Journal of Microbiology

Journal Articles

In vitro disinfection efficacy and clinical protective effects of common disinfectants against acute hepatopancreatic necrosis disease (AHPND)-causing Vibrio isolates in Pacific white shrimp Penaeus vannamei: Peizhuo Zou , Qian Yang , Hailiang Wang , Guosi Xie , Zhi Cao , Xing Chen , Wen Gao , Jie Huang; J. Microbiol. 2020;58(8):675-686. Published online July 27, 2020; DOI: https://doi.org/10.1007/s12275-020-9537-1

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Acute hepatopancreatic necrosis disease (AHPND) is one of the most significant bacterial diseases in global shrimp culture, causing severe economic losses. In the present study, we carried out in vitro antimicrobial tests to investigate the disinfection efficacy of 14 common disinfectants toward different AHPND-causing Vibrio spp., including eight isolates of V. parahaemolyticus, four isolates of V. campbellii, and one isolate of V. owensii. Polyhexamethylene biguanidine hydrochloride (PHMB) was revealed to possess the strongest inhibitory activity. Through analyzing and evaluating the results of antimicrobial tests and acute toxicity test, we selected PHMB and hydrogen peroxide (H2O2) for further clinical protection test. Clinical manifestations indicated that both PHMB (2 mg/L and 4 mg/L) and H2O2 (12 mg/L) could effectively protect juvenile Penaeus vannamei from the infection of V. parahaemolyticus isolate Vp362 at 106 CFU/ml, and the survival rate was over 80%. When the bacterial concentration was reduced to 105 CFU/ml, 104 CFU/ml, and 103 CFU/ml, the survival rate after treated by 1 mg/L PHMB was 64.44%, 93.33%, and 100%, respectively. According to the results, PHMB and H2O2 showed a lower toxicity while a better protection activity, particularly against a lower concentration of the pathogens. Therefore, these two disinfectants are proved to be promising disinfectants that can be applied to prevent and control AHPND in shrimp culture. Moreover, the methods of this study also provided valuable information for the prevention of other important bacterial diseases and suggested a reliable means for screening potential drugs in aquaculture.

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Basigin binds bacteria and activates Dorsal signaling to promote antibacterial defense in Penaeus vannamei
Linwei Yang, Zi-ang Wang, Yushi Gan, Hongliang Zuo, Hengwei Deng, Shaoping Weng, Jianguo He, Xiaopeng Xu
Fish & Shellfish Immunology.2023; 142: 109123. CrossRef
Clinical protective effects of polyhexamethylene biguanide hydrochloride (PHMB) against Vibrio parahaemolyticus causing translucent post-larvae disease (VTPD) in Penaeus vannamei
Tianchang Jia, Tingting Xu, Jitao Xia, Shuang Liu, Wenqiang Li, Ruidong Xu, Jie Kong, Qingli Zhang
Journal of Invertebrate Pathology.2023; 201: 108002. CrossRef

Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus: Hüseyin Ta&# , Ay&# , Nermin Topalo&# , Vildan Alptüzün; J. Microbiol. 2018;56(11):828-837. Published online October 24, 2018; DOI: https://doi.org/10.1007/s12275-018-8244-7

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Abstract

Methicillin resistant Staphylococcus aureus (MRSA) with multiple drug resistance patterns is frequently isolated from skin and soft tissue infections that are involved in chronic wounds. Today, difficulties in the treatment of MRSA associated infections have led to the development of alternative approaches such as antimicrobial photodynamic therapy. This study aimed to investigate photoinactivation with cationic porphyrin derivative compounds against MRSA in in-vitro conditions. In the study, MRSA clinical isolates with different antibiotic resistance profiles were used. The newly synthesized cationic porphyrin derivatives (PM, PE, PPN, and PPL) were used as photosensitizer, and 655 nm diode laser was used as light source. Photoinactivation experiments were performed by optimizing energy doses and photosensitizer concentrations. In photoinactivation experiments with different energy densities and photosensitizer concentrations, more than 99% reduction was achieved in bacterial cell viability. No decrease in bacterial survival was observed in control groups. It was determined that there was an increase in photoinactivation efficiency by increasing the energy dose. At the energy dose of 150 J/cm2 a survival reduction of over 6.33 log10 was observed in each photosensitizer type. While 200 μM PM concentration was required for this photoinactivation, 12.50 μM was sufficient for PE, PPN, and PPL. In our study, antimicrobial photodynamic therapy performed with cationic porphyrin derivatives was found to have potent antimicrobial efficacy against multidrug resistant S. aureus which is frequently isolated from wound infections.

