Journal of Microbiology

Review

The Role of Extracellular Vesicles in Pandemic Viral Infections: Woosung Shim, Anjae Lee, Jung-Hyun Lee; J. Microbiol. 2024;62(6):419-427. Published online June 25, 2024; DOI: https://doi.org/10.1007/s12275-024-00144-x

89 View
0 Download
2 Web of Science
1 Crossref

Extracellular vesicles (EVs), of diverse origin and content, are membranous structures secreted by a broad range of cell types. Recent advances in molecular biology have highlighted the pivotal role of EVs in mediating intercellular communication, facilitated by their ability to transport a diverse range of biomolecules, including proteins, lipids, DNA, RNA and metabolites. A striking feature of EVs is their ability to exert dual effects during viral infections, involving both proviral and antiviral effects. This review explores the dual roles of EVs, particularly in the context of pandemic viruses such as HIV-1 and SARS-CoV-2. On the one hand, EVs can enhance viral replication and exacerbate pathogenesis by transferring viral components to susceptible cells. On the other hand, they have intrinsic antiviral properties, including activation of immune responses and direct inhibition of viral infection. By exploring these contrasting functions, our review emphasizes the complexity of EV-mediated interactions in viral pathogenesis and highlights their potential as targets for therapeutic intervention. The insights obtained from investigating EVs in the context of HIV-1 and SARS-CoV-2 provide a deeper understanding of viral mechanisms and pathologies, and offer a new perspective on managing and mitigating the impact of these global health challenges.

Citations

Citations to this article as recorded by

Differential Impact of Spike Protein Mutations on SARS-CoV-2 Infectivity and Immune Evasion: Insights from Delta and Kappa Variants
Tae-Hun Kim, Sojung Bae, Jinjong Myoung
Journal of Microbiology and Biotechnology.2024; 34(12): 2506. CrossRef

Journal Articles

Comparative study of the geographical spread of genogroup II porcine norovirus and human norovirus: Eung Seo Koo , Yong Seok Jeong; J. Microbiol. 2021;59(7):644-650. Published online July 1, 2021; DOI: https://doi.org/10.1007/s12275-021-1218-1

47 View
0 Download
1 Web of Science
1 Crossref

Abstract

Livestock pigs and porcine norovirus could be candidate tools for future studies on the geographic isolation of norovirus. In this study, we provide the first evidence for geographic isolation of the host as a determinant of the distribution of subgenotypes of the porcine norovirus genogroup II (GII) genotype 11. Environmental water samples were collected from peri-urban streams and estuaries in South Korea between 2014 and 2020. In total, 488 GII region C sequences of norovirus open reading frame 2 were isolated. A total of 14 genotypes were detected, two of which (GII.11 and GII.18) corresponded to porcine norovirus. Five human norovirus genotypes (GII.2, GII.3, GII.4, GII.6, and GII.17) and one porcine norovirus genotype (GII.11) comprised the subgenotypes. Integrated analysis of seasonal and geographical factors revealed that the possibility of the co-emergence of different GII.11 subgenotypes in the same province was lower than that of human norovirus subgenotypes in the same province. Additional algorithms designed to eliminate potential biases further supported the estimated restricted geographical spread of the GII.11 subgenotypes. Fecal contamination source tracking revealed low detection rates of porcine norovirus in the absence of upstream pig farms. These results suggest that a one-sided viral transmission route, mainly dependent on indirect contact owing to the limited chance of direct contact between geographically separated livestock pig populations, may be responsible for the restricted geographical spread of the GII.11 subgenotypes.

Citations

Citations to this article as recorded by

Swine Norovirus: Past, Present, and Future
Lara Cavicchio, Andrea Laconi, Alessandra Piccirillo, Maria Serena Beato
Viruses.2022; 14(3): 537. CrossRef

Coptidis Rhizoma extract inhibits replication of respiratory syncytial virus in vitro and in vivo by inducing antiviral state: Byeong-Hoon Lee , Kiramage Chathuranga , Md Bashir Uddin , Prasanna Weeratunga , Myun Soo Kim , Won-Kyung Cho , Hong Ik Kim , Jin Yeul Ma , Jong-Soo Lee; J. Microbiol. 2017;55(6):488-498. Published online May 28, 2017; DOI: https://doi.org/10.1007/s12275-017-7088-x

