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- Exploring the Therapeutic Potential of Scorpion‑Derived Css54 Peptide Against Candida albicans
- Jonggwan Park , Hyeongsun Kim , Da Dam Kang , Yoonkyung Park
- J. Microbiol. 2024;62(2):101-112. Published online April 8, 2024
- DOI: https://doi.org/10.1007/s12275-024-00113-4
- 469 View
- 13 Download
- 7 Web of Science
- 7 Crossref
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Abstract
PDF - Candida albicans (C. albicans) is one of the most common opportunistic fungi worldwide, which is associated with a high mortality rate. Despite treatment, C. albicans remains the leading cause of life-threatening invasive infections. Consequently, antimicrobial peptides (AMPs) are potential alternatives as antifungal agents with excellent antifungal activity. We previously reported that Css54, found in the venom of Centrurodies suffusus suffusus (C. s. suffusus) showed antibacterial activity against zoonotic bacteria. However, the antifungal activity of Css54 has not yet been elucidated. The obj!ective of this study was to identify the antifungal activity of Css54 against C. albicans and analyze its mechanism. Css54 showed high antifungal activity against C. albicans. Css54 also inhibited biofilm formation in fluconazole-resistant fungi. The antifungal mechanism of action of Css54 was investigated using membrane-related assays, including the membrane depolarization assay and analysis of the membrane integrity of C. albicans after treatment with Css54. Css54 induced reactive oxygen species (ROS) production in C. albicans, which affected its antifungal activity. Our results indicate that Css54 causes membrane damage in C. albicans, highlighting its value as a potential therapeutic agent against C. albicans infection.
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Citations
Citations to this article as recorded by
- Natural product-derived antifungals against Candida albicans: Chemical diversity and mechanisms of action
Runchu Li, Xiaoxu Yang, Wenjia Dan, Jiangkun Dai
Bioorganic & Medicinal Chemistry.2026; 132: 118435. CrossRef - Animal-derived peptides from Traditional Chinese medicines: medicinal potential, mechanisms, and prospects
Jiahui Zhang, Siyi Li, Yueyi Qi, Jieyu Shen, Aijing Leng, Jialin Qu
Journal of Ethnopharmacology.2025; 349: 119872. CrossRef - Scorpion venom as a natural peptide source for innovative therapeutic solutions: A comprehensive review of its potential in emerging medical frontiers
Radwa Abdallnasser Amen, Rawan Atef Essmat, Alyaa Farid, Mohamed A. Abdel-Rahman, Ahmed A. El-Sherif, Yonghong Zhang
Toxicon.2025; 268: 108603. CrossRef - Design and Characterization of Antibacterial Peptide Nanofibrils as Components of Composites for Biomaterial Applications
Justyna Sawicka, Piotr Bollin, Anna Sylla, Miroslawa Panasiuk, Michalina Wilkowska, Lidia Ciolek, Mateusz Leśniewski, Aleksandra Konopka, Karol Struniawski, Gabriela Calka-Kuc, Adam Liwo, Piotr Hanczyc, Maciej Kozak, Beata Gromadzka, Monika Biernat, Sylwi
Current Protein & Peptide Science.2025; 26(10): 875. CrossRef - Properties and Pharmacology of Scorpion Toxins and Their Biotechnological Potential in Agriculture and Medicine
Cháriston André Dal Belo, Stephen Hyslop, Célia Regina Carlini
Toxins.2025; 17(10): 497. CrossRef - Antimicrobial Potential of Scorpion-Venom-Derived Peptides
Zhiqiang Xia, Lixia Xie, Bing Li, Xiangyun Lv, Hongzhou Zhang, Zhijian Cao
Molecules.2024; 29(21): 5080. CrossRef - Synthetic Short Cryptic Antimicrobial Peptides as Templates for the Development of Novel Biotherapeutics Against WHO Priority Pathogen
Manjul Lata, Vrushti Telang, Pooja Gupta, Garima Pant, Mitra Kalyan, Jesu Arockiaraj, Mukesh Pasupuleti
International Journal of Peptide Research and Therapeutics.2024;[Epub] CrossRef
- Natural product-derived antifungals against Candida albicans: Chemical diversity and mechanisms of action
- [Protocol] Detecting Salmonella Type II flagella production by transmission electron microscopy and immunocytochemistry
- Yoontak Han , Eun-Jin Lee
- J. Microbiol. 2020;58(4):245-251. Published online November 23, 2019
- DOI: https://doi.org/10.1007/s12275-020-9297-y
- 303 View
- 1 Download
- 8 Web of Science
- 8 Crossref
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Abstract
PDF
- The bacterial flagellum is an appendage structure that provides a means for motility to promote survival in fluctuating environments. For the intracellular pathogen Salmonella enterica serovar Typhimurium to survive within macrophages, flagellar gene expression must be tightly regulated, and thus, is controlled at multiple levels, including DNA recombination, transcription, post-transcription, protein synthesis, and assembly within host cells. To understand the contribution of flagella to Salmonella pathogenesis within the host, it is critical to detect flagella production within macrophages via microscopy. In this paper, we describe two methods for detecting bacterial flagella by microscopy both in vitro and in vivo infection models.
