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- Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium
- Nakyeong Ha , Eun-Jin Lee
- J. Microbiol. 2023;61(3):289-296. Published online March 2, 2023
- DOI: https://doi.org/10.1007/s12275-023-00027-7
- 75 View
- 0 Download
- 8 Web of Science
- 8 Crossref
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Abstract
- The metal cofactors are essential for the function of many enzymes. The host restricts the metal acquisition of pathogens for their immunity and the pathogens have evolved many ways to obtain metal ions for their survival and growth. Salmonella enterica serovar Typhimurium also needs several metal cofactors for its survival, and manganese has been found to contribute to Salmonella pathogenesis. Manganese helps Salmonella withstand oxidative and nitrosative stresses. In addition, manganese affects glycolysis and the reductive TCA, which leads to the inhibition of energetic and biosynthetic metabolism. Therefore, manganese homeostasis is crucial for full virulence of Salmonella. Here, we summarize the current information about three importers and two exporters of manganese that have been identified in Salmonella. MntH, SitABCD, and ZupT have been shown to participate in manganese uptake. mntH and sitABCD are upregulated by low manganese concentration, oxidative stress, and host NRAMP1 level. mntH also contains a Mn2+- dependent riboswitch in its 5′ UTR. Regulation of zupT expression requires further investigation. MntP and YiiP have been identified as manganese efflux proteins. mntP is transcr!ptionally activated by MntR at high manganese levels and repressed its activity by MntS at low manganese levels. Regulation of yiiP requires further analysis, but it has been shown that yiiP expression is not dependent on MntS. Besides these five transporters, there might be additional transporters that need to be identified.
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Citations
Citations to this article as recorded by
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Functional characterization of a TerC family protein of
Riemerella anatipestifer
in manganese detoxification and virulence
Qinyuan Chen, Fang Guo, Li Huang, Mengying Wang, Chunfeng Shi, Shutong Zhang, Yizhou Yao, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Bin Tian, Juan Huang, Xumin Ou, Qun Gao, Di Sun, Ling Zhang, Yanling
Applied and Environmental Microbiology.2024;[Epub] CrossRef - NO enhances the adaptability to high-salt environments by regulating osmotic balance, antioxidant defense, and ion homeostasis in eelgrass based on transcriptome and metabolome analysis
Xianyan Wang, Tongtong Wang, Pei Yu, Yuchun Li, Xinfang Lv
Frontiers in Plant Science.2024;[Epub] CrossRef - High-throughput fitness experiments reveal specific vulnerabilities of human-adapted Salmonella during stress and infection
Benjamin X. Wang, Dmitry Leshchiner, Lijuan Luo, Miles Tuncel, Karsten Hokamp, Jay C. D. Hinton, Denise M. Monack
Nature Genetics.2024; 56(6): 1288. CrossRef -
Biological characteristics of manganese transporter MntP in
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Wei Peng, Yafei Xu, Yilin Yin, Jichen Xie, Renhui Ma, Guoyuan Song, Zhiqiang Zhang, Qiuhang Quan, Qinggen Jiang, Moran Li, Bei Li, Michael David Leslie Johnson
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Salmonella
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Ludovico Screpanti, Nathalie Desmasures, Margot Schlusselhuber
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Aisha Farhana, Abdullah Alsrhani, Hasan Ejaz, Muharib Alruwaili, Ayman A. M. Alameen, Emad Manni, Zafar Rasheed, Yusuf Saleem Khan
Medicina.2024; 60(11): 1891. CrossRef - Structures and coordination chemistry of transporters involved in manganese and iron homeostasis
Shamayeeta Ray, Rachelle Gaudet
Biochemical Society Transactions.2023; 51(3): 897. CrossRef - Bacterial Regulatory Mechanisms for the Control of Cellular Processes: Simple Organisms’ Complex Regulation
Jin-Won Lee
Journal of Microbiology.2023; 61(3): 273. CrossRef
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Functional characterization of a TerC family protein of
Riemerella anatipestifer
in manganese detoxification and virulence
Journal Article
- Garden microbiomes of Apterostigma dentigerum and Apterostigma pilosum fungus-growing ants (Hymenoptera: Formicidae)
- Cely T. González , Kristin Saltonstall , Hermógenes Fernández-Marín
- J. Microbiol. 2019;57(10):842-851. Published online August 3, 2019
- DOI: https://doi.org/10.1007/s12275-019-8639-0
- 43 View
- 0 Download
- 5 Web of Science
- 5 Crossref
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Abstract
- Fungus-growing ants share a complex symbiosis with microbes, including fungal mutualists, antibiotic-producing bacteria, and fungal pathogens. The bacterial communities associated with this symbiosis are poorly understood but likely play important roles in maintaining the health and function of fungal gardens. We studied bacterial communities in gardens of two Apterostigma species, A. dentigerum, and A. pilosum, using next-generation sequencing to evaluate differences between the two ant species, their veiled and no-veiled fungal garden types, and across three collection locations. We also compared different parts of nests to test for homogeneity within nests. Enterobacteriaceae dominated gardens of both species and common OTUs were shared across both species and nest types. However, differences in community diversity were detected between ant species, and in the communities of A. dentigerum veiled and no-veiled nests within sites. Apterostigma pilosum had a higher proportion of Phyllobacteriaceae and differed from A. dentigerum in the proportions of members of the order Clostridiales. Within A. dentigerum, nests with veiled and no-veiled fungus gardens had similar taxonomic profiles but differed in the relative abundance of some groups, with veiled gardens having more Rhodospirillaceae and Hyphomicrobiaceae, and no-veiled having more Xanthomonadaceae and certain genera in the Enterobacteriaceae C. However, bacterial communities in Apterostigma fungal gardens are highly conserved and resemble those of the nests of other attine ants with dominant taxa likely playing a role in biomass degradation and defense. Further work is required to understand and explain how bacterial community composition of fungus-growing nests is maintained.
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Citations
Citations to this article as recorded by- The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates
Elias Eduardo Barbosa da Rosa, Frederico Schmitt Kremer
Brazilian Journal of Microbiology.2024;[Epub] CrossRef - Pharmacological potential of ants and their symbionts – a review
Surbhi Agarwal, Garima Sharma, Kavita Verma, Narayanan Latha, Vartika Mathur
Entomologia Experimentalis et Applicata.2022; 170(12): 1032. CrossRef - Disease management in two sympatric Apterostigma fungus‐growing ants for controlling the parasitic fungus Escovopsis
Yuliana Christopher, William T. Wcislo, Sergio Martínez‐Luis, William O.H. Hughes, Nicole M. Gerardo, Hermógenes Fernández‐Marín
Ecology and Evolution.2021; 11(11): 6041. CrossRef - The Microbiome of Neotropical Water Striders and Its Potential Role in Codiversification
Anakena M. Castillo, Kristin Saltonstall, Carlos F. Arias, Karina A. Chavarria, Luis A. Ramírez-Camejo, Luis C. Mejía, Luis F. De León
Insects.2020; 11(9): 578. CrossRef - Bacteria Contribute to Plant Secondary Compound Degradation in a Generalist Herbivore System
Charlotte B. Francoeur, Lily Khadempour, Rolando D. Moreira-Soto, Kirsten Gotting, Adam J. Book, Adrián A. Pinto-Tomás, Ken Keefover-Ring, Cameron R. Currie, Margaret J. McFall-Ngai
mBio.2020;[Epub] CrossRef
- The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates
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