51 View
0 Download
21 Crossref

Abstract

Coptidis Rhizoma is derived from the dried rhizome of Ranun-culaceous plants and is a commonly used traditional Chinese medicine. Although Coptidis Rhizoma is commonly used for its many therapeutic effects, antiviral activity against respi-ratory syncytial virus (RSV) has not been reported in detail. In this study, we evaluated the antiviral activities of Coptidis Rhizoma extract (CRE) against RSV in human respiratory tract cell line (HEp2) and BALB/c mice. An effective dose of CRE significantly reduces the replication of RSV in HEp2 cells and reduces the RSV-induced cell death. This antiviral activity against RSV was through the induction of type I inter-feron-related signaling and the antiviral state in HEp2 cells. More importantly, oral administration of CRE exhibited prophylactic effects in BALB/c mice against RSV. In HPLC analysis, we found the presence of several compounds in the aqueous fraction and among them; we confirmed that pal-matine was related to the antiviral properties and immune- modulation effect. Taken together, an extract of Coptidis Rhi-zoma and its components play roles as immunomodulators and could be a potential source as promising natural antivirals that can confer protection to RSV. These outcomes should encourage further allied studies in other natural products.

Citations

Citations to this article as recorded by

Antiviral effect of palmatine against infectious bronchitis virus through regulation of NF-κB/IRF7/JAK-STAT signalling pathway and apoptosis
W. Zhang, Y. Chen, F. Yang, H. Zhang, T. Su, J. Wang, Y. Zhang, X. Song
British Poultry Science.2024; 65(2): 119. CrossRef
In Vitro Inhibitory Effect of Berberine Against Rotavirus
Hue Thi Nguyen, Thi Nguyen Hoa‐Tran, Huy Quang Tran, Thuy Thi Thu Nguyen
Chemistry & Biodiversity.2024;[Epub] CrossRef
Network Pharmacology and Experimental Validation of Qingwen Baidu Decoction Therapeutic Potential in COVID-19-related Lung Injury
Ju Yang, Zhao Zhang, Honghong Liu, Jiawei Wang, Shuying Xie, Pengyan Li, Jianxia Wen, Shizhang Wei, Ruisheng Li, Xiao Ma, Yanling Zhao
Combinatorial Chemistry & High Throughput Screening.2024; 27(9): 1286. CrossRef
Effect of miR-17 on Polygonum Cillinerve polysaccharide against transmissible gastroenteritis virus
Xueqin Duan, Mengxin Xu, Yunying Wang, Nishang Liu, Xingchen Wang, Yingqiu Liu, Weimin Zhang, Wuren Ma, Lin Ma, Yunpeng Fan
Frontiers in Veterinary Science.2024;[Epub] CrossRef
The novel immunobiotic Clostridium butyricum S-45-5 displays broad-spectrum antiviral activity in vitro and in vivo by inducing immune modulation
Kiramage Chathuranga, Yeseul Shin, Md Bashir Uddin, Jayoung Paek, W. A. Gayan Chathuranga, Yebin Seong, Lu Bai, Hongik Kim, Jeong Hwan Shin, Young-Hyo Chang, Jong-Soo Lee
Frontiers in Immunology.2023;[Epub] CrossRef
Interventional effect of processing temperature on anti-angiogenesis of Coptis chinensis and screening of active components by UPLC-MS/MS on quail chick chorioallantoic membrane model
Dan Wang, Miao Qi, Hedi Zhao, Haozhong Wu, Han Chen, Yanan Lan, Yanmin Wang, Yani Jiang, Jingjuan Wang
Journal of Ethnopharmacology.2023; 305: 116014. CrossRef
Coptisine Inhibits Influenza Virus Replication by Upregulating p21
Ming-Feng He, Jian-Hui Liang, Yan-Ni Shen, Chao-Wei Zhang, Kuang-Yang Yang, Li-Chu Liu, Qian Xie, Chun Hu, Xun Song, Yan Wang
Molecules.2023; 28(14): 5398. CrossRef
Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus
Anna A. Shtro, Elizaveta D. Gladkova, Anastasia V. Galochkina, Yulia V. Nikolaeva, Angelika V. Garshinina, Darya N. Razgulyaeva, Evgeniy V. Sorokin, Tatyana R. Tsareva, Olga A. Luzina, Nariman F. Salakhutdinov
