Journal of Microbiology

Journal Articles

Delineating the Acquired Genetic Diversity and Multidrug Resistance in Alcaligenes from Poultry Farms and Nearby Soil: Abhilash Bhattacharjee, Anil Kumar Singh; J. Microbiol. 2024;62(7):511-523. Published online June 21, 2024; DOI: https://doi.org/10.1007/s12275-024-00129-w

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Alcaligenes faecalis is one of the most important and clinically significant environmental pathogens, increasing in importance due to its isolation from soil and nosocomial environments. The Gram-negative soil bacterium is associated with skin endocarditis, bacteremia, dysentery, meningitis, endophthalmitis, urinary tract infections, and pneumonia in patients. With emerging antibiotic resistance in A. faecalis, it has become crucial to understand the origin of such resistance genes within this clinically significant environmental and gut bacterium. In this research, we studied the impact of antibiotic overuse in poultry and its effect on developing resistance in A. faecalis. We sampled soil and faecal materials from five poultry farms, performed whole genome sequencing & analysis and identified four strains of A. faecalis. Furthermore, we characterized the genes in the genomic islands of A. faecalis isolates. We found four multidrug-resistant A. faecalis strains that showed resistance against vancomycin (MIC >1000 μg/ml), ceftazidime (50 μg/ml), colistin (50 μg/ml) and ciprofloxacin (50 μg/ml). From whole genome comparative analysis, we found more than 180 resistance genes compared to the reference sequence. Parts of our assembled contigs were found to be similar to different bacteria which included pbp1A and pbp2 imparting resistance to amoxicillin originally a part of Helicobacter and Bordetella pertussis. We also found the Mycobacterial insertion element IS6110 in the genomic islands of all four genomes. This prominent insertion element can be transferred and induce resistance to other bacterial genomes. The results thus are crucial in understanding the transfer of resistance genes in the environment and can help in developing regimes for antibiotic use in the food and poultry industry.

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First Case of Respiratory Infection in Rabbits Caused by Alcaligenes faecalis in Romania
Vlad Iorgoni, Ionica Iancu, Ionela Popa, Alexandru Gligor, Gabriel Orghici, Bogdan Sicoe, Corina Badea, Cristian Dreghiciu, Călin Pop, Timea Bochiș, Janos Degi, Luminita Costinar, Corina Pascu, Viorel Herman
Veterinary Sciences.2025; 12(1): 33. CrossRef

The synergy effect of arbuscular mycorrhizal fungi symbiosis and exogenous calcium on bacterial community composition and growth performance of peanut (Arachis hypogaea L.) in saline alkali soil: Dunwei Ci , Zhaohui Tang , Hong Ding , Li Cui , Guanchu Zhang , Shangxia Li , Liangxiang Dai , Feifei Qin , Zhimeng Zhang , Jishun Yang , Yang Xu; J. Microbiol. 2021;59(1):51-63. Published online November 17, 2020; DOI: https://doi.org/10.1007/s12275-021-0317-3

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Abstract PDF

Peanut (Arachis hypogaea. L) is an important oil seed crop. Both arbuscular mycorrhizal fungi (AMF) symbiosis and calcium (Ca2+) application can ameliorate the impact of saline soil on peanut production, and the rhizosphere bacterial communities are also closely correlated with peanut salt tolerance; however, whether AMF and Ca2+ can withstand high-salinity through or partially through modulating rhizosphere bacterial communities is unclear. Here, we used the rhizosphere bacterial DNA from saline alkali soil treated with AMF and Ca2+ alone or together to perform high-throughput sequencing of 16S rRNA genes. Taxonomic analysis revealed that AMF and Ca2+ treatment increased the abundance of Proteobacteria and Firmicutes at the phylum level. The nitrogenfixing bacterium Sphingomonas was the dominant genus in these soils at the genus level, and the soil invertase and urease activities were also increased after AMF and Ca2+ treatment, implying that AMF and Ca2+ effectively improved the living environment of plants under salt stress. Moreover, AMF combined with Ca2+ was better than AMF or Ca2+ alone at altering the bacterial structure and improving peanut growth in saline alkali soil. Together, AMF and Ca2+ applications are conducive to peanut salt adaption by regulating the bacterial community in saline alkali soil.

