Journal of Microbiology

Journal Article

Physiological roles of catalases Cat1 and Cat2 in Myxococcus xanthus: Kimura Yoshio , Yuri Yoshioka , Kie Toshikuni; J. Microbiol. 2022;60(12):1168-1177. Published online October 24, 2022; DOI: https://doi.org/10.1007/s12275-022-2277-7

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Catalases are key antioxidant enzymes in aerobic organisms. Myxococcus xanthus expresses two monofunctional catalases, small-subunit Cat1 and large-subunit Cat2. The Km of H2O2 for recombinant Cat1 and Cat2 were 14.0 and 9.0 mM, respectively, and the catalytic efficiency of Cat2 (kcat/Km = 500 sec-1 mM-1) was 4-fold higher than that of Cat1. The activity ratio of Cat1 to Cat2 in the exponential growth phase of M. xanthus was 1 to 3–4. A Cat1-deficient strain was constructed, whereas a Cat2-deficient strain could not be produced. In H2O2-supplemented medium, the cat1 mutant exhibited marked growth retardation and a longer generation time than the wild-type (wt) strain. After 2 h of incubation in 0.5 mM H2O2-supplemented medium, the catalase activity of the wt strain significantly increased (by 64-fold), but that of the cat1 mutant strain did not. Under starvation-induced developmental conditions, catalase activity was induced by approximately 200-fold in both wt and cat1 strains, although in the mutant the activity increase as well as spore formation occurred one day later, indicating that the induction of catalase activity during starvation was due to Cat2. In wt starved cells, catalase activity was not induced by H2O2. These results suggest that Cat2 is the primary housekeeping catalase during M. xanthus growth and starvation-induced development, whereas Cat1 may have a complementary role, being responsible for the rapid degradation of H2O2 in proliferating vegetative cells subjected to oxidative stress.

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Enzymatic characterization of five thioredoxins and a thioredoxin reductase from Myxococcus xanthus
Ryota Tanifuji, Yoshio Kimura
FEMS Microbiology Letters.2024;[Epub] CrossRef
Overexpression of cat2 restores antioxidant properties and production traits in degenerated strains of Volvariella volvacea
Jianing Zhu, Wenpei Wang, Wanhe Sun, Yuanxi Lei, Qiangfei Tan, Gahong Zhao, Jianmin Yun, Fengyun Zhao
Free Radical Biology and Medicine.2024; 215: 94. CrossRef
Alleviation of H2O2 toxicity by extracellular catalases in the phycosphere of Microcystis aeruginosa
Yerim Park, Wonjae Kim, Yeji Cha, Minkyung Kim, Woojun Park
Harmful Algae.2024; 137: 102680. CrossRef
Cis-3-Indoleacrylic Acid: A Nematicidal Compound from Streptomyces youssoufiensis YMF3.862 as V-ATPase Inhibitor on Meloidogyne incognita
Min Chen, Ying Huang, Li Ma, Jian-Jin Liu, Yi Cao, Pei-Ji Zhao, Ming-He Mo
Journal of Agricultural and Food Chemistry.2024; 72(44): 24347. CrossRef
Broad-spectrum ROS autonomous scavenging polysaccharide-based vehicle to improve the bioactivity of blueberry anthocyanidins through intestinal synergistic mucoadhesion
Jingwen Xu, Yue Zhang, Xiaolin Yao, Sijuan Wang, Guangwen Luo, Kaiqiang Lv, Yongkang Zhang, Guoliang Li
Food Hydrocolloids.2024; 152: 109899. CrossRef
Polyphosphate Plays a Significant Role in the Maturation of Spores in Myxococcus xanthus
Daiki Harita, Hiroka Matsukawa, Yoshio Kimura
Current Microbiology.2024;[Epub] CrossRef
Discovery of 2-Naphthol from the Leaves of Actephila merrilliana as a Natural Nematicide Candidate
Xi Zhang, Zhan Hu, Shuai Wang, Fengman Yin, Yuyang Wei, Jia Xie, Ranfeng Sun
Journal of Agricultural and Food Chemistry.2023; 71(36): 13209. CrossRef

