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- Membrane Proteins as a Regulator for Antibiotic Persistence in Gram‑Negative Bacteria
- Jia Xin Yee , Juhyun Kim , Jinki Yeom
- J. Microbiol. 2023;61(3):331-341. Published online February 17, 2023
- DOI: https://doi.org/10.1007/s12275-023-00024-w
- 66 View
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- 3 Web of Science
- 3 Crossref
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Abstract
- Antibiotic treatment failure threatens our ability to control bacterial infections that can cause chronic diseases. Persister bacteria are a subpopulation of physiological variants that becomes highly tolerant to antibiotics. Membrane proteins play crucial roles in all living organisms to regulate cellular physiology. Although a diverse membrane component involved in persistence can result in antibiotic treatment failure, the regulations of antibiotic persistence by membrane proteins has not been fully understood. In this review, we summarize the recent advances in our understanding with regards to membrane proteins in Gram-negative bacteria as a regulator for antibiotic persistence, highlighting various physiological mechanisms in bacteria.
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Citations
Citations to this article as recorded by
- Amino Acid and Au(III) Self-Assembled Supramolecular Nanozymes for Antimicrobial Applications
Yunzhu Xu, Dahai Hou, Min Zhao, Tong Zhao, Yong Ma, Yafeng Zhang, Yang Guo, Weiwei Tao, Hui Wang
ACS Applied Nano Materials.2024; 7(19): 22505. CrossRef -
PhoPQ-mediated lipopolysaccharide modification governs intrinsic resistance to tetracycline and glycylcycline antibiotics in
Escherichia coli
Byoung Jun Choi, Umji Choi, Dae-Beom Ryu, Chang-Ro Lee, Mehrad Hamidian, You-Hee Cho
mSystems.2024;[Epub] CrossRef - Bacterial Regulatory Mechanisms for the Control of Cellular Processes: Simple Organisms’ Complex Regulation
Jin-Won Lee
Journal of Microbiology.2023; 61(3): 273. CrossRef
- Amino Acid and Au(III) Self-Assembled Supramolecular Nanozymes for Antimicrobial Applications
- REVIEW] Ribosome dependence of persister cell formation and resuscitation
- Thomas K. Wood , Sooyeon Song , Ryota Yamasaki
- J. Microbiol. 2019;57(3):213-219. Published online February 26, 2019
- DOI: https://doi.org/10.1007/s12275-019-8629-2
- 46 View
- 0 Download
- 35 Web of Science
- 35 Crossref
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Abstract
- Since most bacterial cells are starving, they must enter a resting stage. Persister is the term used for metabolically-dormant cells that are not spores, and these cells arise from stress such as that from antibiotics as well as that from starvation. Because of their lack of metabolism, persister cells survive exposure to multiple stresses without undergoing genetic change; i.e., they have no inherited phenotype and behave as wild-type cells once the stress is removed and nutrients are presented. In contrast, mutations allow resistant bacteria to grow in the presence of antibiotics and slow growth allows tolerant cells to withstand higher concentrations of antibiotics; hence, there are three closely-related phenotypes: persistent, resistant, and tolerant. In addition, since dormancy is so prevalent, persister cells must have a means for resuscitating (since so many cells should obtain this resting state). In this review, we focus on what is known about the formation and resuscitation of persister cells.
