Journal of Microbiology

Journal Articles

Silver Nanoparticles Modified with Polygonatum sibiricum Polysaccharide Improve Biocompatibility and Infected Wound Bacteriostasis: Ruonan Wang , Rongyu Li , Peng Zheng , Zicheng Yang , Cheng Qian , Zhou Wang , Senhe Qian; J. Microbiol. 2023;61(5):543-558. Published online April 13, 2023; DOI: https://doi.org/10.1007/s12275-023-00042-8

96 View
0 Download
12 Web of Science
10 Crossref

Silver nanoparticles (AgNPs) exhibit strong antibacterial activity and do not easily induce drug resistance; however, the poor stability and biocompatibility in solution limit their widespread application. In this study, AgNPs were modified with Polygonatum sibiricum Polysaccharide (PSP) to synthesize PSP@AgNPs with good stability, biocompatibility, and antibacterial activity. When PSP@AgNP synthesis was performed under a reaction time of 70 min, a reaction temperature of 35 °C, and an AgNO3- to-PSP volume ratio of 1:1, the synthesized PSP@AgNPs were more regular and uniform than AgNPs, and their particle size was around 10 nm. PSP@AgNPs exhibited lower cytotoxicity and hemolysis, and stronger bacteriostatic activity. PSP@AgNPs damage the integrity and internal structure of cells, resulting in the leakage of intracellular nucleic acids and proteins. The rate of cell membrane damage in Escherichia coli and Staphylococcus aureus treated with PSP@ AgNPs increased by 38.52% and 43.75%, respectively, compared with that of AgNPs. PSP@AgNPs inhibit the activities of key enzymes related to antioxidant, energy and substance metabolism in cells. The inhibitory effects on the activities of superoxide dismutase (SOD), catalase (CAT), adenosine triphosphate enzyme (ATPase), malate dehydrogenase (MDH), and succinate dehydrogenase (SDH) in E. coli and S. aureus cells were significantly higher than those of AgNPs. In addition, compared with AgNPs, PSP@AgNPs promote faster healing of infected wounds. Therefore, PSP@AgNPs represent potential antibacterial agents against wound infections.

Citations

Citations to this article as recorded by

Fabrication of Highly Stable Polyurushiol-Decorated Silver Nanoparticles and Evaluation of Their Antibacterial and Anti-Microalgae Activities
Lu Zheng, Jide Zhu, Jipeng Chen, Yanlian Xu, Lilong Jiang
Journal of Inorganic and Organometallic Polymers and Materials.2025; 35(1): 570. CrossRef
Preparation, Structure, Function, and Application of Dietary Polysaccharides from Polygonatum sibiricum in the Food Industry: A Review
Peilin Li, Huimin Yao, Hao Yue, Jiali Huang, Qi Wang, Chuanbo Ding, Lina Ma, Xinglong Liu, Min Yang
Molecules.2025; 30(5): 1098. CrossRef
Improving the biocompatibility and antibacterial efficacy of silver nanoparticles functionalized with (LLRR)3 antimicrobial peptide
Rongyu Li, Jiaqing Mao, Peng Zheng, Ruonan Wang, Zicheng Yang, Senhe Qian
World Journal of Microbiology and Biotechnology.2024;[Epub] CrossRef
Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles
J. Nandhini, E. Karthikeyan, E. Elizabeth Rani, V.S. Karthikha, D. Sakthi Sanjana, H. Jeevitha, S. Rajeshkumar, Vijayan Venugopal, A. Priyadharshan
Engineered Regeneration.2024; 5(3): 306. CrossRef
Effect of Polygonatum sibiricum on biological toxicity of zinc oxide nanoparticles during respiratory exposure
Jingjing Yao, Wanqing Yang, Liang Tang, Dicheng Yang, Yan Xu, Shenmin Zhu, Jun Zhu
RSC Advances.2024; 14(43): 31360. CrossRef
Enhancing Healing of Infected Wounds with Glycerin‐Modified Sodium Alginate/Silk Sericin Composite Film Functionalized with Polygonatum sibiricum Polysaccharide‐Capped Silver Nanoparticles
Zicheng Yang, Rongyu Li, Ruonan Wang, Senhe Qian
ChemistrySelect.2024;[Epub] CrossRef
Host Defense Peptides: Exploiting an Innate Immune Component Against Infectious Diseases and Cancer
Taiwo Scholes Adewole, Oladiran Boniface Oladokun, Adenike Kuku
International Journal of Peptide Research and Therapeutics.2024;[Epub] CrossRef
Research progress on medicinal components and pharmacological activities of polygonatum sibiricum
Ruilian Liu, Xili Zhang, Yuhan Cai, Shuang Xu, Qian Xu, Chengli Ling, Xin Li, Wenjiao Li, Pingan Liu, Wenlong Liu
Journal of Ethnopharmacology.2024; 328: 118024. CrossRef
A comprehensive review on the potential applications of medicine Polygonatum species in the food sector
Mi Li, Bingzong Xie, Lewen Li, Yunge Zhang, Qingmin Chen, Jian Ju, Yanli Ma
Food Bioscience.2024; 60: 104116. CrossRef
Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review
Xiao Tang, Li Li, Gehang You, Xinyi Li, Jian Kang
Frontiers in Bioengineering and Biotechnology.2023;[Epub] CrossRef

Antibiofilm effect of biofilm-dispersing agents on clinical isolates of Pseudomonas aeruginosa with various biofilm structures: Soo-Kyoung Kim , Xi-Hui Li , Hyeon-Ji Hwang , Joon-Hee Lee; J. Microbiol. 2018;56(12):902-909. Published online October 25, 2018; DOI: https://doi.org/10.1007/s12275-018-8336-4

71 View
0 Download
6 Crossref

Abstract

Pseudomonas aeruginosa, an opportunistic human pathogen, causes many biofilm-mediated chronic infections. In this study, biofilm structures of various clinical strains of P. aeruginosa isolated from hospitalized patients were examined and their influence on the biofilm-dispersing effects of chemicals was investigated. The clinical isolates formed structurally distinct biofilms that could be classified into three different groups: 1) mushroom-like, 2) thin flat, and 3) thick flat structures. A dispersion of these differently structured biofilms was induced using two biofilm-dispersing agents, anthranilate and sodium nitroprusside (SNP). Although both SNP and anthranilate could disperse all types of biofilms, the thick flat biofilms were dispersed less efficiently than the biofilms of other structures. This suggests that biofilm-dispersing agents have higher potency on the biofilms of porous structures than on densely packed biofilms.

