Journal Article
- Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection
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Xiaomin Lin, Chun Lin, Xin Li, Fen Yao, Xiaoling Guo, Meimei Wang, Mi Zeng, Yumeng Yuan, Qingdong Xie, Xudong Huang, Xiaoyang Jiao
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J. Microbiol. 2024;62(12):1113-1124. Published online December 2, 2024
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DOI: https://doi.org/10.1007/s12275-024-00190-5
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Abstract
- To study the role of intestinal flora in the development of bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into the study and their intestinal flora was measured by 16S rRNA gene sequencing.
The bacterial diversity was significantly lower in the BSI group compared with that in the HCs (P < 0.001), and beta diversity was significantly differentiated between the two groups (PERMANOVA, P = 0.001). The four keystone species [Roseburia, Faecalibacterium, Prevotella, and Enterococcus (LDA > 4)] differed significantly between the two groups. Dysbiosis of fecal microbial ecology is a common condition present in patients with BSI. The proliferation of certain pathogens or reduction of SCFA-producing bacteria would cause susceptibility to BSI.
Research Support, Non-U.S. Gov't
- Lactobacillus rhamnosus CCFM1107 treatment ameliorates alcohol-induced liver injury in a mouse model of chronic alcohol feeding
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Fengwei Tian , Feifei Chi , Gang Wang , Xiaoming Liu , Qiuxiang Zhang , Yongquan Chen , Hao Zhang , Wei Chen
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J. Microbiol. 2015;53(12):856-863. Published online December 2, 2015
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DOI: https://doi.org/10.1007/s12275-015-5239-5
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Abstract
- Lactobacillus rhamnosus CCFM1107 was screened for high
antioxidative activity from 55 lactobacilli. The present study
attempted to explore the protective properties of L. rhamnosus
CCFM1107 in alcoholic liver injury. A mouse model
was induced by orally feeding alcohol when simultaneously
treated with L. rhamnosus CCFM1107, the drug Hu-Gan-
Pian (HGP), L. rhamnosus GG (LGG), and L. plantarum
CCFM1112 for 3 months. Biochemical analysis was performed
for both serum and liver homogenate. Detailed intestinal flora
and histological analyses were also carried out. Our results
indicated that the administration of L. rhamnosus CCFM1107
significantly inhibited the increase in the levels of serum aminotransferase
and endotoxin, as well as the levels of triglyceride
(TG) and cholesterol (CHO) in the serum and in the
liver. Glutathione (GSH), glutathione peroxidase (GSH-Px)
and superoxide dismutase (SOD) were elevated while the levels
of malondialdehyde (MDA) were decreased. The enteric dysbiosis
caused by alcohol was restored by increasing the numbers
of both lactobacilli and bifidobacteria and decreasing
the numbers of both enterococci and enterobacter. Histological
analysis confirmed the protective effect of L. rhamnosus
CCFM1107. Compared with the other lactobacilli and to
the drug Hu-Gan-Pian, there is a high chance that L. rhamnosus
CCFM1107 provides protective effects on alcoholic
liver injury by reducing oxidative stress and restoring the
intestinal flora.
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Citations
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