Review

Insights into the immune responses of SARS-CoV-2 in relation to COVID-19 vaccines: Heedo Park , Mee Sook Park , Jong Hyeon Seok , Jaehwan You , Jineui Kim , Jeonghun Kim , Man-Seong Park; J. Microbiol. 2022;60(3):308-320. Published online March 2, 2022; DOI: https://doi.org/10.1007/s12275-022-1598-x

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Abstract

The three types of approved coronavirus disease 2019 (COVID- 19) vaccines that have been emergency-use listed (EUL) by the World Health Organization are mRNA vaccines, adenovirus- vectored vaccines, and inactivated vaccines. Canonical vaccine developments usually take years or decades to be completed to commercialization; however, the EUL vaccines being used in the current situation comprise several COVID- 19 vaccine candidates applied in studies and clinical settings across the world. The extraordinary circumstances of the COVID-19 pandemic have necessitated the emergency authorization of these EUL vaccines, which have been rapidly developed. Although the benefits of the EUL vaccines outweigh their adverse effects, there have been reports of rare but fatal cases directly associated with COVID-19 vaccinations. Thus, a reassessment of the immunological rationale underlying EUL vaccines in relation to COVID-19 caused by SARSCOV- 2 virus infection is now required. In this review, we discuss the manifestations of COVID-19, immunologically projected effects of EUL vaccines, reported immune responses, informed issues related to COVID-19 vaccination, and the potential strategies for future vaccine use against antigenic variants.

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Journal Articles

Direct current exerts electricidal and bioelectric effects on Porphyromonas gingivalis biofilms partially via promoting oxidative stress and antibiotic transport: Peihui Zou , Peng Li , Jia Liu , Pei Cao , Qingxian Luan; J. Microbiol. 2022;60(1):70-78. Published online November 26, 2021; DOI: https://doi.org/10.1007/s12275-022-1238-5

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Abstract

Low electric current can inhibit certain microbial biofilms and enhance the efficacy of antimicrobials against them. This study investigated the electricidal and bioelectric effects of direct current (DC) against Porphyromonas gingivalis biofilms as well as the underlying mechanisms. Here, we firstly showed that DC significantly suppressed biofilm formation of P. gingivalis in time- and intensity-dependent manners, and markedly inhibited preformed P. gingivalis biofilms. Moreover, DC enhanced the killing efficacy of metronidazole (MTZ) and amoxicillin with clavulanate potassium (AMC) against the biofilms. Notably, DC-treated biofilms displayed upregulated intracellular ROS and expression of ROS related genes (sod, feoB, and oxyR) as well as porin gene. Interestingly, DC-induced killing of biofilms was partially reversed by ROS scavenger N-dimethylthiourea (DMTU), and the synergistic effect of DC with MTZ/AMC was weakened by small interfering RNA of porin gene (si-Porin). In conclusion, DC can exert electricidal and bioelectric effects against P. gingivalis biofilms partially via promotion of oxidative stress and antibiotic transport, which offers a promising approach for effective management of periodontitis.

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Increased susceptibility against Cryptococcus neoformans of lupus mouse models (pristane-induction and FcGRIIb deficiency) is associated with activated macrophage, regardless of genetic background: Saowapha Surawut , Jiradej Makjaroen , Arthid Thim-uam , Jutamas Wongphoom , Tanapat Palaga , Prapaporn Pisitkun , Ariya Chindamporn , Asada Leelahavanichkul; J. Microbiol. 2019;57(1):45-53. Published online November 19, 2018; DOI: https://doi.org/10.1007/s12275-019-8311-8

