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Repeated Exposure of Vancomycin to Vancomycin-Susceptible Staphylococcus aureus (VSSA) Parent Emerged VISA and VRSA Strains with Enhanced Virulence Potentials: An Nguyen, J Jean Sophy Roy, Ji-Hoon Kim, Kyung-Hee Yun, Wonsik Lee, Kyeong Kyu Kim, Truc Kim, Akhilesh Kumar Chaurasia; J. Microbiol. 2024;62(7):535-553. Published online May 30, 2024; DOI: https://doi.org/10.1007/s12275-024-00139-8

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The emergence of resistance against the last-resort antibiotic vancomycin in staphylococcal infections is a serious concern for human health. Although various drug-resistant pathogens of diverse genetic backgrounds show higher virulence potential, the underlying mechanism behind this is not yet clear due to variability in their genetic dispositions. In this study, we investigated the correlation between resistance and virulence in adaptively evolved isogenic strains. The vancomycin-susceptible Staphylococcus aureus USA300 was exposed to various concentrations of vancomycin repeatedly as a mimic of the clinical regimen to obtain mutation(s)-accrued-clonally-selected (MACS) strains. The phenotypic analyses followed by expression of the representative genes responsible for virulence and resistance of MACS strains were investigated. MACS strains obtained under 2 and 8 µg/ml vancomycin, named Van2 and Van8, respectively; showed enhanced vancomycin minimal inhibitory concentrations (MIC) to 4 and 16 µg/ml, respectively. The cell adhesion and invasion of MACS strains increased in proportion to their MICs. The correlation between resistance and virulence potential was partially explained by the differential expression of genes known to be involved in both virulence and resistance in MACS strains compared to parent S. aureus USA300. Repeated treatment of vancomycin against vancomycin-susceptible S. aureus (VSSA) leads to the emergence of vancomycin-resistant strains with variable levels of enhanced virulence potentials.

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Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus
Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia, Kyeong Kyu Kim
Journal of Biomedical Science.2025;[Epub] CrossRef

Ten Novel Species Belonging to the Genus Flavobacterium, Isolated from Freshwater Environments: F. praedii sp. nov., F. marginilacus sp. nov., F. aestivum sp. nov., F. flavigenum sp. nov., F. luteolum sp. nov., F. gelatinilyticum sp. nov., F. aquiphilum sp. nov., F. limnophilum sp. nov., F. lacustre: Hyunyoung Jo , Miri S. Park , Yeonjung Lim , Ilnam Kang , Jang-Cheon Cho; J. Microbiol. 2023;61(5):495-510. Published online May 23, 2023; DOI: https://doi.org/10.1007/s12275-023-00054-4

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Eleven bacterial strains were isolated from freshwater environments and identified as Flavobacterium based on 16S rRNA gene sequence analyses. Complete genome sequences of the 11 strains ranged from 3.45 to 5.83 Mb with G + C contents of 33.41–37.31%. The average nucleotide identity (ANI) values showed that strains IMCC34515T and IMCC34518 belonged to the same species, while the other nine strains represented each separate species. The ANI values between the strains and their closest Flavobacterium species exhibited ≤ 91.76%, indicating they represent each novel species. All strains had similar characteristics such as being Gram-stain-negative, rod-shaped, and contained iso-C15:0 as the predominant fatty acid, menaquinone-6 as the respiratory quinone, and phosphatidylethanolamine and aminolipids as major polar lipids. Genomic, phylogenetic, and phenotypic characterization confirmed that the 11 strains were distinct from previously recognized Flavobacterium species. Therefore, Flavobacterium praedii sp. nov. (IMCC34515T = KACC 22282T = NBRC 114937T), Flavobacterium marginilacus sp. nov. (IMCC34673T = KACC 22284T = NBRC 114940T), Flavobacterium aestivum sp. nov. (IMCC34774T = KACC 22285T = NBRC 114941T), Flavobacterium flavigenum sp. nov. (IMCC34775T = KACC22286T = NBRC 114942T), Flavobacterium luteolum sp. nov. (IMCC34776T = KACC 22287T = NBRC 114943T), Flavobacterium gelatinilyticum sp. nov. (IMCC34777T = KACC 22288T = NBRC 114944T), Flavobacterium aquiphilum sp.nov. (IMCC34779T = KACC 22289T = NBRC 114945T), Flavobacterium limnophilum sp. nov. (IMCC36791T = KACC22290T = NBRC 114947T), Flavobacterium lacustre sp. nov. (IMCC36792T = KACC 22291T = NBRC 114948T), and Flavobacterium eburneipallidum sp. nov. (IMCC36793T = KACC 22292T = NBRC 114949T) are proposed as novel species.

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Indoor pollution of funeral homes and potential health risk of workers: A case study in central China
Jinjun Ye, Zhengtao Ai, Lup Wai Chew
Building and Environment.2025; 272: 112677. CrossRef
Flavobacterium magnesitis sp. nov. and Flavobacterium zubiriense sp. nov., two novel Flavobacterium species isolated from alkaline magnesite residues
Leonor Matos, Lorrie Maccarrio, Ana Paula Chung, Diogo N. Proença, Søren Sørensen, Paula V. Morais, Romeu Francisco
International Journal of Systematic and Evolutionary Microbiology .2025;[Epub] CrossRef
Comparative genomics and evolutionary insights into zeaxanthin biosynthesis in two novel Flavobacterium species
Ye Zhuo, Chun-Zhi Jin, Chang-Soo Lee, Kee-Sun Shin, Hyung-Gwan Lee
BMC Microbiology.2025;[Epub] CrossRef
Comprehensive genome analysis of five novel flavobacteria: Flavobacterium piscisymbiosum sp. nov., Flavobacterium pisciphilum sp. nov., Flavobacterium flavipigmentatum sp. nov., Flavobacterium lipolyticum sp. nov. and Flavobacterium cupriresistens sp. nov
Izzet Burcin Saticioglu, Hilal Ay, Soner Altun, Nihed Ajmi, Enes Said Gunduz, Huban Gocmen, Muhammed Duman
Systematic and Applied Microbiology.2024; 47(4): 126518. CrossRef
Leuconostoc aquikimchii sp. nov., a Lactic Acid Bacterium Isolated from Cabbage Watery Kimchi
Subin Kim, Se Hee Lee, Ki Hyun Kim, Misun Yun
Journal of Microbiology.2024; 62(12): 1089. CrossRef
Overproduction of Xanthophyll Pigment in Flavobacterium sp. JSWR-1 under Optimized Culture Conditions
Jegadeesh Raman, Young-Joon Ko, Jeong-Seon Kim, Da-Hye Kim, Soo-Jin Kim
Journal of Microbiology and Biotechnology.2024; 34(3): 710. CrossRef
Flavobacterium rivulicola sp. nov., Isolated from a Freshwater Stream
Sumin Kim, Miri S. Park, Ilnam Kang, Jang-Cheon Cho
Current Microbiology.2024;[Epub] CrossRef
Congregibacter variabilis sp. nov. and Congregibacter brevis sp. nov. Within the OM60/NOR5 Clade, Isolated from Seawater, and Emended Description of the Genus Congregibacter
Hyeonsu Tak, Miri S. Park, Hyerim Cho, Yeonjung Lim, Jang-Cheon Cho
Journal of Microbiology.2024; 62(9): 739. CrossRef
Validation List no. 213. Valid publication of new names and new combinations effectively published outside the IJSEM
Aharon Oren, Markus Göker
International Journal of Systematic and Evolutionary Microbiology .2023;[Epub] CrossRef

[PROTOCOL]Analyzing viral epitranscriptomes using nanopore direct RNA sequencing: Ari Hong , Dongwan Kim , V. Narry Kim , Hyeshik Chang; J. Microbiol. 2022;60(9):867-876. Published online August 24, 2022; DOI: https://doi.org/10.1007/s12275-022-2324-4

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RNA modifications are a common occurrence across all domains of life. Several chemical modifications, including N6- methyladenosine, have also been found in viral transcripts and viral RNA genomes. Some of the modifications increase the viral replication efficiency while also helping the virus to evade the host immune system. Nonetheless, there are numerous examples in which the host's RNA modification enzymes function as antiviral factors. Although established methods like MeRIP-seq and miCLIP can provide a transcriptome- wide overview of how viral RNA is modified, it is difficult to distinguish between the complex overlapping viral transcript isoforms using the short read-based techniques. Nanopore direct RNA sequencing (DRS) provides both long reads and direct signal readings, which may carry information about the modifications. Here, we describe a refined protocol for analyzing the RNA modifications in viral transcriptomes using nanopore technology.

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From DNA Methylation and Histone Modifications to Non-Coding RNAs: Evaluating Tools for Epigenetic Research
Ines Benčik, Lara Saftić Martinović, Tea Mladenić, Saša Ostojić, Sanja Dević Pavlić
Applied Sciences.2025; 15(18): 9940. CrossRef
Computational methods for the analysis of long-read RNA-seq data
Kristina Santucci, Yuning Cheng, Si-Mei Xu, Michael Janitz
Genomics.2025; 117(6): 111144. CrossRef
Enhanced detection of RNA modifications in Escherichia coli utilizing direct RNA sequencing
Zhihao Guo, Yanwen Shao, Lu Tan, Beifang Lu, Xin Deng, Sheng Chen, Runsheng Li
Cell Reports Methods.2025; 5(9): 101168. CrossRef
Utilization of nanopore direct RNA sequencing to analyze viral RNA modifications
Lu Tan, Zhihao Guo, Xiaoming Wang, Dal Young Kim, Runsheng Li, Pedro H. Oliveira
mSystems.2024;[Epub] CrossRef
Current progress in strategies to profile transcriptomic m6A modifications
Yuening Yang, Yanming Lu, Yan Wang, Xianghui Wen, Changhai Qi, Weilan Piao, Hua Jin
Frontiers in Cell and Developmental Biology.2024;[Epub] CrossRef
Improved sub-genomic RNA prediction with the ARTIC protocol
Thomas Baudeau, Kristoffer Sahlin
Nucleic Acids Research.2024; 52(17): e82. CrossRef
Non-Targeted RNA Sequencing: Towards the Development of Universal Clinical Diagnosis Methods for Human and Veterinary Infectious Diseases
Stephen Spatz, Claudio L. Afonso
Veterinary Sciences.2024; 11(6): 239. CrossRef
Quantitative profiling N1-methyladenosine (m1A) RNA methylation from Oxford nanopore direct RNA sequencing data
Shenglun Chen, Jia Meng, Yuxin Zhang
Methods.2024; 228: 30. CrossRef
Multicellular, IVT-derived, unmodified human transcriptome for nanopore-direct RNA analysis
Caroline A. McCormick, Stuart Akeson, Sepideh Tavakoli, Dylan Bloch, Isabel N. Klink, Miten Jain, Sara H. Rouhanifard
Gigabyte.2024; 2024: 1. CrossRef
Dissecting the effects of METTL3 on alternative splicing in prostate cancer
Lin Wang, Ling Shi, Yonghao Liang, Judy Kin-Wing Ng, Chan Hoi Yin, Lingyi Wang, Jinpao Hou, Yiwei Wang, Cathy Sin-Hang Fung, Peter Ka-Fung Chiu, Chi-Fai Ng, Stephen Kwok-Wing Tsui
Frontiers in Oncology.2023;[Epub] CrossRef