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An escape from ESKAPE pathogens: A comprehensive review on current and emerging therapeutics against antibiotic resistance
Anamika Singh, Mansi Tanwar, T.P. Singh, Sujata Sharma, Pradeep Sharma
International Journal of Biological Macromolecules.2024; 279: 135253. CrossRef
Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency
Jiajing Zhang, Xiaoqian Yuan, Hongsen Li, Liting Yu, Yulong Zhang, Keyi Pang, Chaoyue Sun, Zhongyang Liu, Jie Li, Liying Ma, Jinming Song, Lingxin Chen
RSC Advances.2024; 14(5): 3122. CrossRef
Photo-Inactivation of Staphylococcus aureus by Diaryl-Porphyrins
Viviana Teresa Orlandi, Eleonora Martegani, Nicola Trivellin, Fabrizio Bolognese, Enrico Caruso
Antibiotics.2023; 12(2): 228. CrossRef
Enhancement of the mechanical and antibacterial properties of Bis-GMA/TEGDMA dental composite incorporated with ZnO/CS and Si/PMMA core–shell nanostructures
Izel Ok, Ahmet Aykac
Chemical Papers.2023; 77(11): 6959. CrossRef
Antimicrobial photodynamic in vitro inactivation of Enterococcus spp. and Staphylococcus spp. strains using tetra-cationic platinum(II) porphyrins
Ticiane da Rosa Pinheiro, Carolina Gonzalez Urquhart, Thiago Vargas Acunha, Roberto Christ Vianna Santos, Bernardo Almeida Iglesias
Photodiagnosis and Photodynamic Therapy.2023; 42: 103542. CrossRef
Shear bond characteristics and surface roughness of poly-ether-ether-ketone treated with contemporary surface treatment regimes bonded to composite resin
Mashael Binhasan, Mai M. Alhamdan, Khulud A. Al-Aali, Fahim Vohra, Tariq Abduljabbar
Photodiagnosis and Photodynamic Therapy.2022; 38: 102765. CrossRef
Antimicrobial efficacy of in vitro and ex vivo photodynamic therapy using porphyrins against Moraxella spp. isolated from bovine keratoconjunctivitis
M. G. Seeger, C. S. Machado, B. A. Iglesias, F. S. F. Vogel, J. F. Cargnelutti
World Journal of Microbiology and Biotechnology.2022;[Epub] CrossRef
The antibacterial activity of photodynamic agents against multidrug resistant bacteria causing wound infection
Ayşe Akbiyik, Hüseyin Taşli, Nermin Topaloğlu, Vildan Alptüzün, Sülünay Parlar, Selçuk Kaya
Photodiagnosis and Photodynamic Therapy.2022; 40: 103066. CrossRef
Efficacy of chemical and photoactivated disinfectants against Candida Albicans and assessment of hardness, roughness, and mass loss of acrylic denture base resin
Fahad Alkhtani
Photodiagnosis and Photodynamic Therapy.2022; 39: 102911. CrossRef
Efficacy of the therapy of 5-aminolevulinic acid photodynamic therapy combined with human umbilical cord mesenchymal stem cells on methicillin-resistant Staphylococcus aureus-infected wound in a diabetic mouse model