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Abstract

The severity of cryptococcosis in lupus from varying geneticbackgrounds might be different due to the heterogeneity of lupus-pathogenesis. This study explored cryptococcosis in lupus mouse models of pristane-induction (normal geneticbackground) and FcGRIIb deficiency (genetic defect). Because the severity of lupus nephritis, as determined by proteinuria and serum creatinine, between pristane and FcGRIIb-/- mice were similar at 6-month-old, Cryptococcus neoformans was intravenously administered in 6-month-old mice and were age-matched with wild-type. Indeed, the cryptococcosis disease severity, as evaluated by mortality rate, internal-organ fungal burdens and serum cytokines, between pristane and FcGRIIb-/- mice was not different. However, the severity of cryptococcosis in wild-type was less severe than the lupus mice. On the other hand, phagocytosis activity of peritoneal macrophages from lupus mice (pristane and FcGRIIb-/-) was more predominant than the wild-type without the difference in macrophage killing-activity among these groups. In addition, the number of active T helper cells (Th-cell) in the spleen, including Th-cells with intracellular IFN-γ, from lupus mice (pristane and FcGRIIb-/-) was higher than wildtype. Moreover, these active Th-cells were even higher after 2 weeks of cryptococcal infection. These data support enhanced macrophage activation through prominent Th-cells in both lupus models. In conclusion, an increased susceptibility of cryptococcosis in both lupus models was independent to genetic background. This might due to Th-cell enhanced macrophage phagocytosis with the interference of macrophage killing activity from Cryptococcal immune-evasion properties.

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Comparative time-series analyses of gut microbiome profiles in genetically and chemically induced lupus-prone mice and the impacts of fecal transplantation
Piraya Chatthanathon, Asada Leelahavanichkul, Thanya Cheibchalard, Alisa Wilantho, Nattiya Hirankarn, Naraporn Somboonna
Scientific Reports.2024;[Epub] CrossRef
Fungal microbiome in gut of systemic lupus erythematosus (SLE)-prone mice (pristane and FCGRIIb deficiency), a possible impact of fungi in lupus
Thanya Cheibchalard, Asada Leelahavanichkul, Piraya Chatthanathon, Piriya Klankeo, Nattiya Hirankarn, Naraporn Somboonna, Veena Taneja
PLOS ONE.2024; 19(12): e0314662. CrossRef
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Journal of Innate Immunity.2023; 15(1): 240. CrossRef
Myracrodruon urundeuva lectins present anticancer and anticryptococcal activities with low cytotoxic or genotoxic effects
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Supichcha Saithong, Wilasinee Saisorn, Peerapat Visitchanakun, Kritsanawan Sae-khow, Direkrit Chiewchengchol, Asada Leelahavanichkul
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Vacuolar zinc transporter Zrc1 is required for detoxification of excess intracellular zinc in the human fungal pathogen Cryptococcus neoformans: Minsu Cho , Guanggan Hu , Mélissa Caza , Linda C. Horianopoulos , James W. Kronstad , Won Hee Jung; J. Microbiol. 2018;56(1):65-71. Published online January 4, 2018; DOI: https://doi.org/10.1007/s12275-018-7475-y

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Abstract

Zinc is an important transition metal in all living organisms and is required for numerous biological processes. However, excess zinc can also be toxic to cells and cause cellular stress. In the model fungus Saccharomyces cerevisiae, a vacuolar zinc transporter, Zrc1, plays important roles in the storage and detoxification of excess intracellular zinc to protect the cell. In this study, we identified an ortholog of the S. cerevisiae ZRC1 gene in the human fungal pathogen Cryptococcus neoformans. Zrc1 was localized in the vacuolar membrane in C. neoformans, and a mutant lacking ZRC1 showed significant growth defects under high-zinc conditions. These results suggested a role for Zrc1 in zinc detoxification. However, contrary to our expectation, the expression of Zrc1 was induced in cells grown in zinc-limited conditions and decreased upon the addition of zinc. These expression patterns were similar to those of Zip1, the high-affinity zinc transporter in the plasma membrane of C. neoformans. Furthermore, we used the zrc1 mutant in a murine model of cryptococcosis to examine whether a mammalian host could inhibit the survival of C. neoformans using zinc toxicity. We found that the mutant showed no difference in virulence compared with the wildtype strain. This result suggests that Zrc1-mediated zinc detoxification is not required for the virulence of C. neoformans, and imply that zinc toxicity may not be an important aspect of the host immune response to the fungus.