Medicinal Chemistry Research.2023; 32(11): 2325. CrossRef
A Global Perspective on Medicinal Plants and Phytochemicals with Antiviral Potentials in the Respiratory System
Neda Mohamadi, Fariba Sharififar, Maryam Rameshk, Shahram Kalantari Khandani
Anti-Infective Agents.2023;[Epub] CrossRef
Refractory Chest Pain in Mild to Moderate Coronavirus Disease 2019 Successfully Treated with Saikanto, a Japanese Traditional Medicine
Ryutaro Arita, Rie Ono, Natsumi Saito, Satoko Suzuki, Akiko Kikuchi, Minoru Ohsawa, Yasunori Tadano, Tetsuya Akaishi, Takeshi Kanno, Michiaki Abe, Ko Onodera, Shin Takayama, Tadashi Ishii
The Tohoku Journal of Experimental Medicine.2022; 257(3): 241. CrossRef
Pine Needle Extract Applicable to Topical Treatment for the Prevention of Human Papillomavirus Infection
Hee-Jung Lee, Mina Park, HeeJae Choi, Aleksandra Nowakowska, Chiung Moon, Jong Hwan Kwak, Young Bong Kim
Journal of Microbiology and Biotechnology.2021; 31(1): 137. CrossRef
In Silico Target Analysis of Treatment for COVID-19 Using Huang-Lian-Shang-Qing-Wan, a Traditional Chinese Medicine Formula
Ching-Wen Huang, Hai-Anh Ha, Shih-Chang Tsai, Chi-Cheng Lu, Chao-Ying Lee, Yuh-Feng Tsai, Fuu-Jen Tsai, Yu-Jen Chiu, Guo-Kai Wang, Chung-Hua Hsu, Jai-Sing Yang
Natural Product Communications.2021;[Epub] CrossRef
Exploring the Potential Targets and Mechanisms of Huang Lian Jie Du Decoction in the Treatment of Coronavirus Disease 2019 Based on Network Pharmacology
Wang Liu, Yu Zeng, Yanda Li, Nanhong Li, Min Peng, Junfen Cheng, Binbin Tian, Mingdi Chen
International Journal of General Medicine.2021; Volume 14: 9873. CrossRef
Inhibitory Effect of Sargassum fusiforme and Its Components on Replication of Respiratory Syncytial Virus In Vitro and In Vivo
Kiramage Chathuranga, Asela Weerawardhana, Niranjan Dodantenna, Lakmal Ranathunga, Won-Kyung Cho, Jin Yeul Ma, Jong-Soo Lee
Viruses.2021; 13(4): 548. CrossRef
Giloy Ghanvati (Tinospora cordifolia (Willd.) Hook. f. and Thomson) Reversed SARS-CoV-2 Viral Spike-Protein Induced Disease Phenotype in the Xenotransplant Model of Humanized Zebrafish
Acharya Balkrishna, Lakshmipathi Khandrika, Anurag Varshney
Frontiers in Pharmacology.2021;[Epub] CrossRef
Systematic screening and characterization of absorbed constituents and in vivo metabolites in rats after oral administration of Rhizoma coptidis using UPLC‐Q‐TOF/MS
Xinchi Feng, Kun Wang, Xintong Hu, Liwei Chai, Shijie Cao, Liqin Ding, Feng Qiu
Biomedical Chromatography.2020;[Epub] CrossRef
Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation
Acharya Balkrishna, Siva Kumar Solleti, Sudeep Verma, Anurag Varshney
Molecules.2020; 25(21): 5091. CrossRef
Palmatine: A review of pharmacological properties and pharmacokinetics
Dominik Tarabasz, Wirginia Kukula‐Koch
Phytotherapy Research.2020; 34(1): 33. CrossRef
Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo
Kiramage Chathuranga, Myun Soo Kim, Hyun-Cheol Lee, Tae-Hwan Kim, Jae-Hoon Kim, W. A. Gayan Chathuranga, Pathum Ekanayaka, H. M. S. M. Wijerathne, Won-Kyung Cho, Hong Ik Kim, Jin Yeul Ma, Jong-Soo Lee
Viruses.2019; 11(7): 604. CrossRef
Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection
Ting-Chun Hung, Alagie Jassey, Chien-Ju Lin, Ching-Hsuan Liu, Chun-Ching Lin, Ming-Hong Yen, Liang-Tzung Lin
Viruses.2018; 10(12): 669. CrossRef
Metabolism of Rhizoma coptidis in Human Urine by Ultra-High-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry
Qingshan Zhang, Gaowa Wang, Xi Chen, Zhiqiang Han, Xiangmei Chen, Risu Na, Haburi Jin, Ping Li, Renbatu Bu
European Journal of Drug Metabolism and Pharmacokinetics.2018; 43(4): 441. CrossRef