Analysis of phylogenetic markers for classification of a hydrogen peroxide producing Streptococcus oralis isolated from saliva by a newly devised differential medium: Ha Pham , Thi Dieu Thuy Tran , Youri Yang , Jae-Hyung Ahn , Hor-Gil Hur , Yong-Hak Kim; J. Microbiol. 2022;60(8):795-805. Published online July 14, 2022; DOI: https://doi.org/10.1007/s12275-022-2261-2

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Hydrogen peroxide (H2O2) is produced by alpha-hemolytic streptococci in aerobic conditions. However, the suitable method for detection of H2O2-producing streptococci in oral microbiota has not been setup. Here we show that o-dianisidine dye and horseradish peroxidase were useful in tryptic soy agar medium to detect and isolate H2O2-producing bacteria with the detection limit of one target colony in > 106 colony-forming units. As a proof, we isolated the strain HP01 (KCTC 21190) from a saliva sample using the medium and analyzed its characteristics. Further tests showed that the strain HP01 belongs to Streptococcus oralis in the Mitis group and characteristically forms short-chain streptococcal cells with a high capacity of acid tolerance and biofilm formation. The genome analysis revealed divergence of the strain HP01 from the type strains of S. oralis. They showed distinctive phylogenetic distances in their ROS-scavenging proteins, including superoxide dismutase SodA, thioredoxin TrxA, thioredoxin reductase TrxB, thioredoxin-like protein YtpP, and glutaredoxin- like protein NrdH, as well as a large number of antimicrobial resistance genes and horizontally transferred genes. The concatenated ROS-scavenging protein sequence can be used to identify and evaluate Streptococcus species and subspecies based on phylogenetic analysis.

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Alleviation of H2O2 toxicity by extracellular catalases in the phycosphere of Microcystis aeruginosa
Yerim Park, Wonjae Kim, Yeji Cha, Minkyung Kim, Woojun Park
Harmful Algae.2024; 137: 102680. CrossRef

Yeast polyubiquitin unit regulates synaptonemal complex formation and recombination during meiosis: Min-Kyung Jo , Kiwon Rhee , Keun Pil Kim , Soogil Hong; J. Microbiol. 2022;60(7):705-714. Published online July 4, 2022; DOI: https://doi.org/10.1007/s12275-022-2204-y

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Ubiquitin is highly conserved in most eukaryotes and involved in diverse physiological processes, including cell division, protein quality control, and protein degradation mediated by the ubiquitin-proteasome system after heat shock, glucose-starvation, and oxidative stress. However, the role of the ubiquitin gene UBI4, which contains five consecutive head-to-tail ubiquitin repeats, in meiosis has not been investigated. In this study, we show that the Saccharomyces cerevisiae polyubiquitin precursor gene, UBI4, is required to promote synaptonemal complex (SC) formation and suppress excess doublestrand break formation. Moreover, the proportion of Zip1 polycomplexes, which indicate abnormal SC formation, in cells with a mutation in UBI4 (i.e., ubi4Δ cells) is higher than that of wild-type cells, implying that the UBI4 plays an important role in the early meiotic prophase I. Interestingly, although ubi4Δ cells rarely form full-length SCs in the pachytene stage of prophase I, the Zip3 foci are still seen, as in wild-type cells. Moreover, ubi4Δ cells proficiently form crossover and noncrossover products with a slight delay compared to wild-type cells, suggesting that UBI4 is dispensable in SCcoupled recombination. Our findings demonstrate that UBI4 exhibits dual functions that are associated with both positive and negative roles in SC formation and recombination during meiosis.

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The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance
Cathleen M. Lake, Jennifer Gardner, Salam Briggs, Zulin Yu, Grace McKown, R. Scott Hawley
Proceedings of the National Academy of Sciences.2024;[Epub] CrossRef

Lactobacillus plantarum-derived metabolites sensitize the tumorsuppressive effects of butyrate by regulating the functional expression of SMCT1 in 5-FU-resistant colorectal cancer cells: Hye-Ju Kim , JaeJin An , Eun-Mi Ha; J. Microbiol. 2022;60(1):100-117. Published online December 29, 2021; DOI: https://doi.org/10.1007/s12275-022-1533-1

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A critical obstacle to the successful treatment of colorectal cancer (CRC) is chemoresistance. Chemoresistant CRC cells contribute to treatment failure by providing a mechanism of drug lethargy and modifying chemoresistance-associated molecules. The gut microbiota provide prophylactic and therapeutic effects by targeting CRC through anticancer mechanisms. Among them, Lactobacillus plantarum contributes to the health of the host and is clinically effective in treating CRC. This study confirmed that 5-fluorouracil (5-FU)-resistant CRC HCT116 (HCT116/5FUR) cells acquired butyrateinsensitive properties. To date, the relationship between 5- FU-resistant CRC and butyrate resistance has not been elucidated. Here, we demonstrated that the acquisition of butyrate resistance in HCT116/5FUR cells was strongly correlated with the inhibition of the expression and function of SMCT1, a major transporter of butyrate in colonocytes. L. plantarum-cultured cell-free supernatant (LP) restored the functional expression of SMCT1 in HCT116/5FUR cells, leading to butyrate-induced antiproliferative effect and apoptosis. These results suggest that LP has a synergistic effect on the SMCT1/butyrate-mediated tumor suppressor function and is a potential chemosensitizer to overcome dual 5-FU and butyrate resistance in HCT116 cells.

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Advancements in the Pathogenesis, Diagnosis, and Therapeutic Implications of Intestinal Bacteria
Duofei Lu, Xianxiong Ma, Kaixiong Tao, Hongwei Lei
Current Issues in Molecular Biology.2025; 47(2): 106. CrossRef
The benefits of Lactiplantibacillus plantarum: From immunomodulator to vaccine vector
Joshua Tobias, Stefan Heinl, Kristina Dendinovic, Ajša Ramić, Anna Schmid, Catherine Daniel, Ursula Wiedermann
Immunology Letters.2025; 272: 106971. CrossRef
Advances in understanding therapeutic mechanisms of probiotics in cancer management, with special emphasis on breast cancer: A comprehensive review
A S Angel Nama, G Mary Sandeepa, Viswanath Buddolla, Anthati Mastan
European Journal of Pharmacology.2025; 995: 177410. CrossRef
Unlocking the power of probiotics, postbiotics: targeting apoptosis for the treatment and prevention of digestive diseases
Qiuyan Xie, Ji Liu, Ping Yu, Ting Qiu, Shanyu Jiang, Renqiang Yu
Frontiers in Nutrition.2025;[Epub] CrossRef
Unveiling the Interplay Between the Human Microbiome and Gastric Cancer: A Review of the Complex Relationships and Therapeutic Avenues
Jenan Al-Matouq, Hawra Al-Ghafli, Noura N. Alibrahim, Nida Alsaffar, Zaheda Radwan, Mohammad Daud Ali
Cancers.2025; 17(2): 226. CrossRef
The role of gut microbiota and metabolites in cancer chemotherapy
Shiyu Li, Shuangli Zhu, Jun Yu
Journal of Advanced Research.2024; 64: 223. CrossRef
Sodium Butyrate Inhibits the Expression of Thymidylate Synthase and Induces Cell Death in Colorectal Cancer Cells
Nayeon Kim, Changwon Yang
International Journal of Molecular Sciences.2024; 25(3): 1572. CrossRef
Anticancer Properties of Saccharomyces boulardii Metabolite Against Colon Cancer Cells
Babak Pakbin, Samaneh Allahyari, Shaghayegh Pishkhan Dibazar, Amir Peymani, Mozhdeh Khajeh Haghverdi, Khadijeh Taherkhani, Maryam Javadi, Razzagh Mahmoudi
Probiotics and Antimicrobial Proteins.2024; 16(1): 224. CrossRef
The effect of oral butyrate on colonic short-chain fatty acid transporters and receptors depends on microbial status
Karla Vagnerová, Tomáš Hudcovic, Martin Vodička, Peter Ergang, Petra Klusoňová, Petra Petr Hermanová, Dagmar Šrůtková, Jiří Pácha
Frontiers in Pharmacology.2024;[Epub] CrossRef
Exploiting lactic acid bacteria for colorectal cancer: a recent update
Yang Chen, Bo Yang, Jianxin Zhao, R. Paul Ross, Catherine Stanton, Hao Zhang, Wei Chen
Critical Reviews in Food Science and Nutrition.2024; 64(16): 5433. CrossRef
Gut microbial metabolites: Shaping future diagnosis and treatment against gastrointestinal cancer
Hongyan Gou, Ruijie Zeng, Harry Cheuk Hay Lau, Jun Yu
Pharmacological Research.2024; 208: 107373. CrossRef
Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies
Suki Ha, Xiang Zhang, Jun Yu
Chinese Medical Journal.2024; 137(1): 8. CrossRef
A Narrative Review on the Advance of Probiotics to Metabiotics
Hye Ji Jang, Na-Kyoung Lee, Hyun-Dong Paik
Journal of Microbiology and Biotechnology.2024; 34(3): 487. CrossRef
Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
Karolina Kaźmierczak-Siedlecka, Nikola Bulman, Paweł Ulasiński, Bartosz Kamil Sobocki, Karol Połom, Luigi Marano, Leszek Kalinowski, Karolina Skonieczna-Żydecka
Gut Microbes.2023;[Epub] CrossRef
Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer
Dalong Liu, Yun Wang, Xiaojiang Li, Yan Wang, Zhiqiang Zhang, Zhifeng Wang, Xudong Zhang
Amino Acids.2023; 55(10): 1223. CrossRef
Microbial metabolites in colorectal tumorigenesis and cancer therapy
Yali Liu, Harry Cheuk-Hay Lau, Jun Yu
Gut Microbes.2023;[Epub] CrossRef
Lactobacillus plantarum Metabolites Elicit Anticancer Effects by Inhibiting Autophagy-Related Responses
Sihyun Jeong, Yuju Kim, Soyeong Park, Doyeon Lee, Juho Lee, Shwe Phyu Hlaing, Jin-Wook Yoo, Sang Hoon Rhee, Eunok Im
Molecules.2023; 28(4): 1890. CrossRef
Lactobacillus plantarum modulate gut microbiota and intestinal immunity in cyclophosphamide-treated mice model
Zhibo Zeng, Zonghao Huang, Wen Yue, Shah Nawaz, Xinzhu Chen, Jing Liu
Biomedicine & Pharmacotherapy.2023; 169: 115812. CrossRef
Gut Microbiome in Colorectal Cancer: Clinical Diagnosis and Treatment
Yali Liu, Harry Cheuk-Hay Lau, Wing Yin Cheng, Jun Yu
Genomics, Proteomics & Bioinformatics.2023; 21(1): 84. CrossRef
Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer
Xiang Lin, Xinyu Yang, Yushang Yang, Hangbin Zhang, Xuan Huang
Frontiers in Oncology.2023;[Epub] CrossRef
Characterization of Wnt signaling pathway under treatment of Lactobacillus acidophilus postbiotic in colorectal cancer using an integrated in silico and in vitro analysis
Nafiseh Erfanian, Saeed Nasseri, Adib Miraki Feriz, Hossein Safarpour, Mohammad Hassan Namaei
Scientific Reports.2023;[Epub] CrossRef
A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy
Qiqing Yang, Bin Wang, Qinghui Zheng, Heyu Li, Xuli Meng, Fangfang Zhou, Long Zhang
Advanced Science.2023;[Epub] CrossRef
Anti-tumour effect of Huangqin Decoction on colorectal cancer mice through microbial butyrate mediated PI3K/Akt pathway suppression
Jia-Jie Zhu, Hai-Yan Liu, Liang-Jun Yang, Zheng Fang, Rui Fu, Jia-Bin Chen, Shan Liu, Bao-Ying Fei
Journal of Medical Microbiology .2023;[Epub] CrossRef
Fecal levels of SCFA and BCFA during capecitabine in patients with metastatic or unresectable colorectal cancer
Janine Ziemons, Romy Aarnoutse, Anne Heuft, Lars Hillege, Janneke Waelen, Judith de Vos-Geelen, Liselot Valkenburg-van Iersel, Irene E. G. van Hellemond, Geert-Jan M. Creemers, Arnold Baars, Johanna H. M. J. Vestjens, John Penders, Koen Venema, Marjolein
Clinical and Experimental Medicine.2023; 23(7): 3919. CrossRef
Probiotic-Derived Bioactive Compounds in Colorectal Cancer Treatment
Christina Thoda, Maria Touraki
Microorganisms.2023; 11(8): 1898. CrossRef
Gut microbiota and microbiota-derived metabolites in colorectal cancer: enemy or friend
Xinyi Wang, Xicai Sun, Jinjin Chu, Wenchang Sun, Shushan Yan, Yaowen Wang
World Journal of Microbiology and Biotechnology.2023;[Epub] CrossRef
Determination of the effect of L. plantarum AB6-25, L. plantarum MK55 and S. boulardii T8-3C microorganisms on colon, cervix, and breast cancer cell lines: Molecular docking, and molecular dynamics study
Seda Yalçınkaya, Serap Yalçın Azarkan, Aynur Gül Karahan Çakmakçı
Journal of Molecular Structure.2022; 1261: 132939. CrossRef
Extracellular vesicles derived from Lactobacillus plantarum restore chemosensitivity through the PDK2-mediated glucose metabolic pathway in 5-FU-resistant colorectal cancer cells
JaeJin An, Eun-Mi Ha
Journal of Microbiology.2022; 60(7): 735. CrossRef

