Journal of Microbiology

Journal Articles

Pten gene deletion in intestinal epithelial cells enhances susceptibility to Salmonella Typhimurium infection in mice: Cody Howe , Jonathon Mitchell , Su Jin Kim , Eunok Im , Sang Hoon Rhee; J. Microbiol. 2019;57(11):1012-1018. Published online September 25, 2019; DOI: https://doi.org/10.1007/s12275-019-9320-3

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Although phosphatase and tensin homolog (PTEN) is typically considered a tumor-suppressor gene, it was recently suggested that PTEN regulates TLR5-induced immune and inflammatory responses in intestinal epithelial cells (IECs), suggesting an immunomodulatory function of PTEN in the gut. However, this alternative function of PTEN has not yet been evaluated in an in vivo context of protection against enteropathogenic bacteria. To address this, we utilized IECrestricted Pten knockout (PtenΔIEC/ΔIEC) and littermate Pten+/+ mice. These mice were subjected to the streptomycin-pretreated mouse model of Salmonella infection, and subsequently given an oral gavage of a low inoculum (2 × 104 CFU) of Salmonella enterica serovar Typhimurium (S. Typhimurium). This bacterial infection not only increased the mortality of PtenΔIEC/ΔIEC mice compared to Pten+/+ mice, but also induced deleterious gastrointestinal inflammation in PtenΔIEC/ΔIEC mice manifested by massive histological damage to the intestinal mucosa. S. Typhimurium infection upregulated pro-inflammatory cytokine production in the intestine of PtenΔIEC/ΔIEC mice compared to controls. Furthermore, bacterial loads were greatly increased in the liver, mesenteric lymph node, and spleen of PtenΔIEC/ΔIEC mice compared to controls. Together, these results suggest that IEC-restricted Pten deficiency renders the host greatly susceptible to Salmonella infection and support an immuneregulatory role of PTEN in the gut.

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Exploring Protein Functions of Gut Bacteriome and Mycobiome in Thai Infants Associated with Atopic Dermatitis Through Metaproteomic and Host Interaction Analysis
Thanawit Chantanaskul, Preecha Patumcharoenpol, Sittirak Roytrakul, Amornthep Kingkaw, Wanwipa Vongsangnak
International Journal of Molecular Sciences.2024; 25(24): 13533. CrossRef
QTL Mapping-Based Identification of Visceral White-Nodules Disease Resistance Genes in Larimichthys polyactis
Qian Li, Jiajie Zhu, Sifang Liu, Haowen Liu, Tianle Zhang, Ting Ye, Bao Lou, Feng Liu
International Journal of Molecular Sciences.2024; 25(20): 10872. CrossRef
Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection
Lakmini S. Premadasa, Eunhee Lee, Marina McDew-White, Xavier Alvarez, Sahana Jayakumar, Binhua Ling, Chioma M. Okeoma, Siddappa N. Byrareddy, Smita Kulkarni, Mahesh Mohan
JCI Insight.2023;[Epub] CrossRef
Regulator of RNase E activity modulates the pathogenicity of Salmonella Typhimurium
Jaejin Lee, Eunkyoung Shin, Ji-Hyun Yeom, Jaeyoung Park, Sunwoo Kim, Minho Lee, Kangseok Lee
Microbial Pathogenesis.2022; 165: 105460. CrossRef
Endoribonuclease-mediated control of hns mRNA stability constitutes a key regulatory pathway for Salmonella Typhimurium pathogenicity island 1 expression
Minho Lee, Minkyung Ryu, Minju Joo, Young-Jin Seo, Jaejin Lee, Hong-Man Kim, Eunkyoung Shin, Ji-Hyun Yeom, Yong-Hak Kim, Jeehyeon Bae, Kangseok Lee, William Navarre
PLOS Pathogens.2021; 17(2): e1009263. CrossRef
Corticotropin-Releasing Hormone Receptor Alters the Tumor Development and Growth in Apcmin/+ Mice and in a Chemically-Induced Model of Colon Cancer
Yunna Lee, Elise L. Ma, Marisa Patel, Gayoung Kim, Cody Howe, Charalabos Pothoulakis, Yong Sung Kim, Eunok Im, Sang Hoon Rhee
International Journal of Molecular Sciences.2021; 22(3): 1043. CrossRef
Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor
Tianyu He, Xiaoyun Zhang, Jianyu Hao, Shigang Ding
Frontiers in Physiology.2021;[Epub] CrossRef
Phosphatase and Tensin Homolog (PTEN) of Japanese Flounder—Its Regulation by miRNA and Role in Autophagy, Apoptosis and Pathogen Infection
Wenrui Li, Xiaolu Guan, Li Sun
International Journal of Molecular Sciences.2020; 21(20): 7725. CrossRef
Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway
Shirui Tan, Fang Yan, Qingrong Li, Yaping Liang, Junxu Yu, Zhenjun Li, Feifei He, Rongpeng Li, Ming Li
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef

