Journal of Microbiology

Review

Minor and major circRNAs in virus and host genomes: Zhihao Lou , Rui Zhou , Yinghua Su , Chun Liu , Wenting Ruan , Che Ok Jeon , Xiao Han , Chun Lin , Baolei Jia; J. Microbiol. 2021;59(3):324-331. Published online February 23, 2021; DOI: https://doi.org/10.1007/s12275-021-1021-z

47 View
0 Download
6 Web of Science
5 Crossref

As a special type of noncoding RNA, circular RNAs (circRNAs) are prevalent in many organisms. They can serve as sponges for microRNAs and protein scaffolds, or templates for protein translation, making them linked to cellular homeostasis and disease progression. In recent years, circRNAs have been found to be abnormally expressed during the processes of viral infection and pathogenesis, and can help a virus escape the immune response of a host. Thus, they are now considered to play important functions in the invasion and development of viruses. Moreover, the potential application of circRNAs as biomarkers of viral infection or candidates for therapeutic targeting deserves consideration. This review summarizes circRNAs in the transcriptome, including their classification, production, functions, and value as biomarkers. This review paper also describes research progress on circRNAs in viral infection (mainly hepatitis B virus, HIV, and some human herpes viruses) and aims to provide new ideas for antiviral therapies targeting circRNAs.

Citations

Citations to this article as recorded by

Host combats porcine reproductive and respiratory syndrome virus infection at non-coding RNAs level
Zhi Qin, Weiye Liu, Zhihua Qin, Hongliang Zhang, Xuewei Huang
Virulence.2024;[Epub] CrossRef
miRNA, lncRNA and circRNA: targeted molecules with therapeutic promises in Mycoplasma pneumoniae infection
Tian Gan, Jianwei Yu, Jun He
Archives of Microbiology.2023;[Epub] CrossRef
Circ_0138959/miR-495-3p/TRAF6 axis regulates proliferation, wound healing and osteoblastic differentiation of periodontal ligament cells in periodontitis
Wenjuan Deng, Xiaoliang Wang, Jin Zhang, Sainan Zhao
Journal of Dental Sciences.2022; 17(3): 1125. CrossRef
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials
Yuncong Shi, Huanji Zhang, Suli Huang, Li Yin, Feng Wang, Pei Luo, Hui Huang
Signal Transduction and Targeted Therapy.2022;[Epub] CrossRef
Omics-based microbiome analysis in microbial ecology: from sequences to information
Jang-Cheon Cho
Journal of Microbiology.2021; 59(3): 229. CrossRef

Journal Articles

Azohydromonas aeria sp. nov., isolated from air: Han Xue , Chun-gen Piao , Dan-ran Bian , Min-wei Guo , Yong Li; J. Microbiol. 2020;58(7):543-549. Published online June 27, 2020; DOI: https://doi.org/10.1007/s12275-020-9423-x

49 View
0 Download
5 Web of Science
4 Crossref

Abstract

A grey pink colored bacterium, strain t3-1-3T, was isolated from the air at the foot of the Xiangshan Mountain in Beijing, China. The cells are aerobic, Gram-stain-negative, non-sporeforming, motile and coccoid-rod shaped (0.9–1.2 × 1.9–2.1 μm). Strain t3-1-3T was catalase-positive and oxidase-negative and this strain grew at 4–42°C (optimum 28°C), a pH of 4.0–9.0 (optimum pH 7.0) and under 0–2% (w/v) NaCl (optimum 0–1% NaCl). A phylogenetic analysis based on 16S rRNA gene sequences revealed that strain t3-1-3T was closely related to Azohydromonas riparia UCM-11T (97.4% similarity), followed by Azohydromonas australica G1-2T (96.8%) and Azohydromonas ureilytica UCM-80T (96.7%). The genome of strain t3-1-3T contains 6,895 predicted protein-encoding genes, 8 rRNA genes, 62 tRNA genes and one sRNA gene, as well as five potential biosynthetic gene clusters, including clusters of genes coding for non-ribosomal peptide synthetase (NRPS), bacteriocin and arylpolyene and two clusters of genes for terpene. The predominant cellular fatty acids (> 10.0% of the total) in strain t3-1-3T were summed feature 3 (C16:1ω7c and/or C16:1ω6c, 37.8%), summed feature 8 (C18:1ω7c and/or C18:1ω6c, 29.7%) and C16:0 (17.3%). Strain t3-1-3T contained ubiquinone-8 (Q-8) as the predominant respiratory quinone. The polar lipids of strain t3-1-3T comprised phosphatidyl ethanolamine (PE), phosphatidyl glycerol (PG), diphosphatidyl glycerol (DPG), an unidentified glycolipid (GL), an unidentified aminophospholipid (APL), two unidentified phospholipid (PL1-2) and five unidentified lipid (L1-5). The DNA G + C content of the type strain is 70.3%. The broader range of growth temperature, assimilation of malic acid and trisodium citrate, presence of C18:3ω6c and an unidentified glycolipid and absence of C12:0 2-OH and C16:0iso differentiate strain t3-1-3T from related species. Based on the taxonomic data presented in this study, we suggest that strain t3-1-3T represents a novel species within the genus Azohydromonas, for which the name Azohydromonas aeria sp. nov. is proposed. The type strain of Azohydromonas aeria is t3-1-3T (= CFCC 13393T = LMG 30135T).

Citations

Citations to this article as recorded by

The phylogeny of the genus Azohydromonas supports its transfer to the family Comamonadaceae
Ezequiel Gerardo Mogro, Juan Hilario Cafiero, Mauricio Javier Lozano, Walter Omar Draghi
International Journal of Systematic and Evolutionary Microbiology.2022;[Epub] CrossRef
In situ injectable nano-complexed hydrogel based on chitosan/dextran for combining tumor therapy via hypoxia alleviation and TAMs polarity regulation
Wenxue Zhang, Yan Shi, Hu Li, Miao Yu, Jiaxuan Zhao, Hao Chen, Ming Kong
Carbohydrate Polymers.2022; 288: 119418. CrossRef
Transformation of N and S pollutants and characterization of microbial communities in constructed wetlands with Vallisneria natans
Feichao Fu, Shaobin Huang, Heping Hu, Yao Lu, Yanlin Wang, Jianqi Yuan, Zerui Gong, Jinhua Wu, Yongqing Zhang
Journal of Water Process Engineering.2021; 42: 102186. CrossRef
Azohydromonas caseinilytica sp. nov., a Nitrogen-Fixing Bacterium Isolated From Forest Soil by Using Optimized Culture Method
Ram Hari Dahal, Dhiraj Kumar Chaudhary, Dong-Uk Kim, Jaisoo Kim
Frontiers in Microbiology.2021;[Epub] CrossRef

A histone deacetylase, MoHOS2 regulates asexual development and virulence in the rice blast fungus: Jongjune Lee , Jae-Joon Lee , Junhyun Jeon; J. Microbiol. 2019;57(12):1115-1125. Published online November 22, 2019; DOI: https://doi.org/10.1007/s12275-019-9363-5

48 View
0 Download
15 Web of Science
16 Crossref

Abstract

Histone acetylation/deacetylation represent a general and efficient epigenetic mechanism through which fungal cells control gene expression. Here we report developmental requirement of MoHOS2-mediated histone deacetylation (HDAC) for the rice blast fungus, Magnaporthe oryzae. Structural similarity and nuclear localization indicated that MoHOS2 is an ortholog of Saccharomyces cerevisiae Hos2, which is a member of class I histone deacetylases and subunit of Set3 complex. Deletion of MoHOS2 led to 25% reduction in HDAC activity, compared to the wild-type, confirming that it is a bona-fide HDAC. Lack of MoHOS2 caused decrease in radial growth and impinged dramatically on asexual sporulation. Such reduction in HDAC activity and phenotypic defects of ΔMohos2 were recapitulated by a single amino acid change in conserved motif that is known to be important for HDAC activity. Expression analysis revealed up-regulation of MoHOS2 and concomitant down-regulation of some of the key genes involved in asexual reproduction under sporulation-promoting condition. In addition, the deletion mutant exhibited defect in appressorium formation from both germ tube tip and hyphae. As a result, ΔMohos2 was not able to cause disease symptoms. Wound-inoculation showed that the mutant is compromised in its ability to grow inside host plants as well. We found that some of ROS detoxifying genes and known effector genes are de-regulated in the mutant. Taken together, our data suggest that MoHOS2-dependent histone deacetylation is pivotal for proper timing and induction of transcription of the genes that coordinate developmental changes and host infection in M. oryzae.

Citations

Citations to this article as recorded by

Glsirt1-mediated deacetylation of GlCAT regulates intracellular ROS levels, affecting ganoderic acid biosynthesis in Ganoderma lucidum
Jing Han, Lingshuai Wang, Xin Tang, Rui Liu, Liang Shi, Jing Zhu, Mingwen Zhao
Free Radical Biology and Medicine.2024; 216: 1. CrossRef
Histone (de)acetylation in epigenetic regulation of Phytophthora pathobiology
Yufeng Guan, Joanna Gajewska, Jolanta Floryszak‐Wieczorek, Umesh Kumar Tanwar, Ewa Sobieszczuk‐Nowicka, Magdalena Arasimowicz‐Jelonek
Molecular Plant Pathology.2024;[Epub] CrossRef
FolSas2 is a regulator of early effector gene expression during Fusarium oxysporum infection
Limin Song, Yalei Wang, Fahui Qiu, Xiaoxia Li, Jingtao Li, Wenxing Liang
New Phytologist.2024;[Epub] CrossRef
Regulatory roles of epigenetic modifications in plant-phytopathogen interactions
Zeng Tao, Fei Yan, Matthias Hahn, Zhonghua Ma
Crop Health.2023;[Epub] CrossRef
The additional PRC2 subunit and Sin3 histone deacetylase complex are required for the normal distribution of H3K27me3 occupancy and transcriptional silencing in Magnaporthe oryzae
Chuyu Lin, Zhongling Wu, Huanbin Shi, Jinwei Yu, Mengting Xu, Fucheng Lin, Yanjun Kou, Zeng Tao
New Phytologist.2022; 236(2): 576. CrossRef
Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens
Yiling Lai, Lili Wang, Weilu Zheng, Sibao Wang
Journal of Fungi.2022; 8(6): 565. CrossRef
Polycomb Repressive Complex 2-Mediated H3K27 Trimethylation Is Required for Pathogenicity in Magnaporthe oryzae
Zhongling Wu, Jiehua Qiu, Huanbin Shi, Chuyu Lin, Jiangnan Yue, Zhiquan Liu, Wei Xie, Naweed I. Naqvi, Yanjun Kou, Zeng Tao
Rice Science.2022; 29(4): 363. CrossRef
Protein acetylation and deacetylation in plant‐pathogen interactions
Jing Wang, Chao Liu, Yun Chen, Youfu Zhao, Zhonghua Ma
Environmental Microbiology.2021; 23(9): 4841. CrossRef
Emerging Roles of Posttranslational Modifications in Plant-Pathogenic Fungi and Bacteria
Wende Liu, Lindsay Triplett, Xiao-Lin Chen
Annual Review of Phytopathology.2021; 59(1): 99. CrossRef
Fungal Lysine Deacetylases in Virulence, Resistance, and Production of Small Bioactive Compounds
Ingo Bauer, Stefan Graessle
Genes.2021; 12(10): 1470. CrossRef
A Histone Deacetylase, Magnaporthe oryzae RPD3, Regulates Reproduction and Pathogenic Development in the Rice Blast Fungus
Song Hee Lee, Mohamed El-Agamy Farh, Jaejoon Lee, Young Taek Oh, Eunbyeol Cho, Jiyeun Park, Hokyoung Son, Junhyun Jeon, Antonio Di Pietro
mBio.2021;[Epub] CrossRef
The Histone Deacetylases MoRpd3 and MoHst4 Regulate Growth, Conidiation, and Pathogenicity in the Rice Blast Fungus Magnaporthe oryzae
Chaoxiang Lin, Xue Cao, Ziwei Qu, Shulin Zhang, Naweed I. Naqvi, Yi Zhen Deng, Aaron P. Mitchell
mSphere.2021;[Epub] CrossRef
Histone Acetyltransferases and Deacetylases Are Required for Virulence, Conidiation, DNA Damage Repair, and Multiple Stresses Resistance of Alternaria alternata
Haijie Ma, Lei Li, Yunpeng Gai, Xiaoyan Zhang, Yanan Chen, Xiaokang Zhuo, Yingzi Cao, Chen Jiao, Fred G. Gmitter, Hongye Li
Frontiers in Microbiology.2021;[Epub] CrossRef
Function of PoLAE2, a laeA homolog, in appressorium formation and cAMP signal transduction in Pyricularia oryzae
Pradabrat Prajanket, Kim-Chi Thi Vu, Jun Arai, Worawan Sornkom, Ayumi Abe, Teruo Sone
Bioscience, Biotechnology, and Biochemistry.2020; 84(11): 2401. CrossRef
A Histone Deacetylase, MoHDA1 Regulates Asexual Development and Virulence in the Rice Blast Fungus
Taehyun Kim, Song Hee Lee, Young Taek Oh, Junhyun Jeon
The Plant Pathology Journal.2020; 36(4): 314. CrossRef
Protein Acetylation/Deacetylation: A Potential Strategy for Fungal Infection Control
Junzhu Chen, Qiong Liu, Lingbing Zeng, Xiaotian Huang
Frontiers in Microbiology.2020;[Epub] CrossRef