Jianhua Huang, Shutian Wu, Minfeng Wu, Qingyu Zeng, Xiuli Wang, Hongwei Wang
Photodiagnosis and Photodynamic Therapy.2021; 36: 102480. CrossRef
Efficacy of porphyrin derivative, Chlorhexidine and PDT in the surface disinfection and roughness of Cobalt chromium alloy removable partial dentures
Eman M. AlHamdan, Samar Al-Saleh, Sidra Sadaf Nisar, Ibraheem Alshiddi, Abdulaziz S. Alqahtani, Khaled M. Alzahrani, Mustafa Naseem, Fahim Vohra, Tariq Abduljabbar
Photodiagnosis and Photodynamic Therapy.2021; 36: 102515. CrossRef
Effectiveness of synthetic and natural photosensitizers and different chemical disinfectants on the contaminated metal crown
Samar Al-Saleh, Ahmed Heji Albaqawi, Feras Alrawi, Huda I. Tulbah, Amal S Al-Qahtani, Emal Heer, Sidra Sadaf Nisar, Fahim Vohra, Tariq Abduljabbar
Photodiagnosis and Photodynamic Therapy.2021; 36: 102601. CrossRef
Natural Photosensitizers in Antimicrobial Photodynamic Therapy
Ece Polat, Kyungsu Kang
Biomedicines.2021; 9(6): 584. CrossRef
In vitro antimicrobial photodynamic therapy using tetra-cationic porphyrins against multidrug-resistant bacteria isolated from canine otitis
M.G. Seeger, A.S. Ries, L.T. Gressler, S.A. Botton, B.A. Iglesias, J.F. Cargnelutti
Photodiagnosis and Photodynamic Therapy.2020; 32: 101982. CrossRef
Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections
Yu‐Xuan Ma, Chen‐Yu Wang, Yuan‐Yuan Li, Jing Li, Qian‐Qian Wan, Ji‐Hua Chen, Franklin R. Tay, Li‐Na Niu
Advanced Science.2020;[Epub] CrossRef
Effect of methylene blue photodynamic therapy on human neutrophil functional responses
Elisa Trevisan, Renzo Menegazzi, Giuliano Zabucchi, Barbara Troian, Stefano Prato, Francesca Vita, Valentina Rapozzi, Micaela Grandolfo, Violetta Borelli
Journal of Photochemistry and Photobiology B: Biology.2019; 199: 111605. CrossRef
In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection
Jing Shen, Qingfeng Liang, Guanyu Su, Yang Zhang, Zhiqun Wang, Christophe Baudouin, Antoine Labbé
Translational Vision Science & Technology.2019; 8(3): 45. CrossRef
Synthesis and photo-bactericidal properties of a cationic porphyrin grafted onto kraft pulp fibers
Zineb Khaldi, Jean K. Nzambe Takeki, Tan-Sothea Ouk, Romain Lucas, Rachida Zerrouki
Journal of Porphyrins and Phthalocyanines.2019; 23(04n05): 489. CrossRef
Preliminary evaluation of the positively and negatively charge effects of tetra-substituted porphyrins on photoinactivation of rapidly growing mycobacteria
Kevim Bordignon Guterres, Grazielle Guidolin Rossi, Lucas Brandalise Menezes, Marli Matiko Anraku de Campos, Bernardo Almeida Iglesias
Tuberculosis.2019; 117: 45. CrossRef

