Journal Articles
- Antiviral activity of Schizonepeta tenuifolia Briquet against noroviruses via induction of antiviral interferons
-
Yee Ching Ng , Ye Won Kim , Jeong-Su Lee , Sung Joon Lee , Moon Jung Song
-
J. Microbiol. 2018;56(9):683-689. Published online August 23, 2018
-
DOI: https://doi.org/10.1007/s12275-018-8228-7
-
-
45
View
-
0
Download
-
16
Crossref
-
Abstract
-
Human noroviruses are the causative agents of non-bacterial
gastroenteritis worldwide. The rapid onset and resolution of
disease symptoms suggest that innate immune responses are
critical for controlling norovirus infection; however, no effective
antivirals are yet available. The present study was conducted
to examine the antiviral activities of Schizonepeta
tenuifolia Briquet extract (STE) against noroviruses. Treatment
of human norovirus replicon-bearing HG23 cells with
STE at 5 and 10 mg/ml concentrations resulted in the reduction
in the viral RNA levels by 77.2% and 85.9%, respectively.
STE had no cytotoxic effects on HG23 cells. Treatment of
RAW 264.7 cells infected with murine norovirus 1 (MNV-1),
a surrogate virus of human noroviruses, with STE at 10 and
20 μg/ml concentrations resulted in the reduction of viral
replication by 58.5% and 84.9%, respectively. STE treatment
induced the expression of mRNAs for type I and type II interferons
in HG23 cells and upregulated the transcription of
interferon-β in infected RAW 264.7 cells via increased phosphorylation
of interferon regulatory factor 3, a critical transcription
regulator for type I interferon production. These
results
suggest that STE inhibits norovirus replication through
the induction of antiviral interferon production during virus
replication and may serve as a candidate antiviral substance
for treatment against noroviruses.
-
Citations
Citations to this article as recorded by

- Comparison of Three Different Extraction Methods on Schizonepeta tenuifolia (Benth.) Briq Essential Oil: Chemical Constituents and in Vitro and in Silico Biological Activities
Linhong He, Lijuan Zhang, Xi Bai
Chemistry & Biodiversity.2024;[Epub] CrossRef - Systems Pharmacological Approach to Identification of Schizonepeta teunifolia Extract via Active Ingredients Analysis and Cytotoxicity Effect on A549 Cell Lines
Ga Ram Yang, Ji Eun Choo, Youn Sook Kim, Won Gun Ahn
Korean Journal of Acupuncture.2024; 41(1): 7. CrossRef - Chemical Characteristics and Comparison of Schizonepetae Herba and Schizonepetae Herba Carbonisata by Combination of GC–MS and UHPLC–MS Strategies
Ding Xiaoying, Shenghui Hao, Hengyang Li, Tao Wang, Wenjie Li, Shengjiang Guan, Yuguang Zheng, Long Guo, Dan Zhang
Journal of AOAC International.2023; 106(4): 970. CrossRef - Efficacy analysis and research progress of complementary and alternative medicines in the adjuvant treatment of COVID-19
Jaung-Geng Lin, Guan-Jhong Huang, Yi-Chang Su
Journal of Biomedical Science.2023;[Epub] CrossRef - Colorimetric Parameters Correlated with the Variation in the Marker Constituent Contents During the Stir-fry Processing of Schizonepetae Spica
Xindan Liu, Ying Zhang, Menghua Wu, Zhiguo Ma, Hui Cao
Food Analytical Methods.2022; 15(5): 1300. CrossRef - Discrimination and Characterization of the Volatile Organic Compounds in Schizonepetae Spica from Six Regions of China Using HS-GC-IMS and HS-SPME-GC-MS
Chao Li, Huiying Wan, Xinlong Wu, Jiaxin Yin, Limin Zhu, Hanjiang Chen, Xinbo Song, Lifeng Han, Wenzhi Yang, Heshui Yu, Zheng Li
Molecules.2022; 27(14): 4393. CrossRef - Review on Chemical Constituents of Schizonepeta tenuifolia Briq. and Their Pharmacological Effects
Xueying Zhao, Mingwei Zhou
Molecules.2022; 27(16): 5249. CrossRef - A Comprehensive Strategy Based on UPLC-Q/TOF-MS for the Identification of Compounds in a Chinese Patent Medicine, Xiao’er Chiqiao Qingre Granules
Gang Tian, Mengting Gao, Chao Li, Fei Shen, Feng Zhu, Xin Li, Yifei Wang, Beihua Bao, Li Zhang, Zongli Huo, Weifeng Yao
Journal of Chromatographic Science.2022; 61(1): 38. CrossRef - A review of the botany, traditional uses, phytochemistry and pharmacology of Nepeta tenuifolia Briq.