Constantimarinum furrinae gen. nov., sp. nov., a marine bacterium isolated from saline volcanic rock aquifer (lava seawater) at Jeju Island, Republic of Korea: Sung-Hyun Yang , Hyun-Myung Oh , Mi-Jeong Park , Dongil Jang , Kae Kyoung Kwon; J. Microbiol. 2022;60(1):11-17. Published online December 29, 2021; DOI: https://doi.org/10.1007/s12275-022-1468-6

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A Gram-stain-negative, aerobic, rod-shaped (0.3–0.5 × 1.0– 1.9 μm), non-motile marine bacterium designated as ALE3EIT was isolated from a saline volcanic rock aquifer (lava seawater) on Jeju Island, Republic of Korea. The 16S rRNA gene sequence analysis revealed that strain ALE3EIT showed high similarity to ‘Altibacter lentus’ JLT2010T (97.2%), followed by Marixanthomonas ophiurae KMM 3046T (94.5%). Growth was observed at 10–41°C (optimum, 30°C), at pH 6.0–8.5 (optimum, pH 7.5) and at 0.5–8% (optimum, 4.0%) NaCl. The predominant cellular fatty acids were iso-C15:0 (23.5%), iso-C16:0 (10.2%), iso-C16:0 3OH (10.5%), and iso-C17:0 3OH (16.8%). The DNA G + C contents was 40.4 mol%. The major respiratory quinone was MK-6. The major polar lipids were determined to be phosphatidylethanolamine, two unidentified glycolipids, and two unidentified aminolipids. Several phenotypic characteristics such as production of acetoin, activities of arginine dihydrolase and acid phosphatase, and utilization pattern of carbon sources differentiate strain ALE3EIT from ‘A. lentus’ JLT2010T. Activities of the lipase, trypsin, α- chymotrypsin and gelatinase and utilization pattern of carbon sources differentiate strain ALE3EIT from M. ophiurae KMM 3046T. The genome of strain ALE3EIT is 3.0 Mbp long and its ANI and AAI values against ‘A. lentus’ JLT2010T were 76.58 and 72.76, respectively, however, AAI values against members in other genera were lower than 72%. The phylogenomic tree inferred by PhyloPhlAn clearly differentiated the strain ALE3EIT together with strain JLT2010T from other genera in the Falvobacteriaceae. This polyphasic taxonomic data indicates that strain ALE3EIT should be identified as a novel species in the genus ‘Altibacter’, however, the name has not been validated. Therefore, the strain is classified as a novel genus and is proposed as Constantimarinum furrinae gen. nov., sp. nov. The type strain is ALE3EIT (= KCCM 43303T = JCM 33022T).

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Mesohalobacter salilacus sp. nov., a novel halotolerant, flexirubin-type pigment-producing bacterium of the family Flavobacteriaceae
Shuai-Bo Han, Yang-Huan Yu, Xiao-Long He, Jin-Jia Liang, Min Wu, Can Chen, Xue-Wei Xu
International Journal of Systematic and Evolutionary Microbiology .2025;[Epub] CrossRef
Mystique and Pristine Microbiome of Jeju Lava (Yongam) Seawater: Comparative Insights with Mineral Water and Adjacent Seawater
So-Hyun An, Kwang-Hyo Ko, Won-Guk Jang, Chang-Gu Hyun
Water.2025; 17(22): 3306. CrossRef
Comparison of the anti-inflammatory effects of carotenoids-rich product from microalgal mass-cultured between natural seawater and magma seawater
Jayeon Cheon, Eun-A Kim, Nalae Kang, Taeho Kim, Lei Wang, Soo-Jin Heo, Seon-Heui Cha
Biocatalysis and Agricultural Biotechnology.2024; 62: 103420. CrossRef
Validation List no. 212. Valid publication of new names and new combinations effectively published outside the IJSEM
Aharon Oren, Markus Göker
International Journal of Systematic and Evolutionary Microbiology .2023;[Epub] CrossRef

A study of P release from Fe-P and Ca-P via the organic acids secreted by Aspergillus niger: Da Tian , Liyan Wang , Jun Hu , Liangliang Zhang , Ningning Zhou , Jingjing Xia , Meiyue Xu , Kianpoor Kalkhajeh Yusef , Shimei Wang , Zhen Li , Hongjian Gao; J. Microbiol. 2021;59(9):819-826. Published online August 12, 2021; DOI: https://doi.org/10.1007/s12275-021-1178-5

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Phosphate solubilizing fungi (PSF) have been widely applied to dissolve insoluble phosphates (IPs). However, the PSF usually demonstrates a different phosphate solubilizing capacity for various IPs. This study explored the mechanisms of Aspergillus niger for the dissolution of ferric phosphate (FePO4, Fe-P), and tricalcium phosphate (Ca3[PO4]2, Ca-P) regarding the tricarboxylic acid (TCA) cycle. Aspergillus niger has higher phosphorus (P) content released from Ca-P, reached the maximum value of 861 mg/L after seven days of incubation, compared with the 169 mg/L from Fe-P. Oxalic acid promoted the release of P from Ca-P through the formation of calcium oxalate. The presence of Fe-P can stimulate A. niger to secrete large amounts of citric acid, confirmed by the enhancement of citrate synthase (CS) activity. However, citric acid only promotes 0.5% of P released from Fe-P. Meanwhile, although oxalic acid still dominates the release of P from Fe-P, its abundance was significantly declined. In contrast, oxalic acid also shows a higher P release ratio in Ca-P than citric acid, i.e., 36% vs. 22%. This study points to the future usage of A. niger to dissolve IPs in soil required to enhance oxalic acid secretion.

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Review

Dissection of plant microbiota and plant-microbiome interactions: Kihyuck Choi , Raees Khan , Seon-Woo Lee; J. Microbiol. 2021;59(3):281-291. Published online February 23, 2021; DOI: https://doi.org/10.1007/s12275-021-0619-5

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Abstract PDF

Plants rooted in soil have intimate associations with a diverse array of soil microorganisms. While the microbial diversity of soil is enormous, the predominant bacterial phyla associated with plants include Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, and Verrucomicrobia. Plants supply nutrient niches for microbes, and microbes support plant functions such as plant growth, development, and stress tolerance. The interdependent interaction between the host plant and its microbes sculpts the plant microbiota. Plant and microbiome interactions are a good model system for understanding the traits in eukaryotic organisms from a holobiont perspective. The holobiont concept of plants, as a consequence of co-evolution of plant host and microbiota, treats plants as a discrete ecological unit assembled with their microbiota. Dissection of plant-microbiome interactions is highly complicated; however, some reductionist approaches are useful, such as the synthetic community method in a gnotobiotic system. Deciphering the interactions between plant and microbiome by this reductionist approach could lead to better elucidation of the functions of microbiota in plants. In addition, analysis of microbial communities’ interactions would further enhance our understanding of coordinated plant microbiota functions. Ultimately, better understanding of plantmicrobiome interactions could be translated to improvements in plant productivity.

