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- Pioneering strategies for overcoming bacterial drug resistance (2026)
- Advancing microbial engineering through synthetic biology (2025)
- Host-associated microbiome (2024)
- Bacterial regulatory mechanisms for the control of complex cellular mechanisms (2023)
- Two years into COVID-19 pandemic: Where are we? (2022)
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Review
- Genomic Evolution and Recombination Dynamics of Human Adenovirus D Species: Insights from Comprehensive Bioinformatic Analysis
- Anyeseu Park, Chanhee Lee, Jeong Yoon Lee
- J. Microbiol. 2024;62(5):393-407. Published online March 7, 2024
- DOI: https://doi.org/10.1007/s12275-024-00112-5
- 555 View
- 11 Download
- 7 Web of Science
- 6 Crossref
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Abstract
PDF - Human adenoviruses (HAdVs) can infect various epithelial mucosal cells, ultimately causing different symptoms in infected organ systems. With more than 110 types classified into seven species (A-G), HAdV-D species possess the highest number of viruses and are the fastest proliferating. The emergence of new adenovirus types and increased diversity are driven by homologous recombination (HR) between viral genes, primarily in structural elements such as the penton base, hexon and fiber proteins, and the E1 and E3 regions. A comprehensive analysis of the HAdV genome provides valuable insights into the evolution of human adenoviruses and identifies genes that display high variation across the entire genome to determine recombination patterns. Hypervariable regions within genetic sequences correlate with functional characteristics, thus allowing for adaptation to new environments and hosts. Proteotyping of newly emerging and already established adenoviruses allows for prediction of the characteristics of novel viruses. HAdV-D species evolved in a direction that increased diversity through gene recombination. Bioinformatics analysis across the genome, particularly in highly variable regions, allows for the verification or re-evaluation of recombination patterns in both newly introduced and pre-existing viruses, ultimately aiding in tracing various biological traits such as virus tropism and pathogenesis. Our research does not only assist in predicting the emergence of new adenoviruses but also offers critical guidance in regard to identifying potential regulatory factors of homologous recombination hotspots.
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Citations
Citations to this article as recorded by
- Adenovirus Genotypes Associated With Severe Acute Respiratory Infections Outbreak in Children, in Antioquia, Colombia, 2022–2023
María Angélica Maya, Celeny Ortiz, Francisco Averhoff, Ana Isabel Davila, Diego Bastidas, Michael G. Berg, Gavin A. Cloherty, Laura S. Perez-Restrepo, Karl Ciuoderis-Aponte, Jaime Usuga, Isabel Moreno, Juan P. Hernandez-Ortiz, Paulina A. Rebolledo, Jorge
Pediatric Infectious Disease Journal.2026; 45(2): 112. CrossRef - Exploration of genes and identification of evolutionary evidence in adeno-associated viruses
Chanhee Lee, Jihong Min, Somin Lim, Anyeseu Park, Seokjin Kwak, Soyeon Hwang, Sooyeon Park, Yong-Suk Jang, Se-Yeoun Cha, Sung-Gook Cho, Jeong Yoon Lee
Journal of Microbiology.2026; 64(2): e2511016. CrossRef - A novel chimpanzee-derived adenovirus, a recombinant of Mastadenovirus exoticum and Mastadenovirus blackbeardi members, reveals lineage-specific recombination hotspots in simian adenoviruses
