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- Recent Advances of Nipah Virus Disease: Pathobiology to Treatment and Vaccine Advancement
- Sagnik Saha, Manojit Bhattacharya, Sang-Soo Lee, Chiranjib Chakraborty
- J. Microbiol. 2024;62(10):811-828. Published online September 18, 2024
- DOI: https://doi.org/10.1007/s12275-024-00168-3
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- 6 Download
- 2 Web of Science
- 3 Crossref
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Abstract
PDF - The zoonotic infection of the Nipah virus (NiV) has yet again appeared in 2023 in Kerala state, India. The virus, which has a mortality rate ranging from about 40 to 70%, has already infected India five times, the first being in 2001. The current infection is the sixth virus outbreak in the Indian population. In 1998, the first NiV infection was noted in one village in Malaysia. After that, outbreaks from other South and Southeast Asian countries have been reported periodically. It can spread between humans through contact with body fluids. Therefore, it is unlikely to generate a new pandemic. However, there is a considerable knowledge gap in the different areas of NiV. To date, no approved vaccines or treatments have been available. To fulfil the knowledge gap, the review article provided a detailed overview of the genome and genome-encoded proteins, epidemiology, transmission, pathobiology, immunobiology, diagnosis, prevention and control measures, therapeutics (monoclonal antibodies and drug molecules), and vaccine advancement of the emerging and deadly pathogen. The advanced information will help researchers to develop safe and effective NiV vaccine and treatment regimens worldwide.
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Citations
Citations to this article as recorded by
- An Overview of Nipah Virus Infection
Ujjawal Singh, Ramsha Sharma, Raj Kamal, Ranjeet Kumar
Anti-Infective Agents.2025;[Epub] CrossRef - Antiviral effects of heme oxygenase-1 against canine coronavirus and canine influenza virus in vitro
Jae-Hyeong Kim, Dong-Hwi Kim, Kyu-Beom Lim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Dong-Hun Lee, Do-Geun Kim, Hun-Young Yoon, In-Soo Choi
Journal of Microbiology.2025; 63(5): e2501029. CrossRef - Efficient and modular reverse genetics system for rapid generation of recombinant severe acute respiratory syndrome coronavirus 2
Sojung Bae, Jinjong Myoung
Journal of Microbiology.2025; 63(7): e2504015. CrossRef
- An Overview of Nipah Virus Infection
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