Citations

Citations to this article as recorded by

New insights into antimicrobial and antibiofilm effects of edible mushrooms
Ashaimaa Y. Moussa, Shaimaa Fayez, Hang Xiao, Baojun Xu
Food Research International.2022; 162: 111982. CrossRef
Modified poly(L-lysine)-based structures as novel antimicrobials for diabetic foot infections, an in-vitro study
Alicia Grace, Robert Murphy, Aoife Dillon, Diarmuid Smith, Sally-Ann Cryan, Andreas Heise, Deirdre Fitzgerald-Hughes
HRB Open Research.2022; 5: 4. CrossRef
Anthranilate Acts as a Signal to Modulate Biofilm Formation, Virulence, and Antibiotic Tolerance of Pseudomonas aeruginosa and Surrounding Bacteria
Hyeon-Ji Hwang, Xi-Hui Li, Soo-Kyoung Kim, Joon-Hee Lee, Cezar M. Khursigara
Microbiology Spectrum.2022;[Epub] CrossRef
Early plaque formation on PTFE membranes with expanded or dense surface structures applied in the oral cavity of human volunteers
Alberto Turri, Emina Čirgić, Furqan A. Shah, Maria Hoffman, Omar Omar, Christer Dahlin, Margarita Trobos
Clinical and Experimental Dental Research.2021; 7(2): 137. CrossRef
Antipathogenic Compounds That Are Effective at Very Low Concentrations and Have Both Antibiofilm and Antivirulence Effects against Pseudomonas aeruginosa
Hyeon-Ji Hwang, Heejeong Choi, Sojeong Hong, Hyung Ryong Moon, Joon-Hee Lee, Amanda G. Oglesby
Microbiology Spectrum.2021;[Epub] CrossRef
Thermoregulation of Pseudomonas aeruginosa Biofilm Formation
Suran Kim, Xi-Hui Li, Hyeon-Ji Hwang, Joon-Hee Lee, Danilo Ercolini
Applied and Environmental Microbiology.2020;[Epub] CrossRef

A murine colitis model developed using a combination of dextran sulfate sodium and Citrobacter rodentium: Jin-Il Park , Sun-Min Seo , Jong-Hyung Park , Hee-Yeon Jeon , Jun-Young Kim , Seung-Hyun Ryu , Yang-Kyu Choi; J. Microbiol. 2018;56(4):272-279. Published online April 2, 2018; DOI: https://doi.org/10.1007/s12275-018-7504-x

70 View
0 Download
7 Crossref

Abstract

Adult mice were treated with dextran sulfate sodium (DSS) and infected with Citrobacter rodentium for developing a novel murine colitis model. C57BL/6N mice (7-week-old) were divided into four groups. Each group composed of control, dextran sodium sulfate-treated (DSS), C. rodentiuminfected (CT), and DSS-treated and C. rodentium-infected (DSS-CT) mice. The DSS group was administered 1% DSS in drinking water for 7 days. The CT group was supplied with normal drinking water for 7 days and subsequently infected with C. rodentium via oral gavage. The DSS-CT group was supplied with 1% DSS in drinking water for 7 days and subsequently infected with C. rodentium via oral gavage. The mice were sacrificed 10 days after the induction of C. rodentium infection. The DSS-CT group displayed significantly shorter colon length, higher spleen to body weight ratio, and higher histopathological score compared to the other three groups. The mRNA expression levels of tumor necrosis factor (TNF)-α and interferon (INF)-γ were significantly upregulated; however, those of interleukin (IL)-6 and IL-10 were significantly downregulated in the DSS-CT group than in the control group. These results demonstrated that a combination of low DSS concentration (1%) and C. rodentium infection could effectively induce inflammatory bowel disease (IBD) in mice. This may potentially be used as a novel IBD model, in which colitis is induced in mice by the combination of a chemical and a pathogen.

Citations

Citations to this article as recorded by

Compound Xuejie Preparation Improved Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Mitigating Inflammation-Induced Damage and Downregulating TNF-α Expression
M.M. Yajiao Zhao, M.D. Lin Jin, M.M. Xiaolong Yuan, M.D. Xiaochuan Liu, M.M. Guiming Zang
International Journal of Pharmacology.2024; 20(4): 652. CrossRef
Development of a novel complex inflammatory bowel disease mouse model: Reproducing human inflammatory bowel disease etiologies in mice
Sun-Min Seo, Na-Won Kim, Eun-Seon Yoo, Ji-Hun Lee, Ah-Reum Kang, Han-Bi Jeong, Won-Yong Shim, Dong-Hyun Kim, Young-Jun Park, Kieun Bae, Kyong-Ah Yoon, Yang-Kyu Choi, Pradeep Dudeja
PLOS ONE.2024; 19(11): e0311310. CrossRef
Protective Role of the Toll-Like Receptor 5 Agonist KMRC011 against Murine Colitis Induced by Citrobacter rodentium and Dextran Sulfate Sodium
Jun-Young Kim, Sun-Min Seo, Han-Woong Kim, Woo-Jong Lee, Yang-Kyu Choi
Journal of Microbiology and Biotechnology.2023; 33(1): 35. CrossRef
The inhibition of HACE1 ameliorates inflammatory responses in citrobacter rodentium-induced murine colitis through Nrf2/ NLRP3 signaling pathway
Ting QIU, Lu NIU, Yu ZHANG, Yifei LV
Food Science and Technology.2023;[Epub] CrossRef
Association between intestinal microbiota and inflammatory bowel disease
Yunchang Zhang, Xuemeng Si, Ling Yang, Hui Wang, Ye Sun, Ning Liu
Animal Models and Experimental Medicine.2022; 5(4): 311. CrossRef
Noni juice-fortified yogurt mitigates dextran sodium sulfate-induced colitis in mice through the modulation of inflammatory cytokines
So-Hee Kwon, Damini Kothari, Hae-In Jung, Jeong-Min Lim, Woong-Lae Kim, Hyuk-Cheol Kwon, Sung-Gu Han, Sun-Min Seo, Yang-Kyu Choi, Soo-Ki Kim
Journal of Functional Foods.2021; 86: 104652. CrossRef
Probiotic Bacillus cereus Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice through Improvement of the Intestinal Barrier Function, Anti-Inflammation, and Gut Microbiota Modulation
Kangliang Sheng, Yifan Xu, Xiaowei Kong, Jingmin Wang, Xiangdong Zha, Yongzhong Wang
Journal of Agricultural and Food Chemistry.2021; 69(49): 14810. CrossRef