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Citations
Citations to this article as recorded by- Glucose Supplementation Enhances the Bactericidal Effect of Penicillin and Gentamicin on Streptococcus sanguinis Persisters
Kazuya Takada, Yoshie Yoshioka, Kazumasa Morikawa, Wataru Ariyoshi, Ryota Yamasaki
Antibiotics.2025; 14(1): 36. CrossRef -
Molecular physiological characterization of the dynamics of persister formation in
Staphylococcus aureus
Shiqi Liu, Yixuan Huang, Sean Jensen, Paul Laman, Gertjan Kramer, Sebastian A. J. Zaat, Stanley Brul, Benjamin P. Howden
Antimicrobial Agents and Chemotherapy.2024;[Epub] CrossRef - Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance
Osvaldo Inostroza, Juan A. Fuentes, Paulina Yáñez, Giovanni Espinoza, Omar Fica, Camila Queraltó, José Rodríguez, Isidora Flores, Ruth González, Jorge A. Soto, Iván L. Calderón, Fernando Gil
Microorganisms.2024; 12(7): 1394. CrossRef - Toxin/antitoxin systems induce persistence and work in concert with restriction/modification systems to inhibit phage
Laura Fernández-García, Sooyeon Song, Joy Kirigo, Michael E. Battisti, Maiken E. Petersen, María Tomás, Thomas K. Wood, M. -N. Frances Yap
Microbiology Spectrum.2024;[Epub] CrossRef - Ribosomal dormancy at the nexus of ribosome homeostasis and protein synthesis
Saloni Koli, Sunil Shetty
BioEssays.2024;[Epub] CrossRef - Cyclic di-GMP as an antitoxin regulates bacterial genome stability and antibiotic persistence in biofilms
Hebin Liao, Xiaodan Yan, Chenyi Wang, Chun Huang, Wei Zhang, Leyi Xiao, Jun Jiang, Yongjia Bao, Tao Huang, Hanbo Zhang, Chunming Guo, Yufeng Zhang, Yingying Pu
eLife.2024;[Epub] CrossRef - Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance
Sayed Golam Mohiuddin, Han Ngo, Mehmet A. Orman
npj Antimicrobials and Resistance.2024;[Epub] CrossRef - Molecular typing and genome sequencing allow the identification of persistent Listeria monocytogenes strains and the tracking of the contamination source in food environments
R. Lucchini, L. Carraro, M. Pauletto, M. Gallo, N.A. Andreani, G. Weiss, C. Tessaro, M. Babbucci, B. Cardazzo
International Journal of Food Microbiology.2023; 386: 110025. CrossRef - Staphylococcus aureus Dormancy: Waiting for Insurgency
Ahmad Nasser, Shiva Jahanbakhshi, Mohammad Mehdi Soltan Dallal, Maryam Banar, Azin Sattari-Maraji, Taher Azimi
Current Pharmaceutical Biotechnology.2023; 24(15): 1898. CrossRef - Persister Cell Formation and Elevated lsrA and lsrC Gene Expression upon Hydrogen Peroxide Exposure in a Periodontal Pathogen Aggregatibacter actinomycetemcomitans
Yohei Nakamura, Koji Watanabe, Yoshie Yoshioka, Wataru Ariyoshi, Ryota Yamasaki
Microorganisms.2023; 11(6): 1402. CrossRef - Proteomic analysis of the initial wake up of vibrio splendidus persister cells
Guohua Jiang, Ya Li, Jinxia Zhang, Weisheng Li, Wei Dang, Weiwei Zhang
World Journal of Microbiology and Biotechnology.2023;[Epub] CrossRef - Exposure to stressors and antimicrobials induces cell-autonomous ultrastructural heterogeneity of an intracellular bacterial pathogen
Marc Schulte, Michael Hensel, Katarzyna Miskiewicz
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef - Feasibility of novel approaches to detect viable Mycobacterium tuberculosis within the spectrum of the tuberculosis disease
Sogol Alebouyeh, Brian Weinrick, Jacqueline M. Achkar, Maria J. García, Rafael Prados-Rosales
Frontiers in Medicine.2022;[Epub] CrossRef - Overexpression of a DNA Methyltransferase Increases Persister Cell Formation in Acinetobacter baumannii
Hyunkeun Kim, Jee Hong Kim, Hongbaek Cho, Kwan Soo Ko, Minsu Kim
Microbiology Spectrum.2022;[Epub] CrossRef - Rare UV-resistant cells in clonal populations of Escherichia coli
Shunsuke Ichikawa, Mika Okazaki, Mina Okamura, Norihiro Nishimura, Hideto Miyake
Journal of Photochemistry and Photobiology B: Biology.2022; 231: 112448. CrossRef - Magnesium Hydroxide Nanoparticles Kill Exponentially Growing and Persister Escherichia coli Cells by Causing Physical Damage
Yohei Nakamura, Kaede Okita, Daisuke Kudo, Dao Nguyen Duy Phuong, Yoshihito Iwamoto, Yoshie Yoshioka, Wataru Ariyoshi, Ryota Yamasaki
Nanomaterials.2021; 11(6): 1584. CrossRef - Contribution of Drugs Interfering with Protein and Cell Wall Synthesis to the Persistence of Pseudomonas aeruginosa Biofilms: An In Vitro Model
Gianmarco Mangiaterra, Elisa Carotti, Salvatore Vaiasicca, Nicholas Cedraro, Barbara Citterio, Anna La Teana, Francesca Biavasco
International Journal of Molecular Sciences.2021; 22(4): 1628. CrossRef - Cellular Self-Digestion and Persistence in Bacteria
Sayed Golam Mohiuddin, Sreyashi Ghosh, Han G. Ngo, Shayne Sensenbach, Prashant Karki, Narendra K. Dewangan, Vahideh Angardi, Mehmet A. Orman
Microorganisms.2021; 9(11): 2269. CrossRef - The progress of type II persisters of Escherichia coli O157:H7 to a non-culturable state during prolonged exposure to antibiotic stress with revival being aided through acid-shock treatment and provision of methyl pyruvate
Heather Chen, Andrew Green, Kailey Martz, Xueyang Wu, Abdulhakeem Alzahrani, Keith Warriner
Canadian Journal of Microbiology.2021; 67(7): 518. CrossRef - RNA Modifications in Pathogenic Bacteria: Impact on Host Adaptation and Virulence
Laura Antoine, Roberto Bahena-Ceron, Heemee Devi Bunwaree, Martin Gobry, Victor Loegler, Pascale Romby, Stefano Marzi
Genes.2021; 12(8): 1125. CrossRef - Self-healing functionalization of sulfonated hafnium oxide and copper oxide nanocomposite for effective biocidal control of multidrug-resistant bacteria
Ranjith Kumar Manoharan, Prakash Gangadaran, Sivasankaran Ayyaru, Byeong-Cheol Ahn, Young-Ho Ahn
New Journal of Chemistry.2021; 45(21): 9506. CrossRef - Are we really studying persister cells?