Reviews

REVIEW] Zika virus: An emerging flavivirus: Sang-Im Yun , Young-Min Lee; J. Microbiol. 2017;55(3):204-219. Published online February 28, 2017; DOI: https://doi.org/10.1007/s12275-017-7063-6

49 View
0 Download
72 Crossref

Abstract

Zika virus (ZIKV) is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, all of which are primarily transmitted by blood-sucking mosquitoes. Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range, from equatorial Africa and Asia to the Pacific Islands, then further afield to South and Central America and the Caribbean. Currently, ZIKV is actively circulating not only in much of Latin America and its neighbors but also in parts of the Pacific Islands and Southeast Asia. Although ZIKV infection generally causes only mild symptoms in some infected individuals, it is associated with a range of neuroimmunological disorders, including Guillain-Barré syndrome, meningoencephalitis, and myelitis. Recently, maternal ZIKV infection during pregnancy has been linked to neonatal malformations,
result
ing in various degrees of congenital abnormalities, microcephaly, and even abortion. Despite its emergence as an important public health problem, however, little is known about ZIKV biology, and neither vaccine nor drug is available to control ZIKV infection. This article provides a brief introduction to ZIKV with a major emphasis on its molecular virology, in order to help facilitate the development of diagnostics, therapeutics, and vaccines.