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Riley J. Hodgson, Christian Cando‐Dumancela, Craig Liddicoat, Sunita A. Ramesh, Robert A. Edwards, Martin F. Breed
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Irradiance level and elevation shape the soil microbiome communities of Coffea arabica L.
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Science of The Total Environment.2023; 871: 162152. CrossRef
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Journal Articles

Leucobacter coleopterorum sp. nov., Leucobacter insecticola sp. nov., and Leucobacter viscericola sp. nov., isolated from the intestine of the diving beetles, Cybister brevis and Cybister lewisianus, and emended description of the genus Leucobacter: Dong-Wook Hyun , Hojun Sung , Pil Soo Kim , Ji-Hyun Yun , Jin-Woo Bae; J. Microbiol. 2021;59(4):360-368. Published online January 26, 2021; DOI: https://doi.org/10.1007/s12275-021-0472-6

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Abstract PDF

Three novel bacterial strains, HDW9AT, HDW9BT, and HDW9CT, isolated from the intestine of the diving beetles Cybister lewisianus and Cybister brevis, were characterized as three novel species using a polyphasic approach. The isolates were Gram-staining-positive, strictly aerobic, non-motile, and rod-shaped. They grew optimally at 30°C (pH 7) in the presence of 0.5% (wt/vol) NaCl. Phylogenetic analysis based on the 16S rRNA gene sequences revealed that they belong to the genus Leucobacter and are closely related to L. denitrificans M1T8B10T (98.4–98.7% sequence similarity). Average nucleotide identity (ANI) values among the isolates were 76.4–84.1%. ANI values for the isolates and the closest taxonomic species, L. denitrificans KACC 14055T, were 72.3–73.1%. The isolates showed ANI values of < 76.5% with all analyzable Leucobacter strains in the EzBioCloud database. The genomic DNA G + C content of the isolates was 60.3–62.5%. The polar lipid components were phosphatidylglycerol, diphosphatidylglycerol, and other unidentified glycolipids, phospholipids, and lipids. The major cellular fatty acids were anteiso- C15:0, iso-C16:0, and anteiso-C17:0. MK-10 was the major respiratory quinone, and MK-7 and MK-11 were the minor respiratory quinones. The whole-cell sugar components of the isolates were ribose, glucose, galactose, and mannose. The isolates harbored L-2,4-diaminobutyric acid, L-serine, L-lysine, L-aspartic acid, glycine, and D-glutamic acid within the cell wall peptidoglycan. Based on phylogenetic, phenotypic, chemotaxonomic, and genotypic analyses, strains HDW9AT, HDW9BT, and HDW9CT represent three novel species within the genus Leucobacter. We propose the name Leucobacter coleopterorum sp. nov. for strain HDW9AT (= KACC 21331T = KCTC 49317T = JCM 33667T), the name Leucobacter insecticola sp. nov. for strain HDW9BT (= KACC 21332T = KCTC 49318T = JCM 33668T), and the name Leucobacter viscericola sp. nov. for strain HDW9CT (= KACC 21333T = KCTC 49319T = JCM 33669T).

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Mohamed N. Abd El-Ghany, Salwa A. Hamdi, Shereen M. Korany, Reham M. Elbaz, Ahmed N. Emam, Mohamed G. Farahat
Microorganisms.2023; 11(4): 1006. CrossRef
Leucobacter tenebrionis sp. nov., isolated from the gut of Tenebrio molitor
Yu Ying, Bo Yuan, Tingting Liu, Xiaoshuan Bai, Haifeng Zhao
International Journal of Systematic and Evolutionary Microbiology .2023;[Epub] CrossRef
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International Journal of Systematic and Evolutionary Microbiology .2023;[Epub] CrossRef
Leucobacter chinensis sp. nov., with plant growth-promoting potential isolated from field soil after seven-years continuous maize cropping
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International Journal of Systematic and Evolutionary Microbiology .2022;[Epub] CrossRef
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Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Lysobacter ciconiae sp. nov., and Lysobacter avium sp. nov., isolated from the faeces of an Oriental stork
So-Yeon Lee, Pil Soo Kim, Hojun Sung, Dong-Wook Hyun, Jin-Woo Bae
Journal of Microbiology.2022; 60(5): 469. CrossRef
Valid publication of new names and new combinations effectively published outside the IJSEM. Validation List no. 203
Aharon Oren, George M. Garrity
International Journal of Systematic and Evolutionary Microbiology .2022;[Epub] CrossRef
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Peter Kämpfer, John A. McInroy, Dominique Clermont, Meina Neumann-Schaal, Alexis Criscuolo, Hans-Jürgen Busse, Stefanie P. Glaeser
International Journal of Systematic and Evolutionary Microbiology .2021;[Epub] CrossRef
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International Journal of Environmental Research and Public Health.2021; 18(18): 9713. CrossRef

Autophagy of bovine mammary epithelial cell induced by intracellular Staphylococcus aureus: Na Geng , Kangping Liu , Jianwei Lu , Yuliang Xu , Xiaozhou Wang , Run Wang , Jianzhu Liu , Yongxia Liu , Bo Han; J. Microbiol. 2020;58(4):320-329. Published online February 26, 2020; DOI: https://doi.org/10.1007/s12275-020-9182-8

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Abstract PDF

Bovine mastitis is a common disease in the dairy industry that causes great economic losses. As the primary pathogen of contagious mastitis, Staphylococcus aureus (S. aureus) can invade bovine mammary epithelial cells, thus evading immune defenses and resulting in persistent infection. Recently, autophagy has been considered an important mechanism for host cells to clear intracellular pathogens. In the current study, autophagy caused by S. aureus was detected, and the correlation between autophagy and intracellular S. aureus survival was assessed. First, a model of intracellular S. aureus infection was established. Then, the autophagy of MAC-T cells was evaluated by confocal microscopy and western blot. Moreover, the activation of the PI3K-Akt-mTOR and ERK1/2 signaling pathways was determined by western blot. Finally, the relationship between intracellular bacteria and autophagy was analyzed by using autophagy regulators (3-methyladenine [3-MA], rapamycin [Rapa] and chloroquine [CQ]). The
results
showed that S. aureus caused obvious induction of autophagosome formation, transformation of LC3I/II, and degradation of p62/SQSTM1 in MAC-T cells; furthermore, the PI3K-Akt-mTOR and ERK1/2 signaling pathways were activated. The number of intracellular S. aureus increased significantly with autophagy activation by rapamycin, whereas the number decreased when the autophagy flux was inhibited by chloroquine. Therefore, this study indicated that intracellular S. aureus can induce autophagy and utilize it to survive in bovine mammary epithelial cells.

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Sterilization efficiency of pathogen-contaminated cottons in a laundry machine: Yoonjae Shin , Jungha Park , Woojun Park; J. Microbiol. 2020;58(1):30-38. Published online November 25, 2019; DOI: https://doi.org/10.1007/s12275-020-9391-1

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Abstract PDF

Pathogenic bacteria on abiotic surfaces such as fabrics, bedding, patient wears, and surgical tools are known to increase the risk of bacterial diseases in infants and the elderly. The desiccation tolerance of bacteria affects their viability in cotton. Thus, washing and drying machines are required to use conditions that ensure the sterilization of bacteria in cotton. The objective of this study is to determine the effects of various sterilization conditions of washing and drying machines on the survival of three pathogenic bacteria (Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus) commonly presented in contaminated cotton and two non-pathogenic bacteria (Bacillus subtilis and Escherichia coli) in cotton. High survival rates of A. baumannii and S. aureus in desiccated cotton were observed based on scanning electron microscope and replicate organism direct agar contact assay. The survival rates of A. baumannii and S. aureus exposed in desiccated cotton for 8 h were higher (14.4 and 5.0%, respectively) than those of other bacteria (< 0.5%). All tested bacteria were eradicated at low-temperature (< 40°C) washing with activated oxygen bleach (AOB). However, bacterial viability was shown in low temperature washing without AOB. High-temperature (> 60°C) washing was required to achieve 99.9% of the sterilization rate in washing without AOB. The sterilization rate was 93.2% using a drying machine at 60°C for 4 h. This level of sterilization was insufficient in terms of time and energy efficiency. High sterilization efficiency (> 99.9%) at 75°C for 3 h using a drying machine was confirmed. This study suggests standard conditions of drying machines to remove bacterial contamination in cotton by providing practical data.

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Partial characteristics of hemolytic factors secreted from airborne Aspergillus and Penicillium, and an enhancement of hemolysis by Aspergillus micronesiensis CAMP-like factor via Staphylococcus aureus-sphingomyelinase: Sumonrat Kaveemongkonrat , Kwanjit Duangsonk , Jos Houbraken , Phimchat Suwannaphong , Nongnuch Vanittanakom Vanittanakom , Malee Mekaprateep; J. Microbiol. 2019;57(12):1086-1094. Published online November 4, 2019; DOI: https://doi.org/10.1007/s12275-019-9133-4

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One of the advantages for initial survival of inhaled fungal spores in the respiratory tract is the ability for iron acquisition via hemolytic factor-production. To examine the ability of indoor Aspergillus and Penicillium affecting hemolysis, the secreted factors during the growth of thirteen strains from eight species were characterized in vitro for their hemolytic activity (HA) and CAMP-like reaction. The hemolytic index of HA on human blood agar of Aspergillus micronesiensis, Aspergillus wentii, Aspergillus westerdijkiae, Penicillium citrinum, Penicillium copticola, Penicillium paxilli, Penicillium steckii, and Penicillium sumatrense were 1.72 ± 0.34, 1.61 ± 0.41, 1.69 ± 0.16, 1.58 ± 0.46, 3.10 ± 0.51, 1.22 ± 0.19, 2.55 ± 0.22, and 1.90 ± 0.14, respectively. The secreted factors of an Aspergillus wentii showed high HA when grown in undernourished broth at 25°C at an exponential phase and were heat sensitive. Its secreted proteins have an estimated relative molecular weight over 50 kDa. Whereas, the factors of Penicillium steckii were secreted in a similar condition at a late exponential phase but showed low HA and heat tolerance. In a CAMP-like test with sheep blood, the synergistic hemolytic reactions between most tested mold strains and Staphylococcus aureus were identified. Moreover, the enhancement of α-hemolysis of Staphylococcus aureus could occur through the interaction of Staphylococcus aureus-sphingomyelinase and CAMP-like factors secreted from Aspergillus micronesiensis. Further studies on the characterization of purified hemolytic- and CAMP-like-factors secreted from Aspergillus wentii and Aspergillus micronesiensis may lead to more understanding of their involvement of hemolysis

