MSK
Search
- Page Path
- HOME > Search
Journal Article
- Dense Granule Protein-7 (GRA-7) of Toxoplasma gondii inhibits viral replication in vitro and in vivo
- Prasanna Weeratunga , Thilina U. B. Herath , Tae-Hwan Kim , Hyun-Cheol Lee , Jae-Hoon Kim , Byeong-Hoon Lee , Eun-Seo Lee , Kiramage Chathuranga , W. A. Gayan Chathuranga , Chul-Su Yang , Jin Yeul Ma , Jong-Soo Lee
- J. Microbiol. 2017;55(11):909-917. Published online October 27, 2017
- DOI: https://doi.org/10.1007/s12275-017-7392-5
- 49 View
- 0 Download
- 15 Crossref
-
Abstract
- Dense granule protein-7 (GRA-7) is an excretory protein of Toxoplasma gondii. It is a potential serodiagnostic marker and vaccine candidate for toxoplasmosis. Previous reports demonstrated that GRA-7 induces innate immune responses in macrophages by interacting with TRAF6 via the MyD88- dependent pathway. In the present study, we evaluated the antiviral activity and induction of an antiviral state by GRA-7 both in vitro and in vivo. It was observed that GRA-7 markedly reduced the replication of vesicular stomatitis virus (VSVGFP), influenza A virus (PR8-GFP), coxsackievirus (H3- GFP), herpes simplex virus (HSV-GFP), and adenovirus-GFP in epithelial (HEK293T/HeLa) and immune (RAW264.7) cells. These antiviral activities of GRA-7 were attributed to the induction of type I interferon (IFN) signaling, resulting in the secretion of IFNs and pro-inflammatory cytokines. Additionally, in BALB/c mice, intranasal administration of GRA-7 prevented lethal infection by influenza A virus (H1N1) and exhibited prophylactic effects against respiratory syncytial virus (RSV-GFP). Collectively, these results suggested that GRA-7 exhibits immunostimulatory and broad spectrum antiviral activities via type I IFN signaling. Thus, GRA-7 can be potentially used as a vaccine adjuvant or as a candidate drug with prophylactic potential against viruses.
-
Citations
Citations to this article as recorded by
- Effect of SARS-CoV-2 and Toxoplasma gondii co-infection on IFN-γ and TNF-α expression and its impact on disease severity
Magda S.A. Abdeltawab, Mohamed Fateen, Shimaa Saad El-Din, Riem M. Elmessiery, Osama Mohammady Mohamed, Khaled Marzouk Sadek, Engy Medhat, Alshaimaa M.R. Hamed
Cytokine.2024; 177: 156545. CrossRef - Impact of latent toxoplasmosis on pneumonic and non-pneumonic COVID-19 patients with estimation of relevant oxidative stress biomarkers
Doaa A. Hamdy, Ragaey A. Eid, Heba Abdel-Tawab, Mohamed A. El-Badry, Abdelrahman M. Abdallah, Wegdan M. Abd El Wahab
Folia Parasitologica.2024;[Epub] CrossRef - IFNs in host defence and parasite immune evasion during Toxoplasma gondii infections
Carsten G. K. Lüder
Frontiers in Immunology.2024;[Epub] CrossRef - Current vaccine candidate of toxoplasmosis
Eden WOLDEGERIMA, Fasika GETACHEW, Meseret MISGANAW, Yohannes MESFIN, Debaka BELETE, Tekeba SISAY, Nega BERHANE
Journal of Life Science and Biomedicine.2024; : 54. CrossRef - Prevalence of Toxoplasma gondii infection in COVID-19 patients: A systematic review and meta-analysis
Mahdi Fakhar, Khadijeh Najafi Ghobadi, Nastaran Barati, Salman Zafari, Seyed Ali Hosseini, Eissa Soleymani, Seyedmousa Motavallihaghi
