Journal of Microbiology

Reviews

Application of Microbiome‑Based Therapies in Chronic Respiratory Diseases: Se Hee Lee, Jang Ho Lee, Sei Won Lee; J. Microbiol. 2024;62(3):201-216. Published online April 18, 2024; DOI: https://doi.org/10.1007/s12275-024-00124-1

79 View
1 Download
3 Web of Science
3 Crossref

The application of microbiome-based therapies in various areas of human disease has recently increased. In chronic respiratory disease, microbiome-based clinical applications are considered compelling options due to the limitations of current treatments. The lung microbiome is ecologically dynamic and afected by various conditions, and dysbiosis is associated with disease severity, exacerbation, and phenotype as well as with chronic respiratory disease endotype. However, it is not easy to directly modulate the lung microbiome. Additionally, studies have shown that chronic respiratory diseases can be improved by modulating gut microbiome and administrating metabolites. Although the composition, diversity, and abundance of the microbiome between the gut and lung are considerably diferent, modulation of the gut microbiome could improve lung dysbiosis. The gut microbiome infuences that of the lung via bacterial-derived components and metabolic degradation products, including short-chain fatty acids. This phenomenon might be associated with the cross-talk between the gut microbiome and lung, called gut-lung axis. There are multiple alternatives to modulate the gut microbiome, such as prebiotics, probiotics, and postbiotics ingestion and fecal material transplantation. Several studies have shown that high-fber diets, for example, present benefcial efects through the production of short-chain fatty acids. Additionally, genetically modifed probiotics to secrete some benefcial molecules might also be utilized to treat chronic respiratory diseases. Further studies on microbial modulation to regulate immunity and potentiate conventional pharmacotherapy will improve microbiome modulation techniques, which will develop as a new therapeutic area in chronic respiratory diseases.

Citations

Citations to this article as recorded by

Bacteria and Allergic Diseases
Svetlana V. Guryanova
International Journal of Molecular Sciences.2024; 25(19): 10298. CrossRef
The emerging roles of microbiome and short-chain fatty acids in the pathogenesis of bronchopulmonary dysplasia
Yuan Gao, Kaixuan Wang, Zupan Lin, Shujing Cai, Aohui Peng, Le He, Hui Qi, Zhigang Jin, Xubo Qian
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef

REVIEW] Chronic Obstructive Pulmonary Disease (COPD): Evaluation From Clinical, Immunological and Bacterial Pathogenesis Perspectives: Daniel J. Hassett , Michael T. Borchers , Ralph J. Panos; J. Microbiol. 2014;52(3):211-226. Published online March 1, 2014; DOI: https://doi.org/10.1007/s12275-014-4068-2

43 View
0 Download
47 Crossref

Abstract

Chronic obstructive pulmonary disease (COPD), a disease manifested by significantly impaired airflow, afflicts ~14.2 million cases in the United States alone with an estimated 63 million people world-wide. Although there are a number of causes, the predominant cause is excessive tobacco smoke. In fact, in China, there have been estimates of 315,000,000 people that smoke. Other less frequent causes are associated with indirect cigarette smoke, air pollutants, biomass fuels, and genetic mutations. COPD is often associated with heart disease, lung cancer, osteoporosis and conditions can worsen in patients with sudden falls. COPD also affects both innate and adaptive immune processes. Cigarette smoke increases the expression of matrix metalloproteases and proinflammatory chemokines and increases lung titers of natural killer cells and neutrophils. Yet, neutrophil reactive oxygen species (ROS) mediated by the phagocytic respiratory burst and phagocytosis is impaired by nicotine. In contrast to innate immunity in COPD, dendritic cells represent leukocytes recruited to the lung that link the innate immune responses to adaptive immune responses by activating naïve T cells through antigen presentation. The autoimmune process that is also a significant part of inflammation associated with COPD. Moreover, coupled with restricted FEV1 values, are the prevalence of patients with single or multiple infections by bacteria, viruses and fungi. Finally, we focus on one of the more problematic infectious agents, the Gram-negative opportunistic pathogenic bacterium, Pseudomonas aeruginosa. Specifically, we delve into the development of highly problematic biofilm infections that are highly refractory to conventional antibiotic therapies in COPD. We offer a nonconventional, biocidal treatment that may be effective for COPD airway infections as well as with combinations of current antibiotic regimens for more effective treatment outcomes and relief for patients with COPD.