A lactic acid bacterium isolated from kimchi ameliorates intestinal inflammation in DSS-induced colitis: Jin-Soo Park , Inseong Joe , Paul Dong Rhee , Choon-Soo Jeong , Gajin Jeong; J. Microbiol. 2017;55(4):304-310. Published online January 26, 2017; DOI: https://doi.org/10.1007/s12275-017-6447-y

73 View
0 Download
47 Crossref

Abstract

Some species of lactic acid bacteria have been shown to be beneficial in inflammatory bowel disease (IBD). In the pre-sent study, a strain of lactic acid bacterium (Lactobacillus paracasei LS2) was isolated from the Korean food, kimchi, and was shown to inhibit the development of experimental colitis induced by dextran sulfate sodium (DSS). To inves-tigate the role of LS2 in IBD, mice were fed DSS in drinking water for seven days along with LS2 bacteria which were administered intragastrically to some of the mice, while phos-phate-buffered saline (PBS) was administered to others (the controls). The administration of LS2 reduced body weight loss and increased survival, and disease activity indexes (DAI) and histological scores indicated that the severity of colitis was significantly reduced. The production of inflammatory cy-tokines and myeloperoxidase (MPO) activity also decreased. Flow cytometry analysis showed that the number of Th1 (IFN-γ) population cells was significantly reduced in the LS2- administered mice compared with the controls. The admini-stration of LS2 induced the increase of CD4+FOXP3+ Treg cells, which are responsible for IL-10. Numbers of macro-phages (CD11b+ F4/80+), and neutrophils (CD11b+ Gr-1+) among lamina propria lymphocytes (LPL) were also reduced. These results indicate that LS2 has an anti-inflammatory effect and ameliorates DSS-induced colitis.