Sooyeon Song, Thomas K. Wood
Environmental Microbiology Reports.2021; 13(1): 3. CrossRef - Antibiotic tolerance is associated with a broad and complex transcriptional response in E. coli
Heather S. Deter, Tahmina Hossain, Nicholas C. Butzin
Scientific Reports.2021;[Epub] CrossRef - Vibrio splendidus persister cells induced by host coelomic fluids show a similar phenotype to antibiotic‐induced counterparts
Yanan Li, Thomas K. Wood, Weiwei Zhang, Chenghua Li
Environmental Microbiology.2021; 23(9): 5605. CrossRef - Ciprofloxacin-induced persister-cells in Campylobacter jejuni
Armen Ovsepian, Marianne Halberg Larsen, Christina Skovgaard Vegge, Hanne Ingmer
Microbiology .2020; 166(9): 849. CrossRef - Reactive Oxygen Species Penetrate Persister Cell Membranes of Escherichia coli for Effective Cell Killing
Aki Kawano, Ryota Yamasaki, Tatsuya Sakakura, Yoshiyuki Takatsuji, Tetsuya Haruyama, Yoshie Yoshioka, Wataru Ariyoshi
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef - Persister cells resuscitate via ribosome modification by 23S rRNA pseudouridine synthase RluD
Sooyeon Song, Thomas K. Wood
Environmental Microbiology.2020; 22(3): 850. CrossRef - Evidence of defined temporal expression patterns that lead a gram-negative cell out of dormancy
Nandhini Ashok, Carl E. Bauer, Cinthia Núñez
PLOS Genetics.2020; 16(3): e1008660. CrossRef - Role of Tobramycin in the Induction and Maintenance of Viable but Non-Culturable Pseudomonas aeruginosa in an In Vitro Biofilm Model
Gianmarco Mangiaterra, Nicholas Cedraro, Salvatore Vaiasicca, Barbara Citterio, Roberta Galeazzi, Emiliano Laudadio, Giovanna Mobbili, Cristina Minnelli, Davide Bizzaro, Francesca Biavasco
Antibiotics.2020; 9(7): 399. CrossRef - ‘Artemisinin Resistance’: Something New or Old? Something of a Misnomer?