Mingqiu Shan, Yulan Jiang, Yuanyuan Fu, Yongyi Zhou, Zhihui Lu, Sheng Yu, Hui Yan, Chanchan Liu, Peidong Chen, Beihua Bao, Li Zhang, Qinan Wu
Phytochemistry Reviews.2021; 20(5): 991. CrossRef - β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19
Niraj Kumar Jha, Charu Sharma, Hebaallah Mamdouh Hashiesh, Seenipandi Arunachalam, MF Nagoor Meeran, Hayate Javed, Chandragouda R. Patil, Sameer N. Goyal, Shreesh Ojha
Frontiers in Pharmacology.2021;[Epub] CrossRef - Spectrum–effect relationship between GC‐QTOF‐MS fingerprint and antioxidant, anti‐inflammatory activities of Schizonepeta tenuifolia essential oil
Xi Bai, Liu Liu, Junping Zhang, Li Chen, Tao Wu, Haji Akber Aisa, Maitinuer Maiwulanjiang
Biomedical Chromatography.2021;[Epub] CrossRef - Interferon responses to norovirus infections: current and future perspectives
Aminu S. Jahun, Ian G. Goodfellow
Journal of General Virology
.2021;[Epub] CrossRef - Comparisons of the anti-inflammatory, antiviral, and hemostatic activities and chemical profiles of raw and charred Schizonepetae Spica
Xindan Liu, Zihan Huang, Jinju Zhang, Yu Zhou, Ying Zhang, Menghua Wu, Zhiguo Ma, Hui Cao
Journal of Ethnopharmacology.2021; 278: 114275. CrossRef - The Potential Transformation Mechanisms of the Marker Components of Schizonepetae Spica and Its Charred Product
Xindan Liu, Ying Zhang, Menghua Wu, Zhiguo Ma, Hui Cao
Molecules.2020; 25(16): 3749. CrossRef - Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
Xindan Liu, Ying Zhang, Menghua Wu, Zhiguo Ma, Hui Cao, Joseph Banoub
PLOS ONE.2020; 15(1): e0227235. CrossRef - Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus
Karla D. Passalacqua, Jia Lu, Ian Goodfellow, Abimbola O. Kolawole, Jacob R. Arche, Robert J. Maddox, Kelly E. Carnahan, Mary X. D. O’Riordan, Christiane E. Wobus, Mary K. Estes
mBio.2019;[Epub] CrossRef
- Dense Granule Protein-7 (GRA-7) of Toxoplasma gondii inhibits viral replication in vitro and in vivo
-
Prasanna Weeratunga , Thilina U. B. Herath , Tae-Hwan Kim , Hyun-Cheol Lee , Jae-Hoon Kim , Byeong-Hoon Lee , Eun-Seo Lee , Kiramage Chathuranga , W. A. Gayan Chathuranga , Chul-Su Yang , Jin Yeul Ma , Jong-Soo Lee
-
J. Microbiol. 2017;55(11):909-917. Published online October 27, 2017
-
DOI: https://doi.org/10.1007/s12275-017-7392-5
-
-
49
View
-
0
Download
-
15
Crossref
-
Abstract
-
Dense granule protein-7 (GRA-7) is an excretory protein of
Toxoplasma gondii. It is a potential serodiagnostic marker
and vaccine candidate for toxoplasmosis. Previous reports
demonstrated that GRA-7 induces innate immune responses
in macrophages by interacting with TRAF6 via the MyD88-
dependent pathway. In the present study, we evaluated the
antiviral activity and induction of an antiviral state by GRA-7
both in vitro and in vivo. It was observed that GRA-7 markedly
reduced the replication of vesicular stomatitis virus (VSVGFP),
influenza A virus (PR8-GFP), coxsackievirus (H3-
GFP), herpes simplex virus (HSV-GFP), and adenovirus-GFP
in epithelial (HEK293T/HeLa) and immune (RAW264.7)
cells. These antiviral activities of GRA-7 were attributed to
the induction of type I interferon (IFN) signaling, resulting
in the secretion of IFNs and pro-inflammatory cytokines.