Citations

Citations to this article as recorded by

Effects of psychological stress on inflammatory bowel disease via affecting the microbiota–gut–brain axis
Yuhan Chen, Xiaofen Chen, Suqin Lin, Shengjun Huang, Lijuan Li, Mingzhi Hong, Jianzhou Li, Lili Ma, Juan Ma
Chinese Medical Journal.2025; 138(6): 664. CrossRef
The key quorum sensing gene luxS in Lactobacillus acidophilus CICC 6074 and Lactobacillus helveticus R0052 mediates organic acid production and promotes protein hydrolysis in yogurt
Ruitong Zhang, Zihang Shi, Xiankang Fan, Tao Zhang, Maolin Tu, Zhen Wu, Xiaoqun Zeng, Weichen Bao, Bo Chen, Daodong Pan
Journal of Dairy Science.2025; 108(5): 4734. CrossRef
Galectin from Trichinella spiralis alleviates DSS-induced colitis in mice by regulating the intestinal microbiota
Jianqing Li, Xiangjiang Wang, Qiuhui Wang, Yishen Hu, Shouan Wang, Jia Xu, Jianbin Ye
Veterinary Research.2024;[Epub] CrossRef
Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food
Emanuelle Natalee Santos, Karina Teixeira Magalhães-Guedes, Fernando Elias de Melo Borges, Danton Diego Ferreira, Daniele Ferreira da Silva, Pietro Carlos Gonçalves Conceição, Ana Katerine de Carvalho Lima, Lucas Guimarães Cardoso, Marcelo Andrés Umsza-Gu
Foods.2024; 13(24): 4097. CrossRef
Effect of by BIOVITA 3 (a Blend of Three Probiotics) on Dextran Sulfate Sodium-Induced Colitis in Mice
Han Sol Choi, Dayoung Kim, Ye-Ji Jang, Jin Seok Moon, Ikhoon Oh
Food Supplements and Biomaterials for Health.2024;[Epub] CrossRef
Probiotic Lactiplantibacillus plantarum subsp. plantarum Dad-13 Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Through Short-Chain Fatty Acid Production and Inflammatory Cytokine Regulation
Rimba Bunga Pertiwi, Yosinta Christie Setiabudi, Yunika Mayangsari, Dian Anggraini Suroto, Endang Sutriswati Rahayu
Preventive Nutrition and Food Science.2024; 29(3): 270. CrossRef
Fermented foods and gastrointestinal health: underlying mechanisms
Arghya Mukherjee, Samuel Breselge, Eirini Dimidi, Maria L. Marco, Paul D. Cotter
Nature Reviews Gastroenterology & Hepatology.2024; 21(4): 248. CrossRef
Pasteurized form of a potential probiotic lactobacillus brevis IBRC-M10790 exerts anti-inflammatory effects on inflammatory bowel disease in vitro
Ardeshir Ebrahiminejad, Abbas Akhavan Sepahi, Abbas Yadegar, Anna Meyfour
BMC Complementary Medicine and Therapies.2024;[Epub] CrossRef
A Review of the Health Benefits of Kimchi Functional Compounds and Metabolites
Hyun Ju Kim, Min Sung Kwon, Hyelyeon Hwang, Ha-Sun Choi, WooJe Lee, Sang-Pil Choi, Haeun Jo, Sung Wook Hong
Microbiology and Biotechnology Letters.2023; 51(4): 353. CrossRef
Preventive therapeutic effect of Lactobacillus‐fermented black wolfberry juice on sodium dextran sulfate‐induced ulcerative colitis in mice
Ruilin Wei, Chen Zhu, Sheng Chen, Jingxin Wang, Zhikang Zeng, Lin Lan, Zaixing Sun, Ji Lei, Yufeng Li
Journal of Food Science.2023; 88(7): 3102. CrossRef
Are Fermented Foods Effective against Inflammatory Diseases?
Alok K. Paul, Chooi Ling Lim, Md. Aminul Islam Apu, Karma G. Dolma, Madhu Gupta, Maria de Lourdes Pereira, Polrat Wilairatana, Mohammed Rahmatullah, Christophe Wiart, Veeranoot Nissapatorn
International Journal of Environmental Research and Public Health.2023; 20(3): 2481. CrossRef
Comparative Genomic Analysis and Physiological Properties of Limosilactobacillus fermentum SMFM2017-NK2 with Ability to Inflammatory Bowel Disease
Sumin Ann, Yukyung Choi, Yohan Yoon
Microorganisms.2023; 11(3): 547. CrossRef
Sustained ameliorative effect of Lactobacillus acidophilus LA85 on dextran sulfate sodium‐induced colitis in mice
Mei Han, Wenyan Liao, Yao Dong, Teng Fei, Zhonghui Gai
Journal of Food Science.2023; 88(9): 3893. CrossRef
Multifunctional LPxTG‐motif surface protein derived from Limosilactobacillus reuteri SH 23 in DSS‐induced ulcerative colitis of mice
Manli Zong, Chun Chang, Rameesha Anjum, Hai Xu, Yuxing Guo, Daodong Pan, Zhen Wu
The FASEB Journal.2023;[Epub] CrossRef
High-degree polymerizate IMOs of dextranase hydrolysates enhance Lactobacillus acid metabolism: Based on growth, and metabolomic and transcriptomic analyses
Qianru Lin, Mingwang Liu, Hao Ni, Yue Hao, Yiqun Yu, Yiran Chen, Qing Wu, Yi Shen, Lei Zhang, Mingsheng Lyu, Shujun Wang
LWT.2023; 187: 115345. CrossRef
Kimchi and Leuconostoc mesenteroides DRC 1506 Alleviate Dextran Sulfate Sodium (DSS)-Induced Colitis via Attenuating Inflammatory Responses
Hye-Jung Moon, Suk-Heung Oh, Ki-Bum Park, Youn-Soo Cha
Foods.2023; 12(3): 584. CrossRef
A systematic review on selection characterization and implementation of probiotics in human health
Shreyasi Pramanik, Swethaa Venkatraman, Pothiyappan Karthik, Vinoth Kumar Vaidyanathan
Food Science and Biotechnology.2023; 32(4): 423. CrossRef
Chemical Composition and Sensory Profile of Sauerkraut from Different Cabbage Hybrids
Elena Yanchenko, Galina Volkova, Elena Kuksova, Ivan Virchenko, Aleksey Yanchenko, Elena Serba, Maria Ivanova
Food Processing: Techniques and Technology.2023; 53(1): 131. CrossRef
Effect of kimchi intake on body weight of general community dwellers: a prospective cohort study
Li-Juan Tan, Ye-Rang Yun, Sung Wook Hong, Sangah Shin
Food & Function.2023; 14(4): 2162. CrossRef
Latilactobacillus curvatus BYB3 Isolated from Kimchi Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice by Inhibiting IL-6 and TNF-R1 Production
Xing Wang, Dingyun Li, Ziyao Meng, Kiyeop Kim, Sejong Oh
Journal of Microbiology and Biotechnology.2022; 32(3): 348. CrossRef
Fermented foods: An update on evidence-based health benefits and future perspectives
Iñaki Diez-Ozaeta, Oihana Juaristi Astiazaran
Food Research International.2022; 156: 111133. CrossRef
Preventive and therapeutic aspects of fermented foods
Rwivoo Baruah, Mousumi Ray, Prakash M. Halami
Journal of Applied Microbiology.2022; 132(5): 3476. CrossRef
Lactobacillus plantarum strains attenuated DSS-induced colitis in mice by modulating the gut microbiota and immune response
Israr Khan, Junshu Wei, Anping Li, Zhirong Liu, Pingrong Yang, Yaping Jing, Xinjun Chen, Tang Zhao, Yanrui Bai, Lajia Zha, Chenhui Li, Naeem Ullah, Tuanjie Che, Chunjiang Zhang
International Microbiology.2022; 25(3): 587. CrossRef
Fermented products and bioactive food compounds as a tool to activate autophagy and promote the maintenance of the intestinal barrier function
Aleksandra Maria Kocot, Barbara Wróblewska
Trends in Food Science & Technology.2021; 118: 905. CrossRef
Serum Untargeted Metabolism Reveals the Mechanism of L. plantarum ZDY2013 in Alleviating Kidney Injury Induced by High-Salt Diet
Cuixiang Wan, Shufang Chen, Kui Zhao, Zhongyue Ren, Lingling Peng, Huiling Xia, Hua Wei, Bo Yu
Nutrients.2021; 13(11): 3920. CrossRef
Anti-Inflammatory and Immunomodulatory Properties of Fermented Plant Foods
Roghayeh Shahbazi, Farzaneh Sharifzad, Rana Bagheri, Nawal Alsadi, Hamed Yasavoli-Sharahi, Chantal Matar
Nutrients.2021; 13(5): 1516. CrossRef
Probiotic Lactobacilli Isolated from Kefir Promote Down-Regulation of Inflammatory Lamina Propria T Cells from Patients with Active IBD
Renata Curciarello, Karina E. Canziani, Ileana Salto, Emanuel Barbiera Romero, Andrés Rocca, Ivan Doldan, Emmanuel Peton, Santiago Brayer, Alicia M. Sambuelli, Silvina Goncalves, Pablo Tirado, Gustavo J. Correa, Martín Yantorno, Laura Garbi, Guillermo H.
Frontiers in Pharmacology.2021;[Epub] CrossRef
Recently Progressed Postbiotics as Nutraceuticals
Gajin Jeong
Food Supplements and Biomaterials for Health.2021;[Epub] CrossRef
Comparison of the Probiotic Potential between Lactiplantibacillus plantarum Isolated from Kimchi and Standard Probiotic Strains Isolated from Different Sources
Chang-Hee Jeong, Hyejin Sohn, Hyelyeon Hwang, Ho-Jae Lee, Tae-Woon Kim, Dong-Sub Kim, Chun-Sung Kim, Sung-Gu Han, Sung-Wook Hong
Foods.2021; 10(9): 2125. CrossRef
Goji berry juice fermented by probiotics attenuates dextran sodium sulfate-induced ulcerative colitis in mice
Yuxuan Liu, Haitian Fang, Huiyan Liu, Huan Cheng, Lin Pan, Mingzhen Hu, Xuyang Li
Journal of Functional Foods.2021; 83: 104491. CrossRef
Alleviating Gut Inflammation with Latilactobacillus curvatus Isolated from Kimchi
Subin Kim, Xing Wang, Sejong Oh
Trends in Agriculture & Life Sciences.2021; 59: 29. CrossRef
Unraveling microbial fermentation features in kimchi: from classical to meta-omics approaches
Se Hee Lee, Tae Woong Whon, Seong Woon Roh, Che Ok Jeon
Applied Microbiology and Biotechnology.2020; 104(18): 7731. CrossRef
Protective Effect of Prunus mume Fermented with Mixed Lactic Acid Bacteria in Dextran Sodium Sulfate-Induced Colitis
Jeong-Ho Kim, Yeong-Seon Won, Hyun-Dong Cho, Seong-Min Hong, Kwang-Deog Moon, Kwon-Il Seo
Foods.2020; 10(1): 58. CrossRef
Xanthoangelol Isolated from Angelica keiskei Roots Prevents Dextran Sulfate Sodium-Treated Colitis in Mice
Yoshiyuki Kimura, Kimye Baba
The Natural Products Journal.2020; 10(5): 655. CrossRef
Porphyromonas gingivalis and Lactobacillus rhamnosus GG regulate the Th17/Treg balance in colitis via TLR4 and TLR2
Lu Jia, Ruiqing Wu, Nannan Han, Jingfei Fu, Zhenhua Luo, Lijia Guo, Yingying Su, Juan Du, Yi Liu
Clinical & Translational Immunology.2020;[Epub] CrossRef
Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway
Ji Hyun Choi, Chang Mo Moon, Tae-Seop Shin, Eun Kyoung Kim, Andrea McDowell, Min-Kyung Jo, Yang Hee Joo, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim, Sung-Ae Jung, Yoon-Keun Kim
Experimental & Molecular Medicine.2020; 52(3): 423. CrossRef
Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis
Mi-Young Shin, Cheng-Chung Yong, Sejong Oh
Foods.2020; 9(7): 864. CrossRef
Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease
Eirini Dimidi, Selina Cox, Megan Rossi, Kevin Whelan
Nutrients.2019; 11(8): 1806. CrossRef
Human gut microbes are susceptible to antimicrobial food additives in vitro
Lucia Hrncirova, Tomas Hudcovic, Eliska Sukova, Vladimira Machova, Eva Trckova, Jan Krejsek, Tomas Hrncir
Folia Microbiologica.2019; 64(4): 497. CrossRef
Administration of Lactobacillus paracasei strains improves immunomodulation and changes the composition of gut microbiota leading to improvement of colitis in mice
Woon-Ki Kim, You Jin Jang, Boram Seo, Dae Hee Han, SungJun Park, GwangPyo Ko
Journal of Functional Foods.2019; 52: 565. CrossRef
Diets, functional foods, and nutraceuticals as alternative therapies for inflammatory bowel disease: Present status and future trends
Mohammad Al Mijan, Beong Ou Lim
World Journal of Gastroenterology.2018; 24(25): 2673. CrossRef
Isolation and Characterization of Potentially Probiotic Bacterial Strains from Mice: Proof of Concept for Personalized Probiotics
Larissa S. Celiberto, Roseli Aparecida Pinto, Elizeu Antonio Rossi, Bruce A. Vallance, Daniela C. U. Cavallini
Nutrients.2018; 10(11): 1684. CrossRef
Effect of Wildlife Access on Microbial Safety of Irrigation Water Used in the Cultivation of Chinese Cabbage in Goesan
Bohyun Yun, Sang-Jin Lim, Young-Chul Park, Nguyen Bao Hung, Daesoo Park, Won-Il Kim, Gyu Seok Jung, Hyeonheui Ham, Hyun Ju Kim, Kyoungyul Ryu, Se-Ri Kim
Journal of Food Hygiene and Safety.2018; 33(6): 447. CrossRef
IL‐35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells
Yuan Wang, Ying Mao, Junfeng Zhang, Gang Shi, Lin Cheng, Yi Lin, Yiming Li, Xiaomei Zhang, Yujing Zhang, Xiaolei Chen, Jie Deng, Xiaolan Su, Lei Dai, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei, Hongxin Deng
Journal of Cellular and Molecular Medicine.2018; 22(2): 1014. CrossRef
A probiotic complex, rosavin, zinc, and prebiotics ameliorate intestinal inflammation in an acute colitis mouse model
Jin-Sil Park, JeongWon Choi, Ji Ye Kwon, Kyung-Ah Jung, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
Journal of Translational Medicine.2018;[Epub] CrossRef
Preventative effects of Lactobacillus plantarum YS-3 on oxazolone-induced BALB/c colitis in mice
Xia Feng, Jing Zhang, Yu Qian, Ruokun Yi, Peng Sun, Jianfei Mu, Xin Zhao, Jia-Le Song
Applied Biological Chemistry.2018; 61(3): 355. CrossRef
A survey of research papers on the health benefits of kimchi and kimchi lactic acid bacteria
Bohkyung Kim, Eun-Gyung Mun, Doyeon Kim, Young Kim, Yongsoon Park, Hae-Jeung Lee, Youn-Soo Cha
Journal of Nutrition and Health.2018; 51(1): 1. CrossRef