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Diversified Soil Types Differentially Regulated the Peanut (Arachis hydropoaea L.) Growth and Rhizosphere Bacterial Community Structure
Wenfei Lan, Hong Ding, Zhimeng Zhang, Fan Li, Hao Feng, Qing Guo, Feifei Qin, Guanchu Zhang, Manlin Xu, Yang Xu
Plants.2025; 14(8): 1169. CrossRef
Stratified Fertilization Increases Peanut Yield and Quality by Enhancing Photosynthesis and Modulating Antioxidative, Carbon and Nitrogen Metabolic Enzymes
Tong Si, Jinhao Lu, Zhaojun Liang, Jie Kong, Xiaona Yu, Xiaojun Zhang, Xiaoxia Zou
Journal of Soil Science and Plant Nutrition.2025; 25(2): 4925. CrossRef
Microbial inoculants – fostering sustainability in groundnut production
Kaviya Sree Krishnan, Anandham Rangasamy, Yuvasri Errakutty Arunan, Balachandar Dananjeyan, Thiyageshwari Subramanium, Vincent Saminathan
Science Progress.2025;[Epub] CrossRef
Location-optimized remediation measures for soil multifunctionality and carbon sequestration of saline-alkali land in China
Zhaoqiang Han, Yi Leng, Zhe Xu, Longping Tu, Chao Wang, Shuqing Li, Shuang Wu, Yawen Huang, Shuwei Liu, Jinyang Wang, Philippe Ciais, Ruoya Ma, Jianwen Zou
Journal of Cleaner Production.2025; 519: 146017. CrossRef
Morphological and molecular identification of indigenous arbuscular mycorrhizal fungi in the rhizosphere of chickpea (Cicer arietinum) and their role in nutrient uptake
Kamran Akbar, Tabassum Yaseen, Banzeer Ahsan Abbasi, Javed Iqbal, Badr Alharthi, Sajid Fiaz, Salma Noureen, Shumaila Ijaz, Ejaz Aziz, Rashid Iqbal, Muhammad Zaheer
Functional Plant Biology.2025;[Epub] CrossRef
Arbuscular mycorrhizal fungi drive bacterial community assembly in halophyte Suaeda salsa
Fengwei Diao, Bingbing Jia, Junqing Luo, Shengli Ding, Tai Liu, Wei Guo
Microbiological Research.2024; 282: 127657. CrossRef
Functional Characterization of Core and Unique Calcite-Dissolving Bacteria Communities from Peanut Fields
Alan Peper, Carter J. Newton, Sheena Lim, Wendy Zheng, Timothy Brenneman, Li Yang
Phytopathology®.2024; 114(5): 1011. CrossRef
Bacterial community composition of Hungarian salt-affected soils under different land uses
Ravi Kumar Gangwar, András Táncsics, Marianna Makádi, Milán Farkas, Mátyás Cserháti, Erika Michéli, Márta Fuchs, Tamás Szegi
Biologia Futura.2024; 75(3): 339. CrossRef
Peanut production in saline-alkali land of Yellow River Delta: influence of spatiotemporal changes of meteorological conditions and soil properties
Feifei Qin, Zhihong Xin, Jianguo Wang, Jialei Zhang, Jishun Yang, Feng Guo, Zhaohui Tang, Dunwei Ci
BMC Plant Biology.2024;[Epub] CrossRef
Multi-year crop rotation and quicklime application promote stable peanut yield and high nutrient-use efficiency by regulating soil nutrient availability and bacterial/fungal community
Liyu Yang, Caibin Wang, Xinhua He, Haiyan Liang, Qi Wu, Xuewu Sun, Miao Liu, Pu Shen
Frontiers in Microbiology.2024;[Epub] CrossRef
Arbuscular Mycorrhizal Fungi Restored the Saline–Alkali Soil and Promoted the Growth of Peanut Roots
Dunwei Ci, Feifei Qin, Zhaohui Tang, Guanchu Zhang, Jialei Zhang, Tong Si, Jishun Yang, Yang Xu, Tianyi Yu, Manlin Xu, Kang He
Plants.2023; 12(19): 3426. CrossRef
Green manure increases peanut production by shaping the rhizosphere bacterial community and regulating soil metabolites under continuous peanut production systems
