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- Molecular genomic characterization of severe fever with thrombocytopenia syndrome virus isolates from South Korea
- Yu Jung Won , Lae Hyung Kang , Sung Geun Lee , Seung Won Park , Jae Ik Han , Soon Young Paik
- J. Microbiol. 2019;57(10):927-937. Published online August 3, 2019
- DOI: https://doi.org/10.1007/s12275-019-9174-8
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- 7 Crossref
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Abstract
- Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne emerging infectious disease caused by the SFTS virus (SFTSV) and is a threat to public health due to its high fatality rate. However, details on tick-to-human transmission of SFTSV are limited. In this study, we determined the wholegenome sequence of a South Korean SFTSV strain (CUKJJ01), compared it to those of other recent human SFTSV isolates, and identified the genetic variations and relationships among the SFTSV strains. The genome of CUK-JJ01 was consistent with the genome of other members of the genus Phlebovirus, including the large (L), medium (M), and small (S) segments of 6368, 3378, and 1744 nucleotides, respectively. Based on amino acid sequences of the M and S segments, which are used to distinguish the six SFTSV genotypes, CUK-JJ01 was classified as genotype B. Segment analysis revealed that the L, M, and S segments were 97.49%, 97.18%, and 97.94% similar to those of KAJNH2/2013/ Korea, ZJZHSH-FDE/2012/China, and KADGH/2013/Korea, respectively. Currently, only few studies on SFTSV have been conducted in Korean population and most were limited to serological analysis. Although the present study has limitations in terms of number of sample analyzed, the findings may serve as basis to understand the transmission and spread of SFTSV, as well as for the development of diagnostic and detection methods for viral recombinants by comparing the whole genome sequence of SFTSV isolates from South Korea and that of foreign isolates.
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Citations
Citations to this article as recorded by
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Journal of Clinical Virology Plus.2024; 4(3): 100188. CrossRef - Multiple Genotypes and Reassortants of Severe Fever With Thrombocytopenia Syndrome Virus Co‐Circulating in Hangzhou in Southeastern China, 2013–2023
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Journal of Medical Virology.2024;[Epub] CrossRef - Genetic Diversity, Regional Distribution, and Clinical Characteristics of Severe Fever with Thrombocytopenia Syndrome Virus in Gangwon Province, Korea, a Highly Prevalent Region, 2019–2021
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Parasites & Vectors.2022;[Epub] CrossRef - Analysis of cross neutralizing activity of antibodies from sera of severe fever with thrombocytopenia syndrome patients to deal with different genotype strains
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Frontiers in Microbiology.2022;[Epub] CrossRef - Development of a real-time loop-mediated isothermal amplification method for the detection of severe fever with thrombocytopenia syndrome virus
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Journal of Microbiology.2020; 58(8): 711. CrossRef
- Circulation of tick-borne pathogens in wildlife of the Republic of Korea
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