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Mallory B. Ballard, Vicki Mercado-Evans, Madelynn G. Marunde, Hephzibah Nwanosike, Jacob Zulk, Kathryn A. Patras, Mariola J. Edelmann
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Evolution of a major bovine mastitic genotype (rpoB sequence type 10-2) of Staphylococcus aureus in cows: Dae-Sung Ko , Danil Kim , Eun-Kyung Kim , Jae-Hong Kim , Hyuk-Joon Kwon; J. Microbiol. 2019;57(7):587-596. Published online June 27, 2019; DOI: https://doi.org/10.1007/s12275-019-8699-1

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Staphylococcus aureus is the major pathogen leading to bovine mastitis globally while livestock-associated methicillin resistant S. aureus (LA-MRSA) has become a potential threat to public health. MRSA from bovine mastitis is not common but a methicillin susceptible S. aureus (MSSA) genotype, rpoB sequence type (RST)10-2 (RST10-2), is prevalent in Korea. To date, many genomic sequences from S. aureus have been elucidated, but the complete genome sequences of RST10-2 MSSA from bovine mastitis has never been reported. In this study, we determined the complete genome sequence of two RST10-2 MSSA that differ from each other in staphylococcal protein A and molecular prophage types [PMB64-1 (t2489/ mPPT0) and PMB81-4 (t127/mPPT1-2-3)] and conducted a comparative genomics study. The genomic sequences of PMB64-1 and PMB81-4 were more homologous to the representative human RST10-2 strains (MSSA476, MW2 etc.) compared to other RSTs. Most of them shared five common pseudogenes, along with high amino acid identity of four variable virulence genes that were identified in this study. However, PMB64-1 and PMB81-4 acquired different strainspecific pseudogenes and mobile genetic elements than the human strains. The unique pseudogene profile and high identity of the virulence genes were verified in RST10-2 field strains from bovine mastitis. Thus, bovine mastitic RST10-2 MSSA may have an evolutionary relationship with the human RST10- 2 community-associated (CA) MSSA and CA-MRSA strains but may have adapted to cows.

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Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus: Hüseyin Ta&# , Ay&# , Nermin Topalo&# , Vildan Alptüzün; J. Microbiol. 2018;56(11):828-837. Published online October 24, 2018; DOI: https://doi.org/10.1007/s12275-018-8244-7

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Methicillin resistant Staphylococcus aureus (MRSA) with multiple drug resistance patterns is frequently isolated from skin and soft tissue infections that are involved in chronic wounds. Today, difficulties in the treatment of MRSA associated infections have led to the development of alternative approaches such as antimicrobial photodynamic therapy. This study aimed to investigate photoinactivation with cationic porphyrin derivative compounds against MRSA in in-vitro conditions. In the study, MRSA clinical isolates with different antibiotic resistance profiles were used. The newly synthesized cationic porphyrin derivatives (PM, PE, PPN, and PPL) were used as photosensitizer, and 655 nm diode laser was used as light source. Photoinactivation experiments were performed by optimizing energy doses and photosensitizer concentrations. In photoinactivation experiments with different energy densities and photosensitizer concentrations, more than 99% reduction was achieved in bacterial cell viability. No decrease in bacterial survival was observed in control groups. It was determined that there was an increase in photoinactivation efficiency by increasing the energy dose. At the energy dose of 150 J/cm2 a survival reduction of over 6.33 log10 was observed in each photosensitizer type. While 200 μM PM concentration was required for this photoinactivation, 12.50 μM was sufficient for PE, PPN, and PPL. In our study, antimicrobial photodynamic therapy performed with cationic porphyrin derivatives was found to have potent antimicrobial efficacy against multidrug resistant S. aureus which is frequently isolated from wound infections.

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[PROTOCOL] Drosophila melanogaster as a polymicrobial infection model for Pseudomonas aeruginosa and Staphylococcus aureus: Young-Joon Lee , Hye-Jeong Jang , In-Young Chung , You-Hee Cho; J. Microbiol. 2018;56(8):534-541. Published online July 25, 2018; DOI: https://doi.org/10.1007/s12275-018-8331-9

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Non-mammalian infection models have been developed over the last two decades, which is a historic milestone to understand the molecular basis of bacterial pathogenesis. They also provide small-scale research platforms for identification of virulence factors, screening for antibacterial hits, and evaluation of antibacterial efficacy. The fruit fly, Drosophila melanogaster is one of the model hosts for a variety of bacterial pathogens, in that the innate immunity pathways and tissue physiology are highly similar to those in mammals. We here present a relatively simple protocol to assess the key aspects of the polymicrobial interaction in vivo between the human opportunistic pathogens, Pseudomonas aeruginosa and Staphylococcus aureus, which is based on the systemic infection by needle pricking at the dorsal thorax of the flies. After infection, fly survival and bacteremia over time for both P. aeruginosa and S. aureus within the infected flies can be monitored as a measure of polymicrobial virulence potential. The infection takes ~24 h including bacterial cultivation. Fly survival and bacteremia are assessed using the infected flies that are monitored up to ~60 h post-infection. These methods can be used to identify presumable as well as unexpected phenotypes during polymicrobial interaction between P. aeruginosa and S. aureus mutants, regarding bacterial pathogenesis and host immunity.

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Phenotypic and genotypic correlates of daptomycin-resistant methicillin-susceptible Staphylococcus aureus clinical isolates: Kyoung-Mi Kang , Nagendra N. Mishra , Kun Taek Park , Gi-Yong Lee , Yong Ho Park , Arnold S. Bayer , Soo-Jin Yang; J. Microbiol. 2017;55(2):153-159. Published online January 26, 2017; DOI: https://doi.org/10.1007/s12275-017-6509-1

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Abstract PDF

Daptomycin (DAP) has potent activity in vitro and in vivo against both methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) strains. DAP-resistance (DAP-R) in S. aureus has been mainly observed in MRSA strains, and has been linked to single nucleotide polymorphisms (SNPs) within the mprF gene leading to altered cell membrane (CM) phospholipid (PL) profiles, enhanced positive surface charge, and changes in CM fluidity. The current study was designed to delineate whether these same genotypic and phenotypic perturbations are demonstrated in clinically-derived DAP-R MSSA strains. We used three isogenic DAP-susceptible (DAP-S)/DAP-R strainpairs and compared: (i) presence of mprF SNPs, (ii) temporal expression profiles of the two key determinants (mprF and dltABCD) of net positive surface charge, (iii) increased production of mprF-dependent lysinylated-phosphatidylglycerol (L-PG), (iv) positive surface charge assays, and (v) susceptibility to cationic host defense peptides (HDPs) of neutrophil and platelet origins. Similar to prior data in MRSA, DAP-R (vs DAP-S) MSSA strains exhibited hallmark hot-spot SNPs in mprF, enhanced and dysregulated expression of both mprF and dltA, L-PG overproduction, HDP resistance and enhanced positive surface charge profiles. However, in contrast to most DAP-R MRSA strains, there were no changes in CM fluidity seen. Thus, charge repulsion via mprF- and dlt-mediated enhancement of positive surface charge may be the main mechanism to explain DAP-R in MSSA strains.

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Science Translational Medicine.2025;[Epub] CrossRef
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V. V. Gostev, O. S. Kalinogorskaya, O. S. Sulian, P. S. Chulkova, J. V. Sopova, M. E. Velizhanina, V. Yu. Pleshkov, V. A. Ageevets, S. V. Sidorenko
Antibiotics and Chemotherapy.2024; 68(9-10): 25. CrossRef
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Clinical Microbiology and Infection.2023; 29(10): 1334.e1. CrossRef
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Frontiers in Microbiology.2022;[Epub] CrossRef
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Synlett.2022; 33(17): 1695. CrossRef
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Ryan Moreira, Scott D. Taylor
ACS Infectious Diseases.2022; 8(8): 1674. CrossRef
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Elizabeth V. K. Ledger, Akshay Sabnis, Andrew M. Edwards
Microbiology .2022;[Epub] CrossRef
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Journal of Clinical Microbiology.2021;[Epub] CrossRef
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Jordy Evan Sulaiman, Henry Lam, Patricia A. Bradford
mSphere.2021;[Epub] CrossRef
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Ying Jian, Min Li
Journal of Bio-X Research.2021; 04(01): 1. CrossRef
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Rachel E. Jenson, Sarah L. Baines, Benjamin P. Howden, Nagendra N. Mishra, Sabrina Farah, Cassandra Lew, Andrew D. Berti, Sanjay K. Shukla, Arnold S. Bayer, Warren E. Rose
Antimicrobial Agents and Chemotherapy.2020;[Epub] CrossRef
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V. V. Gostev, Yu. V. Sopova, O. S. Kalinogorskaya, I. A. Tsvetkova, S. V. Sidorenko
Russian Journal of Genetics.2020; 56(3): 289. CrossRef
Association of mprF mutations with cross-resistance to daptomycin and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA)
Kanate Thitiananpakorn, Yoshifumi Aiba, Xin-Ee Tan, Shinya Watanabe, Kotaro Kiga, Yusuke Sato’o, Tanit Boonsiri, Feng-Yu Li, Teppei Sasahara, Yusuke Taki, Aa Haeruman Azam, Yuancheng Zhang, Longzhu Cui
Scientific Reports.2020;[Epub] CrossRef
Multidrug-Resistant Bacteria and Alternative Methods to Control Them: An Overview
Roberto Vivas, Ana Andréa Teixeira Barbosa, Silvio Santana Dolabela, Sona Jain
Microbial Drug Resistance.2019; 25(6): 890. CrossRef
Insights Into the Evolution of Staphylococcus aureus Daptomycin Resistance From an in vitro Bioreactor Model
Erica Lasek-Nesselquist, Jackson Lu, Ryan Schneider, Zhuo Ma, Vincenzo Russo, Smruti Mishra, Manjunath P. Pai, Janice D. Pata, Kathleen A. McDonough, Meenakshi Malik
Frontiers in Microbiology.2019;[Epub] CrossRef
Antibiotic Resistance and the MRSA Problem
Martin Vestergaard, Dorte Frees, Hanne Ingmer, Vincent A. Fischetti, Richard P. Novick, Joseph J. Ferretti, Daniel A. Portnoy, Miriam Braunstein, Julian I. Rood
Microbiology Spectrum.2019;[Epub] CrossRef
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Ghufran Barnawi, Michael Noden, Robert Taylor, Chuda Lohani, David Beriashvili, Michael Palmer, Scott D. Taylor
Peptide Science.2019;[Epub] CrossRef
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Ayan Majumder, Malay Ranjan Biswal, Meher K. Prakash
ACS Omega.2019; 4(3): 4977. CrossRef
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Yuyao Yin, Hongbin Chen, Shuguang Li, Hua Gao, Shijun Sun, Henan Li, Ruobing Wang, Longyang Jin, Yudong Liu, Hui Wang
International Journal of Antimicrobial Agents.2019; 54(6): 673. CrossRef
IS256-Mediated Overexpression of the WalKR Two-Component System Regulon Contributes to Reduced Vancomycin Susceptibility in a Staphylococcus aureus Clinical Isolate
Makoto Kuroda, Tsuyoshi Sekizuka, Hidehito Matsui, Jun Ohsuga, Toshio Ohshima, Hideaki Hanaki
Frontiers in Microbiology.2019;[Epub] CrossRef
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Journal of Biological Chemistry.2018; 293(46): 17985. CrossRef
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Frontiers in Microbiology.2018;[Epub] CrossRef
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Vera Pader, Andrew M Edwards
Future Microbiology.2017; 12(6): 461. CrossRef