Citations

Citations to this article as recorded by

In vitro lung epithelial cell model reveals novel roles for Pseudomonas aeruginosa siderophores
Donghoon Kang, Qi Xu, Natalia V. Kirienko, Giordano Rampioni
Microbiology Spectrum.2024;[Epub] CrossRef
A metaplasia escamosa em dpoc: uma revisão sistemática
Daniela Sasso Pasquini, Isabella Vieira Laporte Ambrozewicz, Sofia Garcia Santana
Journal Archives of Health.2024; 5(1): 399. CrossRef
Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response
Rhea Nickerson, Christina S. Thornton, Brent Johnston, Amy H. Y. Lee, Zhenyu Cheng
Frontiers in Immunology.2024;[Epub] CrossRef
Unlocking the potential of lactic acid bacteria mature biofilm extracts as antibiofilm agents
Pamela Hindieh, Joseph Yaghi, Jean Claude Assaf, Ali Chokr, Ali Atoui, Nicolas Louka, André El Khoury
AMB Express.2024;[Epub] CrossRef
Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine: A Fresh Perspective
Pierachille Santus, Juan Camilo Signorello, Fiammetta Danzo, Giada Lazzaroni, Marina Saad, Dejan Radovanovic
Journal of Clinical Medicine.2024; 13(14): 4127. CrossRef
Biofilms as Battlefield Armor for Bacteria against Antibiotics: Challenges and Combating Strategies
Sara Bano, Noor Hassan, Muhammad Rafiq, Farwa Hassan, Maliha Rehman, Naveed Iqbal, Hazrat Ali, Fariha Hasan, Ying-Qian Kang
Microorganisms.2023; 11(10): 2595. CrossRef
Antibiofilm agents with therapeutic potential against enteroaggregative Escherichia coli
David A. Kwasi, Chinedum P. Babalola, Olujide O. Olubiyi, Jennifer Hoffmann, Ikemefuna C. Uzochukwu, Iruka N. Okeke, Luther A. Bartelt
PLOS Neglected Tropical Diseases.2022; 16(10): e0010809. CrossRef
Resistance Is Not Futile: The Role of Quorum Sensing Plasticity in Pseudomonas aeruginosa Infections and Its Link to Intrinsic Mechanisms of Antibiotic Resistance
Kayla A. Simanek, Jon E. Paczkowski
Microorganisms.2022; 10(6): 1247. CrossRef
Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features
Yingjian Yang, Wei Li, Yingwei Guo, Yang Liu, Qiang Li, Kai Yang, Shicong Wang, Nanrong Zeng, Wenxin Duan, Ziran Chen, Huai Chen, Xian Li, Wei Zhao, Rongchang Chen, Yan Kang
Frontiers in Medicine.2022;[Epub] CrossRef
The effect of N-acetylcysteine in patients with non-cystic fibrosis bronchiectasis (NINCFB): study protocol for a multicentre, double-blind, randomised, placebo-controlled trial
Yue Liao, Yanqiu Wu, Kai Zi, Yongchun Shen, Tao Wang, Jiangyue Qin, Lei Chen, Mei Chen, Lin Liu, Weiming Li, Hui Zhou, Shuguan Xiong, Fuqiang Wen, Jun Chen
BMC Pulmonary Medicine.2022;[Epub] CrossRef
Small-Angle Neutron Scattering Reveals the Nanostructure of Liposomes with Embedded OprF Porins of Pseudomonas aeruginosa
Francesco Spinozzi, Jean-Pierre Alcaraz, Maria Grazia Ortore, Landry Gayet, Aurel Radulescu, Donald K. Martin, Marco Maccarini
Langmuir.2022; 38(49): 15026. CrossRef
Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
Ze-Guang Zheng, Wu-Zhuang Sun, Jie-Ying Hu, Zhi-Jun Jie, Jin-Fu Xu, Jie Cao, Yuan-Lin Song, Chang-Hui Wang, Jing Wang, Hui Zhao, Zhong-Liang Guo, Nan-Shan Zhong
Respiratory Research.2021;[Epub] CrossRef
Health economics matters in the nanomaterial world: Cost-effectiveness of utilizing an inhalable antibacterial nanomaterial for the treatment of multidrug-resistant pneumonia
Vuk Uskoković
Technology in Society.2021; 66: 101641. CrossRef
Microbial biofilm: A matter of grave concern for human health and food industry
Muzamil A. Rather, Kuldeep Gupta, Pritam Bardhan, Munmi Borah, Anupama Sarkar, Khalifa S. H. Eldiehy, Shuvam Bhuyan, Manabendra Mandal
Journal of Basic Microbiology.2021; 61(5): 380. CrossRef
Plant-derived nanotherapeutic systems to counter the overgrowing threat of resistant microbes and biofilms
Sajid Asghar, Ikram Ullah Khan, Saad Salman, Syed Haroon Khalid, Rabia Ashfaq, Thierry F. Vandamme
Advanced Drug Delivery Reviews.2021; 179: 114019. CrossRef
The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies
R. Frèdi Langendonk, Daniel R. Neill, Joanne L. Fothergill
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Tissue-Specific Ultra-Short Telomeres in Chronic Obstructive Pulmonary Disease