Yang Xu, Hong Ding, Guanchu Zhang, Zelun Li, Qing Guo, Hao Feng, Feifei Qin, Liangxiang Dai, Zhimeng Zhang
BMC Plant Biology.2023;[Epub] CrossRef
The multifaceted roles of Arbuscular Mycorrhizal Fungi in peanut responses to salt, drought, and cold stress
Yuexu Liu, Jinhao Lu, Li Cui, Zhaohui Tang, Dunwei Ci, Xiaoxia Zou, Xiaojun Zhang, Xiaona Yu, Yuefu Wang, Tong Si
BMC Plant Biology.2023;[Epub] CrossRef
Advances and future research in ecological stoichiometry under saline-alkali stress
Keyi Zhang, Lei Chang, Guanghui Li, Yuefen Li
Environmental Science and Pollution Research.2023; 30(3): 5475. CrossRef
Arbuscular mycorrhizal fungi increased peanut (Arachis hypogaea L.) yield by changing the rhizosphere microbial community structure in saline-alkali soil
Jia Kang, Wenlong Yang, Shangwu Liu, Ning Xuan, Yahui Shao, Yun Geng, Muhammad Afzal, Yingxin Zhang, Shousong Yue, Rubina Mushtaq, Gao Chen
Frontiers in Microbiology.2023;[Epub] CrossRef
Distribution of microbial communities in seasonally frozen soil layers on the Tibetan Plateau and the driving environmental factors
Xiaojie Wang, Zhiqiang Yu, Guofeng Shen, Hefa Cheng, Shu Tao
Environmental Science and Pollution Research.2023; 30(1): 1919. CrossRef
Effects of phosphogypsum on enzyme activity and microbial community in acid soil
Changan Li, Yonggang Dong, Yun Yi, Juan Tian, Chao Xuan, Yan Wang, Yuanbo Wen, Jianxin Cao
Scientific Reports.2023;[Epub] CrossRef
Microbial keystone taxa drive crop productivity through shifting aboveground-belowground mineral element flows
Jia Lin Wang, Kai Lou Liu, Xue Qiang Zhao, Gui-Feng Gao, Yong Hong Wu, Ren Fang Shen
Science of The Total Environment.2022; 811: 152342. CrossRef
Peanut and cotton intercropping increases productivity and economic returns through regulating plant nutrient accumulation and soil microbial communities
Wei Xie, Kai Zhang, Xiaoying Wang, Xiaoxia Zou, Xiaojun Zhang, Xiaona Yu, Yuefu Wang, Tong Si
BMC Plant Biology.2022;[Epub] CrossRef
Illumina MiSeq Sequencing Reveals Correlations among Fruit Ingredients, Environmental Factors, and AMF Communities in Three Lycium Barbarum Producing Regions of China
Kaili Chen, Gang Huang, Yuekun Li, Xinrui Zhang, Yonghui Lei, Yang Li, Jie Xiong, Yanfei Sun, Kristen M. DeAngelis
Microbiology Spectrum.2022;[Epub] CrossRef
Genome-Wide Identification of Auxin Response Factors in Peanut (Arachis hypogaea L.) and Functional Analysis in Root Morphology
Lu Luo, Qian Wan, Zipeng Yu, Kun Zhang, Xiurong Zhang, Suqing Zhu, Yongshan Wan, Zhaojun Ding, Fengzhen Liu
International Journal of Molecular Sciences.2022; 23(10): 5309. CrossRef
Impact of an arbuscular mycorrhizal fungal inoculum and exogenous methyl jasmonate on the performance of tall fescue under saline-alkali condition
Hui Liu, Huimin Tang, Xiaozhen Ni, Yajie Zhang, Yingchao Wang
Frontiers in Microbiology.2022;[Epub] CrossRef
The resistance of peanut to soil-borne pathogens improved by rhizosphere probiotics under calcium treatment
Wei Zhang, Bo-wen Zhang, Jie-fu Deng, Lin Li, Tu-yong Yi, Yan-yun Hong
BMC Microbiology.2021;[Epub] CrossRef
Arbuscular mycorrhizal fungi alleviate salinity stress in peanut: Evidence from pot‐grown and field experiments
Wenjie Qin, Hengyu Yan, Bingyin Zou, Runze Guo, Dunwei Ci, Zhaohui Tang, Xiaoxia Zou, Xiaojun Zhang, Xiaona Yu, Yuefu Wang, Tong Si
Food and Energy Security.2021;[Epub] CrossRef