Additionally, in BALB/c mice, intranasal administration of
GRA-7 prevented lethal infection by influenza A virus (H1N1)
and exhibited prophylactic effects against respiratory syncytial
virus (RSV-GFP). Collectively, these results suggested
that GRA-7 exhibits immunostimulatory and broad spectrum
antiviral activities via type I IFN signaling. Thus, GRA-7 can
be potentially used as a vaccine adjuvant or as a candidate
drug with prophylactic potential against viruses.
-
Citations
Citations to this article as recorded by

- Effect of SARS-CoV-2 and Toxoplasma gondii co-infection on IFN-γ and TNF-α expression and its impact on disease severity
Magda S.A. Abdeltawab, Mohamed Fateen, Shimaa Saad El-Din, Riem M. Elmessiery, Osama Mohammady Mohamed, Khaled Marzouk Sadek, Engy Medhat, Alshaimaa M.R. Hamed
Cytokine.2024; 177: 156545. CrossRef - Impact of latent toxoplasmosis on pneumonic and non-pneumonic COVID-19 patients with estimation of relevant oxidative stress biomarkers
Doaa A. Hamdy, Ragaey A. Eid, Heba Abdel-Tawab, Mohamed A. El-Badry, Abdelrahman M. Abdallah, Wegdan M. Abd El Wahab
Folia Parasitologica.2024;[Epub] CrossRef - IFNs in host defence and parasite immune evasion during Toxoplasma gondii infections
Carsten G. K. Lüder
Frontiers in Immunology.2024;[Epub] CrossRef - Current vaccine candidate of toxoplasmosis
Eden WOLDEGERIMA, Fasika GETACHEW, Meseret MISGANAW, Yohannes MESFIN, Debaka BELETE, Tekeba SISAY, Nega BERHANE
Journal of Life Science and Biomedicine.2024; : 54. CrossRef - Prevalence of Toxoplasma gondii infection in COVID-19 patients: A systematic review and meta-analysis
Mahdi Fakhar, Khadijeh Najafi Ghobadi, Nastaran Barati, Salman Zafari, Seyed Ali Hosseini, Eissa Soleymani, Seyedmousa Motavallihaghi
Microbial Pathogenesis.2024; 197: 107064. CrossRef - Clinical and Immunological Impacts of Latent Toxoplasmosis on COVID-19 Patients
Samar Habib, Eman Hamza, Randa El-Gamal, Nessma A Nosser, Wafaa A Aboukamar, Sherehan Abdelsalam, Ali Sobh, Mohamed Elegezy, Mohamed Elbayoumy, Waleed Eldars, Khaled Elmasry, Marwa H Elnagdy
Cureus.2023;[Epub] CrossRef - Association between breakthrough infection with COVID-19 and Toxoplasma gondii: a cross-sectional study
Marwa A. Gouda, Hind S. AboShabaan, Ahmed S. Abdelgawad, Aliaa Sabry Abdel Wahed, Khaled A. Abd El-Razik, Yara Elsaadawy, Ayman. A. Abdel-Wahab, Yousry Hawash
Scientific Reports.2023;[Epub] CrossRef - Toxoplasmosis and symptoms severity in patients with COVID-19 in referral centers in Northern Iran
Ali Geraili, Alireza Badirzadeh, Maryam Sadeghi, Seyed Mahmoud Mousavi, Parisa Mousavi, Zabihollah Shahmoradi, Sayed-Mohsen Hosseini, Seyed Hossein Hejazi, Raheleh Rafiei-Sefiddashti
Journal of Parasitic Diseases.2023; 47(1): 185. CrossRef - Synergistic effect of GRA7 and profilin proteins in vaccination against chronic Toxoplasma gondii infection
Nadia Arcon, Mariano S. Picchio, Ignacio M. Fenoy, Rosalía E. Moretta, Ariadna S. Soto, Matías D. Perrone Sibilia, Vanesa R. Sánchez, Cecilia A. Prato, María Virginia Tribulatti, Alejandra Goldman, Valentina Martin