The antimicrobial potential of a new derivative of cathelicidin from Bungarus fasciatus against methicillin-resistant Staphylococcus aureus: Mercedeh Tajbakhsh , Abdollah Karimi , Abolghasem Tohidpour , Naser Abbasi , Fatemeh Fallah , Maziar Mohammad Akhavan; J. Microbiol. 2018;56(2):128-137. Published online February 2, 2018; DOI: https://doi.org/10.1007/s12275-018-7444-5

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Abstract

Cathelicidins are a family of antimicrobial peptides which exhibit broad antimicrobial activities against antibiotic-resistant bacteria. Considering the progressive antibiotic resistance, cathelicidin is a candidate for use as an alternative approach to treat and overcome the challenge of antimicrobial resistance. Cathelicidin-BF (Cath-BF) is a short antimicrobial peptide, which was originally extracted from the venom of Bungarus fasciatus. Recent studies have reported that Cath-BF and some related derivatives exert strong antimicrobial and weak hemolytic properties. This study investigates the bactericidal and cytotoxic effects of Cath-BF and its analogs (Cath-A and Cath-B). Cath-A and Cath-B were designed to increase their net positive charge, to have more activity against methicillin resistant S. aureus (MRSA). The results of this study show that Cath-A, with a +17-net charge, has the most noteworthy antimicrobial activity against MRSA strains, with minimum inhibitory concentration (MIC) ranging between 32–128 μg/ml. The bacterial kinetic analysis by 1 × MIC concentration of each peptide shows that Cath-A neutralizes the clinical MRSA isolate for 60 min. The present data support the notion that increasing the positive net charge of antimicrobial peptides can increase their potential antimicrobial activity. Cath-A also displayed the weakest cytotoxicity effect against human umbilical vein endothelial and H9c2 rat cardiomyoblast cell lines. Analysis of the hemolytic activity reveals that all three peptides exhibit minor hemolytic activity against human erythrocytes at concentrations up to 250 μg/ml. Altogether, these results suggest that Cath-A and Cath-B are competent candidates as novel antimicrobial compounds against MRSA and possibly other multidrug resistant bacteria.

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Cathelicidin-BF regulates the AMPK/SIRT1/NF-κB pathway to ameliorate murine osteoarthritis: In vitro and in vivo studie
Hao Zhou, Linfang Zou, Hui Ren, Zhenyu Shen, Yuanqu Lin, Haikang Cai, Jingdong Zhang
International Immunopharmacology.2024; 134: 112201. CrossRef
Flow-Based Fmoc-SPPS Preparation and SAR Study of Cathelicidin-PY Reveals Selective Antimicrobial Activity
Shama Dissanayake, Junming He, Sung H. Yang, Margaret A. Brimble, Paul W. R. Harris, Alan J. Cameron
Molecules.2023; 28(4): 1993. CrossRef
Rational Design of RN15m4 Cathelin Domain-Based Peptides from Siamese Crocodile Cathelicidin Improves Antimicrobial Activity
Nisachon Jangpromma, Monruedee Konkchaiyaphum, Arpaporn Punpad, Sirinthip Sosiangdi, Sakda Daduang, Sompong Klaynongsruang, Anupong Tankrathok
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Clara Pérez-Peinado, Sira Defaus, David Andreu
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Frontiers in Microbiology.2019;[Epub] CrossRef
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Elias Ferreira Sabiá Júnior, Luis Felipe Santos Menezes, Israel Flor Silva de Araújo, Elisabeth Ferroni Schwartz
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Na Dong, Chensi Wang, Xinran Li, Yuming Guo, Xiaoli Li
International Journal of Molecular Sciences.2019; 20(23): 5904. CrossRef
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Kyle Boone, Kyle Camarda, Paulette Spencer, Candan Tamerler
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Biomolecules.2018; 8(4): 118. CrossRef

Characteristics of the community-genotype sequence type 72 methicillin-resistant Staphylococcus aureus isolates that underlie their persistence in hospitals: Eun-Jeong Joo , Ji-Young Choi , Doo Ryeon Chung , Jae-Hoon Song , Kwan Soo Ko; J. Microbiol. 2016;54(6):445-450. Published online May 27, 2016; DOI: https://doi.org/10.1007/s12275-016-6157-x