Microbial Pathogenesis.2024; 197: 107064. CrossRef - Clinical and Immunological Impacts of Latent Toxoplasmosis on COVID-19 Patients
Samar Habib, Eman Hamza, Randa El-Gamal, Nessma A Nosser, Wafaa A Aboukamar, Sherehan Abdelsalam, Ali Sobh, Mohamed Elegezy, Mohamed Elbayoumy, Waleed Eldars, Khaled Elmasry, Marwa H Elnagdy
Cureus.2023;[Epub] CrossRef - Association between breakthrough infection with COVID-19 and Toxoplasma gondii: a cross-sectional study
Marwa A. Gouda, Hind S. AboShabaan, Ahmed S. Abdelgawad, Aliaa Sabry Abdel Wahed, Khaled A. Abd El-Razik, Yara Elsaadawy, Ayman. A. Abdel-Wahab, Yousry Hawash
Scientific Reports.2023;[Epub] CrossRef - Toxoplasmosis and symptoms severity in patients with COVID-19 in referral centers in Northern Iran
Ali Geraili, Alireza Badirzadeh, Maryam Sadeghi, Seyed Mahmoud Mousavi, Parisa Mousavi, Zabihollah Shahmoradi, Sayed-Mohsen Hosseini, Seyed Hossein Hejazi, Raheleh Rafiei-Sefiddashti
Journal of Parasitic Diseases.2023; 47(1): 185. CrossRef - Synergistic effect of GRA7 and profilin proteins in vaccination against chronic Toxoplasma gondii infection
Nadia Arcon, Mariano S. Picchio, Ignacio M. Fenoy, Rosalía E. Moretta, Ariadna S. Soto, Matías D. Perrone Sibilia, Vanesa R. Sánchez, Cecilia A. Prato, María Virginia Tribulatti, Alejandra Goldman, Valentina Martin
Vaccine.2021; 39(6): 933. CrossRef - GRA8 DNA vaccine formulations protect against chronic toxoplasmosis
Muhammet Karakavuk, Hüseyin Can, Aytül Gül, Aysu Değirmenci Döşkaya, Sedef Erkunt Alak, Cemal Ün, Adnan Yüksel Gürüz, Mert Döşkaya
Microbial Pathogenesis.2021; 158: 105016. CrossRef - Role of interferon gamma in SARS-CoV-2-positive patients with parasitic infections
Enas Fakhry Abdel-Hamed, Mohamed N. Ibrahim, Nahed E. Mostafa, Howayda S. F. Moawad, Nahla E. Elgammal, Ehab M. Darwiesh, Dina S. El-rafey, Nissreen E. ElBadawy, Emad Ali Al-Khoufi, Salwa I. Hindawi
Gut Pathogens.2021;[Epub] CrossRef - The role of polyspecific T-cell exhaustion in severe outcomes for COVID-19 patients having latent pathogen infections such as Toxoplasma gondii
Kevin Roe
Microbial Pathogenesis.2021; 161: 105299. CrossRef - Preparation of colloidal gold immunochromatographic test strips for the diagnosis ofToxoplasma gondii
Yuanxi Shen, Zhaozhe Wang, Jiajing Li, Rui Xu, Rongyi Ji, Jiaojiao Lin, Chuangang Zhu
Food and Agricultural Immunology.2020; 31(1): 630. CrossRef - A negative covariation between toxoplasmosis and CoVID-19 with alternative interpretations
Łukasz Jankowiak, Lajos Rozsa, Piotr Tryjanowski, Anders Pape Møller
Scientific Reports.2020;[Epub] CrossRef - Characterization of a novel secretory spherical body protein in Babesia orientalis and Babesia orientalis-infected erythrocytes
Jiaying Guo, Muxiao Li, Yali Sun, Long Yu, Pei He, Zheng Nie, Xueyan Zhan, Yangnan Zhao, Xiaoying Luo, Sen Wang, Siqi Aoyang, Qin Liu, Cuiqin Huang, Lan He, Junlong Zhao
Parasites & Vectors.2018;[Epub] CrossRef
- Effect of SARS-CoV-2 and Toxoplasma gondii co-infection on IFN-γ and TNF-α expression and its impact on disease severity
First
Prev
TOP