Vaccine.2021; 39(6): 933. CrossRef - GRA8 DNA vaccine formulations protect against chronic toxoplasmosis
Muhammet Karakavuk, Hüseyin Can, Aytül Gül, Aysu Değirmenci Döşkaya, Sedef Erkunt Alak, Cemal Ün, Adnan Yüksel Gürüz, Mert Döşkaya
Microbial Pathogenesis.2021; 158: 105016. CrossRef - Role of interferon gamma in SARS-CoV-2-positive patients with parasitic infections
Enas Fakhry Abdel-Hamed, Mohamed N. Ibrahim, Nahed E. Mostafa, Howayda S. F. Moawad, Nahla E. Elgammal, Ehab M. Darwiesh, Dina S. El-rafey, Nissreen E. ElBadawy, Emad Ali Al-Khoufi, Salwa I. Hindawi
Gut Pathogens.2021;[Epub] CrossRef - The role of polyspecific T-cell exhaustion in severe outcomes for COVID-19 patients having latent pathogen infections such as Toxoplasma gondii
Kevin Roe
Microbial Pathogenesis.2021; 161: 105299. CrossRef - Preparation of colloidal gold immunochromatographic test strips for the diagnosis ofToxoplasma gondii
Yuanxi Shen, Zhaozhe Wang, Jiajing Li, Rui Xu, Rongyi Ji, Jiaojiao Lin, Chuangang Zhu
Food and Agricultural Immunology.2020; 31(1): 630. CrossRef - A negative covariation between toxoplasmosis and CoVID-19 with alternative interpretations
Łukasz Jankowiak, Lajos Rozsa, Piotr Tryjanowski, Anders Pape Møller
Scientific Reports.2020;[Epub] CrossRef - Characterization of a novel secretory spherical body protein in Babesia orientalis and Babesia orientalis-infected erythrocytes
Jiaying Guo, Muxiao Li, Yali Sun, Long Yu, Pei He, Zheng Nie, Xueyan Zhan, Yangnan Zhao, Xiaoying Luo, Sen Wang, Siqi Aoyang, Qin Liu, Cuiqin Huang, Lan He, Junlong Zhao
Parasites & Vectors.2018;[Epub] CrossRef
Research Support, Non-U.S. Gov't
- Cyclic Dipeptides from Lactic Acid Bacteria Inhibit Proliferation of the Influenza A Virus
-
Min-Kyu Kwak , Rui Liu , Jun-Oh Kwon , Min-Kyu Kim , Andrew HyoungJin Kim , Sa-Ouk Kang
-
J. Microbiol. 2013;51(6):836-843. Published online December 19, 2013
-
DOI: https://doi.org/10.1007/s12275-013-3521-y
-
-
39
View
-
0
Download
-
51
Crossref
-
Abstract
-
We isolated Lactobacillus plantarum LBP-K10 from the traditional Korean fermented food kimchi. When organic acids were removed, the culture filtrate of this isolate showed high antiviral activity (measured using a plaque-forming assay) against the influenza A (H3N2) virus. Two fractions that were active against influenza A virus were purified from the culture filtrate using a C18 column with high-performance liquid chromatography. These active fractions were crystallized and identified to be the cyclic dipeptides cis-cyclo (L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) using gas chromatography-mass spectrometry; this identification was confirmed by X-ray crystallography. These cyclic dipeptides were identified in the culture filtrate of other lactic acid bacteria, including Lactobacillus spp., Leuconostoc spp., Weissella spp.,
and Lactococcus lactis.