Citations

Citations to this article as recorded by

Comparison of Five Serological Methods for the Detection of West Nile Virus Antibodies
Philipp Girl, Kathrin Euringer, Mircea Coroian, Andrei Daniel Mihalca, Johannes P. Borde, Gerhard Dobler
Viruses.2024; 16(5): 788. CrossRef
Exploring Zika Virus Impact on Endothelial Permeability: Insights into Transcytosis Mechanisms and Vascular Leakage
Dama Faniriantsoa Henrio Marcellin, Jufang Huang
Viruses.2024; 16(4): 629. CrossRef
Optimal control problem for mathematical modeling of Zika virus transmission using fractional order derivatives
Abdelfatah Kouidere, Amine El Bhih, Issam Minifi, Omar Balatif, Khalid Adnaoui
Frontiers in Applied Mathematics and Statistics.2024;[Epub] CrossRef
Analysis of RNA virus pathogenicity and development of novel prevention methods.
Ryuta URAKI
Uirusu.2024; 74(1): 57. CrossRef
Differences in the Membrane-Binding Properties of Flaviviral Nonstructural 1 (NS1) Protein: Comparative Simulations of Zika and Dengue Virus NS1 Proteins in Explicit Bilayers
Rajagopalan Muthukumaran, Ramasubbu Sankararamakrishnan
ACS Bio & Med Chem Au.2024; 4(3): 137. CrossRef
Bovine serum albumin nanoparticles containing Poly (I:C) can enhance the neutralizing antibody response induced by envelope protein of Orthoflavivirus zikaense
Raíne Piva-Amaral, Gabriel Augusto Pires de Souza, João Carlos Vilela Vieira Júnior, Renato Fróes Goulart de Castro, William Permagnani Gozzi, Sergio Pereira Lima Neto, Ana Luisa Cauvilla dos Santos, Helena Pavani Cassiano, Lorena Christine Ferreira da Si
International Immunopharmacology.2024; 128: 111523. CrossRef
Employing Machine Learning-Based QSAR for Targeting Zika Virus NS3 Protease: Molecular Insights and Inhibitor Discovery
Hisham N. Altayb, Hanan Ali Alatawi
Pharmaceuticals.2024; 17(8): 1067. CrossRef
Mice as an Animal Model for Japanese Encephalitis Virus Research: Mouse Susceptibility, Infection Route, and Viral Pathogenesis
Jordan C. Frank, Byung-Hak Song, Young-Min Lee
Pathogens.2023; 12(5): 715. CrossRef
Zika Virus: A Comprehensive Review
Snehal Dilip Kothavale, Rinaj Rasul Attar, S. K. Mohite, Sagar B. Patil
Research Journal of Pharmacology and Pharmacodynamics.2023; : 24. CrossRef
The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression
Daed El Safadi, Grégorie Lebeau, Jonathan Turpin, Christian Lefebvre d’Hellencourt, Nicolas Diotel, Wildriss Viranaicken, Pascale Krejbich-Trotot
Viruses.2023; 16(1): 24. CrossRef
Synthesis of copaiba (Copaifera officinalis) oil nanoemulsion and the potential against Zika virus: An in vitro study
Tamara Carvalho, Marcela Guimarães Landim, Maria Letícia Duarte Lima, Cíntia Bittar, Beatriz Carvalho de Araújo Oliveira Faria, Paula Rahal, Milena Campelo Freitas de Lima, Valdir Florêncio da Veiga Junior, Graziella Anselmo Joanitti, Marilia Freitas Calm
PLOS ONE.2023; 18(9): e0283817. CrossRef
Epidemiological evidence of acute transmission of Zika virus infection in dengue suspected patients in Sri-Lanka
Mya Myat Ngwe Tun, Sandra Kendra Raini, Lakkumar Fernando, YINS Gunawardene, Shingo Inoue, Yuki Takamatsu, Takeshi Urano, Rohitha Muthugala, Menaka Hapugoda, Kouichi Morita
Journal of Infection and Public Health.2023; 16(9): 1435. CrossRef
The Drosophila melanogaster prophenoloxidase system participates in immunity against Zika virus infection
Ghada Tafesh‐Edwards, Ioannis Eleftherianos
European Journal of Immunology.2023;[Epub] CrossRef
Designing photoaffinity tool compounds for the investigation of the DENV NS2B–NS3 protease allosteric binding pocket
Hannah Maus, Andrea Gellert, Olivia R. Englert, Jia-Xuan Chen, Tanja Schirmeister, Fabian Barthels
RSC Medicinal Chemistry.2023; 14(11): 2365. CrossRef
Quinazolinone Compounds Have Potent Antiviral Activity against Zika and Dengue Virus
Md Ashraf-Uz-Zaman, Xin Li, Yuan Yao, Chandra Bhushan Mishra, Bala Krishna Moku, Yongcheng Song
Journal of Medicinal Chemistry.2023; 66(15): 10746. CrossRef
Reprogramming of red blood cell metabolism in Zika virus–infected donors
Alexis Catala, Mars Stone, Michael P. Busch, Angelo D'Alessandro
Transfusion.2022; 62(5): 1045. CrossRef
Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease
Yanchao Xiong, Fei Cheng, Junyi Zhang, Haixia Su, Hangchen Hu, Yi Zou, Minjun Li, Yechun Xu
Bioorganic Chemistry.2022; 128: 106109. CrossRef
Host Molecules Regulating Neural Invasion of Zika Virus and Drug Repurposing Strategy
Li Yin Tan, Thamil Vaani Komarasamy, William James, Vinod R. M. T. Balasubramaniam
Frontiers in Microbiology.2022;[Epub] CrossRef
Functional Loop Dynamics and Characterization of the Inactive State of the NS2B-NS3 Dengue Protease due to Allosteric Inhibitor Binding
Nisha Amarnath Jonniya, Parimal Kar
Journal of Chemical Information and Modeling.2022; 62(16): 3800. CrossRef
Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Emerging Microbes & Infections.2022; 11(1): 1191. CrossRef
Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling
Christopher J. Davies, Zhiqiang Fan, Kira P. Morgado, Ying Liu, Misha Regouski, Qinggang Meng, Aaron J. Thomas, Sang-Im Yun, Byung-Hak Song, Jordan C. Frank, Iuri V. Perisse, Arnaud Van Wettere, Young-Min Lee, Irina A. Polejaeva
Frontiers in Genetics.2022;[Epub] CrossRef
β-Catenin Restricts Zika Virus Internalization by Downregulating Axl
Oscar A. Jimenez, Srinivas D. Narasipura, Hannah J. Barbian, Yasmeen A. Albalawi, Melanie S. Seaton, KaReisha F. Robinson, Lena Al-Harthi, Susana López
Journal of Virology.2021;[Epub] CrossRef
Zika virus endemic challenges during COVID-19 pandemic in Africa
Abdullahi Tunde Aborode, Mahnoor Sukaina, Harendra Kumar, Tahreem Farooqui, Samar Faheem, Priyanka Chahal, Luay Alkazmi, Helal F. Hetta, Gaber El-Saber Batiha
Tropical Medicine and Health.2021;[Epub] CrossRef
Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected hcMEC/D3 Cells on the Blood–Brain Barrier System
Antonios Fikatas, Jonas Dehairs, Sam Noppen, Jordi Doijen, Frank Vanderhoydonc, Eef Meyen, Johannes V. Swinnen, Christophe Pannecouque, Dominique Schols
Viruses.2021; 13(12): 2363. CrossRef
Nanoparticles as Vaccines to Prevent Arbovirus Infection: A Long Road Ahead
Gabriel Augusto Pires de Souza, Raíssa Prado Rocha, Ricardo Lemes Gonçalves, Cyntia Silva Ferreira, Breno de Mello Silva, Renato Fróes Goulart de Castro, João Francisco Vitório Rodrigues, João Carlos Vilela Vieira Júnior, Luiz Cosme Cotta Malaquias, Jônat
Pathogens.2021; 10(1): 36. CrossRef
Operationalizing Culturally Responsive Research Practices: Documenting the Communication Skills of Children With Confirmed or Possible Exposure to the Zika Virus in Saint Lucia, West Indies
Keisha T. Lindsay Nurse, Kim Gardner, Maria R. Brea
Perspectives of the ASHA Special Interest Groups.2021; 6(1): 191. CrossRef
Synthesis, Structure–Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease
Shenyou Nie, Yuan Yao, Fangrui Wu, Xiaowei Wu, Jidong Zhao, Yuanda Hua, Jingyu Wu, Tong Huo, Yi-Lun Lin, Alexander R. Kneubehl, Megan B. Vogt, Josephine Ferreon, Rebecca Rico-Hesse, Yongcheng Song
Journal of Medicinal Chemistry.2021; 64(5): 2777. CrossRef
Zika virus lateral flow assays using reverse transcription-loop-mediated isothermal amplification
Gna Ahn, SeonHyung Lee, Se Hee Lee, Yun Hee Baek, Min-Suk Song, Yang-Hoon Kim, Ji-Young Ahn
RSC Advances.2021; 11(29): 17800. CrossRef
CRISPR Tackles Emerging Viral Pathogens
Emily N. Kirby, Byron Shue, Paul Q. Thomas, Michael R. Beard
Viruses.2021; 13(11): 2157. CrossRef
Relationship between vertical stratification and feeding habits of mosquito (Diptera: Culicidae) assemblages collected in conservation units in the green belt of the city of São Paulo, Brazil
Eduardo Evangelista, Antônio Ralph Medeiros-Sousa, Walter Ceretti-Junior, Rafael Oliveira-Christe, Ramon Wilk-da-Silva, Ana Maria Ribeiro de Castro Duarte, Daniel Pagotto Vendrami, Gabriela Cristina de Carvalho, Luis Filipe Mucci, Mauro Toledo Marrelli
Acta Tropica.2021; 221: 106009. CrossRef
The Geraniin-Rich Extract from Reunion Island Endemic Medicinal Plant Phyllanthus phillyreifolius Inhibits Zika and Dengue Virus Infection at Non-Toxic Effect Doses in Zebrafish
Juliano G. Haddad, Dovilė Grauzdytė, Andrea Cristine Koishi, Wildriss Viranaicken, Petras Rimantas Venskutonis, Claudia Nunes Duarte dos Santos, Philippe Desprès, Nicolas Diotel, Chaker El Kalamouni
Molecules.2020; 25(10): 2316. CrossRef
Development, Characterization, and Application of Two Reporter-Expressing Recombinant Zika Viruses
Sang-Im Yun, Byung-Hak Song, Michael E. Woolley, Jordan C. Frank, Justin G. Julander, Young-Min Lee
Viruses.2020; 12(5): 572. CrossRef
Field-deployable molecular diagnostic platform for arbovirus detection in Aedes aegypti
Natalie Rutkowski, Yuemei Dong, George Dimopoulos
Parasites & Vectors.2020;[Epub] CrossRef
The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response
Rosa C. Coldbeck-Shackley, Nicholas S. Eyre, Michael R. Beard
Vaccines.2020; 8(3): 530. CrossRef
Detection of Zika and dengue viruses in wild-caught mosquitoes collected during field surveillance in an environmental protection area in São Paulo, Brazil
Karolina Morales Barrio-Nuevo, Mariana Sequetin Cunha, Adriana Luchs, Aristides Fernandes, Iray Maria Rocco, Luis Filipe Mucci, Renato Pereira de Souza, Antônio Ralph Medeiros-Sousa, Walter Ceretti-Junior, Mauro Toledo Marrelli, Humberto Lanz-Mendoza
PLOS ONE.2020; 15(10): e0227239. CrossRef
Future and Perspectives of the Zika Virus: Drug Repurposing as a Powerful Tool for Treatment Insights
Denise Rampini, Diego Campos Prieto, Ana Luisa Colzi, Renan Vinícius de Araújo, Jeanine Giarolla
Mini-Reviews in Medicinal Chemistry.2020; 20(18): 1917. CrossRef
An in silico integrative protocol for identifying key genes and pathways useful to understand emerging virus disease pathogenesis
Gabriel Augusto Pires de Souza, Ezequiel Aparecido Salvador, Fernanda Roza de Oliveira, Luiz Cosme Cotta Malaquias, Jonatas Santos Abrahão, Luiz Felipe Leomil Coelho
Virus Research.2020; 284: 197986. CrossRef
Development of oncolytic virotherapy: from genetic modification to combination therapy
Qiaoshuai Lan, Shuai Xia, Qian Wang, Wei Xu, Haiyan Huang, Shibo Jiang, Lu Lu
Frontiers of Medicine.2020; 14(2): 160. CrossRef
Anti-Zika virus activity and chemical characterization by ultra-high performance liquid chromatography (UPLC-DAD-UV-MS) of ethanol extracts in Tecoma species
Adriana Cotta Cardoso Reis, Breno Mello Silva, Hélia Maria Marques de Moura, Guilherme Rocha Pereira, Geraldo Célio Brandão
BMC Complementary Medicine and Therapies.2020;[Epub] CrossRef
Applying a pan-flavivirus RT-qPCR assay in Brazilian public health surveillance
Mariana Sequetin Cunha, Adriana Luchs, Fabiana Cristina Pereira dos Santos, Giovana Santos Caleiro, Maurício Lacerda Nogueira, Paulo César Maiorka
Archives of Virology.2020; 165(8): 1863. CrossRef
The range of sampling times affects Zika virus evolutionary rates and divergence times
Lucia P. Barzilai, Carlos G. Schrago
Archives of Virology.2019; 164(12): 3027. CrossRef
Prevalence of Zika virus in blood donations: a systematic review and meta-analysis
Rongfei Liu, Xuanzhuo Wang, Yu Ma, Jianyong Wu, Chen Mao, Lihong Yuan, Jiahai Lu
BMC Infectious Diseases.2019;[Epub] CrossRef
Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease
Yuan Yao, Tong Huo, Yi-Lun Lin, Shenyou Nie, Fangrui Wu, Yuanda Hua, Jingyu Wu, Alexander R. Kneubehl, Megan B. Vogt, Rebecca Rico-Hesse, Yongcheng Song
Journal of the American Chemical Society.2019; 141(17): 6832. CrossRef
Molecular epidemiology of dengue, yellow fever, Zika and Chikungunya arboviruses: An update
Adriana Higuera, Juan David Ramírez
Acta Tropica.2019; 190: 99. CrossRef
Crystallographic Snapshots of the Zika Virus NS3 Helicase Help Visualize the Reactant Water Replenishment
Junnan Fang, Xuping Jing, Guoliang Lu, Yi Xu, Peng Gong
ACS Infectious Diseases.2019; 5(2): 177. CrossRef
Zika Fever: Development of Diagnostics, Prevention and Treatment
E. I. Kazachinskaya, D. V. Shan’shin, A. V. Ivanova
Problems of Particularly Dangerous Infections.2019; (2): 6. CrossRef
Selective Disruption of the Blood–Brain Barrier by Zika Virus
Ana Rachel Leda, Luc Bertrand, Ibolya Edit Andras, Nazira El-Hage, Madhavan Nair, Michal Toborek
Frontiers in Microbiology.2019;[Epub] CrossRef
Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity
Eleonora Cimini, Alessandra Sacchi, Sara De Minicis, Veronica Bordoni, Rita Casetti, Germana Grassi, Francesca Colavita, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Maria Giovanna Desimio, Margherita Doria, Chiara Agrati
Microorganisms.2019; 7(9): 350. CrossRef
Distinctive regulatory properties of pyruvate kinase 1 from Aedes aegypti mosquitoes
Natthida Petchampai, Claribel Murillo-Solano, Jun Isoe, Juan C. Pizarro, Patricia Y. Scaraffia
Insect Biochemistry and Molecular Biology.2019; 104: 82. CrossRef
Rational Control of Poliovirus RNA-Dependent RNA Polymerase Fidelity by Modulating Motif-D Loop Conformational Dynamics
Jingjing Shi, Jacob M. Perryman, Xiaorong Yang, Xinran Liu, Derek M. Musser, Alyson K. Boehr, Ibrahim M. Moustafa, Jamie J. Arnold, Craig E. Cameron, David D. Boehr
Biochemistry.2019; 58(36): 3735. CrossRef
Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication
Wai-Lok Yau, Van Nguyen-Dinh, Elin Larsson, Richard Lindqvist, Anna K. Överby, Richard Lundmark, Julie K. Pfeiffer
Journal of Virology.2019;[Epub] CrossRef
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?
Marc Desforges, Alain Le Coupanec, Philippe Dubeau, Andréanne Bourgouin, Louise Lajoie, Mathieu Dubé, Pierre J. Talbot
Viruses.2019; 12(1): 14. CrossRef
Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models
Penghui Li, Xianliang Ke, Ting Wang, Zhongyuan Tan, Dan Luo, Yuanjiu Miao, Jianhong Sun, Yuan Zhang, Yan Liu, Qinxue Hu, Fuqiang Xu, Hanzhong Wang, Zhenhua Zheng, Julie K. Pfeiffer
Journal of Virology.2018;[Epub] CrossRef
The Recent Epidemic Spread of Zika Virus Disease
Chang-Kweng Lim
Uirusu.2018; 68(1): 1. CrossRef
Zika Virus in the Male Reproductive Tract
Liesel Stassen, Charles W. Armitage, David J. Van der Heide, Kenneth W. Beagley, Francesca D. Frentiu
Viruses.2018; 10(4): 198. CrossRef
Maternal immunization with a DNA vaccine candidate elicits specific passive protection against post-natal Zika virus infection in immunocompetent BALB/c mice
Ran Wang, Xianzheng Liao, Dongying Fan, Lei Wang, Ji Song, Kaihao Feng, Mingyuan Li, Peigang Wang, Hui Chen, Jing An
Vaccine.2018; 36(24): 3522. CrossRef
Zika knowledge and preventive practices among reproductive-age women from Lambayeque, Peru
Sara J. Burgos-Muñoz, Carlos J. Toro-Huamanchumo
European Journal of Obstetrics & Gynecology and Reproductive Biology.2018; 228: 255. CrossRef
A panoptic uncovering of the dynamical evolution of the Zika Virus NS5 methyltransferase binding site loops—zeroing in on the molecular landscape
Nikita Devnarain, Mahmoud E. S. Soliman
Chemical Biology & Drug Design.2018; 92(5): 1838. CrossRef
Structural view of the helicase reveals thatZika virususes a conserved mechanism for unwinding RNA
Lei Li, Jin Wang, Zhihui Jia, Neil Shaw
Acta Crystallographica Section F Structural Biology Communications.2018; 74(4): 205. CrossRef
Functional Genomics and Immunologic Tools: The Impact of Viral and Host Genetic Variations on the Outcome of Zika Virus Infection
Sang-Im Yun, Byung-Hak Song, Jordan C. Frank, Justin G. Julander, Aaron L. Olsen, Irina A. Polejaeva, Christopher J. Davies, Kenneth L. White, Young-Min Lee
Viruses.2018; 10(8): 422. CrossRef
Comparative analysis of different cell systems for Zika virus (ZIKV) propagation and evaluation of anti-ZIKV compounds in vitro
Ilaria Vicenti, Adele Boccuto, Alessia Giannini, Filippo Dragoni, Francesco Saladini, Maurizio Zazzi
Virus Research.2018; 244: 64. CrossRef
The use of humanized mice for studies of viral pathogenesis and immunity
Florian Douam, Alexander Ploss
Current Opinion in Virology.2018; 29: 62. CrossRef
Immunization with phage virus-like particles displaying Zika virus potential B-cell epitopes neutralizes Zika virus infection of monkey kidney cells
Rupsa Basu, Lukai Zhai, Alice Contreras, Ebenezer Tumban
Vaccine.2018; 36(10): 1256. CrossRef
Human Sertoli cells support high levels of Zika virus replication and persistence
Anil Kumar, Juan Jovel, Joaquin Lopez-Orozco, Daniel Limonta, Adriana M. Airo, Shangmei Hou, Iryna Stryapunina, Chad Fibke, Ronald B. Moore, Tom C. Hobman
Scientific Reports.2018;[Epub] CrossRef
Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis
Megan E. Cahill, Samantha Conley, Andrew T. DeWan, Ruth R. Montgomery
BMC Infectious Diseases.2018;[Epub] CrossRef
Zika virus and autoimmunity. One-step forward
Diana M. Monsalve, Yovana Pacheco, Yeny Acosta-Ampudia, Yhojan Rodríguez, Carolina Ramírez-Santana, Juan-Manuel Anaya
Autoimmunity Reviews.2017; 16(12): 1237. CrossRef
Recombinant Zika NS1 Protein Secreted from Vero Cells Is Efficient for Inducing Production of Immune Serum Directed against NS1 Dimer
Wildriss Viranaicken, Alexia Ndebo, Sandra Bos, Philippe Souque, Gilles Gadea, Chaker El-Kalamouni, Pascale Krejbich-Trotot, Pierre Charneau, Philippe Desprès, Marjolaine Roche
International Journal of Molecular Sciences.2017; 19(1): 38. CrossRef
Differential diagnosis of multiple sclerosis in Latin America
YD Fragoso, FG Elso, A Carrá
Multiple Sclerosis Journal - Experimental, Translational and Clinical.2017;[Epub] CrossRef
Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system
Nils Lannes, Elisabeth Eppler, Samar Etemad, Peter Yotovski, Luis Filgueira
Oncotarget.2017; 8(69): 114393. CrossRef
Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans
Alba Grifoni, John Pham, John Sidney, Patrick H. O'Rourke, Sinu Paul, Bjoern Peters, Sheridan R. Martini, Aruna D. de Silva, Michael J. Ricciardi, Diogo M. Magnani, Cassia G. T. Silveira, Alvino Maestri, Priscilla R. Costa, Luzia Maria de-Oliveira-Pinto,
Journal of Virology.2017;[Epub] CrossRef
Brain grants permission of access to Zika virus but denies entry to drugs: a molecular modeling perspective to infiltrate the boundary
Nikita Devnarain, Pritika Ramharack, Mahmoud E. Soliman
RSC Adv..2017; 7(75): 47416. CrossRef
Structures and Functions of the Envelope Glycoprotein in Flavivirus Infections
Xingcui Zhang, Renyong Jia, Haoyue Shen, Mingshu Wang, Zhongqiong Yin, Anchun Cheng
Viruses.2017; 9(11): 338. CrossRef

MINIREVIEW] Transcriptional control of sexual development in Cryptococcus neoformans: Matthew E. Mead , Christina M. Hull; J. Microbiol. 2016;54(5):339-346. Published online April 20, 2016; DOI: https://doi.org/10.1007/s12275-016-6080-1

43 View
0 Download
6 Crossref

Abstract

Developmental processes are essential for the normal life cycles of many pathogenic fungi, and they can facilitate survival in challenging environments, including the human host. Sexual development of the human fungal pathogen Cryptococcus neoformans not only produces infectious particles (spores) but has also enabled the evolution of new disease-related traits such as drug resistance. Transcription factor networks are essential to the development and pathogenesis of C. neoformans, and a variety of sequence-specific DNA-binding proteins control both key developmental transitions and virulence by regulating the expression of their target genes. In this review we discuss the roles of known transcription factors that harbor important connections to both development and virulence. Recent studies of these transcription factors have identified a common theme in which metabolic, stress, and other responses that are required for sexual development appear to have been co-opted for survival in the human host, thus facilitating pathogenesis. Future work elucidating the connection between development and pathogenesis will provide vital insights into the evolution of complex traits in eukaryotes as well as mechanisms that may be used to combat fungal pathogens.