Thomas E. Wellems, Juliana M. Sá, Xin-zhuan Su, Sean V. Connelly, Angela C. Ellis
Trends in Parasitology.2020; 36(9): 735. CrossRef - Leveraging Peptide Substrate Libraries to Design Inhibitors of Bacterial Lon Protease
Brett M. Babin, Paulina Kasperkiewicz, Tomasz Janiszewski, Euna Yoo, Marcin Dra̧g, Matthew Bogyo
ACS Chemical Biology.2019; 14(11): 2453. CrossRef - Toxin-Antitoxin Systems and Bacterial Persistence (Review)
M. V. Zamakhaev, A. V. Goncharenko, M. S. Shumkov
Applied Biochemistry and Microbiology.2019; 55(6): 571. CrossRef - Identification of a potent indigoid persister antimicrobial by screening dormant cells
Sooyeon Song, Ting Gong, Ryota Yamasaki, Jun‐Seob Kim, Thomas K. Wood
Biotechnology and Bioengineering.2019; 116(9): 2263. CrossRef - Perspectives towards antibiotic resistance: from molecules to population
Joon-Hee Lee
Journal of Microbiology.2019; 57(3): 181. CrossRef - L-Tryptophan Represses Persister Formation via Inhibiting Bacterial Motility and Promoting Antibiotics Absorption
Yan Li, Bo Liu, Jingjing Guo, Hua Cong, Shenyi He, Huaiyu Zhou, Faliang Zhu, Qun Wang, Lining Zhang
Future Microbiology.2019; 14(9): 757. CrossRef
- Glucose Supplementation Enhances the Bactericidal Effect of Penicillin and Gentamicin on Streptococcus sanguinis Persisters
Journal Article
- Identification and Methicillin Resistance of Coagulase-Negative Staphylococci Isolated from Nasal Cavity of Healthy Horses
- Jolanta Karakulska , Karol Fijałkowski , Paweł Nawrotek , Anna Pobucewicz , Filip Poszumski , Danuta Czernomysy-Furowicz
- J. Microbiol. 2012;50(3):444-451. Published online June 30, 2012
- DOI: https://doi.org/10.1007/s12275-012-1550-6
- 41 View
- 0 Download
- 31 Scopus
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Abstract
- The aim of this study was an analysis of the staphylococcal flora of the nasal cavity of 42 healthy horses from 4 farms, along with species identification of CoNS isolates and determination of resistance to 18 antimicrobial agents, particularly phenotypic and genotypic methicillin resistance. From the 81 swabs, 87 staphylococci were isolated. All isolates possessed the gap gene but the coa gene was not detected in any of these isolates. Using PCR-RFLP of the gap gene, 82.8% of CoNS were identified: S. equorum (14.9%), S. warneri (14.9%), S. sciuri (12.6%), S. vitulinus (12.6%), S. xylosus (11.5% ), S. felis (5.7%), S. haemolyticus (3.4%), S. simulans(3.4%), S. capitis (1.1%), S. chromogenes (1.1%), and S. cohnii subsp. urealyticus (1.1%). To our knowledge, this was the first isolation of S. felis from a horse. The species identity of the remaining Staphylococcus spp. isolates (17.2%) could not be determined from the gap gene PCR-RFLP analysis and 16S rRNA gene sequencing data. Based on 16S-23S intergenic transcribed spacer PCR, 11 different ITS-PCR profiles were identified for the 87 analyzed isolates. Results of API Staph were consistent with molecular identification of 17 (19.5%) isolates. Resistance was detected to only 1 or 2 of the 18 antimicrobial agents tested in the 17.2% CoNS isolates, including 6.9% MRCoNS. The mecA gene was detected in each of the 5 (5.7%) phenotypically cefoxitin-resistant isolates and in 12 (13.8%) isolates susceptible to cefoxitin. In total, from 12 horses (28.6%), 17 (19.5%) MRCoNS were isolated. The highest percentage of MRCoNS was noted among S. sciuri isolates (100%).
- Iron Increases Susceptibilities of Pseudomonas aeruginosa to Ofloxacin by Increasing the Permeability
- Sookyoung Kim , Jinsook Kim , Hyeran Nam , Yusun Jung , Yeonhee Lee
- J. Microbiol. 2000;38(4):265-269.
- 38 View
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Abstract
- Iron increased the susceptibilities of clinical isolates of Pseudomonas aeruginosa to quinolones. In the presence of iron, increased susceptibilities to ofloxacin were observed in twenty-six out of thirty isolates and with no change in four isolates. In the case of norfloxacin, iron increased susceptibilities of twelve isolates but did not render any change in eighteen isolates. In the case of ciprofloxacin, iron decreased the MICs (Minimal Inhibitory Concentration) of twenty isolates, increased the MIC of one isolate, and did not change the MICs of nine isolates. To find out how iron increased susceptibility to ofloxacin, bacterial cells were grown in Muller Hinton (MH) media and succinate minimal media (SMM) to induce iron acquisition systems and the intracellular ofloxacin concentrations were assayed in the presence of iron. The addition of iron to the media decreased the MICs of cells whether they were grown in MH or SMM. Siderophores, carbonyl cyanide m-chlorophenylhydrazone (an inhibitor of proton motive force), and ouabain (an inhibitor of ATPase) did not decrease the effect of iron. Results suggested that the increase in the intracellular ofloxacin concentration by iron is accomplished not by decreasing the efflux but by increasing the ofloxacin permeability.
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