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- Characterization and phylogenetic analysis of Varicella-zoster virus strains isolated from Korean patients
- Min Ho Kim , Jeong Seon Jeon , In Kyo Kim , Ji Seon Park , Hosun Park , Ok Sarah Shin , Chan Hee Lee
- J. Microbiol. 2017;55(8):665-672. Published online July 28, 2017
- DOI: https://doi.org/10.1007/s12275-017-7171-3
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Abstract
- Varicella-zoster virus (VZV) is a causative agent of chickenpox in primary infection and shingles after its reactivation from latency. Complete or almost-complete genomic DNA sequences for various VZV strains have been reported. Recently, clinical VZV strains were isolated from Korean patients whose genome was sequenced using high-throughput sequencing technology. In this study, we analyzed single nucleotide polymorphism (SNP) of VZV strains to genetically characterize Korean clinical isolates. Phylogenetic analyses revealed that three Korean strains, YC01, YC02, and YC03, were linked to clade 2. Comprehensive SNP analysis identified 86 sites specific for the 5 VZV clades. VZV strains isolated from Korea did not form a phylogenetic cluster. Rather, YC02 and YC03 clustered strongly with Chinese strain 84-7 within clade 2, more specifically cluster 2a. Signature sequences for the cluster 2a were identified and found to play an important role in the separation of cluster 2a strains from other clade 2 strains, as shown in substitution studies. Further genetic analysis with additional strains isolated from Japan, China, and other Asian countries would provide a novel insight into the significance of two distinct subclades within clade 2.
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Citations
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- Cross-reactive humoral immunity of clade 2 Oka and MAV/06 strain-based varicella vaccines against different clades of varicella–zoster virus
Ji-Young Hwang, Yunhwa Kim, Kyung-Min Lee, Ok Sarah Shin, Jeong-An Gim, Younchul Shin, Hosun Park
Human Vaccines & Immunotherapeutics.2023;[Epub] CrossRef - Assessment of attenuation of varicella‐zoster virus vaccines based on genomic comparison
Jae Yun Moon, Jina Seo, Jaewoo Lee, Daechan Park
Journal of Medical Virology.2023;[Epub] CrossRef - Immunological characteristics of MAV/06 strain of varicella-zoster virus vaccine in an animal model
Duckhyang Shin, Younchul Shin, Eunmi Kim, Hyojung Nam, Haiyan Nan, Jaewoo Lee
BMC Immunology.2022;[Epub] CrossRef - Human herpesvirus diversity is altered in HLA class I binding peptides
William H. Palmer, Marco Telford, Arcadi Navarro, Gabriel Santpere, Paul J. Norman
Proceedings of the National Academy of Sciences.2022;[Epub] CrossRef - Genetic Change of Varicella-Zoster Virus Propagated in Cell Culture in Non-Natural Conditions
Sang Hoon Yeon, Ji Seon Park, Se Hwan Kang, Chan Hee Lee
Journal of Bacteriology and Virology.2021; 51(4): 178. CrossRef
- Cross-reactive humoral immunity of clade 2 Oka and MAV/06 strain-based varicella vaccines against different clades of varicella–zoster virus
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