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Melatonin attenuates microbiota dysbiosis of jejunum in short-term sleep deprived mice
Ting Gao , Zixu Wang , Jing Cao , Yulan Dong , Yaoxing Chen
J. Microbiol. 2020;58(7):588-597.   Published online May 18, 2020
DOI: https://doi.org/10.1007/s12275-020-0094-4
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  • 22 Web of Science
  • 22 Crossref
AbstractAbstract
Our study demonstrated that sleep deprivation resulted in homeostasis disorder of colon. Our study goes deeper into the positive effects of melatonin on small intestinal microbiota disorder caused by sleep deprivation. We successfully established a multiplatform 72 h sleep deprivation mouse model with or without melatonin supplementation, and analyzed the change of small intestinal microbiota using high-throughput sequencing of the 16S rRNA. We found melatonin supplementation suppressed the decrease of plasma melatonin level in sleep deprivation mice. Meanwhile, melatonin supplementation improved significantly the reduction in OTU numbers and the diversity and richness of jejunal microbiota and the abundance of Bacteroidaeae and Prevotellaceae, as well as an increase in the Firmicutes-to-Bacteroidetes ratio and the content of Moraxellaceae and Aeromonadaceae in the jejunum of sleep deprived-mice. Moreover, melatonin supplementation reversed the change of metabolic pathway in sleep deprived-mice, including metabolism, signal transduction mechanisms and transcription etc, which were related to intestinal health. Furthermore, melatonin supplementation inverted the sleep deprivation-induced a decline of anti-inflammatory cytokines (IL-22) and an increase of the ROS and proinflammatory cytokines (IL-17) in jejunum. These findings suggested that melatonin, similar to a probiotics agent, can reverse sleep deprivation-induced small intestinal microbiota disorder by suppressing oxidative stress and inflammation response.