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Citations
Citations to this article as recorded by- Design and Performance Evaluation of a Graphene Biosensor for Protein Detection with Two, Three Bit Encoding and Machine Learning Optimization
Jacob Wekalao, Yahya Ali Abdelrahman Ali, Taoufik Saidani, Shobhit K. Patel, Abdulkarem H. M. Almawgani, Basim Ahmad Alabsi
Plasmonics.2025;[Epub] CrossRef -
A shared mechanism of multidrug resistance in laboratory-evolved uropathogenic
Escherichia coli
Nakjun Choi, Eunna Choi, Yong-Joon Cho, Min Jung Kim, Hae Woong Choi, Eun-Jin Lee
Virulence.2024;[Epub] CrossRef - QseC regulates chemotaxis, biofilm formation, motility, and virulence in Aeromonas veronii TH0426
Luo-tao Tao, Lu Wang, Jing Xiong, Liang Chen, Ze-lin Zhao, Dong-xing Zhang, Lei Zhang, Wu-wen Sun, Xiao-feng Shan
Aquaculture.2024; 588: 740928. CrossRef - Salinicola avicenniae sp. nov., a Novel Gammaproteobacterium Isolated from Mangrove Plant, Avicennia marina, in Beibu Gulf, China
Wenquan Zhang, Danyun Ou, Yue Ni, Hao Huang, Weiwen Li, Lei Wang, Shunyang Chen, Guangcheng Chen
Current Microbiology.2024;[Epub] CrossRef - Etiological Survey and Traceability Analysis of a Foodborne Disease Outbreak of Salmonella Senftenberg in Guizhou Province
Qian Zhou, Yu-jing Zhong, Zhu-zhou Shan, Xue-xue Pan, Jing-yu Huang, Jing-shu Xiang, De-zhu Zhang, Wei-wei Li, Jun Li, Ying Liu, Shi-jun Li, Li Zhou
Foodborne Pathogens and Disease.2023; 20(8): 351. CrossRef - Sulfamethoxazole degradation by Pseudomonas silesiensis F6a isolated from bioelectrochemical technology-integrated constructed wetlands
Xiaohui Liu, Jing Chen, Ying Liu, Zhengfen Wan, Xiaochun Guo, Shaoyong Lu, Dongru Qiu
Ecotoxicology and Environmental Safety.2022; 240: 113698. CrossRef - Regulator of RNase E activity modulates the pathogenicity of Salmonella Typhimurium
Jaejin Lee, Eunkyoung Shin, Ji-Hyun Yeom, Jaeyoung Park, Sunwoo Kim, Minho Lee, Kangseok Lee
Microbial Pathogenesis.2022; 165: 105460. CrossRef - Regulator of ribonuclease activity modulates the pathogenicity of Vibrio vulnificus
Jaejin Lee, Eunkyoung Shin, Jaeyeong Park, Minho Lee, Kangseok Lee
Journal of Microbiology.2021; 59(12): 1133. CrossRef
- Design and Performance Evaluation of a Graphene Biosensor for Protein Detection with Two, Three Bit Encoding and Machine Learning Optimization
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