Research Support, Non-U.S. Gov'ts

Impact of cry1AC-Carrying Brassica rapa subsp. pekinensis on Leaf Bacterial Community: Young Tae Kim , Kang Seon Lee , Moon Jung Kim , Seung Bum Kim; J. Microbiol. 2009;47(1):33-39. Published online February 20, 2009; DOI: https://doi.org/10.1007/s12275-008-0254-4

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Abstract PDF: The effects of Chinese cabbage (Brassica rapa subsp. pekinensis) carrying cry1AC derived from Bacillus thuringiensis (Bt) on leaf bacterial community were examined by analyzing the horizontal transfer of transgene fragments from plants to bacteria. The effect of plant pathogenic bacteria on the gene transfer was also examined using Pseudomonas syringae pathovar. maculicola. The frequency of hygromycin-resistant bacteria did not alter in Bt leaves, though slight increase was observed in Pseudomonas-infected Bt leaves with no statistical significance. The analysis of bacterial community profiles using the denaturing gradient gel electrophoresis (DGGE) fingerprinting indicated that there were slight differences between Bt and control Chinese cabbage, and also that infected tissues were dominated by P. syringae pv. maculicola. However, the cultured bacterial pools were not found to contain any transgene fragments. Thus, no direct evidence of immediate gene transfer from plant to bacteria or acquisition of hygromycin resistance could be observed. Still, long-term monitoring on the possibility of gene transfer is necessary to correctly assess the environmental effects of the Bt crop on bacteria.

pVC, a Small Cryptic Plasmid from the Environmental Isolate of Vibrio cholerae MP-1: Ruifu Zhang , Yanling Wang , Pak Chow Leung , Ji-Dong Gu; J. Microbiol. 2007;45(3):193-198.; DOI: https://doi.org/2543 [pii]

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Abstract PDF: A marine bacterium was isolated from Mai Po Nature Reserve of Hong Kong and identified as Vibrio cholerae MP-1. It contains a small plasmid designated as pVC of 3.8 kb. Four open reading frames (ORFs) are identified on the plasmid, but none of them shows homology to any known protein. Database search indicated that a 440 bp fragment is 96% identical to a fragment found in a small plasmid of another V. cholerae. Further experiments demonstrated that a 2.3 kb EcoRI fragment containing the complete ORF1, partial ORF4 and their intergenic region could self-replicate. Additional analyses revealed that sequence upstream of ORF1 showed the features characteristic of theta type replicons. Protein encoded by ORF1 has two characteristic motifs existed in most replication initiator proteins (Rep): the leucine zipper (LZ) motif located at the N-terminal region and the alpha helix-turn-alpha helix motif (HTH) located at the C-terminal end. The results suggest that pVC replicates via the theta type mechanism and is likely a novel type of theta replicon.

Source Environment Feature Related Phylogenetic Distribution Pattern of Anoxygenic Photosynthetic Bacteria as Revealed by pufM Analysis: Yonghui Zeng , Nianzhi Jiao; J. Microbiol. 2007;45(3):205-212.; DOI: https://doi.org/2541 [pii]

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Abstract PDF: Anoxygenic photosynthesis, performed primarily by anoxygenic photosynthetic bacteria (APB), has been supposed to arise on Earth more than 3 billion years ago. The long established APB are distributed in almost every corner where light can reach. However, the relationship between APB phylogeny and source environments has been largely unexplored. Here we retrieved the pufM sequences and related source information of 89 pufM containing species from the public database. Phylogenetic analysis revealed that horizontal gene transfer (HGT) most likely occurred within 11 out of a total 21 pufM subgroups, not only among species within the same class but also among species of different phyla or subphyla. A clear source environment feature related phylogenetic distribution pattern was observed, with all species from oxic habitats and those from anoxic habitats clustering into independent subgroups, respectively. HGT among ancient APB and subsequent long term evolution and adaptation to separated niches may have contributed to the coupling of environment and pufM phylogeny.

