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- Fecal Microbiota Transplantation: Indications, Methods, and Challenges.
- Jee Young Lee, Yehwon Kim, Jiyoun Kim, Jiyeun Kate Kim
- J. Microbiol. 2024;62(12):1057-1074. Published online November 18, 2024
- DOI: https://doi.org/10.1007/s12275-024-00184-3
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- 1 Web of Science
- 4 Crossref
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Abstract
- Over the past two decades, as the importance of gut microbiota to human health has become widely known, attempts have been made to treat diseases by correcting dysbiosis of gut microbiota through fecal microbiota transplantation (FMT). Apart from current knowledge of gut microbiota, FMT to treat disease has a long history, from the treatment of food poisoning in the fourth century to the treatment of Clostridioides difficile infections in the twentieth century. In 2013, FMT was recognized as a standard treatment for recurrent C. difficile because it consistently showed high efficacy. Though recurrent C. difficile is the only disease internationally recognized for FMT efficacy, FMT has been tested for other diseases and shown some promising preliminary results. Different FMT methods have been developed using various formulations and administration routes. Despite advances in FMT, some issues remain to be resolved, such as donor screening, manufacturing protocols, and unknown components in the fecal microbiota. In this review, we discuss the mechanisms, clinical indications, methods, and challenges of current FMT. We also discuss the development of alternative therapies to overcome the challenges of FMT.
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Citations
Citations to this article as recorded by
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Applied Microbiology.2025; 5(1): 29. CrossRef - Management of refractory checkpoint inhibitor-induced colitis
Anas Zaher, Maria Julia Moura Nascimento Santos, Hassan Elsaygh, Stephen J. Peterson, Carolina Colli Cruz, Anusha Shirwaikar Thomas, Yinghong Wang
Expert Opinion on Drug Safety.2025; : 1. CrossRef - Fecal Microbiota Transplantation (FMT) in Clostridium difficile Infection: A Paradigm Shift in Gastrointestinal Microbiome Modulation
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Cureus.2025;[Epub] CrossRef - Exploring the gut microbiome’s influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies
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World Journal of Gastrointestinal Pharmacology and Therapeutics.2025;[Epub] CrossRef
- Transplantation of Fecal Flora from Patients with Atherosclerosis to Mice Can Increase Serum Low-Density Lipoprotein Cholesterol and Affect Intestinal Flora and Its Metabolites
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