Retracted Publication

Interferon-mediated antiviral activities of Angelica tenuissima Nakai and its active components: Prasanna Weeratunga , Md Bashir Uddin , Myun Soo Kim , Byeong-Hoon Lee , Tae-Hwan Kim , Ji-Eun Yoon , Jin Yeul Ma , Hongik Kim , Jong-Soo Lee; J. Microbiol. 2016;54(1):57-70. Published online January 5, 2016; DOI: https://doi.org/10.1007/s12275-016-5555-4

47 View
0 Download
5 Crossref

Abstract

Angelica tenuissima Nakai is a widely used commodity in traditional medicine. Nevertheless, no study has been conducted on the antiviral and immune-modulatory properties of an aqueous extract of Angelica tenuissima Nakai. In the present study, we evaluated the antiviral activities and the mechanism of action of an aqueous extract of Angelica tenuissima Nakai both in vitro and in vivo. In vitro, an effective dose of Angelica tenuissima Nakai markedly inhibited the replication of Influenza A virus (PR8), Vesicular stomatitis virus (VSV), Herpes simplex virus (HSV), Coxsackie virus, and Enterovirus (EV-71) on epithelial (HEK293T/HeLa) and immune (RAW264.7) cells. Such inhibition can be described by the induction of the antiviral state in cells by antiviral, IFNrelated gene induction and secretion of IFNs and pro-inflammatory cytokines. In vivo, Angelica tenuissima Nakai treated BALB/c mice displayed higher survivability and lower lung viral titers when challenged with lethal doses of highly pathogenic influenza A subtypes (H1N1, H5N2, H7N3, and H9N2). We also found that Angelica tenuissima Nakai can induce the secretion of IL-6, IFN-λ, and local IgA in bronchoalveolar lavage fluid (BALF) of Angelica tenuissima Nakai treated mice, which correlating with the observed prophylactic effects. In HPLC analysis, we found the presence of several compounds in the aqueous fraction and among them; we evaluated antiviral properties of ferulic acid. Therefore, an extract of Angelica tenuissima Nakai and its components, including ferulic acid, play roles as immunomodulators and may be potential candidates for novel anti-viral/anti-influenza agents.

Citations

Citations to this article as recorded by

The stimulatory effect of Angelica tenuissima Nakai in osteoblastic/odontoblastic differentiation of human periodontal ligament stem cells
Won-Jong Park, Youn Ho Han
Korean Journal of Dental Materials.2022; 49(4): 187. CrossRef
Fermented Angelicae tenussimae with Aspergillus oryzae Improves Skin Barrier Properties, Moisturizing, and Anti-Inflammatory Responses
Chang-Woo Ha, Eun-Hwa Sohn, Sung-Hyeok Kim, Sohee Jang, Myung-Rye Park, Youn-Kyu Kim, In-Young Bae
International Journal of Molecular Sciences.2022; 23(20): 12072. CrossRef
Extract of Polygala tenuifolia, Angelica tenuissima, and Dimocarpus longan Reduces Behavioral Defect and Enhances Autophagy in Experimental Models of Parkinson’s Disease
Huan Li, Joonki Kim, Huynh Nguyen Khanh Tran, Chang Hwan Lee, Jonghyun Hur, Min Cheol Kim, Hyun Ok Yang
NeuroMolecular Medicine.2021; 23(3): 428. CrossRef
Chemical Constituents of the Root of Angelica tenuissima and their Anti-allergic Inflammatory Activity
Hyun Gyu Choi, In-Gyu Je, Geum Jin Kim, Joo-Won Nam, Sang Hee Shim, Sang-Hyun Kim, Hyukjae Choi
Natural Product Communications.2017;[Epub] CrossRef
Inhibitory effects of bee venom and its components against viruses in vitro and in vivo
Md Bashir Uddin, Byeong-Hoon Lee, Chamilani Nikapitiya, Jae-Hoon Kim, Tae-Hwan Kim, Hyun-Cheol Lee, Choul Goo Kim, Jong-Soo Lee, Chul-Joong Kim
Journal of Microbiology.2016; 54(12): 853. CrossRef