Review

The Use of the Rare UUA Codon to Define "Expression Space" for Genes Involved in Secondary Metabolism, Development and Environmental Adaptation in Streptomyces: Keith F. Chater , Govind Chandra; J. Microbiol. 2008;46(1):1-11.; DOI: https://doi.org/10.1007/s12275-007-0233-1

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In Streptomyces coelicolor, bldA encodes the only tRNA for a rare leucine codon, UUA. This tRNA is unnecessary for growth, but is required for some aspects of secondary metabolism and morphological development, as revealed by the phenotypes of bldA mutants in diverse streptomycetes. This article is a comprehensive review of out understanding of this unusual situation. Based on information from four sequenced genomes it now appears that, typically, about 2~3% of genes in any one streptomycete contain a TTA codon, most having been acquired through species-specific horizontal gene transfer. Among the few widely conserved TTA-containing genes, mutations in just one, the pleiotropic regulatory gene adpA, give an obvious phenotype: such mutants are defective in aerial growth and sporulation, but vary in the extent of their impairment in secondary metabolism in different streptomycetes. The TTA codon in adpA is largely responsible for the morphological phenotype of a bldA mutant of S. coelicolor. AdpA-dependent targets include several genes involved in the integrated action of extracellular proteases that, at least in some species, are involved in the conversion of primary biomass into spores. The effects of bldA mutations on secondary metabolism are mostly attributable to the presence of TTA codons in pathway-specific genes, particularly in transcriptional activator genes. This is not confined to S. coelicolor-it is true for about half of all known antibiotic biosynthetic gene sets from streptomycetes. Combined microarray and proteomic analysis of liquid (and therefore non-sporulating) S. coelicolor bldA mutant cultures revealed effects of the mutation during rapid growth, during transition phase, and in stationary phase. Some of these effects may be secondary consequences of changes in the pattern of ppGpp accumulation. It is argued that the preferential accumulation of the bldA tRNA under conditions in which growth is significantly constrained has evolved to favour the expression of genes that confer adaptive benefits in intermittently encountered sub-optimal environments. The evolution of this system may have been a secondary consequence of the selective pressure exerted by bacteriophage attack. Some biotechnological implications of bldA phenomenology are considered.

