Journal of Microbiology

Journal Article

Safety Assessment of Potential Lactic Acid Bacteria Bifidobacterium longum SPM1205 Isolated from Healthy Koreans: Sung Sook Choi , Byung Yong Kang , Myung Jun Chung , Soo Dong Kim , So Hee Park , Jung Soo Kim , Chin Yang Kang , Nam Joo Ha; J. Microbiol. 2005;43(6):493-498.; DOI: https://doi.org/2300 [pii]

Abstract: The safety assessment of Bifidobacterium longum SPM1205 isolated from healthy Koreans and this strain''''''''s inhibitory effects on fecal harmful enzymes of intestinal microflora were investigated. The overall safety of this strain was investigated during a feeding trial. Groups of SD rats were orally administered a test strain or commercial reference strain B. longum 1?109 CFU/kg body weight/day for four weeks. Throughout this time, their feed intake, water intake and live body weight were monitored. Fecal samples were periodically collected to test harmful enzyme activities of intestinal microflora. At the end of the four-week observation period, samples of blood, liver, spleen, kidney, and gut tissues were collected to determine for hematological parameters and histological differences. The results obtained in this experiment demonstrated that four weeks of consumption of this Bifidobacterium strain had no adverse effects on rat''''''''s general health status, blood biochemical parameters or histology. Therefore, it is likely to be safe for human use. Fecal harmful enzymes such as -glucosidase, -glucuronidase, tryptophanase and urease, were effectively inhibited during the administration of the B. longum SPM1205. These results suggested that this B. longum SPM 1205 could be used for humans as a probiotic strain.

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