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- Amino acid residues in the Ler protein critical for derepression of the LEE5 promoter in enteropathogenic E. coli
- Su-Mi Choi , Jae-Ho Jeong , Hyon E. Choy , Minsang Shin
- J. Microbiol. 2016;54(8):559-564. Published online August 2, 2016
- DOI: https://doi.org/10.1007/s12275-016-6027-6
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Abstract
- Enteropathogenic E. coli causes attaching and effacing (A/E) intestinal lesions. The genes involved in the formation of A/E lesions are encoded within a chromosomal island comprising of five major operons, LEE1-5. The global regulator H-NS represses the expression of these operons. Ler, a H-NS homologue, counteracts the H-NS–mediated repression. Using a novel genetic approach, we identified the amino acid residues in Ler that are involved in the interaction with H-NS: I20 and L23 in the C-terminal portion of α-helix 3, and I42 in the following unstructured linker region.
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Citations
Citations to this article as recorded by
- Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens
R. Christopher D. Furniss, Abigail Clements, William Margolin
Journal of Bacteriology.2018;[Epub] CrossRef
- Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens
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