-
Citations
Citations to this article as recorded by

- Antimicrobial Cyclic Dipeptides from Japanese Quail (Coturnix japonica) Eggs Supplemented with Probiotic Lactobacillus plantarum
Sa-Ouk Kang, Min-Kyu Kwak
Journal of Microbiology and Biotechnology.2024; 34(2): 314. CrossRef - Research progress on the microbiota in bladder cancer tumors
Keyuan Lou, Junpeng Chi, Jitao Wu, Jian Ma, Shu Liu, Yuanshan Cui
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef - The high-throughput solid-phase extraction of cis-cyclo(L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) from Lactobacillus plantarum demonstrates efficacy against multidrug-resistant bacteria and influenza A (H3N2) virus
Jaeyoung Son, Yeonju Hong, Hyeri Seong, Yoon Sin Oh, Min-Kyu Kwak
Frontiers in Molecular Biosciences.2024;[Epub] CrossRef - Bioactive metabolites in functional and fermented foods and their role as immunity booster and anti-viral innate mechanisms
Kontham Kulangara Varsha, Vivek Narisetty, Kamalpreet Kaur Brar, Aravind Madhavan, Maria Paul Alphy, Raveendran Sindhu, Mukesh Kumar Awasthi, Sunita Varjani, Parameswaran Binod
Journal of Food Science and Technology.2023; 60(9): 2309. CrossRef - A novel cyclic dipeptide from Lactiplantibacillus plantarum MC39 inhibits proliferation of multidrug-resistant Klebsiella pneumoniae W8 and Enterobacter hormaechei U25
Asmaa Saied Mohamed, Fifi Mohamed Reda, Ahmed Abdel-Hamed Shindia, Wesam Abdel-Ghany Hassanien
International Dairy Journal.2023; 142: 105553. CrossRef - Active Site Aromatic Residues Play a Dual Role in the Substrate Interaction and Protein Structure in Functional Dimers of CYP121A1 of Mycobacterium tuberculosis
Christopher S. Campomizzi, Amit Kumar, Patil Pranita Uttamrao, Jack J. Stallone, George E. Ghanatios, Thenmalarchelvi Rathinavelan, D. Fernando Estrada
ACS Infectious Diseases.2023; 9(4): 827. CrossRef - In Vitro Screening of Antiviral Activity of Lactic Acid Bacteria Isolated from Traditional Fermented Foods
Ramize Hoxha, Daniel Todorov, Anton Hinkov, Kalina Shishkova, Yana Evstatieva, Dilyana Nikolova
Microbiology Research.2023; 14(1): 333. CrossRef - Cyclic dipeptides and the human microbiome: Opportunities and challenges
Charlene Elizabeth Ogilvie, Clarissa Melo Czekster
Bioorganic & Medicinal Chemistry.2023; 90: 117372. CrossRef - Polyols Induce the Production of Antifungal Compounds by Lactobacillus plantarum
Ruben Espinosa-Salgado, Victoria Tamayo-Galván, Isabelle Perraud-Gaime, Gabriela M. Rodríguez-Serrano, Rosa O. González-Robles, Noel Durand, Elena I. Champion-Martínez, Gerardo Saucedo-Castañeda
Current Microbiology.2022;[Epub] CrossRef - Characterization of antifungal cyclic dipeptides of Lacticaseibacillus paracasei ZX1231 and active packaging film prepared with its cell-free supernatant and bacterial nanocellulose
Xuan Zheng, Wenxia Nie, Jun Xu, Hong Zhang, Xinle Liang, Zhongjun Chen
Food Research International.2022; 162: 112024. CrossRef - Cyclic peptide production from lactic acid bacteria (LAB) and their diverse applications
Silpa S, Rupachandra S
Critical Reviews in Food Science and Nutrition.2022; 62(11): 2909. CrossRef - Cyclo(L-Leucyl-L-Prolyl) from Lactobacillus coryniformis BCH-4 inhibits the proliferation of Aspergillus flavus: an in vitro to in silico approach
Mahwish Salman, Anam Tariq, Ghulam Mustafa, Muhammad Rizwan Javed, Shazia Naheed, Sarmad Ahmad Qamar
Archives of Microbiology.2022;[Epub] CrossRef - Minor bioactive indoles from kimchi mirror the regioselectivity in indole-3-carbinol oligomerization
Jia Cheng Qian, Dan Liu, Li Ping Lin, Wen Jing Zhu, Ren Xiang Tan
Food Chemistry.2022; 382: 132571. CrossRef - Recent advances in antiviral effects of probiotics: potential mechanism study in prevention and treatment of SARS-CoV-2
