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Review
- Omics in gut microbiome analysis
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Tae Woong Whon , Na-Ri Shin , Joon Yong Kim , Seong Woon Roh
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J. Microbiol. 2021;59(3):292-297. Published online February 23, 2021
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DOI: https://doi.org/10.1007/s12275-021-1004-0
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Abstract
- Our understanding of the interactions between microbial communities
and their niche in the host gut has improved owing
to recent advances in environmental microbial genomics.
Integration of metagenomic and metataxonomic sequencing
data with other omics data to study the gut microbiome
has become increasingly common, but downstream analysis
after data integration and interpretation of complex omics
data remain challenging. Here, we review studies that have
explored the gut microbiome signature using omics approaches,
including metagenomics, metataxonomics, metatranscriptomics,
and metabolomics. We further discuss recent
analytics programs to analyze and integrate multi-omics datasets
and further utilization of omics data with other advanced
techniques, such as adaptive immune receptor repertoire sequencing,
microbial culturomics, and machine learning, to
evaluate important microbiome characteristics in the gut.
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