Citations

Citations to this article as recorded by  
  • Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders
    Petra Zimmermann, Salome Kurth, Benoit Pugin, Nicholas A. Bokulich
    npj Biofilms and Microbiomes.2024;[Epub]     CrossRef
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    Dun-Xian Tan
    Mitochondrion.2024; 76: 101886.     CrossRef
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    Wei Tao, Yanren Zhang, Bingbin Wang, Saiqun Nie, Li Fang, Jian Xiao, Yanqing Wu
    Journal of Advanced Research.2024;[Epub]     CrossRef
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    George Anderson
    Frontiers in Bioscience-Landmark.2024;[Epub]     CrossRef
  • Melatonin: Both a Messenger of Darkness and a Participant in the Cellular Actions of Non-Visible Solar Radiation of Near Infrared Light
    Dun-Xian Tan, Russel J. Reiter, Scott Zimmerman, Ruediger Hardeland
    Biology.2023; 12(1): 89.     CrossRef
  • Understanding the combined effects of sleep deprivation and acute social stress on cognitive performance using a comprehensive approach
    Charelle Bottenheft, Koen Hogenelst, Ivo Stuldreher, Robert Kleemann, Eric Groen, Jan van Erp, Anne-Marie Brouwer
    Brain, Behavior, & Immunity - Health.2023; 34: 100706.     CrossRef
  • The relationship between sleep, gut microbiota, and metabolome in patients with depression and anxiety: A secondary analysis of the observational study
    Arisa Tanaka, Kenji Sanada, Katsuma Miyaho, Tomoyuki Tachibana, Shunya Kurokawa, Chiharu Ishii, Yoshihiro Noda, Shinichiro Nakajima, Shinji Fukuda, Masaru Mimura, Taishiro Kishimoto, Akira Iwanami, Tanja Grubić Kezele
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    María-Ángeles Bonmatí-Carrión, Maria-Angeles Rol
    Antioxidants.2023; 13(1): 34.     CrossRef
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    Arif Luqman
    Microbial Pathogenesis.2023; 180: 106125.     CrossRef
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    Microbiological Research.2023; 275: 127467.     CrossRef
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    Yanping Wang, Weihong Du, Xiaoyan Hu, Xin Yu, Chun Guo, Xinchun Jin, Wei Wang
    Acta Pharmaceutica Sinica B.2023; 13(12): 4667.     CrossRef
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    Lei Xie, Hang Wu, Xiaohong Huang, Tengbo Yu
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
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    Shuiping Liu, Weili Kang, Xinru Mao, Lei Ge, Heng Du, Jinyan Li, Lili Hou, Dandan Liu, Yulong Yin, Yunhuan Liu, Kehe Huang
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    Wenwen Wang, Yuan Wang, Yuanxiao Duan, Ziqi Meng, Xiaoping An, Jingwei Qi
    Journal of the Science of Food and Agriculture.2022; 102(15): 6992.     CrossRef
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    Han Yu, Fenghua Zhang, Yueqiang Wen, Zhili Zheng, Gaoyang Chen, Yingying Pan, Peijie Wu, Qiaobo Ye, Jun Han, Xiaofeng Chen, Chao Liu, Tao Shen
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats
    Jingru Wu, Mingxue Cao, Ming Hu, Yu Gong, Jianming Xue, Yilin Yang, Hairui Zhou, Duygu Ağagündüz
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
    Yiwen Zhang, Rui Lang, Shunyu Guo, Xiaoqin Luo, Huiting Li, Cencen Liu, Wei Dong, Changshun Bao, Yang Yu
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Impact of the Gastrointestinal Tract Microbiota on Cardiovascular Health and Pathophysiology
    Aysenur Gunaydin Akyildiz, Giuseppe Biondi-Zoccai, Daniela De Biase
    Journal of Cardiovascular Pharmacology.2022; 80(1): 13.     CrossRef
  • Melatonin–Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions
    Mara Ioana Iesanu, Carmen Denise Mihaela Zahiu, Ioana-Alexandra Dogaru, Diana Maria Chitimus, Gratiela Gradisteanu Pircalabioru, Suzana Elena Voiculescu, Sebastian Isac, Felicia Galos, Bogdan Pavel, Siobhain M. O’Mahony, Ana-Maria Zagrean
    Antioxidants.2022; 11(11): 2244.     CrossRef
  • Melatonin and Cancer: A Polyhedral Network Where the Source Matters
    Maria-Angeles Bonmati-Carrion, Antonia Tomas-Loba
    Antioxidants.2021; 10(2): 210.     CrossRef
  • Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou Seed Ameliorates Insomnia in Rats by Regulating Metabolomics and Intestinal Flora Composition
    Yue Hua, Sheng Guo, Hong Xie, Yue Zhu, Hui Yan, Wei-wei Tao, Er-xin Shang, Da-wei Qian, Jin-ao Duan
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
Fungal diversity in soils across a gradient of preserved Brazilian Cerrado
Ademir Sergio Ferreira de Araujo , Walderly Melgaço Bezerra , Vilma Maria dos Santos , Luis Alfredo Pinheiro Leal Nunes , Maria do Carmo Catanho Pereira de Lyra , Marcia do Vale Barreto Figueiredo , Vania Maria Maciel Melo
J. Microbiol. 2017;55(4):273-279.   Published online January 27, 2017
DOI: https://doi.org/10.1007/s12275-017-6350-6
  • 52 View
  • 0 Download
  • 19 Crossref
AbstractAbstract
The preserved Cerrado from Northeastern Brazil presents different physicochemical properties and plant diversity, which can influence the fungal communities. Therefore, we evaluated the fungal diversity in preserved sites, at Sete Ci-dades National Park, across a gradient of vegetation that in-cluded Campo graminoide, Cerrado stricto sensu, Cerradao, and Floresta decidual. Of all of the operational taxonomic units (OTUs) obtained, the Floresta decidual presented the highest richness. Ascomycota were the most abundant phy-lum (45%), followed by Basidiomycota (32%). Basal fungi and other phyla accounted for 23% of the total dataset. Agaricomycetes, Eurotiomycetes, Lecanoromycetes, Basi-diobolus, Dothideomycetes, and Taphrinomycetes were the most abundant classes of fungi found across the gradient of Cerrado vegetation. In conclusion, our study suggests that the Brazilian Cerrado from Sete Cidades National Park pre-sents a high fungal diversity and includes sources of new fungal species for biotechnological purposes.

Citations

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  • Soil microbial diversity and composition response to degradation of the alpine meadow in the southeastern Qinghai-Tibet Plateau
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