Nima Montazeri-Najafabady, Kimia Kazemi, Ahmad Gholami
Biologia.2022; 77(11): 3211. CrossRef - Precision Postbiotics and Mental Health: the Management of Post-COVID-19 Complications
Muskan Pandey, Archana Bhati, Kumari Priya, K. K. Sharma, Barkha Singhal
Probiotics and Antimicrobial Proteins.2022; 14(3): 426. CrossRef - Bioprotection of Zea mays L. from aflatoxigenic Aspergillus flavus by Loigolactobacillus coryniformis BCH-4
Mahwish Salman, Muhammad Rizwan Javed, Hazrat Ali, Ghulam Mustafa, Anam Tariq, Tanzila Sahar, Shazia Naheed, Iqra Gill, Muhammad Abid, Abdul Tawab, Sabrina Sarrocco
PLOS ONE.2022; 17(8): e0271269. CrossRef - An economical approach for peptide synthesisviaregioselective C–N bond cleavage of lactams
Wataru Muramatsu, Hisashi Yamamoto
Chemical Science.2022; 13(21): 6309. CrossRef - Effect of Probiotics on Host-Microbial Crosstalk: A Review on Strategies to Combat Diversified Strain of Coronavirus
Susrita Sahoo, Swati Mohapatra, Swayam prava Dalai, Namrata Misra, Mrutyunjay Suar
Encyclopedia.2022; 2(2): 1138. CrossRef - Characterization of a mercury tolerant strain of Staphylococcus arlettae from Darjeeling hills with an account of its antibiotic resistance pattern and metabolome
Sukanya Acharyya, Sumedha Saha, Soumya Majumder, Malay Bhattacharya
Archives of Microbiology.2021; 203(9): 5745. CrossRef - Cyclodipeptide Synthases of the NYH Subfamily Recognize tRNA Using an α-Helix Enriched with Positive Residues
Anastasia Croitoru, Morgan Babin, Hannu Myllykallio, Muriel Gondry, Alexey Aleksandrov
Biochemistry.2021; 60(1): 64. CrossRef - Korean traditional foods as antiviral and respiratory disease prevention and treatments: A detailed review
Gitishree Das, J. Basilio Heredia, Maria de Lourdes Pereira, Ericsson Coy-Barrera, Sonia Marlene Rodrigues Oliveira, Erick Paul Gutiérrez-Grijalva, Luis Angel Cabanillas-Bojórquez, Han-Seung Shin, Jayanta Kumar Patra
Trends in Food Science & Technology.2021; 116: 415. CrossRef - Structural elucidation and antimicrobial activity of a diketopiperazine isolated from a Bacillus sp. associated with the marine sponge Spongia officinalis
Dhruba Bhattacharya, Tapan Kumar Lai, Amit Saha, Joseph Selvin, Joydeep Mukherjee
Natural Product Research.2021; 35(14): 2315. CrossRef - Probiotics: A potential immunomodulator in COVID-19 infection management
Kuljit Singh, Alka Rao
Nutrition Research.2021; 87: 1. CrossRef - Bioprospecting Antimicrobials from Lactiplantibacillus plantarum: Key Factors Underlying Its Probiotic Action
Maria Teresa Rocchetti, Pasquale Russo, Vittorio Capozzi, Djamel Drider, Giuseppe Spano, Daniela Fiocco
International Journal of Molecular Sciences.2021; 22(21): 12076. CrossRef - Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold
Joanna Bojarska, Adam Mieczkowski, Zyta M. Ziora, Mariusz Skwarczynski, Istvan Toth, Ahmed O. Shalash, Keykavous Parang, Shaima A. El-Mowafi, Eman H. M. Mohammed, Sherif Elnagdy, Maha AlKhazindar, Wojciech M. Wolf
Biomolecules.2021; 11(10): 1515. CrossRef - Bioactive Potential of Extracts of Labrenzia aggregata Strain USBA 371, a Halophilic Bacterium Isolated from a Terrestrial Source
Carolina Díaz-Cárdenas, Laura Yinneth Rojas, Susana Fiorentino, Monica P. Cala, Jorge I Díaz, Freddy A. Ramos, Jean Armengaud, Silvia Restrepo, Sandra Baena
Molecules.2020; 25(11): 2546. CrossRef - Multi-Product Lactic Acid Bacteria Fermentations: A Review
José Aníbal Mora-Villalobos, Jéssica Montero-Zamora, Natalia Barboza, Carolina Rojas-Garbanzo, Jessie Usaga, Mauricio Redondo-Solano, Linda Schroedter, Agata Olszewska-Widdrat, José Pablo López-Gómez
Fermentation.2020; 6(1): 23. CrossRef - Isolation and identification of induced systemic resistance determinants from Bacillus simplex Sneb545 against Heterodera glycines
