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- Assembly of Bacterial Surface Glycopolymers as an Antibiotic Target
- Hongbaek Cho
- J. Microbiol. 2023;61(3):359-367. Published online March 23, 2023
- DOI: https://doi.org/10.1007/s12275-023-00032-w
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- 4 Web of Science
- 4 Crossref
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Abstract
- Bacterial cells are covered with various glycopolymers such as peptidoglycan (PG), lipopolysaccharides (LPS), teichoic acids, and capsules. Among these glycopolymers, PG assembly is the target of some of our most effective antibiotics, consistent with its essentiality and uniqueness to bacterial cells. Biosynthesis of other surface glycopolymers have also been acknowledged as potential targets for developing therapies to control bacterial infections, because of their importance for bacterial survival in the host environment. Moreover, biosynthesis of most surface glycopolymers are closely related to PG assembly because the same lipid carrier is shared for glycopolymer syntheses. In this review, I provide an overview of PG assembly and antibiotics that target this pathway. Then, I discuss the implications of a common lipid carrier being used for assembly of PG and other surface glycopolymers in antibiotic development.
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Citations
Citations to this article as recorded by
- Diversity of sugar-diphospholipid-utilizing glycosyltransferase families
Ida K. S. Meitil, Garry P. Gippert, Kristian Barrett, Cameron J. Hunt, Bernard Henrissat
Communications Biology.2024;[Epub] CrossRef - Metalation of Extracytoplasmic Proteins and Bacterial Cell Envelope Homeostasis
Bixi He, John D. Helmann
Annual Review of Microbiology .2024; 78(1): 83. CrossRef - A hierarchical approach towards identification of novel inhibitors against L, D-transpeptidase YcbB as an anti-bacterial therapeutic target
Abdullah S. Alawam, Lina M. Alneghery, Maher S. Alwethaynani, Mubarak A. Alamri
Journal of Biomolecular Structure and Dynamics.2024; : 1. CrossRef - Bacterial Regulatory Mechanisms for the Control of Cellular Processes: Simple Organisms’ Complex Regulation
Jin-Won Lee
Journal of Microbiology.2023; 61(3): 273. CrossRef
- Diversity of sugar-diphospholipid-utilizing glycosyltransferase families
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