Citations

Citations to this article as recorded by

Effect of a Mating Type Gene Editing in Lentinula edodes Using RNP/Nanoparticle Complex
Minseek Kim, Minji Oh, Ji-Hoon Im, Eun-Ji Lee, Hojin Ryu, Hyeon-Su Ro, Youn-Lee Oh
Journal of Fungi.2024; 10(12): 866. CrossRef
Current Perspectives on Uniparental Mitochondrial Inheritance in Cryptococcus neoformans
Amber R. Matha, Xiaorong Lin
Pathogens.2020; 9(9): 743. CrossRef
Investigation of Mating Pheromone–Pheromone Receptor Specificity in Lentinula edodes
Sinil Kim, Byeongsuk Ha, Minseek Kim, Hyeon-Su Ro
Genes.2020; 11(5): 506. CrossRef
The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi
Sheng Sun, Marco A. Coelho, Márcia David-Palma, Shelby J. Priest, Joseph Heitman
Annual Review of Genetics.2019; 53(1): 417. CrossRef
Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen Rhizopus delemar
Poppy C. S. Sephton-Clark, Jose F. Muñoz, Elizabeth R. Ballou, Christina A. Cuomo, Kerstin Voelz, Aaron P. Mitchell
mSphere.2018;[Epub] CrossRef
Activation of the Mating Pheromone Response Pathway ofLentinula edodesby Synthetic Pheromones
Byeongsuk Ha, Sinil Kim, Minseek Kim, Hyeon-Su Ro
Mycobiology.2018; 46(4): 407. CrossRef

REVIEW] Innate host defenses against Cryptococcus neoformans: Camaron Hole , Floyd L. Wormley Jr.; J. Microbiol. 2016;54(3):202-211. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5625-7

46 View
0 Download
17 Crossref

Abstract

Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, can cause life-threatening infections of the central nervous system in immunocompromised and immunocompetent individuals. Cryptococcal meningoencephalitis is the most common disseminated fungal infection in AIDS patients, and remains the third most common invasive fungal infection among organ transplant recipients. The administration of highly active antiretroviral therapy (HAART) has
result
ed in a decrease in the number of cases of AIDS-related cryptococcosis in developed countries, but in developing countries where HAART is not readily available, Cryptococcus is still a major concern. Therefore, there is an urgent need for the development of novel therapies and/or vaccines to combat cryptococcosis. Understanding the protective immune responses against Cryptococcus is critical for development of vaccines and immunotherapies to combat cryptococcosis. Consequently, this review focuses on our current knowledge of protective immune responses to C. neoformans, with an emphasis on innate immune responses.

Citations

Citations to this article as recorded by

Global trends in Cryptococcus and its interactions with the host immune system: a bibliometric analysis
Shiqin Tang, Ruiying Hao, Xin Liu, Huina He, Yanan Tian, Tingting Jing, Zhao Liu, Yanyan Xu, Xiaojing Li
Frontiers in Immunology.2024;[Epub] CrossRef
The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways
Jennifer L. O'Connor, Jillian C. Nissen
International Journal of Molecular Sciences.2023; 24(5): 4739. CrossRef
Microglia are not protective against cryptococcal meningitis
Sally H. Mohamed, Man Shun Fu, Sofia Hain, Alanoud Alselami, Eliane Vanhoffelen, Yanjian Li, Ebrima Bojang, Robert Lukande, Elizabeth R. Ballou, Robin C. May, Chen Ding, Greetje Vande Velde, Rebecca A. Drummond
Nature Communications.2023;[Epub] CrossRef
Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections
Yanjian Li, Hailong Li, Tianshu Sun, Chen Ding
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis
Tao Zhu, Wan-Ting Luo, Gui-Hua Chen, Yue-Sheng Tu, Shuo Tang, Huo-Jin Deng, Wei Xu, Wei Zhang, Di Qi, Dao-Xin Wang, Chang-Yi Li, He Li, Yan-Qiao Wu, Shen-Jin Li
Chinese Medical Journal.2018; 131(18): 2210. CrossRef
A case report of fatal disseminated Mycobacterium colombiense infection in a renal transplant recipient
Jasmine Gosal, B. Craig Lee
Transplant Infectious Disease.2018;[Epub] CrossRef
The Major Surface Glycoprotein of Pneumocystis murina Does Not Activate Dendritic Cells
Monica Sassi, Geetha Kutty, Gabriela A Ferreyra, Lisa R Bishop, Yueqin Liu, Ju Qiu, Da Wei Huang, Joseph A Kovacs
The Journal of Infectious Diseases.2018; 218(10): 1631. CrossRef
Disseminated Cryptococcosis With Severe Increased Intracranial Pressure Complicated With Cranial Nerve Palsy in a Child
Bilge Aldemir Kocabaş, Mehmet Emin Parlak, Betil Özhak Baysan, Kamil Karaali, Ayşen Bingöl, Şenay Haspolat
Pediatric Infectious Disease Journal.2018; 37(4): 373. CrossRef
Contribution of IL-1RI Signaling to Protection against Cryptococcus neoformans 52D in a Mouse Model of Infection
Mitra Shourian, Ben Ralph, Isabelle Angers, Donald C. Sheppard, Salman T. Qureshi
Frontiers in Immunology.2018;[Epub] CrossRef
Transcriptomic Predictors of Paradoxical Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome
Irina Vlasova-St. Louis, Christina C Chang, Samar Shahid, Martyn A French, Paul R Bohjanen
Open Forum Infectious Diseases.2018;[Epub] CrossRef
Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection
Jintao Xu, Adam Flaczyk, Lori M. Neal, Zhenzong Fa, Alison J. Eastman, Antoni N. Malachowski, Daphne Cheng, Bethany B. Moore, Jeffrey L. Curtis, John J. Osterholzer, Michal A. Olszewski
The Journal of Immunology.2017; 198(9): 3548. CrossRef
Neuro-Immune Mechanisms of Anti-Cryptococcal Protection
Rebecca Drummond
Journal of Fungi.2017; 4(1): 4. CrossRef
Role of microglia in fungal infections of the central nervous system
George W. Koutsouras, Raddy L. Ramos, Luis R. Martinez
Virulence.2017; 8(6): 705. CrossRef
Dectin-3 Is Not Required for Protection against Cryptococcus neoformans Infection
Althea Campuzano, Natalia Castro-Lopez, Karen L. Wozniak, Chrissy M. Leopold Wager, Floyd L. Wormley, Kirsten Nielsen
PLOS ONE.2017; 12(1): e0169347. CrossRef
Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison
Pedro Pais, Catarina Costa, Mafalda Cavalheiro, Daniela Romão, Miguel C. Teixeira
Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef
Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef
Activation strategies for invariant natural killer T cells
Ayano C. Kohlgruber, Carlos A. Donado, Nelson M. LaMarche, Michael B. Brenner, Patrick J. Brennan
Immunogenetics.2016; 68(8): 649. CrossRef

REVIEW] Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans: Lois M. Douglas , James B. Konopka; J. Microbiol. 2016;54(3):178-191. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5621-y

46 View
0 Download
34 Crossref

Abstract

Candida albicans is a human fungal pathogen capable of causing lethal systemic infections. The plasma membrane plays key roles in virulence because it not only functions as a protective barrier, it also mediates dynamic functions including secretion of virulence factors, cell wall synthesis, invasive hyphal morphogenesis, endocytosis, and nutrient uptake. Consistent with this functional complexity, the plasma membrane is composed of a wide array of lipids and proteins. These components are organized into distinct domains that will be the topic of this review. Some of the plasma membrane domains that will be described are known to act as scaffolds or barriers to diffusion, such as MCC/eisosomes, septins, and sites of contact with the endoplasmic reticulum. Other zones mediate dynamic processes, including secretion, endocytosis, and a special region at hyphal tips that facilitates rapid growth. The highly organized architecture of the plasma membrane facilitates the coordination of diverse functions and promotes the pathogenesis of C. albicans.