Research Support, Non-U.S. Gov'ts

Molecular Cloning, Purification, and Characterization of a Superoxide Dismutase from a Fast-Growing Mycobacterium sp. Strain JC1 DSM 3803: Ji-Sun Nam , Jee-Hyun Yoon , Hyun-Il Lee , Si Wouk Kim , Young-Tae Ro; J. Microbiol. 2011;49(3):399-406. Published online June 30, 2011; DOI: https://doi.org/10.1007/s12275-011-1046-9

53 View
0 Download
8 Scopus

Abstract: A cytosolic superoxide dismutase (SOD) was purified and characterized from a fast-growing Mycobacterium sp. strain JC1 DSM 3803 grown on methanol. The native molecular weight of the purified SOD was estimated to be 48 kDa. SDS-PAGE revealed a subunit of 23 kDa, indicating that the enzyme is a homodimer. The enzyme activity was inhibited by H2O2 and azide. The purified SOD contained 1.12 and 0.56 g-atom of Mn and Fe per mol of enzyme, respectively, suggesting that it may be a Fe/Mn cambialistic SOD. The apo-SOD reconstitution study revealed that Mn salts were more specific than Fe salts in the SOD activity. The gene encoding the SOD was identified from the JC1 cosmid genomic library by PCR screening protocol. The cloned gene, sodA, had an open reading frame (ORF) of 624 nt, encoding a protein with a calculated molecular weight of 22,930 Da and pI of 5.33. The deduced SodA sequence exhibited 97.6% identity with that of Mycobacterium fortuitum Mn-SOD and clustered with other mycobacterial Mn-SODs. A webtool analysis on the basis of SOD sequence and structure homologies predicted the SOD as a tetrameric Mn-SOD, suggesting that the protein is a dimeric Mn-SOD having tetramer-specific sequence and structure characteristics.

