Reviews
- COVID-19 vaccine development based on recombinant viral and bacterial vector systems: combinatorial effect of adaptive and trained immunity
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Mi-Hyun Lee , Bum-Joon Kim
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J. Microbiol. 2022;60(3):321-334. Published online February 14, 2022
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DOI: https://doi.org/10.1007/s12275-022-1621-2
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Abstract
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Severe acute respiratory syndrome coronavirus 2 virus (SARSCoV-
2) infection, which causes coronavirus disease 2019
(COVID-19), has led to many cases and deaths worldwide.
Therefore, a number of vaccine candidates have been developed
to control the COVID-19 pandemic. Of these, to date,
21 vaccines have received emergency approval for human
use in at least one country. However, the recent global emergence
of SARS-CoV-2 variants has compromised the efficacy
of the currently available vaccines. To protect against these
variants, the use of vaccines that modulate T cell-mediated
immune responses or innate immune cell memory function,
termed trained immunity, is needed. The major advantage of
a vaccine that uses bacteria or viral systems for the delivery of
COVID-19 antigens is the ability to induce both T cell-mediated
and humoral immune responses. In addition, such
vaccine systems can also exert off-target effects via the vector
itself, mediated partly through trained immunity; compared
to other vaccine platforms, suggesting that this approach can
provide better protection against even vaccine escape variants.
This review presents the current status of the development of
COVID-19 vaccines based on recombinant viral and bacterial
delivery systems. We also discuss the current status of the
use of licensed live vaccines for other infections, including
BCG, oral polio and MMR vaccines, to prevent COVID-19
infections.
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Citations
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- REVIEW] Intestinal microbiota and the immune system in metabolic diseases
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Panida Sittipo , Stefani Lobionda , Yun Kyung Lee , Craig L. Maynard
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J. Microbiol. 2018;56(3):154-162. Published online February 28, 2018
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DOI: https://doi.org/10.1007/s12275-018-7548-y
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47
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0
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91
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Abstract
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The intestinal microbiota is comprised of millions of microorganisms
that reside in the gastrointestinal tract and consistently
interact with the host. Host factors such as diet and
disease status affect the composition of the microbiota, while
the microbiota itself produces metabolites that can further
manipulate host physiology. Dysbiosis of the intestinal microbiota
has been characterized in patients with certain metabolic
diseases, some of which involve damage to the host
intestinal epithelial barrier and alterations in the immune
system. In this review, we will discuss the consequences of dietdependent
bacterial dysbiosis in the gastrointestinal tract, and
how the associated interaction with epithelial and immune
cells impacts metabolic diseases.
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Research Support, Non-U.S. Gov'ts
- Host Species as a Strong Determinant of the Intestinal Microbiota of Fish Larvae
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Xuemei Li , Yuhe Yu , Weisong Feng , Qingyun Yan , Yingchun Gong
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J. Microbiol. 2012;50(1):29-37. Published online February 27, 2012
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DOI: https://doi.org/10.1007/s12275-012-1340-1
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Abstract
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We investigated the influence of host species on intestinal
microbiota by comparing the gut bacterial community structure
of four cohabitating freshwater fish larvae, silver carp,
grass carp, bighead carp, and blunt snout bream, using denaturing
gradient gel electrophoresis (DGGE) of the amplified
16S and 18S rRNA genes. Similarity clustering indicated
that the intestinal microbiota derived from these four fish
species could be divided into four groups based on 16S
rRNA gene similarity, whereas the eukaryotic 18S rRNA
genes showed no distinct groups. The water sample from the
shared environment contained microbiota of an independent
group as indicated by both 16S and 18S rRNA genes segments.
The bacterial community structures were visualized using
rank-abundance plots fitted with linear regression models.
Results
showed that the intestinal bacterial evenness was
significantly different between species (P<0.05) and between
species and the water sample (P<0.01). Thirty-five relatively
dominant bands in DGGE patterns were sequenced and
grouped into five major taxa: Proteobacteria (26), Actinobacteria
(5), Bacteroidetes (1), Firmicutes (2), and Cyanobacterial
(1). Six eukaryotes were detected by sequencing 18S rRNA
genes segments. The present study suggests that the intestines
of the four fish larvae, although reared in the same environment,
contained distinct bacterial populations, while intestinal
eukaryotic microorganisms were almost identical.
- Molecular Analysis of Colonized Bacteria in a Human Newborn Infant Gut
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Hee-Kyung Park , Sung-Sub Shim , Su-Yung Kim , Jae-Hong Park , Su-Eun Park , Hak-Jung Kim , Byeong-Chul Kang , Cheol-Min Kim
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J. Microbiol. 2005;43(4):345-353.
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DOI: https://doi.org/2255 [pii]
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Abstract
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The complex ecosystem of intestinal microflora is estimated to harbor approximately 400 different microbial species, mostly bacteria. However, studies on bacterial colonization have mostly been based on culturing methods, which only detect a small fraction of the whole microbiotic ecosystem of the gut. To clarify the initial acquisition and subsequent colonization of bacteria in an infant within the few days after birth, phylogenetic analysis was performed using 16S rDNA sequences from the DNA isolated from feces on the 1st, 3rd, and 6th day. 16S rDNA libraries were constructed with the amplicons of PCR conditions at 30 cycles and 50^oC annealing temperature. Nine independent libraries were produced by the application of three sets of primers (set A, set B, and set C) combined with three fecal samples for day 1, day 3, and day 6 of life. Approximately 220 clones (76.7%) of all 325 isolated clones were characterized as known species, while other 105 clones (32.3%) were characterized as unknown species. The library clone with set A universal primers amplifying 350 bp displayed increased diversity by days. Thus, set A primers were better suited for this type of molecular ecological analysis. On the first day of the life of the infant, Enterobacter, Lactococcus lactis, Leuconostoc citreum, and Streptococcus mitis were present. The largest taxonomic group was L. lactis. On the third day of the life of the infant, Enterobacter, Enterococcus faecalis, Escherichia coli, S. mitis, and Streptococcus salivarius were present. On the sixth day of the life of the infant, Citrobacter, Clostridium difficile, Enterobacter sp., Enterobacter cloacae, and E. coli were present. The largest taxonomic group was E. coli. These results showed that microbiotic diversity changes very rapidly in the few days after birth, and the acquisition of unculturable bacteria expanded rapidly after the third day.