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Eva G. Barreales, Tamara D. Payero, Ester Jambrina, Jesús F. Aparicio, Rebecca E. Parales
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Phenazine-1-carboxylic acid-producing Pseudomonas synxantha LBUM223 alters the transcriptome of Streptomyces scabies, the causal agent of potato common scab
Tanya Arseneault, Roxane Roquigny, Amy Novinscak, Claudia Goyer, Martin Filion
Physiological and Molecular Plant Pathology.2020; 110: 101480. CrossRef
The Identification and Conservation of Tunicaminyluracil-Related Biosynthetic Gene Clusters in Several Rathayibacter Species Collected From Australia, Africa, Eurasia, and North America
Matthew A. Tancos, Aaron J. Sechler, Edward W. Davis, Jeff H. Chang, Brenda K. Schroeder, Timothy D. Murray, Elizabeth E. Rogers
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Gene miaA for post‐transcriptional modification of tRNAXXA is important for morphological and metabolic differentiation in Streptomyces
Oksana Koshla, Oleksandr Yushchuk, Iryna Ostash, Yuriy Dacyuk, Maksym Myronovskyi, Gunilla Jäger, Roderich D. Süssmuth, Andriy Luzhetskyy, Anders Byström, Leif A. Kirsebom, Bohdan Ostash
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Jia-Yi Fan, Qian Huang, Quan-Quan Ji, En-Duo Wang
Nucleic Acids Research.2019; 47(12): 6369. CrossRef
Genome mining reveals the origin of a bald phenotype and a cryptic nucleocidin gene cluster in Streptomyces asterosporus DSM 41452
Songya Zhang, Dennis Klementz, Jing Zhu, Roman Makitrynskyy, A.R. Ola Pasternak, Stefan Günther, David L. Zechel, Andreas Bechthold
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Genomic Insights into Evolution of AdpA Family Master Regulators of Morphological Differentiation and Secondary Metabolism in Streptomyces
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Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis
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Genome-guided exploration of metabolic features of Streptomyces peucetius ATCC 27952: past, current, and prospect
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In conditions of over-expression, WblI, a WhiB-like transcriptional regulator, has a positive impact on the weak antibiotic production of Streptomyces lividans TK24
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Tracking the Subtle Mutations Driving Host Sensing by the Plant Pathogen Streptomyces scabies
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Genome Analysis of the Fruiting Body-Forming Myxobacterium Chondromyces crocatus Reveals High Potential for Natural Product Biosynthesis
Nestor Zaburannyi, Boyke Bunk, Josef Maier, Jörg Overmann, Rolf Müller, C. Vieille
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Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation
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Overexpression of a pathway specific negative regulator enhances production of daunorubicin in bldA deficient Streptomyces peucetius ATCC 27952
Anaya Raj Pokhrel, Amit Kumar Chaudhary, Hue Thi Nguyen, Dipesh Dhakal, Tuoi Thi Le, Anil Shrestha, Kwangkyoung Liou, Jae Kyung Sohng
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Chenchen Zhu, Qianjin Kang, Linquan Bai, Lin Cheng, Zixin Deng
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Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use
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Development of an Unnatural Amino Acid Incorporation System in the Actinobacterial Natural Product Producer Streptomyces venezuelae ATCC 15439
Jingxuan He, Briana Van Treeck, Han B. Nguyen, Charles E. Melançon
ACS Synthetic Biology.2016; 5(2): 125. CrossRef
The Rare Codon AGA Is Involved in Regulation of Pyoluteorin Biosynthesis in Pseudomonas protegens Pf-5
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Frontiers in Microbiology.2016;[Epub] CrossRef
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Keith F. Chater
F1000Research.2016; 5: 2795. CrossRef
Changing Biosynthetic Profiles by Expressing bldA in Streptomyces Strains
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Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway
Carolina Cano‐Prieto, Raúl García‐Salcedo, Marina Sánchez‐Hidalgo, Alfredo F. Braña, Hans‐Peter Fiedler, Carmen Méndez, José A. Salas, Carlos Olano
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Corey L. Compton, Michael S. Fernandopulle, Rohith T. Nagari, Jason K. Sello, W. W. Metcalf
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Identified members of the Streptomyces lividans AdpA regulon involved in differentiation and secondary metabolism
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BMC Microbiology.2014;[Epub] CrossRef
