Journal of Microbiology

Research Support, Non-U.S. Gov't

Isolation of Multidrug-Resistant Salmonella typhimurium DT104 from Swine in Korea: Ki Eun Lee , Yeonhee Lee; J. Microbiol. 2007;45(6):590-592.; DOI: https://doi.org/2603 [pii]

Abstract: We report the isolation of Salmonella enterica serotype Typhimurium phage type DT104 (CCARM 8104) from swine in Korea. The CCARM 8104 isolate was resistant to nalidixic acid and showed reduced susceptibility to quinolones. The CCARM 8104 isolate had a missense mutation, Asp87Asn, in the quinolone resistance-determining region in gyrA and produced PSE-1. The CCARM 8104 isolate carried two different class 1 integrons, and the PSE-1 β-lactamase gene was inserted into a 1,200 bp class 1 integron. The presence of DT104 with pse-1 in an integron located in a plasmid and reduced susceptibility to quinolone in swine pose a significant threat of possible horizontal spread between swine and humans.

Journal Article

Genomic Relationship of Salmonella enterica Serovar Typhimurium DT104 Isolates from Korea and the United States: Shukho Kim , Sung Guen Chun , Ok Young Lim , Mi Sun Park , Yeon Ho Kang , Yong Ho Park , Bok Kwon Lee; J. Microbiol. 2004;42(1):14-19.; DOI: https://doi.org/2007 [pii]

Abstract: Salmonella enterica serovar Typhimurium DT104 (Salmonella Typhimurium DT104 or DT104) hasbeen emerging as a common pathogen for human in Korea since 1997. In order to compare the genomic relationship and to search for the dominant strains in Korea, we conducted pulsed-field gel electrophoresis (PFGE) and IS200 fingerprinting of 25 epidemiological unrelated isolates from human and animals from Korea and cattle from America. Two Salmonella Typhimurium DT104 isolates from human in Korea and all 8 isolates from American cattle had indistinguishable patterns from the PFGE and IS200 fingerprinting but multidrug-resistant Salmonella Typhimurium isolates, including DT104, from Korean animals had diverse genetic patterns. The data suggest that a dominant DT104 strain might have circulated between Korean and American cattle and that it had a high level of clonality.

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