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- Inferences in microbial structural signatures of acne microbiome and mycobiome
- Jubin Kim , Taehun Park , Hye-Jin Kim , Susun An , Woo Jun Sul
- J. Microbiol. 2021;59(4):369-375. Published online February 10, 2021
- DOI: https://doi.org/10.1007/s12275-021-0647-1
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- 17 Web of Science
- 18 Crossref
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Abstract
-
Acne vulgaris, commonly known as acne, is the most common
skin disorder and a multifactorial disease of the sebaceous
gland. Although the pathophysiology of acne is still
unclear, bacterial and fungal factors are known to be involved
in. This study aimed to investigate whether the microbiomes
and mycobiomes of acne patients are distinct from those of
healthy subjects and to identify the structural signatures of
microbiomes related to acne vulgaris. A total of 33 Korean
female subjects were recruited (Acne group, n = 17; Healthy
group, n = 16), and microbiome samples were collected swabbing
the forehead and right cheek. To characterize the fungal
and bacterial communities, 16S rRNA V4–V5 and ITS1 region,
respectively, were sequenced and analysed using Qiime2.
There were no significant differences in alpha and beta diversities
of microbiomes between the Acne and Healthy groups.
In comparison with the ratio of Cutibacterium to Staphylococcus,
the acne patients had higher abundance of Staphylococcus
compared to Cutibacterium than the healthy individuals.
In network analysis with the dominant microorganism
amplicon sequence variants (ASV) (Cutibacterium, Staphylococcus,
Malassezia globosa, and Malassezia restricta) Cutibacterium
acnes was identified to have hostile interactions
with Staphylococcus and Malassezia globosa. Accordingly, this
results
suggest an insight into the differences in the skin microbiome and mycobiome between acne patients and healthy controls and provide possible microorganism candidates that modulate the microbiomes associated to acne vulgaris. -
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