Molecular Cloning, Purification, and Characterization of a Novel, Acidic, pH-Stable Endoglucanase from Martelella mediterranea: Junli Dong , Yuzhi Hong , Zongze Shao , Ziduo Liu; J. Microbiol. 2010;48(3):393-398. Published online June 23, 2010; DOI: https://doi.org/10.1007/s12275-010-9361-0

33 View
0 Download
31 Scopus

Abstract: A novel gene encoding an endoglucanase designated Cel5D was cloned from a marine bacterium Martelella mediterranea by genomic library. The gene had a 1,113 bp opening reading frame encoding a 371-amino-acid protein with a molecular mass of 40,508 Da and containing a putative signal peptide (41 amino acids). Cel5D had low similarity (48-51% identity) with other known endoglucanases and consisted of one single catalytic domain, which belonged to the glycosyl hydrolase family 5. The maximum activity of Cel5D was observed at 60°C and pH 5.0. Cel5D displayed broad pH stability within the range of pH 3.0-11.0 and retained hydrolytic activity in the presence of a wide variety of metal ions and some chemical reagents. These characteristics suggest that the enzyme has considerable potential in industrial applications.

Iso-Superoxide Dismutase in Deinococcus grandis, a UV Resistant Bacterium: Na-Rae Yun , Young Nam Lee; J. Microbiol. 2009;47(2):172-177. Published online May 2, 2009; DOI: https://doi.org/10.1007/s12275-008-0221-0

53 View
0 Download
3 Scopus

Abstract: Deinococcus grandis possesses two types of superoxide dismutase (SOD, E. C. 1.15.1.1.) that show distinct electrophoretic behavior, one that migrates slowly and the other that migrates rapidly (SOD-1 and SOD-2, respectively). In this study, SOD-1 was uniformly and abundantly detected, regardless of growth phase, whereas SOD-2 was not detected during early growth, but was detectable from the exponential growth phase. In addition, a substantial increase in SOD-2 was observed in cells that were treated with potassium superoxide or UV, which suggests that SOD-2 is an inducible protein produced in response to stressful environments. Insensitivity of SOD-1 to both H2O2 and cyanide treatment suggests that SOD-1 is MnSOD. However, SOD-2 would be FeSOD, since it lost activity in response to H2O2 treatment, but not to cyanide. Localization studies of D. grandis iso-SODs in sucrose-shocked cells suggest that SOD-1 is a membrane-associated enzyme, whereas SOD-2 is a cytosolic enzyme. In conclusion, SOD-1 seems to be an essential constitutive enzyme for viability and SOD-2 appears to be an inducible enzyme that is probably critical for survival upon UV irradiation and oxidative stress.

Cloning, Expression, and Characterization of Thermostable Manganese Superoxide Dismutase from Thermoascus aurantiacus var. levisporus: Ning-Ning Song , Yan Zheng , Shi-Jin E , Duo-Chuan Li; J. Microbiol. 2009;47(1):123-130. Published online February 20, 2009; DOI: https://doi.org/10.1007/s12275-008-0217-9

40 View
0 Download
19 Crossref

Abstract

A superoxide dismutase (SOD) gene of Thermoascus aurantiacus var. levisporus, a thermophilic fungus, was cloned, sequenced, and expressed in Pichia pastoris and its gene product was characterized. The coding sequence predicted a 231 residues protein with a unique 35 amino acids extension at the N-terminus indicating a mitochondrial-targeting sequence. The content of Mn was 2.46 ug/mg of protein and Fe was not detected in the purified enzyme. The enzyme was found to be inhibited by NaN3, but not by KCN or H2O2. These results suggested that the SOD in Thermoascus aurantiacus var. levisporus was the manganese superoxide dismutase type. In comparison with other MnSODs, all manganese-binding sites were also conserved in the sequence (H88, H136, D222, H226). The molecular mass of a single band of the enzyme was estimated to be 21.7 kDa. The protein was expressed in tetramer form with molecular weight of 68.0 kDa. The activity of purified protein was 2,324 U/mg. The optimum temperature of the enzyme was 55oC and it exhibited maximal activity at pH 7.5. The enzyme was thermostable at 50 and 60oC and the half-life at 80oC was approximately 40 min.