Citations

Citations to this article as recorded by

Zingerone effect against Candida albicans growth and biofilm production.
Sayali Chougule, Sargun Basrani, Tanjila Gavandi, Shivani Patil, Shivanand Yankanchi, Ashwini Jadhav, Sankunny Mohan Karuppayil
Journal of Medical Mycology.2024; : 101527. CrossRef
Regulation of yeast polarized exocytosis by phosphoinositide lipids
Matthew W. Volpiana, Aleksa Nenadic, Christopher T. Beh
Cellular and Molecular Life Sciences.2024;[Epub] CrossRef
Sur7 mediates a novel pathway for PI4,5P2 regulation in C. albicans that promotes stress resistance and cell wall morphogenesis
Carla E. Lanze, James B. Konopka, Amy Susanne Gladfelter
Molecular Biology of the Cell.2024;[Epub] CrossRef
Anti-Candida activity of flavonoids - an overview
Savu Mihaela, Marius Stefan
Journal of Experimental and Molecular Biology.2024; 25(1): 67. CrossRef
Emerging Roles of Exocyst Complex in Fungi: A Review
Qussai Zuriegat, Yakubu Saddeeq Abubakar, Zonghua Wang, Meilian Chen, Jun Zhang
Journal of Fungi.2024; 10(9): 614. CrossRef
Candida albicans pathways that protect against organic peroxides and lipid peroxidation
Kara A. Swenson, Kyunghun Min, James B. Konopka, Aaron P. Mitchell
PLOS Genetics.2024; 20(10): e1011455. CrossRef
A Comparative Review of Eugenol and Citral Anticandidal Mechanisms: Partners in Crimes Against Fungi
Zinnat Shahina, Tanya E. S. Dahms
Molecules.2024; 29(23): 5536. CrossRef
Hinokitiol inhibits Aspergillus fumigatus by interfering with the cell membrane and cell wall
Fanyue Meng, Xing Liu, Cui Li, Xudong Peng, Qian Wang, Qiang Xu, Jialin Sui, Guiqiu Zhao, Jing Lin
Frontiers in Microbiology.2023;[Epub] CrossRef
Candida albicans resistance to hypochlorous acid
Lois M. Douglas, Kyunghun Min, James B. Konopka, J. Andrew Alspaugh
mBio.2023;[Epub] CrossRef
Inhibition of cell cycle-dependent hyphal and biofilm formation by a novel cytochalasin 19,20‑epoxycytochalasin Q in Candida albicans
Kwanrutai Watchaputi, L. A. Channa Bhathiya Jayasekara, Khanok Ratanakhanokchai, Nitnipa Soontorngun
Scientific Reports.2023;[Epub] CrossRef
Unique roles of aminophospholipid translocase Drs2p in governing efflux pump activity, ergosterol level, virulence traits, and host–pathogen interaction in Candida albicans
Shweta Singh, Sandeep Hans, Aijaz Ahmad, Zeeshan Fatima, Saif Hameed
International Microbiology.2022; 25(4): 769. CrossRef
Rosemary essential oil and its components 1,8-cineole and α-pinene induce ROS-dependent lethality and ROS-independent virulence inhibition in Candida albicans
Zinnat Shahina, Raymond Al Homsi, Jared D. W. Price, Malcolm Whiteway, Taranum Sultana, Tanya E. S. Dahms, Roy Aziz Khalaf
PLOS ONE.2022; 17(11): e0277097. CrossRef
Cinnamon Leaf and Clove Essential Oils Are Potent Inhibitors of Candida albicans Virulence Traits
Zinnat Shahina, Ali Molaeitabari, Taranum Sultana, Tanya Elizabeth Susan Dahms
Microorganisms.2022; 10(10): 1989. CrossRef
Candida albicans Reactive Oxygen Species (ROS)-Dependent Lethality and ROS-Independent Hyphal and Biofilm Inhibition by Eugenol and Citral
Zinnat Shahina, Easter Ndlovu, Omkaar Persaud, Taranum Sultana, Tanya E. S. Dahms, Damian J. Krysan
Microbiology Spectrum.2022;[Epub] CrossRef
In Vitro and In Silico Analysis of Ascorbic Acid Towards Lanosterol 14-α-Demethylase Enzyme of Fluconazole-Resistant Candida albicans
Arumugam Ganeshkumar, Suvaiyarasan Suvaithenamudhan, Rajendran Rajaram
Current Microbiology.2021; 78(1): 292. CrossRef
The Antibacterial Synthetic Flavonoid BrCl-Flav Exhibits Important Anti-Candida Activity by Damaging Cell Membrane Integrity
Cornelia Babii, Mihaela Savu, Iuliana Motrescu, Lucian Mihail Birsa, Laura Gabriela Sarbu, Marius Stefan
Pharmaceuticals.2021; 14(11): 1130. CrossRef
The Sur7 cytoplasmic C terminus regulates morphogenesis and stress responses in Candida albicans
Carla E. Lanze, Sai Zhou, James B. Konopka
Molecular Microbiology.2021; 116(4): 1201. CrossRef
Differential Roles of a Family of Flavodoxin-Like Proteins That Promote Resistance to Quinone-Mediated Oxidative Stress in Candida albicans
Jenna E. Foderaro, James B. Konopka, Mairi C. Noverr
Infection and Immunity.2021;[Epub] CrossRef
Modulation of Immune Responses by Particle Size and Shape
Maksim V. Baranov, Manoj Kumar, Stefano Sacanna, Shashi Thutupalli, Geert van den Bogaart
Frontiers in Immunology.2021;[Epub] CrossRef
derived 5,6,8-trihydroxy-7,4′ dimethoxy flavone inhibits ergosterol synthesis and the production of hyphae and biofilm in
Mrudula Patel, Vartika Srivastava, Aijaz Ahmad
Journal of Ethnopharmacology.2020; 259: 112965. CrossRef
The Role of Secretory Pathways in Candida albicans Pathogenesis
Christiane Rollenhagen, Sahil Mamtani, Dakota Ma, Reva Dixit, Susan Eszterhas, Samuel A. Lee
Journal of Fungi.2020; 6(1): 26. CrossRef
Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits
Cristina Nicoleta Ciurea, Irina-Bianca Kosovski, Anca Delia Mare, Felicia Toma, Ionela Anca Pintea-Simon, Adrian Man
Microorganisms.2020; 8(6): 857. CrossRef
Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi
Carla E. Lanze, Rafael M. Gandra, Jenna E. Foderaro, Kara A. Swenson, Lois M. Douglas, James B. Konopka
Microbiology and Molecular Biology Reviews.2020;[Epub] CrossRef
Si vis pacem para bellum: A prospective in silico analysis of miRNA-based plant defenses against fungal infections
André F. Gabriel, Marina C. Costa, Francisco J. Enguita, Ana Lúcia Leitão
Plant Science.2019; 288: 110241. CrossRef
Advances in understanding of the oxysterol-binding protein homologous in yeast and filamentous fungi
Shangkun Qiu, Bin Zeng
International Microbiology.2019; 22(2): 169. CrossRef
The Yin and Yang of Current Antifungal Therapeutic Strategies: How Can We Harness Our Natural Defenses?
Tomas Di Mambro, Ilaria Guerriero, Luigi Aurisicchio, Mauro Magnani, Emanuele Marra
Frontiers in Pharmacology.2019;[Epub] CrossRef
Plasma membrane architecture protects Candida albicans from killing by copper
Lois M. Douglas, James B. Konopka, Valeria C. Culotta
PLOS Genetics.2019; 15(1): e1007911. CrossRef
Boric Acid and Commercial Organoboron Products as Inhibitors of Drug-Resistant Candida albicans
Bryan Larsen, Marija Petrovic, Francesco De Seta
Mycopathologia.2018; 183(2): 349. CrossRef
Helminth eggs as parasitic indicators of fecal contamination in agricultural irrigation water, biosolids, soils and pastures
María Claudia Campos, Milena Beltrán, Nancy Fuentes, Gerardo Moreno
Biomédica.2018; 38(1): 42. CrossRef
Selective BET bromodomain inhibition as an antifungal therapeutic strategy
Flore Mietton, Elena Ferri, Morgane Champleboux, Ninon Zala, Danièle Maubon, Yingsheng Zhou, Mike Harbut, Didier Spittler, Cécile Garnaud, Marie Courçon, Murielle Chauvel, Christophe d’Enfert, Boris A. Kashemirov, Mitchell Hull, Muriel Cornet, Charles E.
Nature Communications.2017;[Epub] CrossRef
Calcium Enhances Bile Salt-Dependent Virulence Activation in Vibrio cholerae
Amanda J. Hay, Menghua Yang, Xiaoyun Xia, Zhi Liu, Justin Hammons, William Fenical, Jun Zhu, Nancy E. Freitag
Infection and Immunity.2017;[Epub] CrossRef
MCC/Eisosomes Regulate Cell Wall Synthesis and Stress Responses in Fungi
Jenna Foderaro, Lois Douglas, James Konopka
Journal of Fungi.2017; 3(4): 61. CrossRef
Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef
Fungal cell membrane-promising drug target for antifungal therapy
D.G. Sant, S.G. Tupe, C.V. Ramana, M.V. Deshpande
Journal of Applied Microbiology.2016; 121(6): 1498. CrossRef

MINIREVIEW] The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis: Jaehyuk Choi , Won Hee Jung , James W. Kronstad; J. Microbiol. 2015;53(9):579-587. Published online August 1, 2015; DOI: https://doi.org/10.1007/s12275-015-5247-5

45 View
0 Download
43 Crossref

Abstract

A number of pathogenic species of basidiomycete fungi are either life-threatening pathogens of humans or major economic pests for crop production. Sensing the host is a key aspect of pathogen proliferation during disease, and signal transduction pathways are critically important for detecting environmental conditions and facilitating adaptation. This review focuses on the contributions of the cAMP/protein kinase A (PKA) signaling pathway in Cryptococcus neoformans, a species that causes meningitis in humans, and Ustilago maydis, a model phytopathogen that causes a smut disease on maize. Environmental sensing by the cAMP/PKA pathway regulates the production of key virulence traits in C. neoformans including the polysaccharide capsule and melanin. For U. maydis, the pathway controls the dimorphic transition from budding growth to the filamentous cell type required for proliferation in plant tissue. We discuss recent advances in identifying new components of the cAMP/PKA pathway in these pathogens and highlight an emerging theme that pathway signaling influences iron acquisition.

