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- Pioneering strategies for overcoming bacterial drug resistance (2026)
- Advancing microbial engineering through synthetic biology (2025)
- Host-associated microbiome (2024)
- Bacterial regulatory mechanisms for the control of complex cellular mechanisms (2023)
- Two years into COVID-19 pandemic: Where are we? (2022)
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Article
- Gut microbiota metabolic characteristics in coronary artery disease patients with hyperhomocysteine
- Ran Tian , Hong-Hong Liu , Si-Qin Feng , Yi-Fei Wang , Yi-Yang Wang , Yu-Xiong Chen , Hui Wang , Shu-Yang Zhang
- J. Microbiol. 2022;60(4):419-428. Published online March 4, 2022
- DOI: https://doi.org/10.1007/s12275-022-1451-2
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- 1 Download
- 13 Web of Science
- 13 Crossref
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Abstract
PDF -
Hyperhomocysteine (HHcy) is known as a risk factor for coronary
artery disease (CAD). Despite the knowledge that gut
microbiota related metabolism pathway shares metabolites
with that of Hcy, little has been shown concerning the association
between HHcy and gut microbiota. To explore their
relationship in the context of CAD, 105 patients and 14 healthy
controls were recruited from one single medical center located
in Beijing, China. Their serum and fecal samples were
collected, with multi-omics analyses performed via LC/MS/
MS and 16S rRNA gene V3-V4 region sequencing, respectively.
Participants from the prospective cohort were divided
into CAD, CAD & HHcy and healthy controls (HC) groups
based on the diagnosis and serum Hcy concentration. The
results
revealed significant different metabolic signatures between CAD and CAD & HHcy groups. CAD patients with HHcy suffered a heavier atherosclerotic burden compared to CAD patients, and the difference was closely associated to betaine-homocysteine S-methyltransferase (BHMT)-related metabolites and trimethylamine N-oxide (TMAO)-related metabolites. Dimethylglycine (DMG) exhibited a strong positive correlation with serum total Hcy (tHcy), and TMAO and trimethylysine (TML) were associated with heavier atherosclerotic burden. Multiple other metabolites were also identified to be related to distinct cardiovascular risk factors. Additionally, Clostridium cluster IV and Butyricimonas were enriched in CAD patients with elevated tHcy. Our study suggested that CAD patients with elevated tHcy were correlated with higher atherosclerotic burden, and the impaired Hcy metabolism and cardiovascular risk were closely associated with BHMT-related metabolites, TMAO-related metabolites and impaired gut microbiota homeostasis. -
Citations
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Critical Reviews in Food Science and Nutrition.2026; 66(3): 565. CrossRef - An integrative strategy combining network pharmacology, metabolomics, and gut microbiota analyses to elucidate the bioactive ingredients and underlying mechanisms of Xin-Shu-Ning tablets against myocardial ischemia
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