Ereth A. Robles-Chávez, Raúl E. López, Ramón A. González, Angélica Valle-Constantino, León P. Martínez Castilla, Adan Barbosa-López, Selene Maldonado-López, Julio C. Medina Ávila, Ma Isabel Salazar, Arturo Reyes-Sandoval, Jesús M. Torres-Flores
Virology.2026; 618: 110855. CrossRef - Relationship between adenovirus infection and intussusception via pathological evidence confirms
Lung-Huang Lin, Chi-Jung Huang, Cheng-Yu Lo, Yu-Hsien Lee, Yung-Chuan Chen
Journal of Clinical Pathology.2025; 78(10): 678. CrossRef - Diagnostic Performance of a Silver-Amplified vs. a Non-Amplified Lateral Flow Kit for Adenoviral Conjunctivitis: A Multicenter Prospective Study
Tsuguto Fujimoto, Nozomu Hanaoka, Kenichiro Takahashi, Hisatoshi Kaneko, Masaaki Kobayashi, Hisashi Nakagawa, Hiroshi Hatano, Tomoko Tsukahara-Kawamura, Hironori Migita, Kentaro Nakamura, Kiyoharu Kuramoto, Eiichi Uchio
Viruses.2025; 17(11): 1442. CrossRef - In Silico Intensive Analysis for the E4 Gene Evolution of Human Adenovirus Species D
Chanhee Lee, Anyeseu Park, Jeong Yoon Lee
Journal of Microbiology.2024; 62(5): 409. CrossRef
- Adenovirus Genotypes Associated With Severe Acute Respiratory Infections Outbreak in Children, in Antioquia, Colombia, 2022–2023
Articles
- Effects of Feather Hydrolysates Generated by Probiotic Bacillus licheniformis WHU on Gut Microbiota of Broiler and Common carp
- Kamin Ke, Yingjie Sun, Tingting He, Wenbo Liu, Yijiao Wen, Siyuan Liu, Qin Wang, Xiaowei Gao
- J. Microbiol. 2024;62(6):473-487. Published online February 29, 2024
- DOI: https://doi.org/10.1007/s12275-024-00118-z
- 510 View
- 8 Download
- 6 Web of Science
- 4 Crossref
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Abstract
PDF
- Due to the ever-increasing demand for meat, it has become necessary to identify cheap and sustainable sources of protein for animal feed. Feathers are the major byproduct of poultry industry, which are rich in hard-to-degrade keratin protein. Previously we found that intact feathers can be digested into free amino acids, short peptides, and nano-/micro-keratin particles by the strain Bacillus licheniformis WHU in water, and the resulting feather hydrolysates exhibit prebiotic effects on mice. To explore the potential utilization of feather hydrolysate in the feed industry, we investigated its effects on the gut microbiota of broilers and fish. Our results suggest that feather hydrolysates significantly decrease and increase the diversity of gut microbial communities in broilers and fish, respectively. The composition of the gut microbiota was markedly altered in both of the animals. The abundance of bacteria with potentially pathogenic phenotypes in the gut microbial community of the fish significantly decreased. Staphylococcus spp., Pseudomonas spp., Neisseria spp., Achromobacter spp. were significantly inhibited by the feather hydrolysates. In addition, feather hydrolysates significantly improved proteolytic activity in the guts of broilers and fish. In fish, the expression levels of ZO-1 and TGF-α significantly improved after administration of feather hydrolysates. The results presented here suggest that feather hydrolysates generated by B. licheniformis WHU could be an alternative protein source in aquaculture and could exert beneficial effects on fish.