Zhifu Xing, Xiaojing Wu, Jing Zhao, Xuebing Zhao, Xiaofeng Zhu, Yuanyuan Wang, Haiyan Fan, Lijie Chen, Xiaoyu Liu, Yuxi Duan
Scientific Reports.2020;[Epub] CrossRef - Quantification of Proline-containing Cyclic Dipeptides by LC-MS/MS
Yuuki Otsuka, Tomoko Shimamura, Michio Sakaji, Hikaru Arita, Takehiro Kashiwagi, Hiroyuki Ukeda
Analytical Sciences.2020; 36(8): 977. CrossRef - Characterization of antifungal metabolites produced by Lactobacillus plantarum and Lactobacillus coryniformis isolated from rice rinsed water
Shazia Anwer Bukhari, Mahwish Salman, Muhammad Numan, Muhammad Rizwan Javed, Muhammad Zubair, Ghulam Mustafa
Molecular Biology Reports.2020; 47(3): 1871. CrossRef - Inhibitory effect of lactic acid bacteria isolated from kimchi against murine norovirus
Dong Joo Seo, Day Jung, Soontag Jung, Daseul Yeo, Changsun Choi
Food Control.2020; 109: 106881. CrossRef - Research progress on small peptides in Chinese Baijiu
Yuan Li, Siqi Yuan, Xihao Yong, Ting zhao, Jun Liu
Journal of Functional Foods.2020; 72: 104081. CrossRef - Drug Resistance and the Prevention Strategies in Food Borne Bacteria: An Update Review
Fataneh Hashempour-Baltork, Hedayat Hosseini, Saeedeh Shojaee-Aliabadi, Mohammadali Torbati, Adel Mirza Alizadeh, Matin Alizadeh
Advanced Pharmaceutical Bulletin.2019; 9(3): 335. CrossRef - Probiotic Lactobacillus and Bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining
Ahmed Ghamry Abdelhamid, Samar S. El-Masry, Noha K. El-Dougdoug
EPMA Journal.2019; 10(4): 337. CrossRef - Protective effects of diketopiperazines from Moslae Herba against influenza A virus-induced pulmonary inflammation via inhibition of viral replication and platelets aggregation
Huan-Huan Zhang, Wen-Ying Yu, Lan Li, Fang Wu, Qin Chen, Yang Yang, Chen-Huan Yu
Journal of Ethnopharmacology.2018; 215: 156. CrossRef - The cyclization mechanism of cis DAA-DAA dipeptide: an ab initio study
Sylwia Freza
Structural Chemistry.2018; 29(4): 1025. CrossRef - Taxonomic hierarchy of the phylum Firmicutes and novel Firmicutes species originated from various environments in Korea
Chi Nam Seong, Joo Won Kang, Ji Hee Lee, So Yeon Seo, Jung Jae Woo, Chul Park, Kyung Sook Bae, Mi Sun Kim
Journal of Microbiology.2018; 56(1): 1. CrossRef - A Pilot Study for the Detection of Cyclic Prolyl-Hydroxyproline (Pro-Hyp) in Human Blood after Ingestion of Collagen Hydrolysate
Yasutaka Shigemura, Yu Iwasaki, Mana Tateno, Asahi Suzuki, Mihoko Kurokawa, Yoshio Sato, Kenji Sato
Nutrients.2018; 10(10): 1356. CrossRef -
Cyclo-(
l
-Phe-
l
-Pro), a Quorum-Sensing Signal of Vibrio vulnificus, Induces Expression of Hydroperoxidase through a ToxR-LeuO-HU-RpoS Signaling Pathway To Confer Resistance against Oxidative
In Hwang Kim, So-Yeon Kim, Na-Young Park, Yancheng Wen, Keun-Woo Lee, So-Young Yoon, Haneul Jie, Kyu-Ho Lee, Kun-Soo Kim, Shelley M. Payne
Infection and Immunity.2018;[Epub] CrossRef - Antimicrobial activity of cyclic dipeptides produced by Lactobacillus plantarum LBP-K10 against multidrug-resistant bacteria, pathogenic fungi, and influenza A virus
Min-Kyu Kwak, Rui Liu, Sa-Ouk Kang
Food Control.2018; 85: 223. CrossRef - Induction of systemic disease resistance in Nicotiana benthamiana by the cyclodipeptides cyclo (l‐Pro‐l‐Pro) and cyclo (d‐Pro‐d‐Pro)
Liming Wu, Huijun Wu, Lina Chen, Hongyue Zhang, Xuewen Gao
Molecular Plant Pathology.2017; 18(1): 67. CrossRef - The Antiproliferative Effect of Cyclodipeptides from Pseudomonas aeruginosa PAO1 on HeLa Cells Involves Inhibition of Phosphorylation of Akt and S6k Kinases
Laura Hernández-Padilla, Dolores Vázquez-Rivera, Luis A. Sánchez-Briones, Alma L. Díaz-Pérez, José Moreno-Rodríguez, Mario A. Moreno-Eutimio, Victor Meza-Carmen, Homero Reyes-De la Cruz, Jesús Campos-García