Citations

Citations to this article as recorded by

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens
Veronica Teresa Ober, George Boniface Githure, Yuri Volpato Santos, Sidney Becker, Gabriel Moya Munoz, Jérôme Basquin, Frank Schwede, Esben Lorentzen, Michael Boshart
eLife.2024;[Epub] CrossRef
Disruption of the pkac2 gene in Pleurotus ostreatus alters cell wall structures and enables mycelial dispersion in liquid culture
Yuitsu Otsuka, Moriyuki Kawauchi, Kai Yoshizawa, Saori Endo, Kim Schiphof, Kenya Tsuji, Akira Yoshimi, Chihiro Tanaka, Shigekazu Yano, Vladimir Elisashvili, Takehito Nakazawa, Toshikazu Irie, Yoichi Honda
FEMS Microbiology Letters.2024;[Epub] CrossRef
Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens
Veronica Teresa Ober, George Boniface Githure, Yuri Volpato Santos, Sidney Becker, Gabriel Moya Munoz, Jérôme Basquin, Frank Schwede, Esben Lorentzen, Michael Boshart
eLife.2024;[Epub] CrossRef
How temperature modulates the expression of pathogenesis-related molecules of the cross-kingdom pathogen Lasiodiplodia hormozganensis
Carina Félix, Rodrigo Meneses, Micael F.M. Gonçalves, Ana S. Duarte, Jesus V. Jorrín-Novo, Yves van de Peer, Dieter Deforce, Filip Van Nieuwerburgh, Artur Alves, Ana C. Esteves
Science of The Total Environment.2024; 927: 171917. CrossRef
The Ras small GTPase RSR1 regulates cellulase production in Trichoderma reesei
Ni Li, Zhouyuan Qiu, Wanchuan Cai, Yaling Shen, Dongzhi Wei, Yumeng Chen, Wei Wang
Biotechnology for Biofuels and Bioproducts.2023;[Epub] CrossRef
Small GTPases RasA and RasB regulate development, patulin production, and virulence of Penicillium expansum
Yuanyuan Zong, Xuemei Zhang, Di Gong, Feng Zhang, Lirong Yu, Yang Bi, Edward Sionov, Dov Prusky
Postharvest Biology and Technology.2023; 197: 112192. CrossRef
A Novel FYVE Domain-Containing Protein Kinase, PsZFPK1, Plays a Critical Role in Vegetative Growth, Sporangium Formation, Oospore Production, and Virulence in Phytophthora sojae
Binglu Ru, Xinchang Hao, Wenhao Li, Qin Peng, Jianqiang Miao, Xili Liu
Journal of Fungi.2023; 9(7): 709. CrossRef
Connecting Cryptococcal Meningitis and Gut Microbiome
Yuanyuan Ma, Liang Yang, Mengna Jiang, Xinyuan Zhao, Peng Xue
International Journal of Molecular Sciences.2023; 24(17): 13515. CrossRef
Transcriptomic and Metabolomic Analyses Provide Insights into the Pathogenic Mechanism of the Rice False Smut Pathogen Ustilaginoidea virens
Rongtao Fu, Jian Wang, Cheng Chen, Yao Liu, Liyu Zhao, Daihua Lu
International Journal of Molecular Sciences.2023; 24(13): 10805. CrossRef
Squalene Monooxygenase Gene SsCI80130 Regulates Sporisorium scitamineum Mating/Filamentation and Pathogenicity
Yichang Cai, Yi Zhang, Han Bao, Jiaoyun Chen, Jianwen Chen, Wankuan Shen
Journal of Fungi.2022; 8(5): 470. CrossRef
Iron Deprivation Modulates the Exoproteome in Paracoccidioides brasiliensis
Aparecido Ferreira de Souza, Laurine Lacerda Pigosso, Lana O’Hara Souza Silva, Italo Dany Cavalcante Galo, Juliano Domiraci Paccez, Kleber Santiago Freitas e Silva, Milton Adriano Pelli de Oliveira, Maristela Pereira, Célia Maria de Almeida Soares
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Secretion of the siderophore rhizoferrin is regulated by the cAMP-PKA pathway and is involved in the virulence of Mucor lusitanicus
Viridiana Alejandre-Castañeda, J. Alberto Patiño-Medina, Marco I. Valle-Maldonado, Rosa E. Nuñez-Anita, Gustavo Santoyo, Karla V. Castro-Cerritos, Rafael Ortiz-Alvarado, Alma R. Corrales-Escobosa, Martha I. Ramírez-Díaz, J. Felix Gutiérrez-Corona, Adolfo
Scientific Reports.2022;[Epub] CrossRef
Adenylyl Cyclase and Protein Kinase A Play Redundant and Distinct Roles in Growth, Differentiation, Antifungal Drug Resistance, and Pathogenicity of Candida auris
Ji-Seok Kim, Kyung-Tae Lee, Myung Ha Lee, Eunji Cheong, Yong-Sun Bahn, James W. Kronstad
mBio.2021;[Epub] CrossRef
Signaling pathways involved in virulence and stress response of plant-pathogenic Fusarium species
Łukasz Stępień, Justyna Lalak-Kańczugowska
Fungal Biology Reviews.2021; 35: 27. CrossRef
Comparative Proteomic Analysis within the Developmental Stages of the Mushroom White Hypsizygus marmoreus
Xiuqing Yang, Rongmei Lin, Kang Xu, Lizhong Guo, Hao Yu
Journal of Fungi.2021; 7(12): 1064. CrossRef
Genome-Wide Analysis of Nutrient Signaling Pathways Conserved in Arbuscular Mycorrhizal Fungi
Xiaoqin Zhou, Jiangyong Li, Nianwu Tang, Hongyun Xie, Xiaoning Fan, Hui Chen, Ming Tang, Xianan Xie
Microorganisms.2021; 9(8): 1557. CrossRef
Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1
Enping Cai, Shuquan Sun, Yizhen Deng, Peishen Huang, Xian Sun, Yuting Wang, Changqing Chang, Zide Jiang
Journal of Fungi.2021; 7(8): 610. CrossRef
Current status on the molecular biology of zearalenone: its biosynthesis and molecular detection of zearalenone producing Fusarium species
Sahar Nahle, André El Khoury, Ali Atoui
European Journal of Plant Pathology.2021; 159(2): 247. CrossRef
The heterotrimeric G‐protein beta subunit Gpb1 controls hyphal growth under low oxygen conditions through the protein kinase A pathway and is essential for virulence in the fungusMucor circinelloides
Marco Iván Valle‐Maldonado, José Alberto Patiño‐Medina, Carlos Pérez‐Arques, Nancy Yadira Reyes‐Mares, Irvin Eduardo Jácome‐Galarza, Rafael Ortíz‐Alvarado, Sandeep Vellanki, Martha Isela Ramírez‐Díaz, Soo Chan Lee, Victoriano Garre, Víctor Meza‐Carmen
Cellular Microbiology.2020;[Epub] CrossRef
Defects in the Ferroxidase That Participates in the Reductive Iron Assimilation System Results in Hypervirulence in Botrytis Cinerea
Esteban Vasquez-Montaño, Gustavo Hoppe, Andrea Vega, Consuelo Olivares-Yañez, Paulo Canessa, B. Gillian Turgeon
mBio.2020;[Epub] CrossRef
Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans
Yuan-Hong Li, Tong-Bao Liu
International Journal of Molecular Sciences.2020; 21(4): 1361. CrossRef
Life Cycle ofCryptococcus neoformans
Youbao Zhao, Jianfeng Lin, Yumeng Fan, Xiaorong Lin
Annual Review of Microbiology.2019; 73(1): 17. CrossRef
The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans
Mélissa Caza, James W. Kronstad
Frontiers in Cellular and Infection Microbiology.2019;[Epub] CrossRef
The AGC Kinase SsAgc1 Regulates Sporisorium scitamineum Mating/Filamentation and Pathogenicity
Yixu Wang, Yi Zhen Deng, Guobing Cui, Chengwei Huang, Bin Zhang, Changqing Chang, Zide Jiang, Lian-Hui Zhang, Aaron P. Mitchell
mSphere.2019;[Epub] CrossRef
Induction of signal transduction pathways related to the pathogenicity of Cryptococcus neoformans in the host environment
Yasuhiko Matsumoto, Saki Azami, Haruka Shiga, Tae Nagamachi, Hikari Moriyama, Yuki Yamashita, Asami Yoshikawa, Takashi Sugita
Drug Discoveries & Therapeutics.2019; 13(4): 177. CrossRef
A multi-omics analysis of the grapevine pathogen Lasiodiplodia theobromae reveals that temperature affects the expression of virulence- and pathogenicity-related genes
Carina Félix, Rodrigo Meneses, Micael F. M. Gonçalves, Laurentijn Tilleman, Ana S. Duarte, Jesus V. Jorrín-Novo, Yves Van de Peer, Dieter Deforce, Filip Van Nieuwerburgh, Ana C. Esteves, Artur Alves
Scientific Reports.2019;[Epub] CrossRef
cAMP/PKA signalling pathway regulates redox homeostasis essential for Sporisorium scitamineum mating/filamentation and virulence
Changqing Chang, Enping Cai, Yi Zhen Deng, Dan Mei, Shanxu Qiu, Baoshan Chen, Lian‐Hui Zhang, Zide Jiang
Environmental Microbiology.2019; 21(3): 959. CrossRef
Cloning and disruption of the UeArginase in Ustilago esculenta: evidence for a role of arginine in its dimorphic transition
Yafen Zhang, Min Wu, Qianwen Ge, Mengfei Yang, Wenqiang Xia, Haifeng Cui, Xiaoping Yu, Shangfa Zhang, Zihong Ye
BMC Microbiology.2019;[Epub] CrossRef
Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus
Jing Wang, Yabing Chen, Zhangpeng Chen, Zou Xiang, Jie Ding, Xiaodong Han
Ecotoxicology and Environmental Safety.2018; 163: 391. CrossRef
Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides
Samuel T Coradetti, Dominic Pinel, Gina M Geiselman, Masakazu Ito, Stephen J Mondo, Morgann C Reilly, Ya-Fang Cheng, Stefan Bauer, Igor V Grigoriev, John M Gladden, Blake A Simmons, Rachel B Brem, Adam P Arkin, Jeffrey M Skerker
eLife.2018;[Epub] CrossRef
Signaling pathways governing iron homeostasis in budding yeast
Telma S. Martins, Vítor Costa, Clara Pereira
Molecular Microbiology.2018; 109(4): 422. CrossRef
The PKR regulatory subunit of protein kinase A (PKA) is involved in the regulation of growth, sexual and asexual development, and pathogenesis in Fusarium graminearum
Chaoqun Li, Yonghui Zhang, Huan Wang, Lingfeng Chen, Ju Zhang, Manli Sun, Jin‐Rong Xu, Chenfang Wang
Molecular Plant Pathology.2018; 19(4): 909. CrossRef
Biosynthetic mechanism and regulation of zearalenone in Fusarium graminearum
Jung-Eun Kim, Hokyoung Son, Yin-Won Lee
JSM Mycotoxins.2018; 68(1): 1. CrossRef
Introducing fluorescence resonance energy transfer-based biosensors for the analysis of cAMP-PKA signalling in the fungal pathogenCandida glabrata
Liesbeth Demuyser, Wouter Van Genechten, Hideaki Mizuno, Sonia Colombo, Patrick Van Dijck
Cellular Microbiology.2018; 20(10): e12863. CrossRef
Production of triterpenoids from Ganoderma lucidum : Elicitation strategy and signal transduction
Li Gu, Yimei Zheng, Danhong Lian, Xin Zhong, Xin Liu
Process Biochemistry.2018; 69: 22. CrossRef
A P4-ATPase subunit of the Cdc50 family plays a role in iron acquisition and virulence inCryptococcus neoformans
Guanggan Hu, Mélissa Caza, Erik Bakkeren, Matthias Kretschmer, Gaurav Bairwa, Ethan Reiner, James Kronstad
Cellular Microbiology.2017; 19(6): e12718. CrossRef
mRNA decay: an adaptation tool for the environmental fungal pathogen Cryptococcus neoformans
Amanda L. M. Bloom, Jay Leipheimer, John C. Panepinto
WIREs RNA.2017;[Epub] CrossRef
Iron acquisition in fungal pathogens of humans
Gaurav Bairwa, Won Hee Jung, James W. Kronstad
Metallomics.2017; 9(3): 215. CrossRef
When green and red mycology meet: Impressions from an interdisciplinary forum on virulence mechanisms of phyto- and human-pathogenic fungi
Yidong Yu, Bernhard Hube, Jörg Kämper, Vera Meyer, Sven Krappmann
Virulence.2017; 8(7): 1435. CrossRef
The Cell Biology of the Trichosporon-Host Interaction
Cláudio Duarte-Oliveira, Fernando Rodrigues, Samuel M. Gonçalves, Gustavo H. Goldman, Agostinho Carvalho, Cristina Cunha
Frontiers in Cellular and Infection Microbiology.2017;[Epub] CrossRef
Opposing PKA and Hog1 signals control the post‐transcriptional response to glucose availability in Cryptococcus neoformans
Dithi Banerjee, Amanda L. M. Bloom, John C. Panepinto
Molecular Microbiology.2016; 102(2): 306. CrossRef
Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef
Roles of Rack1 Proteins in Fungal Pathogenesis
Xue Zhang, Rashmi Jain, Guotian Li
BioMed Research International.2016; 2016: 1. CrossRef

Research Support, Non-U.S. Gov'ts

Functional properties of the major outer membrane protein in Stenotrophomonas maltophilia: Yih-Yuan Chen , Han-Chiang Wu , Juey-Wen Lin , Shu-Fen Weng; J. Microbiol. 2015;53(8):535-543. Published online July 31, 2015; DOI: https://doi.org/10.1007/s12275-015-5202-5

48 View
0 Download
5 Crossref

Abstract

Stenotrophomonas maltophilia is an opportunistic pathogen that is closely associated with high morbidity and mortality in debilitated and immunocompromised individuals. Therefore, to investigate the pathogenesis mechanism is urgently required. However, there are very few studies to evaluate the functional properties of outer membrane protein, which may contribute to the pathogenesis in S. maltophilia. In this study, three abundant proteins in the outer membrane fraction of S. maltophilia were identified by liquid chromatography- tandem mass spectrometry as OmpW1, MopB, and a hypothetical protein. MopB, a member of the OmpA family, was firstly chosen for functional investigation in this study because many OmpA-family proteins are known to be involved in pathogenesis and offer potential as vaccines. Membrane fractionation analyses demonstrated that MopB was indeed the most abundant outer membrane protein (OMP) in S. maltophilia. For functional studies, the mopB mutant of S. maltophilia (SmMopB) was constructed by insertional mutation. MopB deficiency resulted in a change in the protein composition of OMPs and altered the architecture of the outer membrane. The SmMopB strain exhibited reduced cytotoxicity toward L929 fibroblasts and was more sensitive to numerous stresses, including human serum, sodium dodecyl sulfate, and hydrogen peroxide compared with wildtype S. maltophilia. These results suggest that MopB may be a good candidate for the design of vaccines or anti-MopB drugs for controlling serious nosocomial infections of multidrug- resistant S. maltophilia, especially in immunosuppressed patients.

Citations

Citations to this article as recorded by

σ P -NagA-L1/L2 Regulatory Circuit Involved in ΔompA 299-356 -Mediated Increase in β-Lactam Susceptibility in Stenotrophomonas maltophilia
Li-Hua Li, Cheng-Mu Wu, Chia-Lun Chang, Hsin-Hui Huang, Chao-Jung Wu, Tsuey-Ching Yang, Silvia T. Cardona
Microbiology Spectrum.2022;[Epub] CrossRef
Advances in the Microbiology of Stenotrophomonas maltophilia
Joanna S. Brooke
Clinical Microbiology Reviews.2021;[Epub] CrossRef
Recombinant Ax21 protein is a promising subunit vaccine candidate against Stenotrophomonas maltophilia in a murine infection model
Amal Tarek Sarhan, Mohammed Bahey-El-Din, Taha Ibrahim Zaghloul
Vaccine.2021; 39(32): 4471. CrossRef
Intranasal immunization with recombinant outer membrane protein A induces protective immune response against Stenotrophomonas maltophilia infection
Yan Li, Xueping Tang, Zunquan Zhao, Hui Wang, Xin Wang, Xueyi Shang, Peng Liu, Zhihua Kou, Yongqiang Jiang, Yan Li, Daniela Flavia Hozbor
PLOS ONE.2019; 14(4): e0214596. CrossRef
The Major Outer Membrane Protein MopB Is Required for Twitching Movement and Affects Biofilm Formation and Virulence in Two Xylella fastidiosa strains
Hongyu Chen, Prem P. Kandel, Luisa F. Cruz, Paul A. Cobine, Leonardo De La Fuente
Molecular Plant-Microbe Interactions®.2017; 30(11): 896. CrossRef

Morphological changes in human gastric epithelial cells induced by nuclear targeting of Helicobacter pylori urease subunit A: Jung Hwa Lee , So Hyun Jun , Jung-Min Kim , Seung Chul Baik , Je Chul Lee; J. Microbiol. 2015;53(6):406-414. Published online May 30, 2015; DOI: https://doi.org/10.1007/s12275-015-5085-5

52 View
0 Download
15 Crossref

Abstract

Nuclear targeting of bacterial proteins and their pathological effects on host cells are an emerging pathogenic mechanism in bacteria. We have previously reported that urease subunit A (UreA) of Helicobacter pylori targets the nuclei of COS-7 cells through nuclear localization signals (NLSs). This study further investigated whether UreA of H. pylori targets the nuclei of gastric epithelial cells and then induces molecular and cellular changes in the host cells. H. pylori 26695 strain produced and secreted outer membrane vesicles (OMVs). UreA was translocated into gastric epithelial AGS cells through outer membrane vesicles (OMVs) and then targeted the nuclei of AGS cells. Nuclear targeting of rUreA did not induce host cell death, but resulted in morphological changes, such as cellular elongation, in AGS cells. In contrast, AGS cells treated with rUreAΔNLS proteins did not show this morphological change. Next generation sequencing revealed that nuclear targeting of UreA differentially regulated 102 morphogenesis- related genes, of which 67 and 35 were up-regulated and down-regulated, respectively. Our results suggest that nuclear targeting of H. pylori UreA induces both molecular and cellular changes in gastric epithelial cells.

