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- Sulforaphane kills Mycobacterium tuberculosis H37Ra and Mycobacterium smegmatis mc2155 through a reactive oxygen species dependent mechanism
- Yongjie Zhao , Shengwen Shang , Ya Song , Tianyue Li , Mingliang Han , Yuexuan Qin , Meili Wei , Jun Xi , Bikui Tang
- J. Microbiol. 2022;60(11):1095-1105. Published online September 1, 2022
- DOI: https://doi.org/10.1007/s12275-022-2284-8
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- 3 Crossref
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Abstract
-
Mycobacterium tuberculosis (M. tuberculosis) is a highly pathogenic
intracellular pathogen that causes tuberculosis (TB),
the leading cause of mortality from single infections. Redox
homeostasis plays a very important role in the resistance of
M. tuberculosis to antibiotic damage and various environmental
stresses. The antioxidant sulforaphane (SFN) has been
reported to exhibit anticancer activity and inhibit the growth
of a variety of bacteria and fungi. Nonetheless, it remains unclear
whether SFN exhibits anti-mycobacterial activity. Our
results
showed that the SFN against M. tuberculosis H37Ra exhibited bactericidal activity in a time and dose-dependent manner. The anti-tubercular activity of SFN was significantly correlated with bacterial reactive oxygen species (ROS) levels. In addition, SFN promoted the bactericidal effect of macrophages on intracellular bacteria in a dose-dependent manner, mediated by increasing intracellular mitochondrial ROS levels and decreasing cytoplasmic ROS levels. Taken together, our data revealed the previously unrecognized antimicrobial functions of SFN. Future studies focusing on the mechanism of SFN in macrophages against M. tuberculosis are essential for developing new host-directed therapeutic approaches against TB. -
Citations
Citations to this article as recorded by
- NK-derived exosome miR-1249-3p inhibits Mycobacterium tuberculosis survival in macrophages by targeting SKOR1
Fengqian Ma, Xuan Wang, Zhanghua Qiu, Shoupeng Ding, Wenya Du, Yumei Dai, Tao Ma, Linzhi Yue, Guofu Wang, Tao Wang, Ling Geng, Lixian Wu
Cytokine.2024; 175: 156481. CrossRef - Lactobacillus plantarum increase the sulforaphane formation efficiency via microbial-targeted delivery system in vivo
Yunping Wang, Yiteng Zhang, Xiude Li, Liping Luo, Fangjian Ning, Tao Liu, Jinwang Li
Food Bioscience.2024; 62: 105544. CrossRef - Identifying autophagy-related genes as potential targets for immunotherapy in tuberculosis
Sifang Xiao, Ting Zhou, Jianhua Pan, Xiaohua Ma, Guomin Shi, Binyuan Jiang, Yan-gen Xiang
International Immunopharmacology.2023; 118: 109956. CrossRef
- NK-derived exosome miR-1249-3p inhibits Mycobacterium tuberculosis survival in macrophages by targeting SKOR1
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