MSK
Search
- Page Path
- HOME > Search
Journal Articles
- Structural and Functional Analyses of the Flavoprotein Disulfide Reductase FN0820 of Fusobacterium nucleatum
- Hyunwoo Shin , Yeongjin Baek , Dukwon Lee , Yongbin Xu , Yonghoon Kwon , Inseong Jo , Nam-Chul Ha
- J. Microbiol. 2023;61(12):1033-1041. Published online December 20, 2023
- DOI: https://doi.org/10.1007/s12275-023-00095-9
- 66 View
- 0 Download
- 1 Web of Science
- 1 Crossref
-
Abstract
- Escherichia coli RclA and Staphylococcus aureus MerA are part of the Group I flavoprotein disulfide reductase (FDR) family and have been implicated in the contribution to bacterial pathogenesis by defending against the host immune response. Fusobacterium nucleatum is a pathogenic, anaerobic Gram-negative bacterial species commonly found in the human oral cavity and gastrointestinal tract. In this study, we discovered that the F. nucleatum protein FN0820, belonging to the Group I FDR family, exhibited a higher activity of a Cu2+- dependent NADH oxidase than E. coli RclA. Moreover, FN0820 decreased the dissolved oxygen level in the solution with higher NADH oxidase activity. We found that L-tryptophan and its analog 5-hydroxytryptophan inhibit the FN0820 activities of NADH oxidase and the concomitant reduction of oxygen. Our results have implications for developing new treatment strategies against pathogens that defend the host immune response with Group I FDRs.
-
Citations
Citations to this article as recorded by
-
The role of metals in hypothiocyanite resistance in
Escherichia coli
Michael J. Gray, Laurie E. Comstock
Journal of Bacteriology.2024;[Epub] CrossRef
-
The role of metals in hypothiocyanite resistance in
Escherichia coli
- Parahaliea maris sp. nov., isolated from surface seawater and emended description of the genus Parahaliea
- Yang Liu , Juan Du , Jun Zhang , Qiliang Lai , Zongze Shao , Honghui Zhu
- J. Microbiol. 2020;58(2):92-98. Published online January 29, 2020
- DOI: https://doi.org/10.1007/s12275-020-9405-z
- 52 View
- 0 Download
- 7 Web of Science
- 8 Crossref
-
Abstract
- A Gram-stain-negative, strictly aerobic, short-rod-shaped, and non-motile bacterial strain designated HSLHS9T was isolated from surface seawater collected from the South China Sea. Strain HSLHS9T could grow at 15–41°C (optimum 28°C), at pH 5.0–9.0 (optimum 6.0–7.0), and in 0–7% (w/v) NaCl (optimum 2–3%). Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain HSLHS9T shared high identities with the closely related Parahaliea aestuarii S2-26T (98.6%) and Parahaliea mediterranea 7SM29T (97.8%) and formed a distinct lineage within the genus Parahaliea. Wholegenome sequencing of strain HSLHS9T revealed the size of 4.8 Mbp and DNA G + C content of 61.8 mol%. Strain HSLHS9T shared the digital DNA-DNA hybridization values of 22.4% and 23.0%, and the average nucleotide identities of 79.7% and 79.9%, respectively, with the two type strains above. The predominant cellular fatty acids of the strain were summed feature 8 (C18:1 ω6c and/or C18:1 ω7c), summed feature 3 (C16:1 ω7c and/or C16:1 ω6c), C17:1 ω8c, and C16:0. The sole isoprenoid quinone was identified as Q-8. The polar lipids were phosphatidylglycerol, diphosphatidylglycerol, phosphatidylethanolamine, aminolipid, and two glycolipids. Based on taxonomic data obtained in this study, it is suggested that strain HSLHS9T represents a novel species of the genus Parahaliea, for which the name Parahaliea maris sp. nov. is proposed. The type strain is HSLHS9T (= MCCC 1A06717T = KCTC 52307T). An emended description of the genus Parahaliea is also provided.
-
Citations
Citations to this article as recorded by- A comparative analysis of the microbial communities and functional genes of the nitrogen cycling in mangroves of China, Indian and Malaysia
Zhihui Qian, Yuyang Li, Amit Pratush, Jie Kan, Ji-Dong Gu, Tao Peng, Tongwang Huang, Zhong Hu
International Biodeterioration & Biodegradation.2024; 190: 105767. CrossRef - Phylogenomic evaluation of Mangrovimicrobium sediminis gen. nov. sp. nov., the first nitrogen fixing member of the family Halieaceae adapted to mangrove habitat and reclassification of Halioglobus pacificus to Pseudohaliglobus pacificus comb. nov.
Pravin Kumar, Ashish Verma, Pooja Yadav, Joyasree Das, Lalit Kumar, Srinivasan Krishnamurthi
Science of The Total Environment.2024; 933: 172995. CrossRef - Abundant and rare bacteria in anthropogenic estuary: Community co-occurrence and assembly patterns
Ziyue Shi, Lili Ma, Yingying Wang, Jie Liu
Ecological Indicators.2023; 146: 109820. CrossRef - Isolation and characterization of tick-borne Roseomonas haemaphysalidis sp. nov. and rodent-borne Roseomonas marmotae sp. nov.
Wentao Zhu, Juan Zhou, Shan Lu, Jing Yang, Xin-He Lai, Dong Jin, Ji Pu, Yuyuan Huang, Liyun Liu, Zhenjun Li, Jianguo Xu
Journal of Microbiology.2022; 60(2): 137. CrossRef -
Sediminihaliea albiluteola gen. nov., sp. nov., a new member of the family Halieaceae, isolated from marine sediment
Shan Jiang, Feng-Bai Lian, You-Yang Sun, Xiao-Kui Zhang, Zong-Jun Du
International Journal of Systematic and Evolutionary Microbiology .2021;[Epub] CrossRef - List of new names and new combinations previously effectively, but not validly, published
Aharon Oren, George M. Garrity
International Journal of Systematic and Evolutionary Microbiology.2020; 70(5): 2960. CrossRef - Notification of changes in taxonomic opinion previously published outside the IJSEM
Aharon Oren, George Garrity
International Journal of Systematic and Evolutionary Microbiology .2020; 70(7): 4061. CrossRef - Aequoribacter fuscus gen. nov., sp. nov., a new member of the family Halieaceae, isolated from coastal seawater
Shan-Hui Li, Jaeho Song, Ilnam Kang, Juchan Hwang, Jang-Cheon Cho
Journal of Microbiology.2020; 58(6): 463. CrossRef
- A comparative analysis of the microbial communities and functional genes of the nitrogen cycling in mangroves of China, Indian and Malaysia
First
Prev
TOP
