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Research Support, Non-U.S. Gov't
- Preliminary Study about Sublingual Administration of Bacteria-expressed Pandemic H1N1 Influenza Vaccine in Miniature Pigs
- Hyekwon Kim , Jeong-Ki Kim , Hohyun Song , Jungah Choi , Byoungshik Shim , Bokyu Kang , Hyoungjoon Moon , Minjoo Yeom , Sang-Hyun Kim , Daesub Song , Manki Song
- J. Microbiol. 2014;52(9):794-800. Published online July 30, 2014
- DOI: https://doi.org/10.1007/s12275-014-4289-4
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Abstract
- Sublingual (SL) administration of influenza vaccine would be non-invasive and effective way to give human populations protective immunity against the virus, especially when pandemic influenza outbreaks. In this study, the efficacy of pandemic influenza virus-based subunit vaccines was tested after sublingual (SL) adjuvant administration in pigs. Eight specific pathogen-free Yucatan pigs were divided into 4 groups: nonvaccinated but challenged (A) and vaccinated and challenged (B, C, and D). The vaccinated groups were subdivided by vaccine type and inoculation route: SL subunit vaccine (hemagglutinin antigen 1 [HA1] + wild-type cholera toxin [wtCT], B); IM subunit vaccine (HA1 + aluminum hydroxide, C); and IM inactivated vaccine (+ aluminum hydroxide, D). The vaccines were administered twice at a 2-week interval. All pigs were challenged with pandemic influenza virus (A/swine/ GCVP-KS01/2009 [H1N1]) and monitored for clinical signs, serology, viral shedding, and histopathology. After vaccination, hemagglutination inhibition titre was higher in group D (320) than in the other vaccinated groups (40–80) at the time of challenge. The mobility and feed intake were reduced in group C. Both viral shedding and histopathological lesions were reduced in groups B and D. Although this study has limitation due to the limited number of pigs (2 pigs per a group), the preliminary data in this study provided the protective potential of SL administration of bacteria-expressed pandemic H1N1 influenza vaccine in pigs. There should be additional animal studies about effective adjuvant system and vaccine types for the use of SL influenza vaccination.
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Citations
Citations to this article as recorded by
- Oral mucosa immunity: ultimate strategy to stop spreading of pandemic viruses
Hyesun Jang, Michele Matsuoka, Marcelo Freire
Frontiers in Immunology.2023;[Epub] CrossRef - Pathological Evaluation of Porcine Circovirus 2d (PCV2d) Strain and Comparative Evaluation of PCV2d and PCV2b Inactivated Vaccines against PCV2d Infection in a Specific Pathogen-Free (SPF) Yucatan Miniature Pig Model
Yun-Hee Noh, Seung-Chai Kim, Chang-Gi Jeong, Seung-Chul Lee, Dong-Uk Lee, In-Joong Yoon, Won-Il Kim
Vaccines.2022; 10(9): 1469. CrossRef - La vacuna sublingual de la gripe
J. Reina
Vacunas.2019; 20(1): 37. CrossRef - The sublingual influenza vaccine
J. Reina
Vacunas (English Edition).2019; 20(1): 37. CrossRef - Experimental miniature piglet model for the infection of human norovirus GII
Dong Joo Seo, Day Jung, Soontag Jung, Seung‐Kwon Ha, Sang‐Do Ha, In‐Soo Choi, Jinjong Myoung, Changsun Choi
Journal of Medical Virology.2018; 90(4): 655. CrossRef
- Oral mucosa immunity: ultimate strategy to stop spreading of pandemic viruses
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