Citations

Citations to this article as recorded by

Effects of Exosomes Derived From Helicobacter pylori Outer Membrane Vesicle-Infected Hepatocytes on Hepatic Stellate Cell Activation and Liver Fibrosis Induction
Masoumeh Ebadi Zahmatkesh, Mariyeh Jahanbakhsh, Negin Hoseini, Saina Shegefti, Amir Peymani, Hossein Dabin, Rasoul Samimi, Shahin Bolori
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Significance of Helicobacter pylori and Its Serological Typing in Gastric Cancer
碧玉张
Advances in Clinical Medicine.2022; 12(12): 11694. CrossRef
Rational Development of Bacterial Ureases Inhibitors
Saurabh Loharch, Łukasz Berlicki
The Chemical Record.2022;[Epub] CrossRef
Emerging therapeutic targets for gastric cancer from a host-Helicobacter pylori interaction perspective
Esmat Abdi, Saeid Latifi-Navid, Fatemeh Abedi Sarvestani, Mohammad Hassan Esmailnejad
Expert Opinion on Therapeutic Targets.2021; 25(8): 685. CrossRef
Non-enzymatic properties of Proteus mirabilis urease subunits
Valquiria Broll, Ana Paula A. Perin, Fernanda C. Lopes, Anne Helene S. Martinelli, Natalia R. Moyetta, Leonardo L. Fruttero, Matheus V.C. Grahl, Augusto F. Uberti, Diogo R. Demartini, Rodrigo Ligabue-Braun, Celia R. Carlini
Process Biochemistry.2021; 110: 263. CrossRef
Nuclear trafficking of bacterial effector proteins
Lena Hoang My Le, Le Ying, Richard L. Ferrero
Cellular Microbiology.2021;[Epub] CrossRef
Proteus mirabilis Urease: Unsuspected Non-Enzymatic Properties Relevant to Pathogenicity
Matheus V. C. Grahl, Augusto F. Uberti, Valquiria Broll, Paula Bacaicoa-Caruso, Evelin F. Meirelles, Celia R. Carlini
International Journal of Molecular Sciences.2021; 22(13): 7205. CrossRef
Helicobacter pylori Outer Membrane Vesicles and Extracellular Vesicles from Helicobacter pylori-Infected Cells in Gastric Disease Development
María Fernanda González, Paula Díaz, Alejandra Sandoval-Bórquez, Daniela Herrera, Andrew F. G. Quest
International Journal of Molecular Sciences.2021; 22(9): 4823. CrossRef
Tracking the cargo of extracellular symbionts into host tissues with correlated electron microscopy and nanoscale secondary ion mass spectrometry imaging
Stephanie K. Cohen, Marie‐Stéphanie Aschtgen, Jonathan B. Lynch, Sabrina Koehler, Fangmin Chen, Stéphane Escrig, Jean Daraspe, Edward G. Ruby, Anders Meibom, Margaret McFall‐Ngai
Cellular Microbiology.2020;[Epub] CrossRef
Role of Probiotics in Prophylaxis of Helicobacter pylori Infection
Kashyapi Chakravarty, Smriti Gaur
Current Pharmaceutical Biotechnology.2019; 20(2): 137. CrossRef
Helicobacter pylori: molecular basis for colonization and survival in gastric environment and resistance to antibiotics. A short review
Sharmila Fagoonee, Rinaldo Pellicano
Infectious Diseases.2019; 51(6): 399. CrossRef
Cross‐Reactivity of Polyclonal Antibodies against Canavalia ensiformis (Jack Bean) Urease and Helicobacter pylori Urease Subunit A Fragments
Zbigniew Jerzy Kaminski, Inga Relich, Iwona Konieczna, Wieslaw Kaca, Beata Kolesinska
Chemistry & Biodiversity.2018;[Epub] CrossRef
Ureases: Historical aspects, catalytic, and non-catalytic properties – A review
Karine Kappaun, Angela Regina Piovesan, Celia Regina Carlini, Rodrigo Ligabue-Braun
Journal of Advanced Research.2018; 13: 3. CrossRef
The Impact of Helicobacter pylori Urease upon Platelets and Consequent Contributions to Inflammation
Adriele Scopel-Guerra, Deiber Olivera-Severo, Fernanda Staniscuaski, Augusto F. Uberti, Natália Callai-Silva, Natália Jaeger, Bárbara N. Porto, Celia R. Carlini
Frontiers in Microbiology.2017;[Epub] CrossRef
A New Role for Helicobacter pylori Urease: Contributions to Angiogenesis
Deiber Olivera-Severo, Augusto F. Uberti, Miguel S. Marques, Marta T. Pinto, Maria Gomez-Lazaro, Céu Figueiredo, Marina Leite, Célia R. Carlini
Frontiers in Microbiology.2017;[Epub] CrossRef

Review

Against friend and foe: Type 6 effectors in plant-associated bacteria: Choong-Min Ryu; J. Microbiol. 2015;53(3):201-208. Published online March 3, 2015; DOI: https://doi.org/10.1007/s12275-015-5055-y

56 View
0 Download
31 Crossref

Abstract

Bacterial secretion systems play critical roles in communication with neighboring bacteria and in the modulation of host immune responses via the secretion of small proteins called effectors. Several secretion systems have been identified and these are denoted types I-II. Of these, the type VI secretion system (T6SS) and its effectors were only recently elucidated. Most studies on the role and significance of the T6SS and its effectors have focused on human pathogens. In this review, type 6 effectors from plant-associated beneficial and pathogenic bacteria are discussed, including effectors from Agrobacterium tumefaciens, Dickeya dadanti, Rhizobium leguminosarum, Pectobacterium atroseptium, Ralstonia solanacearum, Pseudomonas syringae, Pseudomonas fluorescens, and Pseudomonas protegens. Type 6 effectors act in symbiosis, biofilm formation, virulence, and interbacterial competition. Understanding the impact of type 6 effectors on pathogenesis will contribute to the management of bacterial pathogens in crop plants by allowing the manipulation of intra and inter-specific interactions.

Citations

Citations to this article as recorded by

Adapting the inoculation methods of kiwifruit canker disease to identify efficient biocontrol bacteria from branch microbiome
Xiaolong Shao, Qianhua Wu, Li Li, Weimei He, Xueting He, Dongjin Cheng, Aprodisia Murero, Long Lin, Limin Wang, Caihong Zhong, Lili Huang, Guoliang Qian
Molecular Plant Pathology.2024;[Epub] CrossRef
Identification of non‐canonical antagonistic bacteria via interspecies contact‐dependent killing
Long Lin, Min Tao, Wei‐Mei He, Qian‐Hua Wu, Hao‐Kai Huang, Aprodisia Kavutu Murero, Xiao‐Long Shao, Li‐Min Wang, Guo‐Liang Qian
Pest Management Science.2024; 80(8): 3997. CrossRef
Microbiota in a long survival discourse with the human host
Joseph A. Ayariga, Iddrisu Ibrahim, Logan Gildea, James Abugri, Robert Villafane
Archives of Microbiology.2023;[Epub] CrossRef
T6SS: A Key to Pseudomonas’s Success in Biocontrol?
Edwin D. Navarro-Monserrat, Christopher G. Taylor
Microorganisms.2023; 11(11): 2718. CrossRef
Disruption of the metC Gene Affects Methionine Biosynthesis in Pectobacterium carotovorum subsp. carotovorum Pcc21 and Reduces Soft-Rot Disease
Seonmi Yu, Jihee Kang, Eui-Hwan Chung, Yunho Lee
The Plant Pathology Journal.2023; 39(1): 62. CrossRef
Participation of type VI secretion system in plant colonization of phosphate solubilizing bacteria
Cinthia Tamara Lucero, Graciela Susana Lorda, Liliana Mercedes Ludueña, Fiorela Nievas, Pablo Cesar Bogino, Jorge Angelini, Mariela Lis Ambrosino, Tania Taurian
Rhizosphere.2022; 24: 100582. CrossRef
The Bradyrhizobium Sp. LmicA16 Type VI Secretion System Is Required for Efficient Nodulation of Lupinus Spp.
L. Tighilt, F. Boulila, B. F. S. De Sousa, E. Giraud, T. Ruiz-Argüeso, J. M. Palacios, J. Imperial, L. Rey
Microbial Ecology.2022; 84(3): 844. CrossRef
High-resolution spatial and genomic characterization of coral-associated microbial aggregates in the coral Stylophora pistillata
Naohisa Wada, Ming-Tsung Hsu, Kshitij Tandon, Silver Sung-Yun Hsiao, Hsing-Ju Chen, Yu-Hsiang Chen, Pei-Wen Chiang, Sheng-Ping Yu, Chih-Ying Lu, Yu-Jing Chiou, Yung-Chi Tu, Xuejiao Tian, Bi-Chang Chen, Der-Chuen Lee, Hideyuki Yamashiro, David G. Bourne, S
Science Advances.2022;[Epub] CrossRef
Agronomic efficiency and genome mining analysis of the wheat-biostimulant rhizospheric bacterium Pseudomonas pergaminensis sp. nov. strain 1008T
Marisa Díaz, Teresa Bach, Gustavo González Anta, Betina Agaras, Daniel Wibberg, Fabián Noguera, Wilter Canciani, Claudio Valverde
Frontiers in Plant Science.2022;[Epub] CrossRef
Auxin Plays Multiple Roles during Plant–Pathogen Interactions
Barbara N. Kunkel, Joshua M.B. Johnson
Cold Spring Harbor Perspectives in Biology.2021; 13(9): a040022. CrossRef
A Call for Research: A Resource of Core Microbial Symbionts of the Arabidopsis thaliana Microbiome Ready and Awaiting Experimental Exploration
Kenneth Dumack, Melanie Sapp, Tiemo von Steimker, Anna Tatjana Mänz, Laura Ellen Rose, Michael Bonkowski
Phytobiomes Journal.2021; 5(3): 362. CrossRef
Reciprocal adaptation of rice and Xanthomonas oryzae pv. oryzae: cross-species 2D GWAS reveals the underlying genetics
Fan Zhang, Zhiqiang Hu, Zhichao Wu, Jialing Lu, Yingyao Shi, Jianlong Xu, Xiyin Wang, Jinpeng Wang, Fan Zhang, Mingming Wang, Xiaorong Shi, Yanru Cui, Casiana Vera Cruz, Dalong Zhuo, Dandan Hu, Min Li, Wensheng Wang, Xiuqin Zhao, Tianqing Zheng, Binying F
The Plant Cell.2021; 33(8): 2538. CrossRef
Full Issue PDF