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Abstract

Panton-Valentine leukocidin-negative methicillin-resistant Staphylococcus aureus (MRSA) clone ST72, known as a major community-associated MRSA in Korea, has emerged as an important pathogen in hospitals. To understand bacterial properties that underlie transformation of this clone into a nosocomial pathogen, we compared characteristics of the community-genotype ST72 MRSA isolates with those of ST5 and ST239 MRSA, which have been predominant nosocomial MRSA clones in Korea. Several genes associated with adhesion and virulence were absent or rarely found in ST72 isolates. Many ST72 isolates (70.1%) belonged to agr group I, but the agr group of other ST72 isolates could not be determined. As indicated by δ-hemolysin production, ST72 isolates expressed fully functional agr, whereas agr dysfunction was observed in ST5 and ST239 isolates. In the biofilm formation assay, no upregulation of biofilm-forming activity of ST72 MRSA was detected. However, ST72 isolates demonstrated persistence under hypotonic and desiccating conditions (survival rates 72.3% and 33.9%, respectively), which was similar to characteristics of ST5 or ST239 isolates. ST72- MRSA isolates showed low virulence, but properties of their functional agr system could facilitate their spread in hospitals. In conclusion, tolerance to stressful environments, e.g., hypotonic and dry conditions, may also contribute to survival of the community-associated MRSA clones in healthcare facilities.

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Microbiology Spectrum.2023;[Epub] CrossRef
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You-Jin Hwang
Antibiotics.2023; 12(9): 1397. CrossRef
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Jun Sung Hong, Dokyun Kim, Seok Hoon Jeong
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Wangxiao Zhou, Ye Jin, Yanzi Zhou, Yuan Wang, Luying Xiong, Qixia Luo, Yonghong Xiao, Suleyman Yildirim
mSystems.2021;[Epub] CrossRef
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Hyemin Chung, Eunsil Kim, Eunmi Yang, Yun Woo Lee, Joung Ha Park, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim
European Journal of Clinical Microbiology & Infectious Diseases.2021; 40(12): 2497. CrossRef
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Nayab Batool, Amen Shamim, Akhilesh Kumar Chaurasia, Kyeong Kyu Kim
Frontiers in Microbiology.2021;[Epub] CrossRef
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Journal of Korean Medical Science.2021;[Epub] CrossRef
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International Journal of Molecular Sciences.2020; 21(23): 9135. CrossRef
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Infection & Chemotherapy.2017; 49(2): 109. CrossRef
Comparison of subsequent infection in methicillin-resistant Staphylococcus aureus nasal carriers between ST72 community-genotype and hospital genotypes: a retrospective cohort study
So Yeon Park, Doo Ryeon Chung, Yu Ri Kang, So Hyun Kim, Sun Young Cho, Young Eun Ha, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song
Antimicrobial Resistance & Infection Control.2017;[Epub] CrossRef
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Annals of Clinical Microbiology.2016; 19(4): 88. CrossRef

Review

MINIREVIEW] Multidrug efflux pumps in Staphylococcus aureus and their clinical implications: Soojin Jang; J. Microbiol. 2016;54(1):1-8. Published online January 5, 2016; DOI: https://doi.org/10.1007/s12275-016-5159-z

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Abstract

Antibiotic resistance is rapidly spreading among bacteria such as Staphylococcus aureus, an opportunistic bacterial pathogen that causes a variety of diseases in humans. For the last two decades, bacterial multidrug efflux pumps have drawn attention due to their potential association with clinical multidrug resistance. Numerous researchers have demonstrated efflux-mediated resistance in vitro and in vivo and found novel multidrug transporters using advanced genomic information about bacteria. This article aims to provide a concise summary of multidrug efflux pumps and their important clinical implications, focusing on recent findings concerning S. aureus efflux pumps.

