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- Genetic Analysis of the Capsid Region of Norovirus GII.4 Variants Isolated in South Korea
- Ju-Eun Kim , Sung-Geun Lee , Han-Gil Cho , Sang-Ha Han , Lae-Hyung Kang , Youn-Mi Lee , Chul-Jong Park , Soon-Young Paik
- J. Microbiol. 2014;52(5):427-434. Published online April 11, 2014
- DOI: https://doi.org/10.1007/s12275-014-3538-x
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Abstract
- Norovirus is one of the major causes of non-bacterial gas-troenteritis in humans. The aim of this study was to analyze the amino acid variation of open reading frame 2 of GII.4 variants in South Korea during the period from November 2006 to December 2012. Sixty-nine complete nucleotide se-quences of open reading frame 2 were obtained from 113 GII.4 strains. The GII.4 2006b variants were detected pre-dominantly between 2006 and 2009; however, new GII.4 variants, which were termed the 2010 variant and the 2012 variant, emerged in 2010 and 2012, respectively. The num-ber of GII.4 2006b variants steadily decreased until 2012, whereas the number of gastroenteritis cases caused by the new variants increased between 2010 and 2012. The amino acid sequence in the ORF2 region obtained in this study was compared with other GII.4 variants isolated in various countries. Amino acid variations were observed primarily at epitope sites and the surrounding regions. Amino acids 294, 359, 393, and 413 of the P2 subdomain were the most variable sites among the GII.4 variants. The information in this study can be useful in basic research to predict the emergence and determine the genetic functions of new GII.4 variants.
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- Determining the efficacy of 27 commercially available disinfectants against human noroviruses
Jae-Woong Lee, Lae-Hyung Kang, Min-Kyeong Kim, Jeong-Soon Kim, Myung L. Kim, Sung-Geun Lee, In-Hye Choi, Chul-Jong Park, Soon-Young Paik
Journal of Infection and Public Health.2021; 14(2): 244. CrossRef - Evolutionary changes in the capsid P2 region of Australian strains of the norovirus GII.Pe_GII.4
Leesa D. Bruggink, Jean M. Moselen, Jason A. Roberts, John A. Marshall
Journal of Medical Microbiology.2017; 66(7): 1014. CrossRef - A norovirus intervariant GII.4 recombinant in Victoria, Australia, June 2016: the next epidemic variant?
Leesa Bruggink, Michael Catton, John Marshall
Eurosurveillance.2016;[Epub] CrossRef - Complete Nucleotide Sequence Analysis of the Norovirus GII.4 Sydney Variant in South Korea
Ji-Sun Park, Sung-Geun Lee, Ji-Young Jin, Han-Gil Cho, Weon-Hwa Jheong, Soon-Young Paik
BioMed Research International.2015; 2015: 1. CrossRef - Molecular epidemiology of norovirus GII.4 variants in children under 5 years with sporadic acute gastroenteritis in South Korea during 2006–2013
Han-Gil Cho, Sung-Geun Lee, Ju-Eun Kim, Kyeong-Sin Yu, Deog-Yong Lee, Po-Hyun Park, Mi-hye Yoon, Eek-Hoon Jho, Jaehong Kim, Soon-Young Paik
Journal of Clinical Virology.2014; 61(3): 340. CrossRef
- Determining the efficacy of 27 commercially available disinfectants against human noroviruses
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