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CDF family of zinc transporters ZRC-1, MSC-2, and ZRG-17 are involved in survival at high zinc conditions, vegetative development, and cellulase utilization in Neurospora crassa
Serena Ngiimei D, Ranjan Tamuli
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Johannes Sonnberger, Lydia Kasper, Theresa Lange, Sascha Brunke, Bernhard Hube
Molecular Microbiology.2024; 121(3): 341. CrossRef
Zinc Starvation Induces Cell Wall Remodeling and Activates the Antioxidant Defense System in Fonsecaea pedrosoi
Tayná Aparecida de Oliveira Santos, Lucas Weba Soares, Lucas Nojosa Oliveira, Dayane Moraes, Millena Silva Mendes, Célia Maria de Almeida Soares, Alexandre Melo Bailão, Mirelle Garcia Silva Bailão
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Characterization and functional analysis of zinc trafficking in the human fungal pathogen Candida parapsilosis
Tamás Takács, Mihály Tibor Németh, Flóra Bohner, Csaba Vágvölgyi, Ferenc Jankovics, Duncan Wilson, Attila Gácser
Open Biology.2022;[Epub] CrossRef
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Janelle R. Robinson, Omoanghe S. Isikhuemhen, Felicia N. Anike
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Zinc at the Host–Fungus Interface: How to Uptake the Metal?
Lucas Weba Soares, Alexandre Melo Bailão, Célia Maria de Almeida Soares, Mirelle Garcia Silva Bailão
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Transcription factors and transporters in zinc homeostasis: lessons learned from fungi
David J. Eide
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Jaejin Lee, Dong-Ho Lee, Che Ok Jeon, Kangseok Lee
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TheAspergillus fumigatustranscription factor AceA is involved not only in Cu but also in Zn detoxification through regulating transporters CrpA and ZrcA
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Requirement of the isocitrate lyase gene ICL1 for VPS41-mediated starvation response in Cryptococcus neoformans: Zhe Xu , Yafei Zhi , Jianzhang Dong , Benfeng Lin , Di Ye , Xiaoguang Liu; J. Microbiol. 2016;54(7):487-491. Published online June 28, 2016; DOI: https://doi.org/10.1007/s12275-016-6177-6

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Abstract

Cryptococcus neoformans is a major cause of fungal meningitis in individuals with impaired immunity. Our previous studies have shown that the VPS41 gene plays a critical role in the survival of Cryptococcus neoformans under nitrogen starvation; however, the molecular mechanisms underlying VPS41-mediated starvation response remain to be elucidated. In the present study, we show that, under nitrogen starvation, VPS41 strongly enhanced ICL1 expression in C. neoformans and that overexpression of ICL1 in the vps41 mutant dramatically suppressed its defects in starvation response due to the loss of VPS41 function. Moreover, targeted deletion of ICL1 resulted in a dramatic decline in viability of C. neoformans cells under nitrogen deprivation. Taken together, our data suggest a model in which VPS41 up-regulates ICL1 expression, directly or indirectly, to promote survival of C. neoformans under nitrogen starvation.

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Physiological and Transcriptomic Analysis of a Chronologically Long-Lived Saccharomyces cerevisiae Strain Obtained by Evolutionary Engineering
Mevlüt Arslan, Can Holyavkin, Halil İbrahim Kısakesen, Alican Topaloğlu, Yusuf Sürmeli, Zeynep Petek Çakar
Molecular Biotechnology.2018; 60(7): 468. CrossRef

Reviews

REVIEW] All about that fat: Lipid modification of proteins in Cryptococcus neoformans: Felipe H. Santiago-Tirado , Tamara L. Doering; J. Microbiol. 2016;54(3):212-222. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5626-6

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Abstract

Lipid modification of proteins is a widespread, essential process whereby fatty acids, cholesterol, isoprenoids, phospholipids, or glycosylphospholipids are attached to polypeptides. These hydrophobic groups may affect protein structure, function, localization, and/or stability; as a consequence such modifications play critical regulatory roles in cellular systems. Recent advances in chemical biology and proteomics have allowed the profiling of modified proteins, enabling dissection of the functional consequences of lipid addition. The enzymes that mediate lipid modification are specific for both the lipid and protein substrates, and are conserved from fungi to humans. In this article we review these enzymes, their substrates, and the processes involved in eukaryotic lipid modification of proteins. We further focus on its occurrence in the fungal pathogen Cryptococcus neoformans, highlighting unique features that are both relevant for the biology of the organism and potentially important in the search for new therapies.