Research Support, Non-U.S. Gov't

Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model: Joo Yeon Kang , Do Kyung Lee , Nam Joo Ha , Hea Soon Shin; J. Microbiol. 2015;53(11):796-803. Published online October 28, 2015; DOI: https://doi.org/10.1007/s12275-015-5302-2

42 View
0 Download
43 Crossref

Abstract

Rotavirus is worldwide cause of severe gastroenteritis including severe diarrhea and fatal dehydration in infants and young children. There is an available vaccination program for preventing rotavirus infection, but it has limits and restrictions. Probiotics therapy could be an alternative
method
of antiviral prevention and modulation against rotavirus infection. In this study, we screened the antiviral activity of probiotic bacteria such as 3 Lactobacillus spp. and 14 Bifidobacterium spp. isolated from young Korean. Three of the bacteria, Lactobacillus ruminis SPM0211, Bifidobacterium longum SPM1205, and SPM1206, inhibited human strain Wa rotavirus infection in Caco-2 cells. Furthermore, these bacterial strains inhibited rotavirus replication in a rotavirus-infected neonatal mouse model. To clarify the mechanism of inhibition, we investigated gene expression of Interferon (IFN)-signaling components and IFN-inducible antiviral effectors. All 3 probiotics increased IFN-α and IFN- β levels compared with the control. Gene expression of IFNsignaling components and IFN-inducible antiviral effectors also increased. Overall, these results indicate that L. ruminis SPM0211, B. longum SPM1205 and 1206 efficiently inhibit rotavirus replication in vitro and in vivo. Especially, the antiviral effect of Lactobacillus ruminis SPM0211 is worthy of notice. This is the first report of L. ruminis with antiviral activity. Anti-rotaviral effects of the 3 probiotics are likely due to their modulation of the immune response through promoting type I IFNs, which are key regulators in IFN signaling pathway.