Phytobiomes Journal.2021; 5(3): 249. CrossRef
The Azospirillum brasilense type VI secretion system promotes cell aggregation, biocontrol protection against phytopathogens and attachment to the microalgae Chlorella sorokiniana
Fabricio D. Cassan, Anahí Coniglio, Edgar Amavizca, Guillermo Maroniche, Eric Cascales, Yoav Bashan, Luz E. de‐Bashan
Environmental Microbiology.2021; 23(10): 6257. CrossRef
Protective role of the Arabidopsis leaf microbiota against a bacterial pathogen
Christine M. Vogel, Daniel B. Potthoff, Martin Schäfer, Niculò Barandun, Julia A. Vorholt
Nature Microbiology.2021; 6(12): 1537. CrossRef
Xenorhabdus bovienii strain jolietti uses a type 6 secretion system to kill closely related Xenorhabdus strains
Rebecca M Kochanowsky, Christine Bradshaw, Isabel Forlastro, S Patricia Stock
FEMS Microbiology Ecology.2020;[Epub] CrossRef
Secretion Systems of Bacterial Phytopathogens and Mutualists (Review)
L. A. Lomovatskaya, A. S. Romanenko
Applied Biochemistry and Microbiology.2020; 56(2): 115. CrossRef
Two Functionally Deviating Type 6 Secretion Systems Occur in the Nitrogen-Fixing Endophyte Azoarcus olearius BH72
Xun Jiang, Andreas Beust, Praveen K. Sappa, Uwe Völker, Theresa Dinse, Julia Herglotz, Barbara Reinhold-Hurek
Frontiers in Microbiology.2019;[Epub] CrossRef
The phytopathogenic nature of Dickeya aquatica 174/2 and the dynamic early evolution of Dickeya pathogenicity
Alexandre Duprey, Najwa Taib, Simon Leonard, Tiffany Garin, Jean‐Pierre Flandrois, William Nasser, Céline Brochier‐Armanet, Sylvie Reverchon
Environmental Microbiology.2019; 21(8): 2809. CrossRef
Bioinformatic Analysis of the Type VI Secretion System and Its Potential Toxins in the Acinetobacter Genus
Guillermo D. Repizo, Martín Espariz, Joana L. Seravalle, Suzana P. Salcedo
Frontiers in Microbiology.2019;[Epub] CrossRef
The Type VI secretion system of Rhizobium etli Mim1 has a positive effect in symbiosis
Alvaro Salinero-Lanzarote, Alba Pacheco-Moreno, Lucía Domingo-Serrano, David Durán, Ernesto Ormeño-Orrillo, Esperanza Martínez-Romero, Marta Albareda, José Manuel Palacios, Luis Rey
FEMS Microbiology Ecology.2019;[Epub] CrossRef
Convergent Evolution in Intracellular Elements: Plasmids as Model Endosymbionts
Anne-Kathrin Dietel, Martin Kaltenpoth, Christian Kost
Trends in Microbiology.2018; 26(9): 755. CrossRef
In vivo TssA proximity labelling during type VI secretion biogenesis reveals TagA as a protein that stops and holds the sheath
Yoann G. Santin, Thierry Doan, Régine Lebrun, Leon Espinosa, Laure Journet, Eric Cascales
Nature Microbiology.2018; 3(11): 1304. CrossRef
The roles of auxin during interactions between bacterial plant pathogens and their hosts
Barbara N Kunkel, Christopher P Harper
Journal of Experimental Botany.2018; 69(2): 245. CrossRef
Genome-Wide Analysis of Type VI System Clusters and Effectors in Burkholderia Species
Thao Thi Nguyen, Hyun-Hee Lee, Inmyoung Park, Young-Su Seo
The Plant Pathology Journal.2018; 34(1): 11. CrossRef
An Alternative Nested Reading Frame May Participate in the Stress-Dependent Expression of a Plant Gene
Ekaterina V. Sheshukova, Tatiana V. Komarova, Natalia M. Ershova, Anastasia V. Shindyapina, Yuri L. Dorokhov
Frontiers in Plant Science.2017;[Epub] CrossRef
Role of the type VI secretion systems during disease interactions of Erwinia amylovora with its plant host
Tim Kamber, Joël F. Pothier, Cosima Pelludat, Fabio Rezzonico, Brion Duffy, Theo H. M. Smits
BMC Genomics.2017;[Epub] CrossRef
Mutations in Two Paraburkholderia phymatum Type VI Secretion Systems Cause Reduced Fitness in Interbacterial Competition
Samanta Bolzan de Campos, Martina Lardi, Alessia Gandolfi, Leo Eberl, Gabriella Pessi
Frontiers in Microbiology.2017;[Epub] CrossRef
Metal homeostasis in bacteria: the role of ArsR–SmtB family of transcriptional repressors in combating varying metal concentrations in the environment
Rudra P. Saha, Saikat Samanta, Surajit Patra, Diganta Sarkar, Abinit Saha, Manoj Kumar Singh
BioMetals.2017; 30(4): 459. CrossRef
Toxin-Antitoxin Systems: Implications for Plant Disease
T. Shidore, L.R. Triplett
Annual Review of Phytopathology.2017; 55(1): 161. CrossRef
The Plant Microbiota: Systems-Level Insights and Perspectives
Daniel B. Müller, Christine Vogel, Yang Bai, Julia A. Vorholt
Annual Review of Genetics.2016; 50(1): 211. CrossRef

Research Support, Non-U.S. Gov't

Pneumococcal wall teichoic acid is required for the pathogenesis of Streptococcus pneumoniae in murine models: Hongmei Xu , Libin Wang , Jian Huang , Yanqing Zhang , Feng Ma , Jianmin Wang , Wenchun Xu , Xuemei Zhang , Yibing Yin , Kaifeng Wu; J. Microbiol. 2015;53(2):147-154. Published online January 28, 2015; DOI: https://doi.org/10.1007/s12275-015-4616-4

47 View
0 Download
4 Crossref

Abstract

Pneumococcal asymptomatic colonization of the respiratory tracts is a major risk for invasive pneumococcal disease. We have previously shown that pneumococcal wall teichoic acid (WTA) was involved in pneumococcal infection of sepsis and adherence to epithelial and endothelial cells. In this study, we investigated the contribution of pneumococcal WTA to bacterial colonization and dissemination in murine models. The result showed that nasopharynx colonizing D39 bacterial cells have a distinct phenotype showing an increased exposure of teichoic acids relative to medium-grown bacteria. The WTA-deficient mutants were impaired in their colonization to the nasopharynx and lungs, and led to a mild inflammation in the lungs at 36 h post-inoculation. Pretreatment of the murine nares with WTA reduced the ability of wild type D39 bacteria to colonize the nasopharynx. In addition, the WTA-deficient strain was impaired in its ability to invade the blood and brain following intranasal administration. WTA-deficient D39 strain was reduced in C3 deposition but was more susceptible to the killing by the neutrophils as compared with its parent strain. Our results also demonstrated that the WTA enhanced pneumococcal colonization and dissemination independently of the host strains. These results indicate that WTA plays an important role in pneumococcal pathogenesis, both in colonization and dissemination processes.

Citations

Citations to this article as recorded by

Insight into the structure, biosynthesis, isolation method and biological function of teichoic acid in different gram-positive microorganisms: A review
Jiarun Han, Xin Zhao, Xilian Zhao, Ping Li, Qing Gu
International Journal of Biological Macromolecules.2023; 253: 126825. CrossRef
spd1672, a novel in vivo-induced gene, affects inflammatory response in a murine model of Streptococcus pneumoniae infection
Lingling Gan, Xuemei Zhang, Xiuyu Xu, Wenchun Xu, Chang Lu, Jin Cui, Hong Wang
Canadian Journal of Microbiology.2018; 64(6): 401. CrossRef
Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
Nathalie Heß, Franziska Waldow, Thomas P. Kohler, Manfred Rohde, Bernd Kreikemeyer, Alejandro Gómez-Mejia, Torsten Hain, Dominik Schwudke, Waldemar Vollmer, Sven Hammerschmidt, Nicolas Gisch
Nature Communications.2017;[Epub] CrossRef
New chemical tools to probe cell wall biosynthesis in bacteria
Robert T Gale, Eric D Brown
Current Opinion in Microbiology.2015; 27: 69. CrossRef

Review

REVIEW] The Role of Type III Secretion System 2 in Vibrio parahaemolyticus Pathogenicity: Hyeilin Ham , Kim Orth; J. Microbiol. 2012;50(5):719-725. Published online November 4, 2012; DOI: https://doi.org/10.1007/s12275-012-2550-2

36 View
0 Download
46 Scopus

Abstract: Vibrio parahaemolyticus, a Gram-negative marine bacterial pathogen, is emerging as a major cause of food-borne illnesses worldwide due to the consumption of raw seafood leading to diseases including gastroenteritis, wound infection, and septicemia. The bacteria utilize toxins and type III secretion system (T3SS) to trigger virulence. T3SS is a multi-subunit needle-like apparatus used to deliver bacterial proteins, termed effectors, into the host cytoplasm which then target various eukaryotic signaling pathways. V. parahaemolyticus carries two T3SSs in each of its two chromosomes, named T3SS1 and T3SS2, both of which play crucial yet distinct roles during infection: T3SS1 causes cytotoxicity whereas T3SS2 is mainly associated with enterotoxicity. Each T3SS secretes a unique set of effectors that contribute to virulence by acting on different host targets and serving different functions. Emerging studies on T3SS2 of V. parahaemolyticus, reveal its regulation, translocation, discovery, characterization of its effectors, and development of animal models to understand the enterotoxicity. This review on recent findings for T3SS2 of V. parahaemolyticus highlights a novel mechanism of invasion that appears to be conserved by other marine bacteria.

Research Support, Non-U.S. Gov'ts

NOTE] Biological and Genetic Properties of SA14-14-2, a Live-Attenuated Japanese Encephalitis Vaccine That Is Currently Available for Humans: Byung-Hak Song , Gil-Nam Yun , Jin-Kyoung Kim , Sang-Im Yun , Young-Min Lee; J. Microbiol. 2012;50(4):698-706. Published online August 25, 2012; DOI: https://doi.org/10.1007/s12275-012-2336-6

34 View
0 Download
28 Scopus

Abstract: Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is a major cause of acute encephalitis, a disease of significance for global public health. In the absence of antiviral therapy to treat JEV infection, vaccination is the most effective method of preventing the disease. In JE-endemic areas, the most widely used vaccine to date is SA14-14-2, a live-attenuated virus derived from its virulent parent SA14. In this study, we describe the biological properties of SA14-14-2, both in vitro and in vivo, and report the genetic characteristics of its genomic RNA. In BHK-21 (hamster kidney) cells, SA14-14-2 displayed a slight delay in plaque formation and growth kinetics when compared to a virulent JEV strain, CNU/LP2, with no decrease in maximum virus production. The delay in viral growth was also observed in two other cell lines, SH-SY5Y (human neuroblastoma) and C6/36 (mosquito larva), which are potentially relevant to JEV pathogenesis and transmission. In 3-week-old ICR mice, SA14-14-2 did not cause any symptoms or death after either intracerebral or peripheral inoculation with a maximum dose of up to 1.5×103 plaqueforming units (PFU) per mouse. The SA14-14-2 genome consisted of 10977 nucleotides, one nucleotide longer than all the previously reported genomes of SA14-14-2, SA14 and two other SA14-derived attenuated viruses. This difference was due to an insertion of one G nucleotide at position 10701 in the 3' noncoding region. Also, we noted a significant number of nucleotide and/or amino acid substitutions throughout the genome of SA14-14-2, except for the prM protein-coding region, that differed from SA14 and/or the other two attenuated viruses. Our results, together with others’, provide a foundation not only for the study of JEV virulence but also for the development of new and improved vaccines for JEV.

Replication and Pathogenesis of the Pandemic (H1N1) 2009 Influenza Virus in Mammalian Models: Donghyok Kwon , Kyeongcheol Shin , Seungtae Kim , Yooncheol Ha , Jang-Hoon Choi , Jeong Seon Yang , Joo-Yeon Lee , Chanhee Chae , Hee-Bok Oh , Chun Kang; J. Microbiol. 2010;48(5):657-662. Published online November 3, 2010; DOI: https://doi.org/10.1007/s12275-010-0120-z

33 View
0 Download
19 Scopus

Abstract: This study aimed to characterize the replication and pathogenic properties of a Korean pandemic (H1N1) 2009 influenza virus isolate in ferrets and mice. Ferrets infected with A/Korea/01/2009 (H1N1) virus showed mild clinical signs. The virus replicated well in lungs and slightly in brains with no replication in any other organs. Severe bronchopneumonia and thickening of alveolar walls were detected in the lungs. Viral antigens were detected in the bronchiolar epithelial cells, in peribronchial glands with severe peribronchitis and in cells present in the alveoli. A/Korea/01/2009 (H1N1) virus-infected mice showed weight loss and pathological lung lesions including perivascular cuffing, interstitial pneumonia and alveolitis. The virus replicated highly in the lungs and slightly in the nasal tissues. Viral antigens were detected in bronchiolar epithelial cells, pneumocytes and interstitial macrophages. However, seasonal H1N1 influenza virus did not replicate in the lungs of ferrets, and viral antigens were not detected. Thus, this Korean pandemic (H1N1) 2009 isolate infected the lungs of ferrets and mice successfully and caused more pathological lesions than did the seasonal influenza virus.

First
Prev
Page of 2
Next
Last

Search