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Citations
Citations to this article as recorded by- Advancing Fish Health: Systematic and Bibliometric Insights into Functional Feed Additives for Common Carp and Rainbow Trout
Alireza Azizian, Laleh Roomiani, Mehdi Shamsaie Mehrgan, Seyed Pezhman Hosseini Shekarabi
Probiotics and Antimicrobial Proteins.2026;[Epub] CrossRef - Keratinous bioresources: their generation, microbial degradation, and value enhancement for biotechnological applications
Vijan Lal Vikash, Numbi Ramudu Kamini, Ganesan Ponesakki, Suresh Kumar Anandasadagopan
World Journal of Microbiology and Biotechnology.2025;[Epub] CrossRef - Synergistic Therapeutic Efficacy of Engineered Probiotics Embedded in Self-Assembling Keratin Hydrogels for Ulcerative Colitis Treatment
Yijiao Wen, Chunhua Zhang, Xuanting Wang, Yi Shen, Huiwen Luo, Siyuan Liu, Famin Ke, Qin Wang, Xiaowei Gao
ACS Applied Bio Materials.2025; 8(12): 10918. CrossRef - Multi-omic profiling reveals the impact of keratinase kerZJ on mouse gut homeostasis
Xueqing Gan, Yijiao Wen, Si Chen, Famin Ke, Siyuan Liu, Zening Wang, Chunhua Zhang, Xuanting Wang, Qin Wang, Xiaowei Gao
Journal of Microbiology.2025; 63(12): e2509011. CrossRef
- Advancing Fish Health: Systematic and Bibliometric Insights into Functional Feed Additives for Common Carp and Rainbow Trout
- Stenotrophomonas maltophilia outer membrane protein A induces epithelial cell apoptosis via mitochondrial pathways
- Xin Wang , Yan Li , Xueping Tang , Xueyi Shang , Zunquan Zhao , Yongqiang Jiang , Yan Li
- J. Microbiol. 2020;58(10):868-877. Published online September 2, 2020
- DOI: https://doi.org/10.1007/s12275-020-0235-9
- 467 View
- 1 Download
- 11 Web of Science
- 5 Crossref
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Abstract
PDF
- Stenotrophomonas maltophilia (S. maltophilia) is a common opportunistic pathogen in intensive care units and causes infections most often after surgeries in immune-compromised patients such as those undergoing chemotherapy. Outer membrane protein A (OmpA) is the most abundant of the outer membrane proteins in S. maltophilia. Previous studies on OmpA usually focus on its interaction with the host cells and its role in vaccine development. However, the impact of OmpA on the virulence of S. maltophilia to host cells and the effects on apoptosis remain unclear. In this study, we exposed purified recombinant S. maltophilia OmpA (rOmpA) to HEp-2 cells and investigated the effects of OmpA on epithelial cell apoptosis. Morphologic and flow cytometric analyses revealed that HEp-2 cells stimulated with rOmpA multiple apoptosis features, including nuclear roundness and pyknosis, chromatin aggregation, and phosphatidylserine eversion. We found that rOmpA regulated the protein levels of Bax and Bcl-xL in HEp-2 cells, leading to changes in mitochondria permeability and the release of cytochrome c and apoptosis-inducing factors into the cytoplasm. These subsequently activate the caspase-9/caspase-3 pathway that promote apoptosis. We also observed that rOmpA enhanced the generation of reactive oxygen species and increased intracellular Ca2+ levels in HEp-2 cells. Collectively, our data suggested that rOmpA induced epithelial cells apoptosis via mitochondrial pathways.
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Citations
Citations to this article as recorded by- From gatekeepers to mitochondrial mischief: how bacterial outer membrane proteins crash the host cell party
Paloma Osset-Trenor, Markus Proft, Amparo Pascual-Ahuir, Claudio Avignone Rossa
FEMS Microbiology Reviews.2026;[Epub] CrossRef - Functional analysis of OmpA and its contribution to pathogenesis of Edwardsiella tarda
Quan Zhou, Yushuai Hu, Yicheng You, Yingli Gao, Xingqiang Wang, Lei Qin
Microbial Pathogenesis.2024; 193: 106760. CrossRef -
Application of mPEG-CS-cRGD/
Bmi-1RNAi
-PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells
Xiaoyan Xu, Tianhao Zhou, Xudong Wei, Xuelian Jiang, Jiyan Cao
Drug Delivery.2023;[Epub] CrossRef - Control of host mitochondria by bacterial pathogens
Saverio Marchi, Gianluca Morroni, Paolo Pinton, Lorenzo Galluzzi
Trends in Microbiology.2022; 30(5): 452. CrossRef - Lysophosphatidic acid protects cervical cancer HeLa cells from apoptosis induced by doxorubicin hydrochloride
Xibo Wang, Haihua Wang, Xiaoxiao Mou, Yilin Xu, Wenbo Han, Aimin Huang, Yanwei Li, Hui Jiang, Xiaoyun Yang, Zhenbo Hu
Oncology Letters.2022;[Epub] CrossRef
- From gatekeepers to mitochondrial mischief: how bacterial outer membrane proteins crash the host cell party
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