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Research Support, Non-U.S. Gov't
- Prevalence of avian influenza virus in wild birds before and after the HPAI H5N8 outbreak in 2014 in South Korea
- Jeong-Hwa Shin , Chanjin Woo , Seung-Jun Wang , Jipseol Jeong , In-Jung An , Jong-Kyung Hwang , Seong-Deok Jo , Seung Do Yu , Kyunghee Choi , Hyen-Mi Chung , Jae-Hwa Suh , Seol-Hee Kim
- J. Microbiol. 2015;53(7):475-480. Published online June 27, 2015
- DOI: https://doi.org/10.1007/s12275-015-5224-z
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- 14 Crossref
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Abstract
- Since 2003, highly pathogenic avian influenza (HPAI) virus outbreaks have occurred five times in Korea, with four HPAI H5N1 outbreaks and one HPAI H5N8 outbreak. Migratory birds have been suggested to be the first source of HPAI in Korea. Here, we surveyed migratory wild birds for the presence of AI and compared regional AI prevalence in wild birds from September 2012 to April 2014 for birds having migratory pathways in South Korea. Finally, we investigated the prevalence of AI in migratory birds before and after HPAI H5N8 outbreaks. Overall, we captured 1617 migratory wild birds, while 18,817 feces samples and 74 dead birds were collected from major wild bird habitats. A total of 21 HPAI viruses were isolated from dead birds, and 86 low pathogenic AI (LPAI) viruses were isolated from captured birds and from feces samples. Spatiotemporal distribution analysis revealed that AI viruses were spread southward until December, but tended to shift north after January, consistent with the movement of migratory birds in South Korea. Furthermore, we found that LPAI virus prevalences within wild birds were notably higher in 2013?014 than the previous prevalence during the northward migration season. The data from our study demonstrate the importance of the surveillance of AI in wild birds. Future studies including in-depth genetic analysis in combination with evaluation of the movement and ecology of migratory birds might help us to bridge the gaps in our knowledge and better explain, predict, and ultimately prevent future HPAI outbreaks.
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Citations
Citations to this article as recorded by
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Microbial Pathogenesis.2023; 176: 106001. CrossRef - Avian influenza virus surveillance in wild bird in South Korea from 2019 to 2022
Eun-Jee Na, Su-Beom Chae, Jun-Soo Park, Yoon-Ji Kim, Young-Sik Kim, Jae-Ku Oem
Korean Journal of Veterinary Service.2022; 45(4): 285. CrossRef - A literature review of the use of environmental sampling in the surveillance of avian influenza viruses
Grace Hood, Xavier Roche, Aurélie Brioudes, Sophie von Dobschuetz, Folorunso Oludayo Fasina, Wantanee Kalpravidh, Yilma Makonnen, Juan Lubroth, Leslie Sims
Transboundary and Emerging Diseases.2021; 68(1): 110. CrossRef - Fine-scale tracking of wild waterfowl and their impact on highly pathogenic avian influenza outbreaks in the Republic of Korea, 2014–2015
Kyuyoung Lee, Daesung Yu, Beatriz Martínez-López, Hachung Yoon, Sung-Il Kang, Seong-Keun Hong, Ilseob Lee, Yongmyung Kang, Wooseg Jeong, Eunesub Lee
Scientific Reports.2020;[Epub] CrossRef - TARGETED RESEQUENCING OF WETLAND SEDIMENT AS A TOOL FOR AVIAN INFLUENZA VIRUS SURVEILLANCE
Chelsea G. Himsworth, Jun Duan, Natalie Prystajecky, Michelle Coombe, Waren Baticados, Agatha N. Jassem, Patrick Tang, Eric Sanders, William Hsiao
Journal of Wildlife Diseases.2020; 56(2): 397. CrossRef - The Emergence and Decennary Distribution of Clade 2.3.4.4 HPAI H5Nx
Khristine Joy C. Antigua, Won-Suk Choi, Yun Hee Baek, Min-Suk Song
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Ivette A. Nuñez, Ted M. Ross
Therapeutic Advances in Vaccines and Immunotherapy.2019;[Epub] CrossRef - Risk factors associated with highly pathogenic avian influenza subtype H5N8 outbreaks on broiler duck farms in South Korea
W.-H. Kim, J.-U. An, J. Kim, O.-K. Moon, S. H. Bae, J. B. Bender, S. Cho
Transboundary and Emerging Diseases.2018; 65(5): 1329. CrossRef - Multidimensional analysis model for highly pathogenic avian influenza using data cube and data mining techniques
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Filip Claes, Subhash P Morzaria, Ruben O Donis
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- Identification of Pre-Emptive Biosecurity Zone Areas for Highly Pathogenic Avian Influenza Based on Machine Learning-Driven Risk Analysis
- Evaluation of the Efficacy of a Pre-pandemic H5N1 Vaccine (MG1109) in Mouse and Ferret Models
- Min-Suk Song , Ho-Jin Moon , Hyeok-il Kwon , Philippe Noriel Q. Pascua , Jun Han Lee , Yun Hee Baek , Kyu-Jin Woo , Juhee Choi , Sangho Lee , Hyunseung Yoo , In gyeong Oh , Yeup Yoon , Jong-Bok Rho , Moon-Hee Sung , Seung-Pyo Hong , Chul-Joong Kim , Young Ki Choi
- J. Microbiol. 2012;50(3):487-488.
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Abstract
- The threat of a highly pathogenic avian influenza (HPAI) H5N1 virus causing the next pandemic remains a major concern. In this study, we evaluated the immunogenicity and efficacy of an inactivated whole-virus H5N1 pre-pandemic vaccine (MG1109) formulated by Green Cross Co., Ltd containing the hemagglutinin (HA) and neuraminidase (NA) genes of the clade 1 A/Vietnam/1194/04 virus in the backbone of A/Puerto Rico/8/34 (RgVietNam/04xPR8/34). Administration of the MG1109 vaccine (2-doses) in mice and ferrets elicited high HI and SN titers in a dose-dependent manner against the homologous (RgVietNam/04xPR8/34) and various heterologous H5N1 strains, (RgKor/W149/06xPR8/34, RgCambodia/04xPR8/34, RgGuangxi/05xPR8/34), including a heterosubtypic H5N2 (A/Aquatic bird/orea/W81/05) virus. However, efficient cross-reactivity was not observed against heterosubtypic H9N2 (A/Ck/Korea/H0802/08) and H1N1 (PR/8/34) viruses. Mice immunized with 1.9 μg HA/dose of MG1109 were completely protected from lethal challenge with heterologous wild-type HPAI H5N1 A/EM/Korea/W149/06 (clade 2.2) and mouse-adapted H5N2 viruses. Furthermore, ferrets administered at least 3.8 μg HA/dose efficiently suppressed virus growth in the upper respiratory tract and lungs. Vaccinated mice and ferrets also demonstrated attenuation of clinical disease signs and limited virus spread to other organs. Thus, this vaccine provided immunogenic responses in mouse and ferret models even against challenge with heterologous HPAI H5N1 and H5N2 viruses. Since the specific strain of HPAI H5N1 virus that would potentially cause the next outbreak is unknown, pre-pandemic vaccine preparation that could provide crossprotection against various H5 strains could be a useful approach in the selection of promising candidate vaccines in the future.
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