Molecules.2017; 22(6): 1024. CrossRef - Proline-Based Cyclic Dipeptides from Korean Fermented Vegetable Kimchi and from Leuconostoc mesenteroides LBP-K06 Have Activities against Multidrug-Resistant Bacteria
Rui Liu, Andrew H. Kim, Min-Kyu Kwak, Sa-Ouk Kang
Frontiers in Microbiology.2017;[Epub] CrossRef - Bioactive compounds detected for the first time in corn oil: Cyclic dipeptides and other nitrogenated compounds
Jon Alberdi-Cedeño, María L. Ibargoitia, María D. Guillén
Journal of Food Composition and Analysis.2017; 62: 197. CrossRef - Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity
Awdhesh Mishra, Jaehyuk Choi, Seong-Jin Choi, Kwang-Hyun Baek
Molecules.2017; 22(10): 1796. CrossRef - DFT study on reaction mechanisms of cyclic dipeptide generation
Yue Li, Fangfang Li, Yanyan Zhu, Xue Li, Ziyuan Zhou, Chunmei Liu, Wenjing Zhang, Mingsheng Tang
Structural Chemistry.2016; 27(4): 1165. CrossRef - Cyclo(phenylalanine‐proline) induces DNA damage in mammalian cells via reactive oxygen species
Kwanghyun Lee, Jae Eun Jeong, In Hwang Kim, Kun‐Soo Kim, Bong‐Gun Ju
Journal of Cellular and Molecular Medicine.2015; 19(12): 2851. CrossRef - Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model
Joo Yeon Kang, Do Kyung Lee, Nam Joo Ha, Hea Soon Shin
Journal of Microbiology.2015; 53(11): 796. CrossRef - Cytotoxicity of Cyclodipeptides fromPseudomonas aeruginosaPAO1 Leads to Apoptosis in Human Cancer Cell Lines
Dolores Vázquez-Rivera, Omar González, Jaquelina Guzmán-Rodríguez, Alma L. Díaz-Pérez, Alejandra Ochoa-Zarzosa, José López-Bucio, Víctor Meza-Carmen, Jesús Campos-García
BioMed Research International.2015; 2015: 1. CrossRef - Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus
Song-Yi Ha, Hana Youn, Chang-Seon Song, Se Chan Kang, Jong Jin Bae, Hee Tae Kim, Kwang Min Lee, Tae Hoon Eom, In Su Kim, Jong Hwan Kwak
Journal of Microbiology.2014; 52(4): 340. CrossRef - Cyclic dipeptides from lactic acid bacteria inhibit the proliferation of pathogenic fungi
Min-Kyu Kwak, Rui Liu, Min-Kyu Kim, Dohyun Moon, Andrew HyoungJin Kim, Sung-Hyun Song, Sa-Ouk Kang
Journal of Microbiology.2014; 52(1): 64. CrossRef
- Measurement of Antiviral Activities Using Recombinant Human Cytomegalovirus
-
Byung-Hak Song , Gyu-Cheol Lee , Chan-Hee Lee
-
J. Microbiol. 2000;38(4):255-259.
-
-
-
Abstract
-
For rapid and sensitive measurement of antiviral activities, application of a recombinant virus containing firefly luciferase gene was attempted. Recombinant human cytomegalovirus (HCMV) containing luciferase gene driven by HCMV late gene pp28 promoter (HCMV/pp28-luc) was used to test the antiviral activities of three known compounds and the result was compared with results from the conventional plaque assay for measuring the production of infectious viruses. When human fibroblast cells were infected with HCMV/pp28-luc, luciferase activity was observed at 2 days after infection and reached maximum at 6 days after infection, whereas the production of infectious virus was maximal at 4 days after infection. The antiviral activities of ganciclovir, acyclovir, and papaverine were measured in HFF cells infected with HCMV/pp28-luc and the luciferase activity was compared with the infectious virus titers. Luciferase activity decreased as the concentration of ganciclovir or papaverine increased, while there was a slight decrease in luciferase activity with acyclovir. The level of the decrease in luciferase activity was comparable to the level of decrease in the production of infectious virus. Therefore, the antiviral assay using recombinant virus HCMV/pp28-luc resulted in sensitivity similar to the conventional plaque assay with a significant reduction in assay time.