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Biomedicine & Pharmacotherapy.2024; 179: 117291. CrossRef
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Frontiers in Microbiology.2023;[Epub] CrossRef
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PLOS ONE.2022; 17(7): e0272417. CrossRef
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Biomedicines.2022; 10(5): 1121. CrossRef
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ACS Applied Bio Materials.2022; 5(4): 1710. CrossRef
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Antimicrobial Agents and Chemotherapy.2022;[Epub] CrossRef
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Antibiotics.2021; 10(7): 862. CrossRef
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Biomedical Science Letters.2021; 27(4): 195. CrossRef
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Laiying Zhang, Jun He, Lang Bai, Shihua Ruan, Tao Yang, Youfu Luo
Medicinal Research Reviews.2021; 41(4): 1855. CrossRef
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Journal of Dairy Research.2020; 87(3): 309. CrossRef
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Amy R. Nava, Natalia Mauricio, Angel J. Sanca, Delfina C. Domínguez
Frontiers in Microbiology.2020;[Epub] CrossRef
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Sepideh Hassanzadeh, Sara ganjloo, Mohammad Reza Pourmand, Rahil Mashhadi, Kiarash Ghazvini
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Biological Trace Element Research.2019; 191(2): 522. CrossRef
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International Journal of Environmental Science and Technology.2018; 15(1): 243. CrossRef
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Research Support, Non-U.S. Gov't

Responses in the Expression of Extracellular Proteins in Methicillin-Resistant Staphylococcus aureus Treated with Rhodomyrtone: Monton Visutthi , Potjanee Srimanote , Supayang Piyawan Voravuthikunchai; J. Microbiol. 2011;49(6):956-964. Published online December 28, 2011; DOI: https://doi.org/10.1007/s12275-011-1115-0

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Abstract: Rhodomyrtone from a medicinal plant species, Rhodomyrtus tomentosa, is a challenged effective agent against Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA). The present study was undertaken to provide insight into MRSA extracellular protein expression following rhodomyrtone treatment. Secreteomic approach was performed on a representative clinical MRSA isolate exposing to subinhibitory concentration rhodomyrtone (0.174 μg/ml). The identified extracellular proteins of a response of MRSA to rhodomyrtone treated condition were both suppressed and overexpressed. Staphylococcal antigenic proteins, immunodominant antigen A (IsaA) and staphylococcal secretory antigen (SsaA) involved in cell wall hydrolysis were downregulated after the treatment. The results suggested that rhodomyrtone may interfere with WalK/WalR (YycG/YycF) system. Other enzymes such as lipase precursor and another lipase, glycerophosphoryl diester phosphodiesterase, were absent. In contrast, cytoplasmic proteins such as SpoVG and glycerol phosphate lipoteichoic acid synthase, and ribosomal proteins were found in the treated sample. Appearance of several cytoplasmic proteins in the treated culture supernatant revealed that the bacterial cell wall biosynthesis was disturbed. This finding provides a proteomic mapping of extracellular proteins after rhodomytone treatment. Extensive investigation is required for this natural compound as it has a great potency as an alternative anti-MRSA drug.

Journal Article

Emergence of Vancomycin-Intermediate Staphylococcus aureus from Predominant Methicillin-Resistant S. aureus Clones in a Korean Hospital: Hwa Yun Cha , Hyun Ok Kim , Jong Sook Jin , Je Chul Lee; J. Microbiol. 2010;48(4):533-535. Published online August 20, 2010; DOI: https://doi.org/10.1007/s12275-010-0062-5

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Abstract: The genetic and epidemiological features of four vancomycin-intermediate Staphylococcus aureus (VISA) isolates obtained from a Korean hospital were evaluated in this study. The VISA isolates were genotyped as sequence type (ST) 5-staphylococcal cassette chromosome mec (SCCmec) II variant (n=2) and ST239- SCCmec III (n=2), which were derived from the predominant methicillin-resistant S. aureus (MRSA) clones in Korean hospitals. One VISA isolate was acquired during vancomycin treatment, whereas three VISA isolates were obtained from the patients who had not previously been exposed to glycopeptides. As VISA is likely to arise from the predominant MRSA clones and may then possibly spread between patients, the emergence of VISA should be monitored with great care in hospitals.

