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- The velvet repressed vidA gene plays a key role in governing development in Aspergillus nidulans
- Min-Ju Kim , Won-Hee Jung , Ye-Eun Son , Jae-Hyuk Yu , Mi-Kyung Lee , Hee-Soo Park
- J. Microbiol. 2019;57(10):893-899. Published online August 28, 2019
- DOI: https://doi.org/10.1007/s12275-019-9214-4
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- 14 Web of Science
- 12 Crossref
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Abstract
- Fungal development is regulated by a variety of transcription factors in Aspergillus nidulans. Previous studies demonstrated that the NF-κB type velvet transcription factors regulate certain target genes that govern fungal differentiation and cellular metabolism. In this study, we characterize one of the VosA/VelB-inhibited developmental genes called vidA, which is predicted to encode a 581-amino acid protein with a C2H2 zinc finger domain at the C-terminus. Levels of vidA mRNA are high during the early and middle phases of asexual development and decrease during the late phase of asexual development and asexual spore (conidium) formation. Deletion of either vosA or velB results in increased vidA mRNA accumulation in conidia, suggesting that vidA transcript accumulation in conidia is repressed by VosA and VelB. Phenotypic analysis demonstrated that deletion of vidA causes decreased colony growth, reduced production of asexual spores, and abnormal formation of sexual fruiting bodies. In addition, the vidA deletion mutant conidia contain more trehalose and β-glucan than wild type. Overall, these results suggest that VidA is a putative transcription factor that plays a key role in governing proper fungal growth, asexual and sexual development, and conidia formation in A. nidulans.
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Citations
Citations to this article as recorded by
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Journal of Microbiology and Biotechnology.2023; 33(11): 1420. CrossRef - The function of a conidia specific transcription factor CsgA in Aspergillus nidulans
He-Jin Cho, Hee-Soo Park
Scientific Reports.2022;[Epub] CrossRef - The Putative C2H2 Transcription Factor VadH Governs Development, Osmotic Stress Response, and Sterigmatocystin Production in Aspergillus nidulans
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Cells.2022; 11(24): 3998. CrossRef - The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi
Minou Nowrousian
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Journal of Microbiology.2021; 59(8): 746. CrossRef - Unveiling the Functions of the VosA-VelB Target GenevidDinAspergillus nidulans
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Mycobiology.2021; 49(3): 258. CrossRef - Velvet activated McrA plays a key role in cellular and metabolic development in Aspergillus nidulans
Mi-Kyung Lee, Ye-Eun Son, Hee-Soo Park, Ahmad Alshannaq, Kap-Hoon Han, Jae-Hyuk Yu
Scientific Reports.2020;[Epub] CrossRef - The role of the VosA-repressed dnjA gene in development and metabolism in Aspergillus species
Ye-Eun Son, He-Jin Cho, Wanping Chen, Sung-Hun Son, Mi-Kyung Lee, Jae-Hyuk Yu, Hee-Soo Park
Current Genetics.2020; 66(3): 621. CrossRef - Homeobox proteins are essential for fungal differentiation and secondary metabolism in Aspergillus nidulans
Sung-Hun Son, Ye-Eun Son, He-Jin Cho, Wanping Chen, Mi-Kyung Lee, Lee-Han Kim, Dong-Min Han, Hee-Soo Park
Scientific Reports.2020;[Epub] CrossRef - The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum
Chrystian Zetina-Serrano, Ophélie Rocher, Claire Naylies, Yannick Lippi, Isabelle P. Oswald, Sophie Lorber, Olivier Puel
International Journal of Molecular Sciences.2020; 21(18): 6660. CrossRef
- Regulators of the Asexual Life Cycle of Aspergillus nidulans
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