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- Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
- Na-Eun Kim , Yoon-Jae Song
- J. Microbiol. 2022;60(3):300-307. Published online January 28, 2022
- DOI: https://doi.org/10.1007/s12275-022-1502-8
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- 5 Web of Science
- 5 Crossref
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Abstract
- Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. While optimal IFN and inflammasome responses are essential for limiting SARS-CoV-2 infection, aberrant activation of these innate immune responses is associated with COVID-19 pathogenesis. In this review, we focus our discussion on recent findings on SARS-CoV-2-induced type I and III IFNs and NLRP3 inflammasome responses and the viral proteins regulating these mechanisms.
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Citations
Citations to this article as recorded by
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