Citations

Citations to this article as recorded by

Microbial Antioxidative Enzymes: Biotechnological Production and Environmental and Biomedical Applications
V. M. Songire, R. H. Patil
Applied Biochemistry and Microbiology.2025; 61(1): 1. CrossRef
Novel Thermostable Manganese Superoxide Dismutase from Alicyclobacillus sp. with High Specific Activity and Antioxidant Properties
Xihang Sun, Jinping Liu, Qianqian Ge, Yayun Jiang, Yi Xu, Yuying Li, Zhenping Hou, Pengjun Shi
Journal of Agricultural and Food Chemistry.2025; 73(10): 6010. CrossRef
Ca 2+ affects the hyphal differentiation to sclerotia formation of Athelia rolfsii
Kuan-Yu Pan, Hsien-Hao Liu, Min-Nan Tseng, Hao-Xun Chang, Matthew Zack Anderson
Microbiology Spectrum.2024;[Epub] CrossRef
Initial characterization of an iron superoxide dismutase from Thermobifida fusca
Anne Grethe Hamre, Rim Al-Sadawi, Kirsti Merete Johannesen, Bastien Bisarro, Åsmund Røhr Kjendseth, Hanna-Kirsti S. Leiros, Morten Sørlie
JBIC Journal of Biological Inorganic Chemistry.2023; 28(7): 689. CrossRef
Thermoacidophilic Alicyclobacillus Superoxide Dismutase: Good Candidate as Additives in Food and Medicine
Xueqian Dong, Wei Wang, Shannan Li, Hongyu Han, Peiwen Lv, Chunyu Yang
Frontiers in Microbiology.2021;[Epub] CrossRef
Characterisation of recombinant thermostable manganese-superoxide dismutase (NeMnSOD) from Nerium oleander
Rashmi Gangwar, Poonam Kumari, Apurva Chatrath, Ramasare Prasad
Molecular Biology Reports.2020; 47(5): 3251. CrossRef
Characteristics of a Novel Manganese Superoxide Dismutase of a Hadal Sea Cucumber (Paelopatides sp.) from the Mariana Trench
Yanan Li, Xue Kong, Haibin Zhang
Marine Drugs.2019; 17(2): 84. CrossRef
Two superoxide dismutases from TnOtchr are involved in detoxification of reactive oxygen species induced by chromate
Rita Branco, Paula V. Morais
BMC Microbiology.2016;[Epub] CrossRef
Cloning and characterization of a differentially expressed mitochondrial manganese superoxide dismutase gene from Pleurotus ostreatus
Chaomin Yin, Wenxian Zhao, Jihong Zhu, Liesheng Zheng, Liguo Chen, Aimin Ma
Annals of Microbiology.2015; 65(3): 1597. CrossRef
High-level Expression of a Manganese Superoxide Dismutase (PoMn-SOD) from Pleurotus ostreatus in Pichia pastoris
Chaomin Yin, Wenxia Zhao, Liesheng Zheng, Liguo Chen, Qi Tan, Xiaodong Shang, Aimin Ma
Applied Biochemistry and Biotechnology.2014; 174(1): 259. CrossRef
Cloning and characterization of a new manganese superoxide dismutase from deep-sea thermophile Geobacillus sp. EPT3
Yanbing Zhu, Guohong Wang, Hui Ni, Anfeng Xiao, Huinong Cai
World Journal of Microbiology and Biotechnology.2014; 30(4): 1347. CrossRef
A novel mechanism of protein thermostability: a unique N-terminal domain confers heat resistance to Fe/Mn-SODs
Wei Wang, Ting Ma, Baoliang Zhang, Nana Yao, Mingchang Li, Lianlei Cui, Guoqiang Li, Zhenping Ma, Jiansong Cheng
Scientific Reports.2014;[Epub] CrossRef
Purification and biochemical characterization of manganesecontaining superoxide dismutase from deep-sea thermophile Geobacillus sp. EPT3
Yanbing Zhu, Hebin Li, Hui Ni, Jingwen Liu, Anfeng Xiao, Huinong Cai
Acta Oceanologica Sinica.2014; 33(12): 163. CrossRef
High-level expression of a sika deer (Cervus nippon) Cu/Zn superoxide dismutase in Pichia pastoris and its characterization
Ren-Kuan Li, Cai-Li Fu, Ping Chen, Tzi Bun Ng, Xiu-Yun Ye
Environmental Toxicology and Pharmacology.2013; 35(2): 185. CrossRef
Conformational stability of recombinant manganese superoxide dismutase from the filamentous fungus Trichoderma reesei
Felipe S. Chambergo, Estela Y. Valencia, José Ribamar Ferreira-Júnior, César M. Camilo, Patricia T. Campana
International Journal of Biological Macromolecules.2012; 50(1): 19. CrossRef
Activity, thermostability and isozymes of superoxide dismutase in 17 edible mushrooms
Guang Yu Cheng, Jun Liu, Ming Xuan Tao, Chang Mei Lu, Guo Rong Wu
Journal of Food Composition and Analysis.2012; 26(1-2): 136. CrossRef
The basic and applied aspects of superoxide dismutase
Amit Bafana, Som Dutt, Arun Kumar, Sanjay Kumar, Paramvir S. Ahuja
Journal of Molecular Catalysis B: Enzymatic.2011; 68(2): 129. CrossRef
Cloning, Expression, and Characterization of Thermotolerant Manganese Superoxide Dismutase from Bacillus sp. MHS47
Supatra Areekit, Pornpimon Kanjanavas, Paisarn Khawsak, Arda Pakpitchareon, Kajeenart Potivejkul, Gaysorn Chansiri, Kosum Chansiri
International Journal of Molecular Sciences.2011; 12(1): 844. CrossRef
Expression of a novel thermostable Cu, Zn-superoxide dismutase from Chaetomium thermophilum in Pichia pastoris and its antioxidant properties
Li-Qing Zhang, Fang-Xian Guo, Hong-Quan Xian, Xiu-Juan Wang, An-Na Li, Duo-Chuan Li
Biotechnology Letters.2011; 33(6): 1127. CrossRef

Journal Article

In vitro Activity of Sodium Benzoate Against Clinically Relevant Enterococcus faecalis and Enterococcus faecium Isolates: Oguz Karabay , Esra Kocoglu , Nevin Ince , Tufan Sahan , Davut Ozdemir; J. Microbiol. 2006;44(1):129-131.; DOI: https://doi.org/2325 [pii]

40 View
0 Download

Abstract: The antimicrobial effects of sodium benzoate against Enterococcus faecalis and Enterococcus faecium were investigated. The MIC90 of sodium benzoate were 64 mg/L for E. faecalis and 32 mg/L for E. faecium, while the MBC90 were 128 mg/L and 64mg/L, respectively. Although further studies are required for clinical evidence, sodium benzoate seems to be effective against Enterococcus spp.

Increased Activities of SOD and Catalase on Aerobic Growth in Arcobacter nitrofigilis: Park, Young Bok , han, Yeong Hwan; J. Microbiol. 1997;35(3):239-240.

56 View
0 Download

Abstract: A free-living nitrogen fixing Arcobacter nitrofigilis exhibuted the typical characteristics of aerobic growth in which the maximal cell growth was shown under an ambient air atmospjere, whereas no cell growth was shown umder an anaerobic condition. When oxygen concentration was increased, the activities of SOD and catalase were increased. These suggest that the aerobic nature of A. nitrofigilis might be due to the increased levels of both enzymes that scavenge toxic forms of oxygen.

Molecular Cloning and Characterization of Mn-Superoxide Dismutase Gene from Candida sp.: Hong, Yun Mi , Nam, Yong Sik , Choi, Soon Yong; J. Microbiol. 1997;35(4):309-314.