Citations

Citations to this article as recorded by

The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets
Heng Yang, Xiangqi Fan, Xiangbing Mao, Bing Yu, Jun He, Hui Yan, Jianping Wang
Journal of Animal Science and Biotechnology.2024;[Epub] CrossRef
Interplay between Multisystem Inflammatory Syndrome in Children, Interleukin 6, Microbiome, and Gut Barrier Integrity
Ali Zari, Elrashdy M. Redwan, Mikolaj Raszek, David Cowley, Altijana Hromić-Jahjefendić, Vladimir N. Uversky, Mark Fabrowski, Carlo Brogna, Marina Piscopo, Alberto Rubio-Casillas
Immuno.2024; 4(3): 226. CrossRef
Anti-rotavirus Properties and Mechanisms of Selected Gram-Positive and Gram-Negative Probiotics on Polarized Human Colonic (HT-29) Cells
Anand Kumar, Yosra A. Helmy, Zachary Fritts, Anastasia Vlasova, Linda J. Saif, Gireesh Rajashekara
Probiotics and Antimicrobial Proteins.2023; 15(1): 107. CrossRef
Postbiotic Activities of Bifidobacterium adolescentis: Impacts on Viability, Structural Integrity, and Cell Death Markers in Human Intestinal C2BBe1 Cells
María Hernández, Martin Sieger, Alfonso Barreto, Carlos A. Guerrero, Juan Ulloa
Pathogens.2023; 13(1): 17. CrossRef
The metagenomic composition of water kefir microbiota
Oktay Yerlikaya, Ecem Akan, Özer Kinik
International Journal of Gastronomy and Food Science.2022; 30: 100621. CrossRef
Lactation time influences the composition of Bifidobacterium and Lactobacillus at species level in human breast milk
M. Ding, Y. Zheng, F. Liu, F. Tian, R.P. Ross, C. Stanton, R. Yu, J. Zhao, H. Zhang, B. Yang, W. Chen
Beneficial Microbes.2022; 13(4): 319. CrossRef
Immunomodulation Potential of Probiotics: A Novel Strategy for Improving Livestock Health, Immunity, and Productivity
A. K. M. Humayun Kober, Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Julio Villena, Haruki Kitazawa
Microorganisms.2022; 10(2): 388. CrossRef
A review on antiviral efficacy of Bifidobacterium species
Milad Abdi, Reza Ranjbar
Reviews and Research in Medical Microbiology.2022; 33(2): 74. CrossRef
Immune Impairment Associated with Vitamin A Deficiency: Insights from Clinical Studies and Animal Model Research
Joshua O. Amimo, Husheem Michael, Juliet Chepngeno, Sergei A. Raev, Linda J. Saif, Anastasia N. Vlasova
Nutrients.2022; 14(23): 5038. CrossRef
Dietary omega-6/omega-3 ratio is not associated with gut microbiota composition and disease severity in patients with nonalcoholic fatty liver disease
Kathrin Heinzer, Sonja Lang, Fedja Farowski, Hilmar Wisplinghoff, Maria J.G.T. Vehreschild, Anna Martin, Angela Nowag, Anne Kretzschmar, Claus Jürgen Scholz, Christoph Roderburg, Raphael Mohr, Frank Tacke, Philipp Kasper, Tobias Goeser, Hans-Michael Steff
Nutrition Research.2022; 107: 12. CrossRef
Intestinal ‘Infant-Type’ Bifidobacteria Mediate Immune System Development in the First 1000 Days of Life
Chunxiu Lin, Yugui Lin, Heng Zhang, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Nutrients.2022; 14(7): 1498. CrossRef
Bioactive compounds and probiotics–a ray of hope in COVID-19 management
Indu Bhushan, Mahima Sharma, Malvika Mehta, Shivi Badyal, Varun Sharma, Indu Sharma, Hemender Singh, Srinivas Sistla
Food Science and Human Wellness.2021; 10(2): 131. CrossRef
Role of Bifidobacteria on Infant Health
Silvia Saturio, Alicja M. Nogacka, Guadalupe M. Alvarado-Jasso, Nuria Salazar, Clara G. de los Reyes-Gavilán, Miguel Gueimonde, Silvia Arboleya
Microorganisms.2021; 9(12): 2415. CrossRef
Combined use of lactic-acid-producing bacteria as probiotics and rotavirus vaccine candidates expressing virus-specific proteins
Atefeh Afchangi, Tayebeh Latifi, Somayeh Jalilvand, Sayed Mahdi Marashi, Zabihollah Shoja
Archives of Virology.2021; 166(4): 995. CrossRef
Genome Features and In Vitro Activity against Influenza A and SARS-CoV-2 Viruses of Six Probiotic Strains