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Yuan Sui, Michael Wisniewski, Samir Droby, Edoardo Piombo, Xuehong Wu, Junyang Yue
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Peeling the onion: the outer layers of Cryptococcus neoformans
Daniel P Agustinho, Liza C Miller, Lucy X Li, Tamara L Doering
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María-Eugenia Zaballa, F. Gisou van der Goot
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Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation
Xinping Xu, Jianfeng Lin, Youbao Zhao, Elyssa Kirkman, Yee-Seul So, Yong-Sun Bahn, Xiaorong Lin, Aaron P. Mitchell
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REVIEW] Innate host defenses against Cryptococcus neoformans: Camaron Hole , Floyd L. Wormley Jr.; J. Microbiol. 2016;54(3):202-211. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5625-7

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Abstract

Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, can cause life-threatening infections of the central nervous system in immunocompromised and immunocompetent individuals. Cryptococcal meningoencephalitis is the most common disseminated fungal infection in AIDS patients, and remains the third most common invasive fungal infection among organ transplant recipients. The administration of highly active antiretroviral therapy (HAART) has
result
ed in a decrease in the number of cases of AIDS-related cryptococcosis in developed countries, but in developing countries where HAART is not readily available, Cryptococcus is still a major concern. Therefore, there is an urgent need for the development of novel therapies and/or vaccines to combat cryptococcosis. Understanding the protective immune responses against Cryptococcus is critical for development of vaccines and immunotherapies to combat cryptococcosis. Consequently, this review focuses on our current knowledge of protective immune responses to C. neoformans, with an emphasis on innate immune responses.

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Global trends in Cryptococcus and its interactions with the host immune system: a bibliometric analysis
Shiqin Tang, Ruiying Hao, Xin Liu, Huina He, Yanan Tian, Tingting Jing, Zhao Liu, Yanyan Xu, Xiaojing Li
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Journal Article

Isolation of Cryptococcus neoformans var. grubii (serotype A) from Pigeon Droppings in Seoul, Korea: Hee Youn Chee , Kyung Bok Lee; J. Microbiol. 2005;43(5):469-472.; DOI: https://doi.org/2273 [pii]

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Abstract: Seventy-two pigeon dropping samples were collected from 26 different localities in Seoul and investigated for the occurrence of Cryptococcus neoformans. Seventeen samples from 8 different localities were found to be positive for C. neoformans. All isolates were obtained from withered pigeon droppings. Identification and serotyping of the isolates were determined by means of serological testing and DNA fingerprinting. All isolates belonged to C. neoformans var. grubbi (serotype A).

Research Support, Non-U.S. Gov't

EDITORIAL] Human fungal pathogens: Why should we learn?: Jeong-Yoon Kim; J. Microbiol. 2016;54(3):145-148.; DOI: https://doi.org/10.1007/s12275-016-0647-8

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Abstract

Human fungal pathogens that cause invasive infections are hidden killers, taking lives of one and a half million people every year. However, research progress in this field has not been rapid enough to effectively prevent or treat life-threatening fungal diseases. To update recent research progress and promote more active research in the field of human fungal pathogens, eleven review articles concerning the virulence mechanisms and host interactions of four major human fungal pathogens–Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, and Histoplasma capsulatum–are presented in this special issue.

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Serotyping of Cryptococcus neoformans Strains Isolated in Korea: Soo-Myung Hwang; J. Microbiol. 2002;40(2):166-169.

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Abstract: Twenty strains of Cryptococcus neoformans isolated from environmental and clinical sources in Korea were examined for their serotypes. Two environmental isolates from pigeon excreta belonged to C. neoformans var. neoformans serotype A. Of the 18 isolates from clinical specimens, 17 belonged to C. neoformans var. neoformans (serotype A : 16, serotype D : 1) and one belonged to C. neoformans var. gattii serotype B, which was culturally unusual, producing mucous colonies. This is the first report of the identification of C. neoformans var. gattii serotype B from a patient in Korea.

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