Review

MINIREVIEW] Multidrug efflux pumps in Staphylococcus aureus and their clinical implications: Soojin Jang; J. Microbiol. 2016;54(1):1-8. Published online January 5, 2016; DOI: https://doi.org/10.1007/s12275-016-5159-z

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Abstract PDF

Antibiotic resistance is rapidly spreading among bacteria such as Staphylococcus aureus, an opportunistic bacterial pathogen that causes a variety of diseases in humans. For the last two decades, bacterial multidrug efflux pumps have drawn attention due to their potential association with clinical multidrug resistance. Numerous researchers have demonstrated efflux-mediated resistance in vitro and in vivo and found novel multidrug transporters using advanced genomic information about bacteria. This article aims to provide a concise summary of multidrug efflux pumps and their important clinical implications, focusing on recent findings concerning S. aureus efflux pumps.

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Gene.2025; 936: 149105. CrossRef
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ACS Applied Nano Materials.2025; 8(23): 11952. CrossRef
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Exploration of Drug Science.2025;[Epub] CrossRef
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Journal of Biomedical Science.2025;[Epub] CrossRef
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Xiaohui Yu, Miaomiao Liu, Pilong Liu, Zehua Hao, Lili Zhao, Xin Zhao
Microorganisms.2025; 13(5): 1140. CrossRef
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Antibiotics.2024; 13(12): 1197. CrossRef
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Journal of Microbiology.2024; 62(7): 535. CrossRef
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Journal of Molecular Structure.2024; 1312: 138497. CrossRef
Recent advances in the use of resveratrol against Staphylococcus aureus infections (Review)
Wenjing Cui, Yadong Wang, Li Zhang, Fang Liu, Guangcai Duan, Shuaiyin Chen, Jinzhao Long, Yuefei Jin, Haiyan Yang
Medicine International.2024;[Epub] CrossRef
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Patil Amruta Adhikrao, Gudle Mayuri Motiram, Gautam Kumar
Current Topics in Medicinal Chemistry.2024; 24(15): 1291. CrossRef
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Access Microbiology .2024;[Epub] CrossRef
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Mini-Reviews in Medicinal Chemistry.2024; 24(3): 272. CrossRef
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration
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Biomedicine & Pharmacotherapy.2024; 179: 117291. CrossRef
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Zongkai Huang, Lang Bai, Jie Liu, Youfu Luo
Pharmaceutical Fronts.2024; 06(04): e336. CrossRef
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Diagnostics.2023; 13(6): 1050. CrossRef
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Bioorganic & Medicinal Chemistry.2023; 80: 117187. CrossRef
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Frontiers in Microbiology.2023;[Epub] CrossRef
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International Journal of Antimicrobial Agents.2023; 61(6): 106795. CrossRef
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Journal of Environmental Health Science and Engineering.2023; 22(1): 13. CrossRef
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Molecules.2023; 28(4): 1819. CrossRef
Chemical Composition, Antibacterial and Inhibitory Activity of the Efflux Pump of Essential Oils from Croton piauhiensis Müll.
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Nutraceuticals.2023; 3(4): 591. CrossRef
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Photodiagnosis and Photodynamic Therapy.2022; 39: 103010. CrossRef
Oxazolidine Compounds from Neocalytrocalyx Longifolium (Capparaceae) and Their Activity as Msra (ABC) Efflux Pump Inhibitors: An in Vitro and in Silico Approach
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PLOS ONE.2022; 17(7): e0272417. CrossRef
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Research Journal of Pharmacy and Technology.2022; : 4300. CrossRef
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Ciência Rural.2021;[Epub] CrossRef
Molecular Characteristics and Exotoxins of Methicillin-Resistant Staphylococcus aureus
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Laiying Zhang, Jun He, Lang Bai, Shihua Ruan, Tao Yang, Youfu Luo
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Journal of Bioenergetics and Biomembranes.2021; 53(4): 489. CrossRef
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Amy R. Nava, Natalia Mauricio, Angel J. Sanca, Delfina C. Domínguez
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Sanath Kumar, Manjusha Lekshmi, Ammini Parvathi, Manisha Ojha, Nicholas Wenzel, Manuel F. Varela
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Epidemiology of efflux pumps genes mediating resistance among Staphylococcus aureus; A systematic review
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Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
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Efflux pump inhibitors of clinically relevant multidrug resistant bacteria
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Santosh K. Rath, Samsher Singh, Sunil Kumar, Naiem A. Wani, Rajkishor Rai, Surrinder Koul, Inshad A. Khan, Payare L. Sangwan
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L. Mayrink Assis, M. Nedeljković, A. Dessen
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ChemMedChem.2017; 12(14): 1125. CrossRef
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Manuel Alcalde-Rico, Sara Hernando-Amado, Paula Blanco, José L. Martínez
Frontiers in Microbiology.2016;[Epub] CrossRef

Journal Article

Anti protein A antibody-gold nanorods conjugate: a targeting agent for selective killing of methicillin resistant Staphylococcus aureus using photothermal therapy method: Rasoul Shokri , Mojtaba Salouti , Rahim Sorouri Zanjani; J. Microbiol. 2015;53(2):116-121. Published online January 28, 2015; DOI: https://doi.org/10.1007/s12275-015-4519-4

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The high prevalence of methicillin resistant Staphylococcus aureus (MRSA) and developing resistance to antibiotics requires new approaches for treatment of infectious diseases due to this bacterium. In this study, we developed a targeting agent for selective killing of MRSA using photothermal therapy method based on anti protein A antibody and gold nanorods (GNRs). Polystyrene sulfonate (PSS) coated GNRs were conjugated with anti protein A antibody. The FT-IR and UV-vis analyses approved the formation of anti protein A antibody-gold nanorods conjugate. In vitro study of photothermal therapy showed 82% reduction in the MRSA cells viability which was significantly greater than the ablation effect of free GNRs and laser alone. Significant accumulation of anti protein A antibody-GNRs in the infected muscle in comparison with normal muscle approved the targeting ability of new agent. In vivo study of photothermal therapy resulted in a significant reduction (73%) in the bacterial cells viability in the infected mouse model. These results demonstrated the ability of anti protein A antibody-GNRs conjugate in combination with NIR laser energy for selective killing of MRSA in mouse model.

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Yu Zhao, Jiaying Yang, Danli Hao, Ran Xie, Lingyu Jia, Miyi Yang, Hai Ma, Pengqian Wang, Weipeng Yang, Feng Sui, Haiyu Zhao, Yanjun Chen, Qinghe Zhao
Macromolecular Bioscience.2023;[Epub] CrossRef
Nanomaterials-mediated on-demand and precise antibacterial therapies
Shi Cheng, Qihui Wang, Manlin Qi, Wenyue Sun, Kun Wang, Wen Li, Jinying Lin, Biao Dong, Lin Wang
Materials & Design.2023; 230: 111982. CrossRef
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Karol Skłodowski, Sylwia Joanna Chmielewska-Deptuła, Ewelina Piktel, Przemysław Wolak, Tomasz Wollny, Robert Bucki
International Journal of Molecular Sciences.2023; 24(3): 2104. CrossRef
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ACS Applied Materials & Interfaces.2023; 15(10): 13783. CrossRef
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Colloids and Surfaces B: Biointerfaces.2022; 220: 112887. CrossRef
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Applied Microbiology and Biotechnology.2022; 106(11): 3957. CrossRef
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Chemistry – A European Journal.2021; 27(62): 15361. CrossRef
Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment
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Journal of Controlled Release.2020; 328: 251. CrossRef
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ACS Nano.2020; 14(7): 8157. CrossRef
Aptamer-based selective KB cell killing by the photothermal effect of gold nanorods
Yuseon Noh, Min-Jin Kim, Hyoyoung Mun, Eun-Jung Jo, Hoyeon Lee, Min-Gon Kim
Journal of Nanoparticle Research.2019;[Epub] CrossRef
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Nouf N. Mahmoud, Alaaldin M. Alkilany, Enam A. Khalil, Amal G. Al-Bakri
Scientific Reports.2018;[Epub] CrossRef
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Gujie Mi, Di Shi, Mian Wang, Thomas J. Webster
Advanced Healthcare Materials.2018;[Epub] CrossRef
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Blessing Aderibigbe
Molecules.2017; 22(8): 1370. CrossRef
Multianchored Glycoconjugate‐Functionalized Magnetic Nanoparticles: A Tool for Selective Killing of Targeted Bacteria via Alternating Magnetic Fields
Yash S. Raval, Benjamin D. Fellows, Jamie Murbach, Yves Cordeau, Olin Thompson Mefford, Tzuen‐Rong J. Tzeng
Advanced Functional Materials.2017;[Epub] CrossRef
Engineered gold nanoparticles for photothermal cancer therapy and bacteria killing
Alireza Gharatape, Soodabeh Davaran, Roya Salehi, Hamed Hamishehkar
RSC Advances.2016; 6(112): 111482. CrossRef
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Alireza Gharatape, Morteza Milani, Seyed Hossein Rasta, Mohammad Pourhassan-Moghaddam, Sohrab Ahmadi-Kandjani, Soodabeh Davaran, Roya Salehi
RSC Advances.2016; 6(112): 110499. CrossRef
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Ki Woo Kim
Journal of Microbiology.2016; 54(11): 703. CrossRef

