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Review
MINIREVIEW] Multilayered regulations of RIG-I in the anti-viral signaling pathway
Nari Kim , Hesung Now , Nhung T.H. Nguyen , Joo-Yeon Yoo
J. Microbiol. 2016;54(9):583-587.   Published online August 31, 2016
DOI: https://doi.org/10.1007/s12275-016-6322-2
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AbstractAbstract
RIG-I is a cytosolic receptor recognizing virus-specific RNA structures and initiates an antiviral signaling that induces the production of interferons and proinflammatory cytokines. Because inappropriate RIG-I signaling affects either viral clearance or immune toxicity, multiple regulations of RIG-I have been investigated since its discovery as the viral RNA detector. In this review, we describe the recent progress in research on the regulation of RIG-I activity or abundance. Specifically, we focus on the mechanism that modulates RIGI- dependent antiviral response through post-translational modifications of or protein-protein interactions with RIG-I.

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