Huseyin Cagsin, Ali Uzan, Ozgur Tosun, Finn Rasmussen, Nedime Serakinci
International Journal of Chronic Obstructive Pulmonary Disease.2020; Volume 15: 2751. CrossRef
Host responses to mucosal biofilms in the lung and gut
Jada C. Domingue, Julia L. Drewes, Christian A. Merlo, Franck Housseau, Cynthia L. Sears
Mucosal Immunology.2020; 13(3): 413. CrossRef
Overexpression of phzM contributes to much more production of pyocyanin converted from phenazine-1-carboxylic acid in the absence of RpoS in Pseudomonas aeruginosa
Kewen Wang, Le Kai, Kailu Zhang, Mengyue Hao, Yanjie Yu, Xinyu Xu, Zhifen Yu, Lijuan Chen, Xiaoyan Chi, Yihe Ge
Archives of Microbiology.2020; 202(6): 1507. CrossRef
Haemophilus influenzaepersists in biofilm communities in a smoke-exposed ferret model of COPD
Benjamin C. Hunt, Denise Stanford, Xin Xu, Jindong Li, Amit Gaggar, Steven M. Rowe, S. Vamsee Raju, W. Edward Swords
ERJ Open Research.2020; 6(3): 00200-2020. CrossRef
Airway Natural Killer Cells and Bacteria in Health and Disease
Maud Theresine, Neha D. Patil, Jacques Zimmer
Frontiers in Immunology.2020;[Epub] CrossRef
Clinical Significance of Carbapenem-Tolerant Pseudomonas aeruginosa Isolated in the Respiratory Tract
Momoyo Azuma, Keiji Murakami, Rina Murata, Keiko Kataoka, Hideki Fujii, Yoichiro Miyake, Yasuhiko Nishioka
Antibiotics.2020; 9(9): 626. CrossRef
Biofilm dispersion
Kendra P. Rumbaugh, Karin Sauer
Nature Reviews Microbiology.2020; 18(10): 571. CrossRef
Clinical significance of BPI‐ANCA detecting in COPD patients with Pseudomonas aeruginosa colonization
Yongjian Tian, Tingting Zeng, Liming Tan, Yang Wu, Jianlin Yu, Jiayi Huang, Zihuang Pei
Journal of Clinical Laboratory Analysis.2019;[Epub] CrossRef
Signal Sensing and Transduction Are Conserved between the Periplasmic Sensory Domains of BifA and SagS
Jozef Dingemans, Rebecca E. Al-Feghali, Holger Sondermann, Karin Sauer, Bryan Krantz
mSphere.2019;[Epub] CrossRef
Wearable Cardiopulmonary Function Evaluation System for Six-Minute Walking Test
Bor-Shing Lin, Ruei-Jie Jhang, Bor-Shyh Lin
Sensors.2019; 19(21): 4656. CrossRef
Synthesized Heparan Sulfate Competitors Attenuate Pseudomonas aeruginosa Lung Infection
Nicola Lorè, Noemi Veraldi, Camilla Riva, Barbara Sipione, Lorenza Spagnuolo, Ida De Fino, Medede Melessike, Elisa Calzi, Alessandra Bragonzi, Annamaria Naggi, Cristina Cigana
International Journal of Molecular Sciences.2018; 19(1): 207. CrossRef
Mechanisms and Targeted Therapies forPseudomonas aeruginosaLung Infection
Colleen S. Curran, Thomas Bolig, Parizad Torabi-Parizi
American Journal of Respiratory and Critical Care Medicine.2018; 197(6): 708. CrossRef
Establishment and Evaluation of a Rat Model of Sidestream Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Genfa Wang, Nabijan Mohammadtursun, Jing Sun, Yubao Lv, Hualiang Jin, Jinpei Lin, Lingwen Kong, Zhengxiao Zhao, Hongying Zhang, Jingcheng Dong
Frontiers in Physiology.2018;[Epub] CrossRef
Baicalin Exerts Anti‐Airway Inflammation and Anti‐Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease
Genfa Wang, Nabijan Mohammadtursun, Yubao Lv, Hongying Zhang, Jing Sun, Jingcheng Dong, Antonella Di Sotto
Evidence-Based Complementary and Alternative Medicine.2018;[Epub] CrossRef
Multifaceted activity ofN-acetyl-l-cysteine in chronic obstructive pulmonary disease
Luigino Calzetta, Maria Gabriella Matera, Paola Rogliani, Mario Cazzola
Expert Review of Respiratory Medicine.2018; 12(8): 693. CrossRef
MiR-3202 protects smokers from chronic obstructive pulmonary disease through inhibiting FAIM2: An in vivo and in vitro study
Wen Shen, Jia Liu, Minjuan Fan, Shukun Wang, Yang Zhang, Linqiao Wen, Ruili Wang, Wei Wei, Na Li, You Zhang, Guohou Zhao
Experimental Cell Research.2018; 362(2): 370. CrossRef