Water-based extracts of Zizania latifolia inhibit Staphylococcus aureus infection through the induction of human beta-defensin 2 expression in HaCaT cells: Bo Yeon Kang , Seung-Su Lee , Myun-Ho Bang , Hyoik Jeon , Hangeun Kim , Dae Kyun Chung; J. Microbiol. 2018;56(12):910-916. Published online November 27, 2018; DOI: https://doi.org/10.1007/s12275-018-8307-9

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Abstract

Zizania latifolia is a perennial herb belonging to the family Gramineae that has been used as a health food in Asian countries. In this study, we investigated the antimicrobial effect of Z. latifolia, which increased human beta-defensin 2 (hBD2) expression in HaCaT cells. hBD2 expression was further increased in cells treated with Z. latifolia extracts and subsequently infected with Staphylococcus aureus. Inversely, S. aureus infection decreased after treatment. The induction of hBD2 in HaCaT cells was mediated by the Toll-like receptor 2 (TLR2) signaling pathway, including the activation of extracellular signal-regulated kinase (ERK) and activator protein 1 (AP-1). Further study using siRNA revealed that hBD2 played an important role in the inhibition of S. aureus infection in HaCaT cells. Our data suggest that Z. latifolia extracts can be used as an antimicrobial ingredient for skin treatment formulas.

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Recent advances in Zizania latifolia : A comprehensive review on phytochemical, health benefits and applications that maximize its value
Weijie Wu, Yanchao Han, Ben Niu, Baiqi Yang, Ruiling Liu, Xiangjun Fang, Huizhi Chen, Shangyue Xiao, Mohamed A. Farag, Shiqi Zheng, Jianbo Xiao, Hangjun Chen, Haiyan Gao
Critical Reviews in Food Science and Nutrition.2024; 64(21): 7535. CrossRef
Application of melatonin delays lignification in postharvest water bamboo shoots in association with energy metabolism
Baiqi Yang, Yanchao Han, Haiyan Gao, Ruiling Liu, Feng Xu, Ruihai Liu, Shangyue Xiao, Bin Li, Hangjun Chen
Postharvest Biology and Technology.2023; 196: 112149. CrossRef
Toll-Like Receptors Signaling Pathway of Quercetin Regulating Avian Beta-Defensin in the Ileum of Broilers
Linlin Ying, Hao Wu, Shuaishuai Zhou, Han Lu, Manyi Ding, Bo Wang, Shanshan Wang, Yanjun Mao, Fenglin Xiao, Yao Li
Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef
Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms
Przemysław Sitarek, Anna Merecz-Sadowska, Tomasz Kowalczyk, Joanna Wieczfinska, Radosław Zajdel, Tomasz Śliwiński
International Journal of Molecular Sciences.2020; 21(14): 5105. CrossRef
Identification and expression analysis of chitinase genes in Zizania latifolia in response to abiotic stress
Niannian Zhou, Yulan An, Zhicheng Gui, Shuangshuang Xu, Xiaomei He, Jie Gao, Donglin Zeng, Defang Gan, Wenjuan Xu
Scientia Horticulturae.2020; 261: 108952. CrossRef

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