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- The type II histidine triad protein HtpsC facilitates invasion of epithelial cells by highly virulent Streptococcus suis serotype 2
- Yunjun Lu , Shu Li , Xiaodong Shen , Yan Zhao , Dongming Zhou , Dan Hu , Xushen Cai , Lixia Lu , Xiaohui Xiong , Ming Li , Min Cao
- J. Microbiol. 2021;59(10):949-957. Published online September 7, 2021
- DOI: https://doi.org/10.1007/s12275-021-1129-1
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Abstract
- Streptococcus suis serotype 2 (S. suis 2) is an important zoonotic pathogen that presents a significant threat both to pigs and to workers in the pork industry. The initial steps of S. suis 2 pathogenesis are unclear. In this study, we found that the type II histidine triad protein HtpsC from the highly virulent Chinese isolate 05ZYH33 is structurally similar to internalin A (InlA) from Listeria monocytogenes, which plays an important role in mediating listerial invasion of epithelial cells. To determine if HtpsC and InlA function similarly, an isogenic htpsC mutant (ΔhtpsC) was generated in S. suis by homologous recombination. The htpsC deletion strain exhibited a diminished ability to adhere to and invade epithelial cells from different sources. Double immunofluorescence microscopy also revealed reduced survival of the ΔhtpsC mutant after cocultivation with epithelium. Adhesion to epithelium and invasion by the wild type strain was inhibited by a monoclonal antibody against E-cadherin. In contrast, the htpsC-deficient mutant was unaffected by the same treatment, suggesting that E-cadherin is the host-cell receptor that interacts with HtpsC and facilitates bacterial internalization. Based on these results, we propose that HtpsC is involved in the process by which S. suis 2 penetrates host epithelial cells, and that this protein is an important virulence factor associated with cell adhesion and invasion.
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Citations
Citations to this article as recorded by
- Genomic and phenotypic analysis of invasive Streptococcus suis isolated in Spain reveals genetic diversification and associated virulence traits
Cristina Uruén, Ana Fernandez, José Luis Arnal, Mateo del Pozo, Maria Casas Amoribieta, Ignacio de Blas, Paula Jurado, Jorge Hugo Calvo, Marcelo Gottschalk, Luis Daniel González-Vázquez, Miguel Arenas, Clara M. Marín, Jesús Arenas
Veterinary Research.2024;[Epub] CrossRef - A rapid colloidal gold immunochromatographic assay based on polyclonal antibodies against HtpsC protein for the detection of Streptococcus suis
Yawei Lu, Sibo Wang, Xushen Cai, Min Cao, Qingyu Lu, Dan Hu, Qiong Chen, Xiaohui Xiong
Frontiers in Microbiology.2023;[Epub] CrossRef
- Genomic and phenotypic analysis of invasive Streptococcus suis isolated in Spain reveals genetic diversification and associated virulence traits
Review
- Omics in gut microbiome analysis
- Tae Woong Whon , Na-Ri Shin , Joon Yong Kim , Seong Woon Roh
- J. Microbiol. 2021;59(3):292-297. Published online February 23, 2021
- DOI: https://doi.org/10.1007/s12275-021-1004-0
- 43 View
- 0 Download
- 37 Web of Science
- 38 Crossref
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Abstract
- Our understanding of the interactions between microbial communities and their niche in the host gut has improved owing to recent advances in environmental microbial genomics. Integration of metagenomic and metataxonomic sequencing data with other omics data to study the gut microbiome has become increasingly common, but downstream analysis after data integration and interpretation of complex omics data remain challenging. Here, we review studies that have explored the gut microbiome signature using omics approaches, including metagenomics, metataxonomics, metatranscriptomics, and metabolomics. We further discuss recent analytics programs to analyze and integrate multi-omics datasets and further utilization of omics data with other advanced techniques, such as adaptive immune receptor repertoire sequencing, microbial culturomics, and machine learning, to evaluate important microbiome characteristics in the gut.
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Citations
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Food Control.2023; 145: 109392. CrossRef - The gut microbiota: A new perspective for tertiary prevention of hepatobiliary and gallbladder diseases
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Frontiers in Microbiology.2023;[Epub] CrossRef - Potential role of gut microbes in the efficacy and toxicity of immune checkpoints inhibitors
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Frontiers in Microbiology.2022;[Epub] CrossRef - In sickness and in health: Insights into the application of omics in aquaculture settings under a microbiological perspective
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Effect of alfalfa supplementary change dietary non-fibrous carbohydrate (NFC) to neutral detergent fiber (NDF) ratio on rumen fermentation and microbial function in Gansu alpine fine wool sheep (
Ovis aries
)
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