Functional Characterization of Cell-Free Expressed OprF Porin from Pseudomonas aeruginosa Stably Incorporated in Tethered Lipid Bilayers
Marco Maccarini, Landry Gayet, Jean-Pierre Alcaraz, Lavinia Liguori, Barry Stidder, Erik B. Watkins, Jean-Luc Lenormand, Donald K. Martin
Langmuir.2017; 33(38): 9988. CrossRef
Respiratory Microbiome of Endangered Southern Resident Killer Whales and Microbiota of Surrounding Sea Surface Microlayer in the Eastern North Pacific
Stephen A. Raverty, Linda D. Rhodes, Erin Zabek, Azad Eshghi, Caroline E. Cameron, M. Bradley Hanson, J. Pete Schroeder
Scientific Reports.2017;[Epub] CrossRef
The OxyR-regulated phnW gene encoding 2-aminoethylphosphonate:pyruvate aminotransferase helps protect Pseudomonas aeruginosa from tert-butyl hydroperoxide
Warunya Panmanee, Nisanart Charoenlap, Sopapan Atichartpongkul, Aekkapol Mahavihakanont, Matthew D. Whiteside, Geoff Winsor, Fiona S. L. Brinkman, Skorn Mongkolsuk, Daniel J. Hassett, Michael R. Volkert
PLOS ONE.2017; 12(12): e0189066. CrossRef
Master Autophagy Regulator Transcription Factor EB Regulates Cigarette Smoke-Induced Autophagy Impairment and Chronic Obstructive Pulmonary Disease–Emphysema Pathogenesis
Manish Bodas, Neel Patel, David Silverberg, Kyla Walworth, Neeraj Vij
Antioxidants & Redox Signaling.2017; 27(3): 150. CrossRef
Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease
Mariann Szabó, Veronika Sárosi, Zoltán Balikó, Kornélia Bodó, Nelli Farkas, Tímea Berki, Péter Engelmann
Respiratory Research.2017;[Epub] CrossRef
Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae
Begoña Euba, Nahikari López-López, Irene Rodríguez-Arce, Ariadna Fernández-Calvet, Montserrat Barberán, Nuria Caturla, Sara Martí, Roberto Díez-Martínez, Junkal Garmendia
Scientific Reports.2017;[Epub] CrossRef
Human Lung Mononuclear Phagocytes in Health and Disease
Faezzah Baharom, Gregory Rankin, Anders Blomberg, Anna Smed-Sörensen
Frontiers in Immunology.2017;[Epub] CrossRef
IL-17A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa
Nicola Ivan Lorè, Cristina Cigana, Camilla Riva, Ida De Fino, Alessandro Nonis, Lorenza Spagnuolo, Barbara Sipione, Lisa Cariani, Daniela Girelli, Giacomo Rossi, Veronica Basso, Carla Colombo, Anna Mondino, Alessandra Bragonzi
Scientific Reports.2016;[Epub] CrossRef
A Putative ABC Transporter Permease Is Necessary for Resistance to Acidified Nitrite and EDTA in Pseudomonas aeruginosa under Aerobic and Anaerobic Planktonic and Biofilm Conditions
Cameron McDaniel, Shengchang Su, Warunya Panmanee, Gee W. Lau, Tristan Browne, Kevin Cox, Andrew T. Paul, Seung-Hyun B. Ko, Joel E. Mortensen, Joseph S. Lam, Daniel A. Muruve, Daniel J. Hassett
Frontiers in Microbiology.2016;[Epub] CrossRef
Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo
Laura A. Novotny, Joseph A. Jurcisek, Steven D. Goodman, Lauren O. Bakaletz
eBioMedicine.2016; 10: 33. CrossRef
‘”Why me, why now?” Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection
M. Alexandra Lake, Lyn R. Ambrose, Marc C. I. Lipman, David M. Lowe
BMC Medicine.2016;[Epub] CrossRef
Novel Therapies to Inhibit Mucus Synthesis and Secretion in Airway Hypersecretory Diseases
Emily V.S. Ha, Duncan F. Rogers
Pharmacology.2016; 97(1-2): 84. CrossRef
Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short
Carla S. Andrews, Shingo Matsuyama, Byung-Cheol Lee, Jian-Dong Li
Scientific Reports.2016;[Epub] CrossRef
Population pharmacokinetics of fluticasone propionate/salmeterol using two different dry powder inhalers
K. Soulele, P. Macheras, L. Silvestro, S. Rizea Savu, V. Karalis
European Journal of Pharmaceutical Sciences.2015; 80: 33. CrossRef
Molecular microbiology in antibacterial research
You-Hee Cho
Journal of Microbiology.2014; 52(3): 185. CrossRef

First
Prev
Page of 1
Next
Last

Search