Thaxtomin A Production and Virulence Are Controlled by Several bld Gene Global Regulators in Streptomyces scabies
Dawn R. D. Bignell, Isolde M. Francis, Joanna K. Fyans, Rosemary Loria
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Govind Chandra, Keith F. Chater
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The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control
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Applied Microbiology and Biotechnology.2014; 98(11): 4919. CrossRef
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Cytology and Genetics.2014; 48(1): 55. CrossRef
Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei
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Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA
Barbara Gorgoni, Elizabeth Marshall, Matthew R. McFarland, M. Carmen Romano, Ian Stansfield
Biochemical Society Transactions.2014; 42(1): 160. CrossRef
Collismycin A biosynthesis in Streptomyces sp. CS40 is regulated by iron levels through two pathway-specific regulators
Natalia M. Vior, Carlos Olano, Ignacio García, Carmen Méndez, José A. Salas
Microbiology.2014; 160(3): 467. CrossRef
Genes Required for Aerial Growth, Cell Division, and Chromosome Segregation Are Targets of WhiA before Sporulation in Streptomyces venezuelae
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mBio.2013;[Epub] CrossRef
Pleiotropic regulatory genes bldA , adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin
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A Microbial Metagenome (Leucobactersp.) inCaenorhabditisWhole Genome Sequences
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Bioinformatics and Biology Insights.2013; 7: BBI.S11064. CrossRef
Molecular Regulation of Antibiotic Biosynthesis in Streptomyces
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The Journal of Antibiotics.2013; 66(7): 387. CrossRef
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5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus
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Antimicrobial Agents and Chemotherapy.2012; 56(9): 4845. CrossRef
Interspecies modulation of bacterial development through iron competition and siderophore piracy
Matthew F. Traxler, Mohammad R. Seyedsayamdost, Jon Clardy, Roberto Kolter
Molecular Microbiology.2012; 86(3): 628. CrossRef
FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis
Dušan Goranovič, Marko Blažič, Vasilka Magdevska, Jaka Horvat, Enej Kuščer, Tomaž Polak, Javier Santos-Aberturas, Miriam Martínez-Castro, Carlos Barreiro, Peter Mrak, Gregor Kopitar, Gregor Kosec, Štefan Fujs, Juan F Martín, Hrvoje Petković
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Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A
Adam C. Jones, Sabine Ottilie, Alessandra S. Eustáquio, Daniel J. Edwards, Lena Gerwick, Bradley S. Moore, William H. Gerwick
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Joseph R. McCormick, Klas Flärdh
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Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus
Cristina Gómez, Carlos Olano, Carmen Méndez, José A. Salas
Microbiology.2012; 158(10): 2504. CrossRef
Roles of fkbN in Positive Regulation and tcs7 in Negative Regulation of FK506 Biosynthesis in Streptomyces sp. Strain KCTC 11604BP
SangJoon Mo, Young Ji Yoo, Yeon Hee Ban, Sung-Kwon Lee, Eunji Kim, Joo-Won Suh, Yeo Joon Yoon
Applied and Environmental Microbiology.2012; 78(7): 2249. CrossRef
Expression of the chaplin and rodlin hydrophobic sheath proteins in Streptomyces venezuelae is controlled by σBldN and a cognate anti‐sigma factor, RsbN
Maureen J. Bibb, Ágota Domonkos, Govind Chandra, Mark J. Buttner
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tRNA accumulation and suppression of the bldA phenotype during development in Streptomyces coelicolor
B. M. Fredrik Pettersson, Leif A. Kirsebom
Molecular Microbiology.2011; 79(6): 1602. CrossRef
Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor
Ana Yepes, Sergio Rico, Antonio Rodríguez-García, Ramón I. Santamaría, Margarita Díaz, Ching-Hong Yang
PLoS ONE.2011; 6(5): e19980. CrossRef
The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
Gilles P. van Wezel, Kenneth J. McDowall
Natural Product Reports.2011; 28(7): 1311. CrossRef
Strict regulation of morphological differentiation and secondary metabolism by a positive feedback loop between two global regulators AdpA and BldA in Streptomyces griseus
Akiyoshi Higo, Sueharu Horinouchi, Yasuo Ohnishi
Molecular Microbiology.2011; 81(6): 1607. CrossRef
The Level of AdpA Directly Affects Expression of Developmental Genes in Streptomyces coelicolor
Marcin Wolański, Rafał Donczew, Agnieszka Kois-Ostrowska, Paweł Masiewicz, Dagmara Jakimowicz, Jolanta Zakrzewska-Czerwińska