Research Support, Non-U.S. Gov'ts

Involvement of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in β1 Integrin-Mediated Internalization of Staphylococcus aureus by Alveolar Epithelial Cells: Jia-He Wang , Ke Zhang , Nan Wang , Xiao-Min Qiu , Yi-Bing Wang , Ping He; J. Microbiol. 2013;51(5):644-650. Published online June 25, 2013; DOI: https://doi.org/10.1007/s12275-013-3040-x

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Abstract PDF

The invasion of Staphylococcus aureus into alveolar epithelial cells is regarded as the key step for S. aureus lung infection. However, the mechanism of internalization of S. aureus by alveolar epithelial cells is not clear, and was the aim of this investigation Human lung adenocarcinomic epithelial cells and A549 cells were used. Human β1 integrin and rat β1 integrin were detected by real-time reverse transcription (RT)-PCR. The expressions of β1 integrin, Akt and p-Akt were detected by Western blot analysis. To further investigate the role of β1 integrin in S. aureus internalization by alveolar epithelial cells, we next performed siRNA-mediated knockdown of β1 integrin expression. In this study, we found that S. aureus invades human alveolar epithelial cells and rat primary alveolar epithelial cells. The β1 integrin ligand competitive inhibitor, GRGDS-peptide, blocked the internalization of S. aureus by A549 cells. Knockdown of β1 integrin also inhibited the internalization of S. aureus. In addition, the PI3K/Akt signaling pathway in alveolar epithelial cells was activated by the infection with S. aureus. Furthermore, Akt phosphorylation was abolished by transient transfection with β1 integrin siRNA in A549 cells challenged with S. aureus. Our results suggest that the phosphatidylinositol 3-kinase/Akt signaling pathway plays an important role in β1 integrin-mediated internalization of S. aureus by alveolar epithelial cells.

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Yousef Maali, Alan Diot, Patrícia Martins-Simões, Michele Bes, Daniel Bouvard, François Vandenesch, Paul O. Verhoeven, Frederic Laurent, Sophie Trouillet-Assant, Victor J. Torres
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Xu Liang, Changyong Luo, Yan Li, Xin Li, Qian Wang, Shujing Zhang, Qingqiao Sun, Yuanhong Ma, Caihua Xiong, Yanpeng Zeng, Huu-Tung Nguyen
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Tim Schlesier, Anke Siegmund, Ursula Rescher, Christine Heilmann
International Journal of Medical Microbiology.2020; 310(8): 151463. CrossRef
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Margherita Bertuzzi, Gemma E Hayes, Elaine M Bignell
FEMS Microbiology Reviews.2019; 43(2): 145. CrossRef
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Nicolas Richard, Léa Marti, Annabelle Varrot, Loïc Guillot, Juliette Guitard, Christophe Hennequin, Anne Imberty, Harriet Corvol, Michel Chignard, Viviane Balloy
Scientific Reports.2018;[Epub] CrossRef
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Jérôme Josse, Frédéric Laurent, Alan Diot
Frontiers in Microbiology.2017;[Epub] CrossRef
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Jean‐Marc Zingg, Angelo Azzi, Mohsen Meydani
Journal of Cellular Biochemistry.2017; 118(7): 1855. CrossRef
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BMC Microbiology.2017;[Epub] CrossRef
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Davide Campoccia, Francesca Testoni, Stefano Ravaioli, Ilaria Cangini, Alessandra Maso, Pietro Speziale, Lucio Montanaro, Livia Visai, Carla Renata Arciola
Journal of Biomedical Materials Research Part A.2016; 104(3): 788. CrossRef
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Judy Ou, Amanda Drilling, Deepti Singhal, Neil C.‐W. Tan, Deanna Wallis‐Hill, Sarah Vreugde, Alkis J. Psaltis, Peter‐John Wormald
International Forum of Allergy & Rhinology.2016; 6(8): 792. CrossRef
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Emily J. Swindle, Jared M. Brown, Madeleine Rådinger, Frank R. DeLeo, Dean D. Metcalfe
Immunology.2015; 146(3): 470. CrossRef
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Masaaki Nakayama, Tetsuyoshi Inoue, Mariko Naito, Koji Nakayama, Naoya Ohara
Journal of Biological Chemistry.2015; 290(8): 5190. CrossRef
Transcriptional Profile of Mycobacterium tuberculosis Replicating in Type II Alveolar Epithelial Cells
Michelle B. Ryndak, Krishna K. Singh, Zhengyu Peng, Suman Laal, Ludovic Tailleux
PLOS ONE.2015; 10(4): e0123745. CrossRef
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Eun-Jin Choi, Hyung-Ip Kim, Ji-Ae Kim, Soo Youn Jun, Sang Hyeon Kang, Dong June Park, Seok-Jun Son, Younghoon Kim, Ok Sarah Shin
Applied Microbiology and Biotechnology.2015; 99(10): 4387. CrossRef
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Nayeli Alva-Murillo, Joel Edmundo López-Meza, Alejandra Ochoa-Zarzosa
BioMed Research International.2014; 2014: 1. CrossRef
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Frontiers in Microbiology.2014;[Epub] CrossRef

Responses in the Expression of Extracellular Proteins in Methicillin-Resistant Staphylococcus aureus Treated with Rhodomyrtone: Monton Visutthi , Potjanee Srimanote , Supayang Piyawan Voravuthikunchai; J. Microbiol. 2011;49(6):956-964. Published online December 28, 2011; DOI: https://doi.org/10.1007/s12275-011-1115-0

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Abstract PDF: Rhodomyrtone from a medicinal plant species, Rhodomyrtus tomentosa, is a challenged effective agent against Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA). The present study was undertaken to provide insight into MRSA extracellular protein expression following rhodomyrtone treatment. Secreteomic approach was performed on a representative clinical MRSA isolate exposing to subinhibitory concentration rhodomyrtone (0.174 μg/ml). The identified extracellular proteins of a response of MRSA to rhodomyrtone treated condition were both suppressed and overexpressed. Staphylococcal antigenic proteins, immunodominant antigen A (IsaA) and staphylococcal secretory antigen (SsaA) involved in cell wall hydrolysis were downregulated after the treatment. The results suggested that rhodomyrtone may interfere with WalK/WalR (YycG/YycF) system. Other enzymes such as lipase precursor and another lipase, glycerophosphoryl diester phosphodiesterase, were absent. In contrast, cytoplasmic proteins such as SpoVG and glycerol phosphate lipoteichoic acid synthase, and ribosomal proteins were found in the treated sample. Appearance of several cytoplasmic proteins in the treated culture supernatant revealed that the bacterial cell wall biosynthesis was disturbed. This finding provides a proteomic mapping of extracellular proteins after rhodomytone treatment. Extensive investigation is required for this natural compound as it has a great potency as an alternative anti-MRSA drug.

Research Support, N.I.H., Extramural

The Activity of a Small Lytic Peptide PTP-7 on Staphylococcus aureus Biofilms: Riddhi Kharidia , Jun F. Liang; J. Microbiol. 2011;49(4):663-668. Published online September 2, 2011; DOI: https://doi.org/10.1007/s12275-011-1013-5

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Abstract PDF: One of the most important features of bacterial biofilms is their resistance to antibiotics and to the host immune system. In this study, we have found that a small lytic peptide, PTP-7, is very potent to Gram-positive bacteria and is able to kill antibiotic sensitive and resistant Staphylococcus aureus indiscriminately. Further studies have revealed that despite being a cationic peptide, the antibacterial activity of PTP-7 was not affected by the negatively charged extracellular polymeric substance (EPS) of biofilms. PTP-7 could diffuse into the deep layer of S. aureus biofilms to kill bacteria inside biofilms efficiently and effectively. Neither the high concentrations of metal ions nor the acidic pH in biofilms affected the activity of peptide PTP-7. It seems that the unique sequence/structure together with the resistant bacteria killing ability of peptide PTP-7 confers its anti-biofilm activity. This study sheds new light on the treatment of bacterial biofilms, especially various biofilm related infections.

Research Support, Non-U.S. Gov'ts

Synergistic Effects of the Combination of Galangin with Gentamicin against Methicillin-Resistant Staphylococcus aureus: Young-Seob Lee , Ok-Hwa Kang , Jang-Gi Choi , You-Chang Oh , Hee-Sung Chae , Jong Hak Kim , Hyun Park , Dong Hwan Sohn , Zheng-Tao Wang , Dong-Yeul Kwon; J. Microbiol. 2008;46(3):283-288. Published online July 5, 2008; DOI: https://doi.org/10.1007/s12275-008-0012-7

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Abstract PDF

The antimicrobial killing activity toward methicillin-resistant Staphylococcus aureus (MRSA) has been a serious emerging global issue. New effective antimicrobials and/or new approaches to settle this issue are urgently needed. The oriental herb, Alpinia officinarum, has been used in Korea for several hundreds of years to treat various infectious diseases. As it is well known, one of the active constituents of Alpinia officinarum is galangin. Against the 17 strains, the minimum inhibitory concentrations (MICs) of galangin (GAL) were in the range of 62.5~125 μg/ml, and the MICs of gentamicin (GEN) ranged from 1.9 μg/ml to 2,000 μg/ml. The fractional inhibitory concentrations (FICs) of GAL, in combination with GEN, against 3 test strains were 0.4, 3.9, and 250 μg/ml, and were all 15.62 μg/ml in GEN. The FIC index showed marked synergism in the value range of 0.19 to 0.25. By determining time-kill curves, also confirmed the low synergism of the GAL and GEN combination against 4 h, 8 h, 12 h, and 24 h cultured MRSA. The time-kill study results indicated a low synergistic effect against 3 test strains. Thus, the mixture of GAL and GEN could lead to the development of new combination antibiotics against MRSA infection.

