MSK
Search
- Page Path
- HOME > Search
- Characteristics of skin microbiome associated with disease severity in systemic sclerosis
- Kyung-Ann Lee, Asad Ul-Haq, Hoonhee Seo, Sujin Jo, Sukyung Kim, Ho-Yeon Song, Hyun-Sook Kim
- J. Microbiol. 2025;63(1):e.2409018. Published online January 24, 2025
- DOI: https://doi.org/10.71150/jm.2409018
- 530 View
- 48 Download
-
Abstract
PDF
Supplementary Material -
Systemic sclerosis (SSc) is a chronic autoimmune disorder characterised by skin fibrosis and internal organ involvement. Disruptions in the microbial communities on the skin may contribute to the onset of autoimmune diseases that affect the skin. However, current research on the skin microbiome in SSc is lacking. This study aimed to investigate skin microbiome associated with disease severity in SSc. Skin swabs were collected from the upper limbs of 46 healthy controls (HCs) and 36 patients with SSc. Metagenomic analysis based on the 16S rRNA gene was conducted and stratified by cutaneous subtype and modified Rodnan skin score (mRSS) severity. Significant differences in skin bacterial communities were observed between the HCs and patients with SSc, with further significant variations based on subtype and mRSS severity. The identified biomarkers were Bacteroides and Faecalibacterium for patients with diffuse cutaneous SSc with high mRSS (≥ 10) and Mycobacterium and Parabacteroides for those with low mRSS (< 10). Gardnerella, Abies, Lactobacillus, and Roseburia were the biomarkers in patients with limited cutaneous SSc (lcSS) and high mRSS, whereas Coprococcus predominated in patients with lcSS and low mRSS. Cutaneous subtype analysis identified Pediococcus as a biomarker in the HCs, whereas mRSS analysis revealed the presence of Pseudomonas in conjunction with Pediococcus. In conclusion, patients with SSc exhibit distinct skin microbiota compared with healthy controls. Bacterial composition varies by systemic sclerosis cutaneous subtype and skin thickness.
- Characteristic alterations of gut microbiota in uncontrolled gout
- Asad ul-Haq , Kyung-Ann Lee , Hoonhee Seo , Sukyung Kim , Sujin Jo , Kyung Min Ko , Su-Jin Moon , Yun Sung Kim , Jung Ran Choi , Ho-Yeon Song , Hyun-Sook Kim
- J. Microbiol. 2022;60(12):1178-1190. Published online November 24, 2022
- DOI: https://doi.org/10.1007/s12275-022-2416-1
- 60 View
- 0 Download
- 10 Web of Science
- 11 Crossref
-
Abstract
- Microbiome research has been on the rise recently for a more in-depth understanding of gout. Meanwhile, there is a need to understand the gut microbiome related to uric acid-lowering drug resistance. In this study, 16S rRNA gene-based microbiota analysis was performed for a total of 65 stool samples from 17 healthy controls and 48 febuxostat-treated gout patients (including 28 controlled subjects with decreased uric acid levels and 20 uncontrolled subjects with non-reduced uric acid levels). Alpha diversity of bacterial community decreased in the healthy control, controlled, and uncontrolled groups. In the case of beta diversity, the bacterial community was significantly different among groups (healthy control, controlled, and uncontrolled groups). Taxonomic biomarker analysis revealed the increased population of g-Bifidobacterium in healthy controls and g-Prevotella in uncontrolled patients. PCR further confirmed this result at the species level. Additionally, functional metagenomics predictions led to the exploration of various functional biomarkers, including purine metabolism. The results of this study can serve as a basis for developing potential new strategies for diagnosing and treating gout from microbiome prospects.
-
Citations
Citations to this article as recorded by
- Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis
Jae Heon Kim, Hoonhee Seo, Sukyung Kim, Md Abdur Rahim, Sujin Jo, Indrajeet Barman, Hanieh Tajdozian, Faezeh Sarafraz, Ho-Yeon Song, Yun Seob Song
International Journal of Molecular Sciences.2024; 25(16): 8943. CrossRef - Reassessing Gout Management through the Lens of Gut Microbiota
Jean Demarquoy, Oumaima Dehmej
Applied Microbiology.2024; 4(2): 824. CrossRef - Changes in gut microbiota structure and function in gout patients
Feiyan Zhao, Zhixin Zhao, Dafu Man, Zhihong Sun, Ning Tie, Hongbin Li, Heping Zhang
Food Bioscience.2023; 54: 102912. CrossRef - Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series Study
In-Young Jo, Hyung-Kwon Byeon, Myung-Jin Ban, Jae-Hong Park, Sang-Cheol Lee, Yong Kyun Won, Yun-Su Eun, Jae-Yun Kim, Na-Gyeong Yang, Sul-Hee Lee, Pyeongan Lee, Nam-Hun Heo, Sujin Jo, Hoonhee Seo, Sukyung Kim, Ho-Yeon Song, Jung-Eun Kim
Photonics.2023; 10(3): 241. CrossRef - New drug targets for the treatment of gout arthritis: what’s new?
Tiago H. Zaninelli, Geovana Martelossi-Cebinelli, Telma Saraiva-Santos, Sergio M. Borghi, Victor Fattori, Rubia Casagrande, Waldiceu A. Verri
Expert Opinion on Therapeutic Targets.2023; 27(8): 679. CrossRef - A dynamics association study of gut barrier and microbiota in hyperuricemia
Qiulan Lv, Jun Zhou, Changyao Wang, Xiaomin Yang, Yafei Han, Quan Zhou, Ruyong Yao, Aihua Sui
Frontiers in Microbiology.2023;[Epub] CrossRef - Biochemical Recurrence in Prostate Cancer Is Associated with the Composition of Lactobacillus: Microbiome Analysis of Prostatic Tissue
Jae Heon Kim, Hoonhee Seo, Sukyung Kim, Asad Ul-Haq, Md Abdur Rahim, Sujin Jo, Ho-Yeon Song, Yun Seob Song
International Journal of Molecular Sciences.2023; 24(13): 10423. CrossRef - Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis
Vladimir S. Ermakov, Jeffry C. Granados, Sanjay K. Nigam
JCI Insight.2023;[Epub] CrossRef - Causal Relationship between Gut Microbiota and Gout: A Two-Sample Mendelian Randomization Study
Mengna Wang, Jiayao Fan, Zhaohui Huang, Dan Zhou, Xue Wang
Nutrients.2023; 15(19): 4260. CrossRef - Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review
Robert Terkeltaub
Drugs.2023; 83(16): 1501. CrossRef - Characterization of Fecal Microbiomes of Osteoporotic Patients in Korea
Asad Ul-Haq, Hoonhee Seo, Sujin Jo, Hyuna Park, Sukyung Kim, Youngkyoung Lee, Saebim Lee, Je Hoon Jeong, Ho‑Yeon Song
Polish Journal of Microbiology.2022; 71(4): 601. CrossRef
- Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis
First
Prev
TOP