Research Support, Non-U.S. Gov'ts

Synergistic Effects of the Combination of Galangin with Gentamicin against Methicillin-Resistant Staphylococcus aureus: Young-Seob Lee , Ok-Hwa Kang , Jang-Gi Choi , You-Chang Oh , Hee-Sung Chae , Jong Hak Kim , Hyun Park , Dong Hwan Sohn , Zheng-Tao Wang , Dong-Yeul Kwon; J. Microbiol. 2008;46(3):283-288. Published online July 5, 2008; DOI: https://doi.org/10.1007/s12275-008-0012-7

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66 Scopus

Abstract: The antimicrobial killing activity toward methicillin-resistant Staphylococcus aureus (MRSA) has been a serious emerging global issue. New effective antimicrobials and/or new approaches to settle this issue are urgently needed. The oriental herb, Alpinia officinarum, has been used in Korea for several hundreds of years to treat various infectious diseases. As it is well known, one of the active constituents of Alpinia officinarum is galangin. Against the 17 strains, the minimum inhibitory concentrations (MICs) of galangin (GAL) were in the range of 62.5~125 μg/ml, and the MICs of gentamicin (GEN) ranged from 1.9 μg/ml to 2,000 μg/ml. The fractional inhibitory concentrations (FICs) of GAL, in combination with GEN, against 3 test strains were 0.4, 3.9, and 250 μg/ml, and were all 15.62 μg/ml in GEN. The FIC index showed marked synergism in the value range of 0.19 to 0.25. By determining time-kill curves, also confirmed the low synergism of the GAL and GEN combination against 4 h, 8 h, 12 h, and 24 h cultured MRSA. The time-kill study results indicated a low synergistic effect against 3 test strains. Thus, the mixture of GAL and GEN could lead to the development of new combination antibiotics against MRSA infection.

A Comparison of Adult and Pediatric Methicillin-Resistant Staphylococcus aureus Isolates Collected from Patients at a University Hospital in Korea: Jin Yeol Park , Jong Sook Jin , Hee Young Kang , Eun Hee Jeong , Je Chul Lee , Yoo Chul Lee , Sung Yong Seol , Dong Taek Cho , Jungmin Kim; J. Microbiol. 2007;45(5):447-452.; DOI: https://doi.org/2591 [pii]

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Abstract: In this study, we compared the phenotypic and genotypic characteristics of 138 MRSA isolates obtained from adult and pediatric patients (adult, 50; children, 88). The resistance rates against gentamicin, clindamycin, and ciprofloxacin were much higher in the adult MRSA isolates than in the pediatric MRSA isolates. The ermC gene, which is responsible for inducible clindamycin resistance, was detected in 52(59.1%) of the 88 pediatric MRSA isolates but in only 5(10.0%) of the 50 adult MRSA isolates. MRSA isolates of clonal type ST5 with an integration of SCCmec type II/II variants was the most predominant clone among the adult isolates, while clonal type ST72 with an integration of SCCmec IV/IVA was the most predominant clone among the pediatric MRSA isolates. Staphylococcal enterotoxin A and toxic shock syndrome toxin-1 were prevalent among the adult MRSA isolates but not among the pediatric MRSA isolates. The results of this study demonstrated remarkable differences between adult and pediatric MRSA isolates in terms of their antimicrobial susceptibility profiles, SCCmec type, multilocus sequence type, staphylococcal toxin genes, and erythromycin resistance genes.