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Journal of Applied Microbiology.2012; 112(1): 55. CrossRef
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Foodborne Pathogens and Disease.2011; 8(8): 869. CrossRef
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International Journal of Antimicrobial Agents.2011; 38(2): 99. CrossRef
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The Journal of Toxicological Sciences.2011; 36(5): 645. CrossRef
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Letters in Applied Microbiology.2010; : no. CrossRef
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Foodborne Pathogens and Disease.2010; 7(4): 435. CrossRef
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Phytochemistry.2009; 70(17-18): 2040. CrossRef

Sterilization of Bacteria, Yeast, and Bacterial Endospores by Atmospheric-Pressure Cold Plasma using Helium and Oxygen: Kyenam Lee , Kwang-hyun Paek , Won-Tae Ju , Yoenhee Lee; J. Microbiol. 2006;44(3):269-275.; DOI: https://doi.org/2386 [pii]

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Abstract PDF: Atmospheric-pressure cold plasma (APCP) using helium/oxygen was developed and tested as a suitable sterilization method in a clinical environment. The sterilizing effect of this method is not due to UV light, which is known to be the major sterilization factor of APCP, but instead results from the action of reactive oxygen radicals. Escherichia coli, Staphylococcus aureus, and Saccharomyces cerevisiae deposited on a nitrocellulose filter membrane or Bacillus subtilis spores deposited on polypropylene plates were exposed to helium/oxygen plasma generated with AC input power at 10 kHz, 6 kV. After plasma treatment, nitrocellulose filter membranes were overlaid on fresh solid media and CFUs were counted after incubation overnight. D-values were 18 sec for E. coli, 19 sec for S. aureus, 1 min 55 sec for S. cerevisiae, and 14 min for B. subtilis spores. D-values of bacteria and yeast were dependent on the initial inoculation concentration, while the D-value of B. subtilis spores showed no correlation. When treated cells were observed with a scanning electron microscope, E. coli was more heavily damaged than S. aureus, S. cerevisiae exhibited peeling, and B. subtilis spores exhibited shrunken morphology. Results showed that APCP using helium/oxygen has many advantages as a sterilization method, especially in a clinical environment with conditions such as stable temperature, unlimited sample size, and no harmful gas production.

Surveillance of Bacterial Pathogens Associated with Acute Diarrheal Disease in the Republic of Korea During One Year, 2003: Seung-Hak Cho , Jong-Hyun Kim , Jong-Chul Kim , Hyun-Ho Shin , Yeon-Ho Kang , Bok-Kwon Lee; J. Microbiol. 2006;44(3):327-335.; DOI: https://doi.org/2379 [pii]

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Abstract PDF: An epidemiological survey of human enterobacterial infections was conducted to determine the prevalence of enteropathogens in the Republic of Korea during one year, 2003. We tested for infectious diseases in 26,992 stool samples obtained from people who visited clinics located in six big cities and six rural provinces. From these samples, we isolated 1,291 cases of enteritis bacterial infection (4.8%). In the urban areas, 821 cases of bacterial infection (6.4%) were identified and, in the rural areas, 479 bacterial strains (3.3%) were isolated. Seasonal patterns were seen for diarrhea associated with S. aureus, E. coli and V. parahaemolyticus, while Salmonella and Shigella infections showed slight seasonal variation. We found that S. aureus and Salmonella were more frequently isolated from children and the elderly; however, the prevalence of E. coli, V. parahaemolyticus, and Shigella were similar in different age groups. Routine monitoring of these infections is considered a worthwhile means by which to elucidate their epidemiology and modes of transmission and ultimately to control them more effectively. Continuous laboratory-based surveillance for findings of enteritis bacterial infection should be emphasized in the prevention of these infections.

Detection of Escherichia coli O157:H7, Salmonella spp.,Staphylococcus aureus and Listeria monocytogenes in Kimchi by Multiplex Polymerase Chain Reaction (mPCR): Yeon Sun Park , Sang Rok Lee , Young Gon Kim; J. Microbiol. 2006;44(1):92-97.; DOI: https://doi.org/2331 [pii]

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Abstract PDF: We developed an mPCR assay for the simultaneous detection, in one tube, of Escherichia coli O157:H7, Salmonella spp., Staphylococcus aureus and Listeria monocytogenes using species-specific primers. The mPCR employed the E. coli O157:H7 specific primer Stx2A, Salmonella spp. specific primer Its, S. aureus specific primer Cap8A-B and L. monocytogenes specific primer Hly. Amplification with these primers produced products of 553, 312, 405 and 210 bp, respectively. All PCR products were easily detected by agarose gel electrophoresis, and the sequences of the specific amplicons assessed. Potential pathogenic bacteria, in laboratory-prepared and four commercially available kimchi products, were using this mPCR assay, and the amplicons cloned and sequenced. The results correlated exactly with sequences derived for amplicons obtained during preliminry tests with known organisms. The sensitivity of the assay was determined for the purified pathogen DNAs from four strains. The mPCR detected pathogen DNA at concentrations ranging from approximately 0.45 to 0.05 pM/μl. Thus, this mPCR assay may allow for the rapid, reliable and cost-effective identification of four potentially pathogens present in the mixed bacterial communities of commercially available kimchi.

Staphylococcus aureus Siderophore-Mediated Iron-Acquisition System Plays a Dominant and Essential Role in the Utilization of Transferrin-Bound Iron: Ra-Young Park , Hui-Yu Sun , Mi-Hwa Choi , Young-Hoon Bai , Sung-Heui Shin; J. Microbiol. 2005;43(2):183-190.; DOI: https://doi.org/2163 [pii]

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Abstract PDF: Staphylococcus aureus is known to be capable of utilizing transferrin-bound iron, via both siderophore- and transferrin-binding protein (named IsdA)-mediated iron-acquisition systems. This study was designed in order to determine which iron-acquisition system plays the essential or dominant role with respect to the acquisition of iron from human transferrin, in the growth of S. aureus. Holotransferrin (HT) and partially iron-saturated transferrin (PT), but not apotransferrin (AT), were found to stimulate the growth of S. aureus. S. aureus consumed most of the transferrin-bound iron during the exponential growth phase. Extracellular proteases were not, however, involved in the liberation of iron from transferrin. Transferrin-binding to the washed whole cells via IsdA was not observed during the culture. The expression of IsdA was observed only in the deferrated media with AT, but not in the media supplemented with PT or HT. In contrast, siderophores were definitely produced in the deferrated media with PT and HT, as well as in the media supplemented with AT. The siderophores proved to have the ability to remove iron directly from transferrin, but the washed whole cells expressing IsdA did not. In the bioassay, the growth of S. aureus on transferrin-bound iron was stimulated by the siderophores alone. These results demonstrate that the siderophore-mediated iron-acquisition system plays a dominant and essential role in the uptake of iron from transferrin, whereas the IsdA-mediated iron-acquisition system may play only an ancillary role in the uptake of iron from transferrin.

Growth of Staphylococcus aureus with Defective Siderophore Production in Human Peritoneal Dialysate Solution: Ra-Young Park , Hui-Yu Sun , Mi-Hwa Choi , Young-Hoon Bae , Sung-Heui Shin; J. Microbiol. 2005;43(1):54-61.; DOI: https://doi.org/2137 [pii]

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Abstract PDF: In this study, we attempted to determine the effects of iron-availability and the activity of the bacterial iron-uptake system (IUS) on the growth of Staphylococcus aureus in human peritoneal dialysate (HPD) solution. A streptonigrin-resistant S. aureus (SRSA) strain, isolated from S. aureus ATCC 6538, exhibited defective siderophore production, thereby resulting in ineffective uptake of iron from low iron-saturated transferrin. The growth of both strains was stimulated in HPD solution supplemented with FeCl_3 and holotransferrin, but growth was inhibited in HPD solution which had been supplemented with apotransferrin and dipyridyl. The SRSA strain grew less robustly than did its parental strain in both iron-supplemented HPD solution and regular HPD solution. These results indicate that iron-availability and siderophore-mediated IUS activity in particular, the ability to produce siderophores and thus capture iron from low iron-saturated transferrin play critical roles in the growth of S. aureus in HPD solution. Our results also indicated that the possibility of using iron chelators as therapeutic or preventive agents warrants further evaluation.

Phage Typing of Staphylococcus aureus Isolates from Poultry Meat in Spain: Rosa Capita , Maite Alvarez-Astorga , Carlos Alonso-Calleja , Benito Moreno , Maria del Camino Garcia-Fernandez; J. Microbiol. 2001;39(3):219-225.

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Abstract PDF: Phage typing is currently used for typing of Staphylococcus aureus strains beyond the species level in epidemiological studies. A total of 168 Staphylococcus aureus isolates from chicken meat and chicken by-products were phage-typed using the international bacteriophage set for typing Staphylococcus aureus of human origin. One hundred and forty-eight (88.09%) strains were phage-typeable (at least one phage produced 20 or more plaques of lysis). Lysis by phages of group III was the most frequent with 99 (58.93%) sensitive strains. This fact coincides with results of other authors. Twenty-nine different phage patterns were observed and three (95, 75/84 and 6/1030/W57) were most common. One hundred and thirty-two (89.19% of typeable strains) showed these or indistinguishable (only one phage reaction difference) patterns. Twenty-six out of seventy chicken samples (37.14%) harboured more than one phage type of Staphylococcus aureus. This fact emphasizes the convenience of subtyping several Staphylococcus aureus isolates from the same sample in epidemiological studies. 80% of sausages and hamburgers contained the same Staphylococcus aureus phage types, which were not found in any of the other food types. This fact suggests a cross contamination during the processing of these foods. Phages 6, 75, 84, 1030 and W57 showed the greatest activity. None of the Staphylococcus aureus strains were sensitive to phages 47, 81 and 94.

Assessment of Baird-Parker Agar as Screening Test for Determination of Staphylococcus aureus in Poultry Meat: Rosa Capita , Carlos Alonso-Calleja , Benito Moreno , Maria del Camino Garcia-Fernandez; J. Microbiol. 2001;39(4):321-325.

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Abstract PDF: Baird-Parker agar with egg yolk/tellurite emulsion (BPA) is widely accepted as a medium for the enumeration of Staphylococcus aureus in foods. However, it is not completely selective and colonies of other genera or species could be similar to those of Staphylococcus aureus. Moreover, the strains of Staphylococcus aureus that are lecithinase negative could go unnoticed. Both facts could affect the counts. The aim of this study was to determine whether the enumeration of the colonies with the typical morphology of Staphylococcus aureus on BPA is sufficient to quantify this species in poultry meat. Forty chicken carcasses were tested for Staphylococcus aureus by surface plating using BPA. Results indicate that the predictive value of the morphology of the colonies on BPA is 85.71% and 68.42% for typical and atypical colonies of Staphylococcus aureus, respectively. However, Staphylococcus aureus counts (after identification) and counts of typical colonies did not show any significant differences (P>0.05) and are significantly (P<0.001) correlated (r = 0.996). These results suggest that, for screening purposes, enumeration of Staphylococcus aureus from poultry meat does not require any identification of strains, resulting in a saving of time and money.

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