Furan-based Chalcone Annihilates the Multi-Drug-Resistant Pseudomonas aeruginosa and Protects Zebra Fish Against its Infection

Santosh Pushpa Ramya Ranjan Nayak; Catharine Basty; Seenivasan Boopathi; Loganathan Sumathi Dhivya; Khaloud Mohammed Alarjani; Mohamed Ragab Abdel Gawwad; Raghda Hager; Muthu Kumaradoss Kathiravan; Jesu Arockiaraj

doi:10.1007/s12275-024-00103-6

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Furan-based Chalcone Annihilates the Multi-Drug-Resistant Pseudomonas aeruginosa and Protects Zebra Fish Against its Infection: Santosh Pushpa Ramya Ranjan Nayak ¹, Catharine Basty ¹, Seenivasan Boopathi ¹, Loganathan Sumathi Dhivya ², Khaloud Mohammed Alarjani ³, Mohamed Ragab Abdel Gawwad ⁴, Raghda Hager ⁵, Muthu Kumaradoss Kathiravan ², Jesu Arockiaraj ¹; Journal of Microbiology 2024;62(2):75-89
DOI: https://doi.org/10.1007/s12275-024-00103-6
Published online: February 21, 2024

¹Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Chennai, Tamil Nadu 603203, India, ²Dr. APJ Abdul Kalam Research Lab, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Chennai, Tamil Nadu 603203, India, ³Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia, ⁴Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Sarajevo 71210, Bosnia and Herzegovina, ⁵Department of Medical Microbiology and Immunology, King Salman International University, South Sinai, Egypt¹Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Chennai, Tamil Nadu 603203, India, ²Dr. APJ Abdul Kalam Research Lab, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Chennai, Tamil Nadu 603203, India, ³Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia, ⁴Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Sarajevo 71210, Bosnia and Herzegovina, ⁵Department of Medical Microbiology and Immunology, King Salman International University, South Sinai, Egypt

Corresponding author: Muthu Kumaradoss Kathiravan ,
Jesu Arockiaraj ,

Received: 19 September 2023 • Revised: 22 December 2023 • Accepted: 26 December 2023

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Abstract

The emergence of carbapenem-resistant Pseudomonas aeruginosa, a multi-drug-resistant bacteria, is becoming a serious public health concern. This bacterium infects immunocompromised patients and has a high fatality rate. Both naturally and synthetically produced chalcones are known to have a wide array of biological activities. The antibacterial properties of synthetically produced chalcone were studied against P. aeruginosa. In vitro, study of the compound (chalcone derivative named DKO1), also known as (2E)-1-(5-methylfuran-2-yl)-3-(4-nitrophenyl) prop-2-en-1-one, had substantial antibacterial and biofilm disruptive action. DKO1 effectively shielded against P. aeruginosa-induced inflammation, oxidative stress, lipid peroxidation, and apoptosis in zebrafish larvae. In adult zebrafish, the treatment enhanced the chances of survivability and reduced the sickness-like behaviors. Gene expression, biochemical analysis, and histopathology studies found that proinflammatory cytokines (TNF-α, IL-1β, IL-6, iNOS) were down regulated; antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) levels increased, and histoarchitecture was restored in zebrafish. The data indicate that DKO1 is an effective antibacterial agent against P. aeruginosa demonstrated both in vitro and in vivo.

Keywords: Apoptosis;Cytokines;Mycobacterium tuberculosis;PE_PGRS45

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Furan-based Chalcone Annihilates the Multi-Drug-Resistant Pseudomonas aeruginosa and Protects Zebra Fish Against its Infection

J. Microbiol. 2024;62(2):75-89. Published online February 21, 2024

DOI: https://doi.org/10.1007/s12275-024-00103-6

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