Review
- Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium
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Nakyeong Ha , Eun-Jin Lee
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J. Microbiol. 2023;61(3):289-296. Published online March 2, 2023
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DOI: https://doi.org/10.1007/s12275-023-00027-7
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Abstract
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The metal cofactors are essential for the function of many enzymes. The host restricts the metal acquisition of pathogens for
their immunity and the pathogens have evolved many ways to obtain metal ions for their survival and growth. Salmonella
enterica serovar Typhimurium also needs several metal cofactors for its survival, and manganese has been found to contribute
to Salmonella pathogenesis. Manganese helps Salmonella withstand oxidative and nitrosative stresses. In addition,
manganese affects glycolysis and the reductive TCA, which leads to the inhibition of energetic and biosynthetic metabolism.
Therefore, manganese homeostasis is crucial for full virulence of Salmonella. Here, we summarize the current information
about three importers and two exporters of manganese that have been identified in Salmonella. MntH, SitABCD, and ZupT
have been shown to participate in manganese uptake. mntH and sitABCD are upregulated by low manganese concentration,
oxidative stress, and host NRAMP1 level. mntH also contains a Mn2+-
dependent riboswitch in its 5′ UTR. Regulation of
zupT expression requires further investigation. MntP and YiiP have been identified as manganese efflux proteins. mntP is
transcr!ptionally activated by MntR at high manganese levels and repressed its activity by MntS at low manganese levels.
Regulation of yiiP requires further analysis, but it has been shown that yiiP expression is not dependent on MntS. Besides
these five transporters, there might be additional transporters that need to be identified.
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Citations
Citations to this article as recorded by

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Functional characterization of a TerC family protein of
Riemerella anatipestifer
in manganese detoxification and virulence
Qinyuan Chen, Fang Guo, Li Huang, Mengying Wang, Chunfeng Shi, Shutong Zhang, Yizhou Yao, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Bin Tian, Juan Huang, Xumin Ou, Qun Gao, Di Sun, Ling Zhang, Yanling
Applied and Environmental Microbiology.2024;[Epub] CrossRef - NO enhances the adaptability to high-salt environments by regulating osmotic balance, antioxidant defense, and ion homeostasis in eelgrass based on transcriptome and metabolome analysis
Xianyan Wang, Tongtong Wang, Pei Yu, Yuchun Li, Xinfang Lv
Frontiers in Plant Science.2024;[Epub] CrossRef - High-throughput fitness experiments reveal specific vulnerabilities of human-adapted Salmonella during stress and infection
Benjamin X. Wang, Dmitry Leshchiner, Lijuan Luo, Miles Tuncel, Karsten Hokamp, Jay C. D. Hinton, Denise M. Monack
Nature Genetics.2024; 56(6): 1288. CrossRef -
Biological characteristics of manganese transporter MntP in
Klebsiella pneumoniae
Wei Peng, Yafei Xu, Yilin Yin, Jichen Xie, Renhui Ma, Guoyuan Song, Zhiqiang Zhang, Qiuhang Quan, Qinggen Jiang, Moran Li, Bei Li, Michael David Leslie Johnson
mSphere.2024;[Epub] CrossRef -
Exploring resource competition by protective lactic acid bacteria cultures to control
Salmonella
in food: an Achilles’ heel to target?
Ludovico Screpanti, Nathalie Desmasures, Margot Schlusselhuber
Critical Reviews in Food Science and Nutrition.2024; : 1. CrossRef - Substrate-Induced Structural Dynamics and Evolutionary Linkage of Siderophore-Iron ABC Transporters of Mycobacterium tuberculosis
Aisha Farhana, Abdullah Alsrhani, Hasan Ejaz, Muharib Alruwaili, Ayman A. M. Alameen, Emad Manni, Zafar Rasheed, Yusuf Saleem Khan
Medicina.2024; 60(11): 1891. CrossRef - Structures and coordination chemistry of transporters involved in manganese and iron homeostasis
Shamayeeta Ray, Rachelle Gaudet
Biochemical Society Transactions.2023; 51(3): 897. CrossRef - Bacterial Regulatory Mechanisms for the Control of Cellular Processes: Simple Organisms’ Complex Regulation
Jin-Won Lee
Journal of Microbiology.2023; 61(3): 273. CrossRef
Journal Articles
- Garden microbiomes of Apterostigma dentigerum and Apterostigma pilosum fungus-growing ants (Hymenoptera: Formicidae)
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Cely T. González , Kristin Saltonstall , Hermógenes Fernández-Marín
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J. Microbiol. 2019;57(10):842-851. Published online August 3, 2019
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DOI: https://doi.org/10.1007/s12275-019-8639-0
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42
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Abstract
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Fungus-growing ants share a complex symbiosis with microbes,
including fungal mutualists, antibiotic-producing bacteria,
and fungal pathogens. The bacterial communities associated
with this symbiosis are poorly understood but likely
play important roles in maintaining the health and function
of fungal gardens. We studied bacterial communities in gardens
of two Apterostigma species, A. dentigerum, and A. pilosum,
using next-generation sequencing to evaluate differences
between the two ant species, their veiled and no-veiled
fungal garden types, and across three collection locations.