Irina V. Soloveva, Tatyana N. Ilyicheva, Vasiliy Yu. Marchenko, Oleg V. Pyankov, Anna G. Tochilina, Irina V. Belova, Vladimir A. Zhirnov, Nikolay I. Bormotov, Maksim O. Skarnovich, Aleksander G. Durymanov, Svetlana B. Molodtsova, Ekaterina I. Filippova, A
BioMed Research International.2021; 2021: 1. CrossRef
Immunonutrition effects on coping with COVID-19
Rosângela dos Santos Ferreira, Cristiane dos Santos, Lígia Aurélio Bezerra Maranhão Mendonça, Cristiano Marcelo Espinola Carvalho, Octávio Luiz Franco
Food & Function.2021; 12(17): 7637. CrossRef
Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects
Shilia Jacob Kurian, Mazhuvancherry Kesavan Unnikrishnan, Sonal Sekhar Miraj, Debasis Bagchi, Mithu Banerjee, B. Shrikar Reddy, Gabriel Sunil Rodrigues, Mohan K. Manu, Kavitha Saravu, Chiranjay Mukhopadhyay, Mahadev Rao
Archives of Medical Research.2021; 52(6): 582. CrossRef
Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection
Yuhki Indo, Shugo Kitahara, Mikado Tomokiyo, Shota Araki, Md. Aminul Islam, Binghui Zhou, Leonardo Albarracin, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Takato Takenouchi, Hirohide Uenishi, Hisashi Aso, Hideki Takahashi, Shoichiro Kurata, Juli
Frontiers in Immunology.2021;[Epub] CrossRef
Kefir: A protective dietary supplementation against viral infection
Reham Samir Hamida, Ashwag Shami, Mohamed Abdelaal Ali, Zakiah Nasser Almohawes, Afrah E. Mohammed, Mashael Mohammed Bin-Meferij
Biomedicine & Pharmacotherapy.2021; 133: 110974. CrossRef
Antiviral activity of fermented foods and their probiotics bacteria towards respiratory and alimentary tracts viruses
Belal J. Muhialdin, Norhasnida Zawawi, Ahmad Faizal Abdull Razis, Jamilah Bakar, Mohammad Zarei
Food Control.2021; 127: 108140. CrossRef
Egg white ovomucin hydrolysate inhibits intestinal integrity damage in LPS-treated Caco-2 cells
Xiaoyu Bao, Jianping Wu
Journal of Functional Foods.2021; 87: 104822. CrossRef
Lactic Acid Bacteria: Food Safety and Human Health Applications
Raphael D. Ayivi, Rabin Gyawali, Albert Krastanov, Sulaiman O. Aljaloud, Mulumebet Worku, Reza Tahergorabi, Roberta Claro da Silva, Salam A. Ibrahim
Dairy.2020; 1(3): 202. CrossRef
Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG
Ogan K. Kumova, Adam J. Fike, Jillian L. Thayer, Linda T. Nguyen, Joshua Chang Mell, Judy Pascasio, Christopher Stairiker, Leticia G. Leon, Peter D. Katsikis, Alison J. Carey, Sabra L. Klein
PLOS Pathogens.2019; 15(10): e1008072. CrossRef
Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis
Ya-Ting Li, Hong Xu, Jian-Zhong Ye, Wen-Rui Wu, Ding Shi, Dai-Qiong Fang, Yang Liu, Lan-Juan Li
World Journal of Gastroenterology.2019; 25(33): 4999. CrossRef
Immunomodulating dose of levamisole stimulates innate immune response and prevents intestinal damage in porcine rotavirus diarrhea: a restricted-randomized, single-blinded, and placebo-controlled clinical trial
Gollahalli Eregowda Chethan, Ujjwal Kumar De, Jugal Garkhal, Shubhankar Sircar, Yash Pal Singh Malik, Nihar Ranjan Sahoo, Abhishek, Med Ram Verma
Tropical Animal Health and Production.2019; 51(6): 1455. CrossRef
Immunobiotic Strains Modulate Toll-Like Receptor 3 Agonist Induced Innate Antiviral Immune Response in Human Intestinal Epithelial Cells by Modulating IFN Regulatory Factor 3 and NF-κB Signaling
Paulraj Kanmani, Hojun Kim
Frontiers in Immunology.2019;[Epub] CrossRef
Intestinal dysbiosis mediates experimental autoimmune pancreatitis via activation of plasmacytoid dendritic cells
Ken Kamata, Tomohiro Watanabe, Kosuke Minaga, Akane Hara, Tomoe Yoshikawa, Ayana Okamoto, Kentaro Yamao, Mamoru Takenaka, Ah-Mee Park, Masatoshi Kudo
International Immunology.2019; 31(12): 795. CrossRef
Probiotic Lactobacillus and Bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining
Ahmed Ghamry Abdelhamid, Samar S. El-Masry, Noha K. El-Dougdoug
EPMA Journal.2019; 10(4): 337. CrossRef
Interspecies comparison of probiotics isolated from different animals
Amr M. Abdou, Riham H. Hedia, Shimaa T. Omara, Mohamed Abd El-Fatah Mahmoud, Mai M. Kandil, M. A. Bakry