Effect of Saliva miltiorrhiza Bunge on Antimicrobial Activity and Resistant Gene Regulation against Methicillin-Resistant Staphylococcus aureus (MRSA): Ji-Won Lee , Young-Ju Ji , Syng-Ook Lee , In-Seon Lee; J. Microbiol. 2007;45(4):350-357.; DOI: https://doi.org/2561 [pii]

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Abstract: This study was conducted in an effort to evaluate the antimicrobial activity and antibiotic-resistant gene regulation from Saliva miltiorrhiza Bunge on methicillin-resistant Staphylococcus aureus (MRSA). A variety of solvent fractions and methanol extracts of S. miltiorrhiza Bunge were tested in order to determine its antimicrobial activities against S. aureus and MRSA. As a result, the hexane fraction of S. miltiorrhiza Bunge evidenced the highest levels of antimicrobial activity against S. aureus and MRSA. The MICs of the hexane fraction against various MRSA specimens were 64<MICs≤128 μg/ml. The hexane fraction evidenced inhibitory effects superior to those of the chloroform fraction. The results showed inhibition zones of hexane (16 mm) and chloroform (14 mm) fractions against MRSA KCCM 40511 at 1,000 μg/disc. The hexane and chloroform fractions inhibited the expression of the resistant genes, mecA, mecR1, and femA in mRNA. Moreover, the results of Western blotting assays indicated that the hexane and chloroform fractions inhibited the expression of the resistant protein, PBP2a. These results reveal that the hexane and chloroform fractions of S. miltiorrhiza Bunge may prove to be a valuable choice for studies targeted toward the development of new antimicrobial agents.

Production and Biological Activity of Laidlomycin, Anti-MRSA/VRE Antibiotic from Streptomyces sp. CS684: Jin Cheol Yoo , Jun Ho Kim , Jung Wan Ha , Nae Soo Park , Jae Kyung Sohng , June Woo Lee , Seong Chan Park , Mi Sun Kim , Chi Nam Seong; J. Microbiol. 2007;45(1):6-10.; DOI: https://doi.org/2499 [pii]

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Abstract: Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicilin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a C37H62O12Na (M+, 721.3875), and identified as laidlomycin. The anti-MRSA and anti-VRE activity of CSU-1 was stronger than oxacillin and vancomycin. Phylogenetic analysis showed that strain CS684 is very similar to Streptomyces ardus NRRL 2817T, whereas the ability of Streptomyces sp. CS684 to produce laidlomycin was shown to be unique.

Journal Article

Antimicrobial Susceptibility and Clonal Relatedness between Community- and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus from Blood Cultures: Sook-In Jung , Dong Hyeon Shin , Kyeong Hwa Park , Jong Hee Shin; J. Microbiol. 2006;44(3):336-343.; DOI: https://doi.org/2378 [pii]

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Abstract: We compared the antimicrobial resistance and clonal relationships among the communityacquired (CA) and hospital-acquired (HA) methicillin-resistant Staphylococcus aureus (MRSA) strains that were isolated from blood cultures in a university hospital over a 4-year period. A total of 131 MRSA isolates, including 28 CA-MRSA and 103 HA-MRSA strains, were identified; antimicrobial susceptibility testing indicated that the CA-MRSA isolates were more susceptible to erythromycin (21% vs 6%; P=0.02), clindamycin (46% vs 12%; P<0.01), ciprofloxacin (43% vs 11%; P<0.01), and gentamicin (43% vs 6%; P<0.01) than were the HA-MRSA isolates. Pulsed-field gel electrophoresis (PFGE) typing and antimicrobial resistance profiles separated the 20 CA-MRSA isolates into 14 and 10 different patterns, respectively, and the 53 HA-MRSA isolates were separated into 24 and 7 different patterns, respectively. Twenty-one (40%) of the 53 HA-MRSA isolates belonged to two predominant PFGE types, and most of them showed multi-drug resistant patterns. Four (20%) of the 20 CA-MRSA and 10 (19%) of the 53 HA-MRSA isolates fell into two common PFGE patterns, and each of them showed the same multi-drug resistant pattern. This study suggests that, although the CA-MRSA blood isolates showed diverse PFGE and antimicrobial resistance patterns, some of these isolates may have originated from the HA-MRSA strains.

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