We also compared different parts of nests to test for homogeneity
within nests. Enterobacteriaceae dominated gardens
of both species and common OTUs were shared across both
species and nest types. However, differences in community
diversity were detected between ant species, and in the communities
of A. dentigerum veiled and no-veiled nests within
sites. Apterostigma pilosum had a higher proportion of Phyllobacteriaceae
and differed from A. dentigerum in the proportions
of members of the order Clostridiales. Within A. dentigerum,
nests with veiled and no-veiled fungus gardens had
similar taxonomic profiles but differed in the relative abundance
of some groups, with veiled gardens having more Rhodospirillaceae
and Hyphomicrobiaceae, and no-veiled having
more Xanthomonadaceae and certain genera in the Enterobacteriaceae
C. However, bacterial communities in Apterostigma
fungal gardens are highly conserved and resemble
those of the nests of other attine ants with dominant taxa likely
playing a role in biomass degradation and defense. Further
work is required to understand and explain how bacterial
community composition of fungus-growing nests is maintained.
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Citations
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- The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates
Elias Eduardo Barbosa da Rosa, Frederico Schmitt Kremer
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Yuliana Christopher, William T. Wcislo, Sergio Martínez‐Luis, William O.H. Hughes, Nicole M. Gerardo, Hermógenes Fernández‐Marín
Ecology and Evolution.2021; 11(11): 6041. CrossRef - The Microbiome of Neotropical Water Striders and Its Potential Role in Codiversification
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Charlotte B. Francoeur, Lily Khadempour, Rolando D. Moreira-Soto, Kirsten Gotting, Adam J. Book, Adrián A. Pinto-Tomás, Ken Keefover-Ring, Cameron R. Currie, Margaret J. McFall-Ngai
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- Vertical distribution of bacterial community is associated with the degree of soil organic matter decomposition in the active layer of moist acidic tundra
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Hye Min Kim , Min Jin Lee , Ji Young Jung , Chung Yeon Hwang , Mincheol Kim , Hee-Myong Ro , Jongsik Chun , Yoo Kyung Lee
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J. Microbiol. 2016;54(11):713-723. Published online October 29, 2016
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DOI: https://doi.org/10.1007/s12275-016-6294-2
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54
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Abstract
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The increasing temperature in Arctic tundra deepens the
active layer, which is the upper layer of permafrost soil that
experiences repeated thawing and freezing. The increasing
of soil temperature and the deepening of active layer seem
to affect soil microbial communities. Therefore, information
on soil microbial communities at various soil depths is essential
to understand their potential responses to climate change
in the active layer soil. We investigated the community structure
of soil bacteria in the active layer from moist acidic tundra
in Council, Alaska. We also interpreted their relationship
with some relevant soil physicochemical characteristics along
soil depth with a fine scale (5 cm depth interval). The bacterial
community structure was found to change along soil
depth. The relative abundances of Acidobacteria, Gammaproteobacteria,
Planctomycetes, and candidate phylum WPS-2
rapidly decreased with soil depth, while those of Bacteroidetes,
Chloroflexi, Gemmatimonadetes, and candidate AD3 rapidly
increased. A structural shift was also found in the soil bacterial
communities around 20 cm depth, where two organic
(upper Oi and lower Oa) horizons are subdivided. The quality
and the decomposition degree of organic matter might
have influenced the bacterial community structure. Besides
the organic matter quality, the vertical distribution of bacterial
communities was also found to be related to soil pH and
total phosphorus content. This study showed the vertical
change of bacterial community in the active layer with a fine
scale resolution and the possible influence of the quality of soil
organic matter on shaping bacterial community structure.
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- Dominant genera of cyanobacteria in Lake Taihu and their relationships with environmental factors
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Lijun Feng , Shiyou Liu , Wenxian Wu , Jiawen Ma , Pei Li , Hailing Xu , Na Li , Yaoyu Feng
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J. Microbiol. 2016;54(7):468-476. Published online June 28, 2016
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DOI: https://doi.org/10.1007/s12275-016-6037-4
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Abstract
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Cyanobacterial blooms in freshwaters have become one of the
most widespread of environmental problems and threaten
water resources worldwide. Previous studies on cyanobacteria
in Lake Taihu often collected samples from one site (like
Meiliang Bay or Zhushan Bay) and focused on the variation
in patterns or abundance of Microcystis during the blooming
season. However, the distribution of cyanobacteria in Lake
Taihu shows differing pattern in various seasons. In this
study, water samples were collected monthly for one year at
five sites in Lake Taihu with different trophic status and a
physicochemical analysis and denaturing gradient gel electrophoresis
(DGGE) were conducted. DGGE fingerprint analysis
showed that Microcystis (7/35 bands) and Synechococcus
(12/35 bands) were the two most dominant genera present
during the study period at all five sites. Cyanobium (3/35
bands) was the third most common genus which has seldom
been previously reported in Lake Taihu. Redundancy analysis
(RDA) indicated that the cyanobacterial community
structure was significantly correlated with NO3
--N, CODMn,
and NH4
+-N in the winter and spring, whereas it was correlated
with water temperature in the summer and autumn.