Journal of Bacteriology.2011; 193(22): 6358. CrossRef
SanG, a transcriptional activator, controls nikkomycin biosynthesis through binding to the sanN–sanO intergenic region in Streptomyces ansochromogenes
Xihong He, Rui Li, Yuanyuan Pan, Gang Liu, Huarong Tan
Microbiology .2010; 156(3): 828. CrossRef
Differential proteomic analysis reveals novel links between primary metabolism and antibiotic production in Amycolatopsis balhimycina
Giuseppe Gallo, Giovanni Renzone, Rosa Alduina, Efthimia Stegmann, Tilmann Weber, Anna Eliasson Lantz, Jette Thykaer, Fabio Sangiorgi, Andrea Scaloni, Anna Maria Puglia
PROTEOMICS.2010; 10(7): 1336. CrossRef
Adaptation of the Highly Productive T7 Expression System to Streptomyces lividans
François-Xavier Lussier, François Denis, François Shareck
Applied and Environmental Microbiology.2010; 76(3): 967. CrossRef
Autoregulation of hpdR and its effect on CDA biosynthesis in Streptomyces coelicolor
Haihua Yang, Yang An, Linqi Wang, Shuli Zhang, Yue Zhang, Yuqing Tian, Gang Liu, Huarong Tan
Microbiology .2010; 156(9): 2641. CrossRef
Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in Streptomyces ambofaciens
Fatma Karray, Emmanuelle Darbon, Hoang Chuong Nguyen, Josette Gagnat, Jean-Luc Pernodet
Journal of Bacteriology.2010; 192(21): 5813. CrossRef
Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity
Bohdan Ostash, Suzanne Walker
Natural Product Reports.2010; 27(11): 1594. CrossRef
Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant
M. T. Lopez-Garcia, I. Santamarta, P. Liras
Microbiology.2010; 156(8): 2354. CrossRef
Quantitative Proteome Analysis of Streptomyces coelicolor Nonsporulating Liquid Cultures Demonstrates a Complex Differentiation Process Comparable to That Occurring in Sporulating Solid Cultures
Angel Manteca, Hye R. Jung, Veit Schwämmle, Ole N. Jensen, Jesus Sanchez
Journal of Proteome Research.2010; 9(9): 4801. CrossRef
Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties
Kien T. Nguyen, Xiaowei He, Dylan C. Alexander, Chen Li, Jian-Qiao Gu, Carmela Mascio, Andrew Van Praagh, Larry Mortin, Min Chu, Jared A. Silverman, Paul Brian, Richard H. Baltz
Antimicrobial Agents and Chemotherapy.2010; 54(4): 1404. CrossRef
Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth
Chris D. Den Hengst, Ngat T. Tran, Maureen J. Bibb, Govind Chandra, Brenda K. Leskiw, Mark J. Buttner
Molecular Microbiology.2010; 78(2): 361. CrossRef
The complex extracellular biology ofStreptomyces
Keith F. Chater, Sandor Biró, Kye Joon Lee, Tracy Palmer, Hildgund Schrempf
FEMS Microbiology Reviews.2010; 34(2): 171. CrossRef
Streptomyces scabies 87-22 Contains a Coronafacic Acid-Like Biosynthetic Cluster That Contributes to Plant–Microbe Interactions
Dawn R. D. Bignell, Ryan F. Seipke, José C. Huguet-Tapia, Alan H. Chambers, Ronald J. Parry, Rosemary Loria
Molecular Plant-Microbe Interactions®.2010; 23(2): 161. CrossRef
Characterization of γ-Butyrolactone Autoregulatory Signaling Gene Homologs in the Angucyclinone Polyketide WS5995B ProducerStreptomyces acidiscabies
Frank G. Healy, Kevin P. Eaton, Prajit Limsirichai, Joel F. Aldrich, Alaina K. Plowman, Russell R. King
Journal of Bacteriology.2009; 191(15): 4786. CrossRef
The pleiotropic regulator AdpA‐L directly controls the pathway‐specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes
Yuanyuan Pan, Gang Liu, Haihua Yang, Yuqing Tian, Huarong Tan
Molecular Microbiology.2009; 72(3): 710. CrossRef
The SmpB-tmRNA Tagging System Plays Important Roles in Streptomyces coelicolor Growth and Development
Chunzhong Yang, John R. Glover, Christophe Herman
PLoS ONE.2009; 4(2): e4459. CrossRef
Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives
Carlos Olano, Cristina Gómez, María Pérez, Martina Palomino, Antonio Pineda-Lucena, Rodrigo J. Carbajo, Alfredo F. Braña, Carmen Méndez, José A. Salas
Chemistry & Biology.2009; 16(10): 1031. CrossRef
Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production inStreptomyces coelicolor
Sean O'Rourke, Andreas Wietzorrek, Kay Fowler, Christophe Corre, Greg L. Challis, Keith F. Chater
Molecular Microbiology.2009; 71(3): 763. CrossRef
Evolutionary flux of potentially bldA-dependent Streptomyces genes containing the rare leucine codon TTA
Govind Chandra, Keith F. Chater
Antonie van Leeuwenhoek.2008; 94(1): 111. CrossRef
novE and novG act as positive regulators of novobiocin biosynthesis
Volker Dangel, Alessandra S. Eustáquio, Bertolt Gust, Lutz Heide
Archives of Microbiology.2008; 190(5): 509. CrossRef
SarA influences the sporulation and secondary metabolism inStreptomyces coelicolorM145
Xijun Ou, Bo Zhang, Lin Zhang, Kai Dong, Chun Liu, Guoping Zhao, Xiaoming Ding
Acta Biochimica et Biophysica Sinica.2008; 40(10): 877. CrossRef

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