51 View
0 Download

Abstract: The manganese-containing superoxide dismutase (MnSOD) is a major component of the cellular defence mechanisms against the toxic effects of the superoxide radical. Within the framework of studies on oxidative stress=responsible enzymes in the Candida sp., the gene encoding the MnSOD was isolated and examined in this study. A specific primer was designed based on conserved regions of MnSOD sequences from other organisms, and was used to isolate the gene by PCR on reverse-transcribed Candida poly(A^+) RNA. The PCR product was used to screen a Candida genomic lambda library and the nucleotide wequence of positive clone was determined. The deduced primary sequence encodes a 25kDa protein which has the conserved residues for enzyme activity and metal binding. The 28 N-terminal amino acids encoded by the Candida cDNA comprise a putatice mitochondrial transit peptide. Potential regulatory elements were identified in the 5' flanking sequences. Northern blot analysis showed that the transcription of the MnSOD gene is induced 5-to 10-fold in response to mercury, cadmium ions and hydrogen peroxide.

Response of CuZnSOD and HP1 conjugated gene in Escherichia coli double mutants to oxidative stress: Park, Hye Young , Kim, Young Gon; J. Microbiol. 1998;36(3):171-178.

56 View
0 Download

Abstract: In Escherichia coli, the counterbalances between superoxide dismutase (SOD) and hydroperoxidase are more important for overall sensitivity to oxidative stress such as paraquat (PQ, 0.1 mM), H_2O_2 (1mM), CuSO_4(0.1 mM), CuSO_4 and heat shock (37℃→42℃) than the level of either SOD or HP1 alone. To evaluate the relative coordinate defense, E. coli SOD and/or hydroperoxidase double mutants were transformed with plasmids expressing SOD^+HP1^-, SOD^-HP1^+ and SOD^-HP1^-, and their physiological response to oxidative stess was measured. SOD was found to be more important than hydroperoxide in preventing oxygen-mediated stress except for the case of H_2O_2 treatment in the presence of SOD. Nevertheless, a balance between both enzymes are necessary for an effective defense against oxygen mediated radicals. The average ratio of SOD:HP1 on activity of various E. coli strains under oxidative stress except copper sulphate treatment show about 1.4 in the wild type. When the ratio, however, was reversed in mutant cells encoded with Photobactrium leiognathi CuZnSOD gene, their sensitivities were more increased. This suggests that although HP1 could reduce the H_2O_2 or hydroxyl radicals, it also inhibited the SOD function against ixygen radicals.

Superoxide Dismutase Profiles in the Mesophilic Deinococcus Species: Young Sun Yun , Young Nam Lee; J. Microbiol. 2001;39(3):232-235.

48 View
0 Download

Abstract: Electrophoretic resolution of superoxide dismutase (SOD) from the highly UV-resistant bacteria, Deinococcus species revealed multiple forms of superoxide dismutases (SODs) in D. radiodurans, D. grandis, and D. proteolyticus, as judged from electrophoretic properties and metal cofactors. A single SOD occurred in both D. radiophilus and D. radiopugnans. Deinococcal SODs were either MnSOD, FeSOD or cambialistic Mn/FeSOD. The unique SOD profile of each mesophilic Deinococcus species, multiplicity and metal cofactors, would be valuable in identifying Deinococcus species.

Isolation and Characterization of the sod2+ Gene Encoding a Putative Mitochondrial Manganese Superoxide Dismutase in Schizosaccharomyces pombe: Jae-Hoon Jeong , Eun-Soo Kwon , Jung-Hye Roe; J. Microbiol. 2001;39(1):37-41.

55 View
0 Download

Abstract: The fission yeast Schizosaccharomyces pombe contains two distinct superoxide dismutase (SOD) activities, one in the cytosol encoded by the sod1+ gene and the other in mitochondria. The sod2+ gene encoding putative mitochondrial manganese superoxide dismutase (MnSOD) was isolated from the S. pombe genomic library using a PCR fragment as the probe. The nucleotide sequence of the sod2+ gene and its flanking region (4051 bp HindIII fragment) was determined. An intron of 123 nt in size was predicted and confirmed by sequencing the cDNA following reverse transcription PCR. The predicted Sod2p consists of 218 amino acid residues with a molecular mass of 24,346 Da. The deduced amino acid sequence showed a high degree of homology with other MnSODs, especially in the metal binding residues at the active site and their relative positions. The transcriptional start site was mapped by primer extension at 231 nt upstream from the ATG codon. A putative TATA box (TATAAAA) was located 58 nt upstream from the transcriptional start site and putative polyadenylation sites were located at 1000, 1062, and 1074 nt downstream from the ATG start codon.

Examination of the Antioxidant Potential of Pycnogenol under Conditions of Oxidative Stress in Escherichia coli Mutants Deficient in HP1 and Superoxide Dismutase Activities: Jeong A Youm , Young Gon Kim; J. Microbiol. 2003;41(1):28-33.

46 View
0 Download

Abstract: Pycnogenol (PYC) is believed to have potential as a therapeutic agent against free radical-mediated oxidative stress. It is important, therefore, to understand the interactions between PYC and cellular defenses against oxidative stress. Toward this end, we analyzed the survival rates on the gene expression responses of E. coli sod katG mutants to PYC after pre-treatment of PQ or H_2O_2-mediated stress under aerobic conditions. We identified SOD induced by PYC, but not HP1 in sod katG mutants. A striking result was the PYC induction of SOD with antioxidant property in single katG mutant cells, particularly MnSOD and CuZnSOD. These inductions were further increased with oxidative stress, while HP1 was not induced in these conditions. The effects of pycnogenol treatment on these cells depend in part on its concentration on the stress response. Protective effects of PYC exposure which affected gene expression in cells were consistent with cell survival rates. Our results demonstrate that pycnogenol may alter the stress response gene expression in a specific manner such as SoxRS because PYC induction of single mutant only worked under increased PQ stress. All together our data indicate that SOD activity is essential for the cellular defense against PQ-mediated oxidative stress, suggesting that PYC may not be effective as an antioxidant in only oxidative stress conditions. On the other hand, it was expected that PYC may play a role as a pro-oxidant and if it is available for use, it should be evaluated carefully.

First
Prev
Page of 1
Next
Last

Search