Limiting the nutrient input (especially of N and C loading) in
Lake Taihu would be a key factor in controlling the growth
of different genera of cyanobacteria.
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Research Support, Non-U.S. Gov'ts
- Effect of Long-Term Different Fertilization on Bacterial Community Structures and Diversity in Citrus Orchard Soil of Volcanic Ash
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Jae Ho Joa , Hang Yeon Weon , Hae Nam Hyun , Young Chull Jeun , Sang Wook Koh
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J. Microbiol. 2014;52(12):995-1001. Published online November 29, 2014
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DOI: https://doi.org/10.1007/s12275-014-4129-6
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Abstract
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This study was conducted to assess bacterial species richness,
diversity and community distribution according to different
fertilization regimes for 16 years in citrus orchard soil of volcanic
ash. Soil samples were collected and analyzed from
Compost (cattle manure, 2,000 kg/10a), 1/2 NPK+compost
(14-20-14+2,000 kg/10a), NPK+compost (28-40-28+2,000
kg/10a), NPK (28-40-28 kg/10a), 3 NPK (84-120-84 kg/10a),
and Control (no fertilization) plot which have been managed
in the same manners with compost and different amount of
chemical fertilization. The range of pyrosequencing reads
and OTUs were 4,687–7,330 and 1,790–3,695, respectively.
Species richness estimates such as Ace, Chao1, and Shannon
index were higher in 1/2 NPK+compost than other treatments,
which were 15,202, 9,112, 7.7, respectively. Dominant
bacterial groups at level of phylum were Proteobacteria, Acidobacteria,
and Actinobacteria. Those were occupied at 70.9%
in 1/2 NPK+compost. Dominant bacterial groups at level
of genus were Pseudolabrys, Bradyrhizobium, and Acidobacteria.
Those were distributed at 14.4% of a total of bacteria
in Compost. Soil pH displayed significantly closely related
to bacterial species richness estimates such as Ace, Chao1
(p<0.05) and Shannon index (p<0.01). However, it showed
the negative correlation with exchangeable aluminum contents
(p<0.05). In conclusion, diversity of bacterial community
in citrus orchard soil was affected by fertilization management,
soil pH changes and characteristics of volcanic ash.
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Citations
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- Monitoring of Bacterial Community in a Coniferous Forest Soil After a Wildfire
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Ok-Sun Kim , Jae-Jun Yoo , Dong-Hun Lee , Tae-Seok Ahn , Hong-Gyu Song
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J. Microbiol. 2004;42(4):278-284.
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DOI: https://doi.org/2110 [pii]
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Abstract
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Changes in the soil bacterial community of a coniferous forest were analyzed to assess microbial responses to wildfire. Soil samples were collected from three different depths in lightly and severely burned areas, as well as a nearby unburned control area. Direct bacterial counts ranged from 3.3-22.6 x10^8 cells/(g . soil). In surface soil, direct bacterial counts of unburned soil exhibited a great degree of fluctuation. Those in lightly burned soil changed less, but no significant variation was observed in the severely burned soil. The fluctuations of direct bacterial count were less in the middle and deep soil layers. The structure of the bacterial community was analyzed via the fluorescent in situ hybridization method. The number of bacteria detected with the eubacteria-targeted probe out of the direct bacterial count varied from 30.3 to 84.7%, and these ratios were generally higher in the burned soils than in the unburned control soils. In the surface unburned soil, the ratios of [alpha]-, [beta]- and [gamma]-proteobacteria, Cytophaga-Flavobacterium group, and other eubacteria groups to total eubacteria were 9.9, 10.6, 15.5, 9.0, and 55.0%, respectively, and these ratios were relatively stable. The ratios of [alpha]-, [beta]- and [gamma]-proteobacteria, and Cytophaga-Flavobacterium group to total eubacteria increased immediately after the wildfire, and the other eubacterial proportions decreased in the surface and middle layer soils. By way of contrast, the composition of the 5 groups of eubacteria in the subsurface soil exhibited no significant fluctuations during the entire period. The total bacterial population and bacterial community structure disturbed by wildfire soon began to recover, and original levels seemed to be restored 3 months after the wildfire.