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- Down-regulation of microRNA-155 suppressed Candida albicans induced acute lung injury by activating SOCS1 and inhibiting inflammation response
- Xiaohua Li , Yuanzhong Gong , Xin Lin , Qiong Lin , Jianxiong Luo , Tianxing Yu , Junping Xu , Lifang Chen , Liyu Xu , Ying Hu
- J. Microbiol. 2022;60(4):402-410. Published online February 14, 2022
- DOI: https://doi.org/10.1007/s12275-022-1663-5
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- 6 Crossref
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Abstract
- Acute lung injury caused by Candida albicans could result in high mortality and morbidity. MicroRNA-155 (miR-155) and suppressor of cytokine signaling 1 (SOCS1) have been believed to play a key in the regulation of inflammatory response. Whether miR-155/SOCS1 axis could regulate the acute lung injury caused by C. albicans has not been reported. The acute lung injury animal model was established with acute infection of C. albicans. miR-155 inhibitor, miR-155 mimic, and sh-SOCS1 were constructed. The binding site between miR- 155 and SOCS1 was identified with dual luciferase reporter assay. Knockdown of miR-155 markedly inhibited the germ tube formation of C. albicans. Knockdown of miR-155 significantly up-regulated the expression of SOCS1, and the binding site between miR-155 and SOCS1 was identified. Knockdown of miR-155 improved the acute lung injury, suppressed inflammatory factors and fungus loading through SOCS1. Knockdown of SOCS1 greatly reversed the influence of miR- 155 inhibitor on the cell apoptosis in vitro. The improvement of acute lung injury caused by C. albicans, suppression of inflammatory response and C. albicans infection, and inhibitor of cell apoptosis were achieved by knocking down miR-155 through SOCS1. This research might provide a new thought for the prevention and treatment of acute lung injury caused by C. albicans through targeting miR-155/SOCS1 axis.
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Citations
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- Role of microRNAs in Immune Regulation with Translational and Clinical Applications
Zsuzsanna Gaál
International Journal of Molecular Sciences.2024; 25(3): 1942. CrossRef - miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α
Yihui Fu, Jie Zhao, Jie Chen, Yamei Zheng, Rubing Mo, Lei Zhang, Bingli Zhang, Qi Lin, Chanyi He, Siguang Li, Lingsang Lin, Tian Xie, Yipeng Ding
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Cancer and Metastasis Reviews.2024; 43(2): 657. CrossRef - MicroRNAs: Regulators of the host antifungal immune response
Yanchen Lin, Ping Li, Jinliang Teng, Chunhua Liao
Perioperative Precision Medicine.2023;[Epub] CrossRef - Total saponins from Panax japonicus reduce inflammation in adipocytes through the miR155/SOCS1/NFκB signaling pathway
Yan Gao, Rui Wang, Luoying Li, Yumin He, Ding Yuan, Yifan Zhang, Yaqi Hu, Shuwen Wang, Chengfu Yuan
Phytomedicine.2023; 115: 154827. CrossRef - Unraveling Therapeutic Opportunities and the Diagnostic Potential of microRNAs for Human Lung Cancer
Osama Sweef, Elsayed Zaabout, Ahmed Bakheet, Mohamed Halawa, Ibrahim Gad, Mohamed Akela, Ehab Tousson, Ashraf Abdelghany, Saori Furuta
Pharmaceutics.2023; 15(8): 2061. CrossRef
- Role of microRNAs in Immune Regulation with Translational and Clinical Applications
Research Support, Non-U.S. Gov't
- Diversity of Microorganisms in Decaying Maize Stalks Revealed by a Molecular Method
- Ming-Xia Yang , Han-Bo Zhang
- J. Microbiol. 2007;45(4):367-370.
- DOI: https://doi.org/2558 [pii]
- 36 View
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Abstract
- Microbial diversity in decaying maize stalk was characterized by constructing and analyzing rRNA gene clone library. Total 47 OTUs were obtained from 82 bacterial clones, including Proteobacteria (64.6%), Actinobacteria (30.5%), Bacteroidetes (2.4%) and Firmicutes (2.4%). Most proteobacterial clones were members of Rhizobium, Pseudomonas and Stenotrophomonas. Eighty-four percent of Actinobacteria was related to Microbacterium. Only 14 OTUs were identified from 124 fungal clones, including Ascomycota (88%) and Basidiomycota (12%). Sixty percent of Ascomycota were members of Eupenicillium and Paecilomyces but all Basidiomycota were close to Kurtzmanomyces nectairei.
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