been available. To fulfil the knowledge gap, the review article provided a detailed overview of the genome and genome-encoded proteins, epidemiology, transmission, pathobiology, immunobiology, diagnosis, prevention and control measures, therapeutics (monoclonal antibodies and drug molecules), and vaccine advancement of the emerging and deadly pathogen. The advanced information will help researchers to develop safe and effective NiV vaccine and treatment regimens worldwide.
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Citations
Citations to this article as recorded by- An Overview of Nipah Virus Infection
Ujjawal Singh, Ramsha Sharma, Raj Kamal, Ranjeet Kumar
Anti-Infective Agents.2025;[Epub] CrossRef - Antiviral effects of heme oxygenase-1 against canine coronavirus and canine influenza virus in vitro
Jae-Hyeong Kim, Dong-Hwi Kim, Kyu-Beom Lim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Dong-Hun Lee, Do-Geun Kim, Hun-Young Yoon, In-Soo Choi
Journal of Microbiology.2025; 63(5): e2501029. CrossRef - Efficient and modular reverse genetics system for rapid generation of recombinant severe acute respiratory syndrome coronavirus 2
Sojung Bae, Jinjong Myoung
Journal of Microbiology.2025; 63(7): e2504015. CrossRef
- An Overview of Nipah Virus Infection
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