Veterinary World.2018; 11(2): 227. CrossRef
Probiotics, mechanisms of action, and clinical perspectives for diarrhea management in children
Monique Santos do Carmo, Camilla itapary dos Santos, Mizael Calácio Araújo, Jorge Alberto Girón, Elizabeth Soares Fernandes, Valério Monteiro-Neto
Food & Function.2018; 9(10): 5074. CrossRef
Exopolysaccharide from Lactobacillus plantarum LRCC5310 offers protection against rotavirus-induced diarrhea and regulates inflammatory response
Kiyoung Kim, Gyeonghweon Lee, Hien Dang Thanh, Jong-Hwa Kim, Maytiya Konkit, Seokmin Yoon, Miri Park, Siyoung Yang, Eunsup Park, Wonyong Kim
Journal of Dairy Science.2018; 101(7): 5702. CrossRef
Bifidobacterium adolescentis (DSM 20083) and Lactobacillus casei (Lafti L26-DSL): Probiotics Able to Block the In Vitro Adherence of Rotavirus in MA104 Cells
Karem Prunella Fernandez-Duarte, Nury Nathalia Olaya-Galán, Sandra Patricia Salas-Cárdenas, Jazmin Lopez-Rozo, Maria Fernanda Gutierrez-Fernandez
Probiotics and Antimicrobial Proteins.2018; 10(1): 56. CrossRef
Quantifying rotavirus kinetics in the REH tumor cell line using in vitro data
Gilberto González-Parra, Hana M. Dobrovolny, Diego F. Aranda, Benito Chen-Charpentier, Rafael Antonio Guerrero Rojas
Virus Research.2018; 244: 53. CrossRef
Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity
Julio Villena, Hisashi Aso, Victor P. M. G. Rutten, Hideki Takahashi, Willem van Eden, Haruki Kitazawa
Frontiers in Immunology.2018;[Epub] CrossRef
Immunomodulatory potential of β-glucan as supportive treatment in porcine rotavirus enteritis
Gollahalli Eregowda Chethan, Jugal Garkhal, Shubhankar Sircar, Yash Pal Singh Malik, Reena Mukherjee, Nihar Ranjan Sahoo, Rajesh Kumar Agarwal, Ujjwal Kumar De
Veterinary Immunology and Immunopathology.2017; 191: 36. CrossRef
Modulation of rotavirus severe gastroenteritis by the combination of probiotics and prebiotics
Guadalupe Gonzalez-Ochoa, Lilian K. Flores-Mendoza, Ramona Icedo-Garcia, Ricardo Gomez-Flores, Patricia Tamez-Guerra
Archives of Microbiology.2017; 199(7): 953. CrossRef
Development of an in vitro immunobiotic evaluation system against rotavirus infection in bovine intestinal epitheliocytes
H. Kobayashi, P. Kanmani, T. Ishizuka, A. Miyazaki, J. Soma, L. Albarracin, Y. Suda, T. Nochi, H. Aso, N. Iwabuchi, J.-Z. Xiao, T. Saito, J. Villena, H. Kitazawa
Beneficial Microbes.2017; 8(2): 309. CrossRef
Can probiotics enhance vaccine-specific immunity in children and adults?
J.Y. Kwak, E.S.N. Lamousé-Smith
Beneficial Microbes.2017; 8(5): 657. CrossRef
A Comparative Characterization of Different Host-sourced Lactobacillus ruminis Strains and Their Adhesive, Inhibitory, and Immunomodulating Functions
Xia Yu, Silja Åvall-Jääskeläinen, Joanna Koort, Agneta Lindholm, Johanna Rintahaka, Ingemar von Ossowski, Airi Palva, Ulla Hynönen
Frontiers in Microbiology.2017;[Epub] CrossRef
Oral administration of Bifidobacterium bifidum G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing mucosal protective factors
Tomohiro Kawahara, Yutaka Makizaki, Yosuke Oikawa, Yoshiki Tanaka, Ayako Maeda, Masaki Shimakawa, Satoshi Komoto, Kyoko Moriguchi, Hiroshi Ohno, Koki Taniguchi, Francesco Cappello
PLOS ONE.2017; 12(3): e0173979. CrossRef
Competing forces maintain the Hydra metaorganism
Peter Deines, Tim Lachnit, Thomas C. G. Bosch
Immunological Reviews.2017; 279(1): 123. CrossRef
Cytokines in the management of rotavirus infection: A systematic review of in vivo studies
Gopalsamy Rajiv Gandhi, Victor Santana Santos, Marina Denadai, Valdete Kaliane da Silva Calisto, Jullyana de Souza Siqueira Quintans, Ana Mara de Oliveira e Silva, Adriano Antunes de Souza Araújo, Narendra Narain, Luis Eduardo Cuevas, Lucindo José Quintan
Cytokine.2017; 96: 152. CrossRef
New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota
Heetae Lee, GwangPyo Ko
Gut Microbes.2017; 8(6): 616. CrossRef

First
Prev
Page of 1
Next
Last

Search