The interaction between Candida albicans and its host cells is
characterized by a complex interplay between the expression
of fungal virulence factors, which results in adherence, invasion
and cell damage, and the host immune system, which
responds by secreting proinflammatory cytokines, activating
antimicrobial activities and killing the fungal pathogen. In
this review we describe this interplay by taking a closer look
at how C. albicans pathogenicity is induced and executed,
how the host responds in order to prevent and clear an infection,
and which mechanisms C. albicans has evolved to
bypass these immune responses to avoid clearance. Furthermore,
we review studies that show how the presence of other
microorganisms affects this interplay.
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Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin Mónica Galocha, Pedro Pais, Mafalda Cavalheiro, Diana Pereira, Romeu Viana, Miguel C. Teixeira International Journal of Molecular Sciences.2019; 20(9): 2345. CrossRef
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On‐site secretory vesicle delivery drives filamentous growth in the fungal pathogenCandida albicans Allon Weiner, François Orange, Sandra Lacas‐Gervais, Katya Rechav, Vikram Ghugtyal, Martine Bassilana, Robert A. Arkowitz Cellular Microbiology.2019; 21(1): e12963. CrossRef
A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection Wenjuan Wang, Zihou Deng, Hongyu Wu, Qun Zhao, Tiantian Li, Wencheng Zhu, Xiongjun Wang, Longhai Tang, Chengshu Wang, Shu-Zhong Cui, Hui Xiao, Jiangye Chen Nature Communications.2019;[Epub] CrossRef
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Candida albicans cell wall mannoprotein synergizes with lipopolysaccharide to affect RAW264.7 proliferation, phagocytosis and apoptosis Xingxing Bie, Shuguang Zhang, Xue Luo, Rui-Qun Qi Microbial Pathogenesis.2019; 131: 98. CrossRef
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The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways Raju Shivarathri, Michael Tscherner, Florian Zwolanek, Nitesh Kumar Singh, Neeraj Chauhan, Karl Kuchler Scientific Reports.2019;[Epub] CrossRef
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Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicans Olena P. Ishchuk, Olov Sterner, Ulf Ellervik, Sophie Manner Antibiotics.2019; 9(1): 10. CrossRef
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A Phenylthiazole Derivative Demonstrates Efficacy On Treatment of the Cryptococcosis & Candidiasis in Animal Models Nívea P Sá, Caroline M Lima, Julliana R A dos Santos, Marliete C Costa, Patrícia P de Barros, Juliana C Junqueira, Jéssica A Vaz, Renata B Oliveira, Beth B Fuchs, Eleftherios Mylonakis, Carlos A Rosa, Daniel A Santos, Susana Johann Future Science OA.2018;[Epub] CrossRef
Role of the Inducible Adhesin CpAls7 in Binding of Candida parapsilosis to the Extracellular Matrix under Fluid Shear Matthew N. Neale, Kyle A. Glass, Sarah J. Longley, Denny J. Kim, Sonia S. Laforce-Nesbitt, Jeremy D. Wortzel, Sunil K. Shaw, Joseph M. Bliss, George S. Deepe Infection and Immunity.2018;[Epub] CrossRef
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Non-canonical Activities of Hog1 Control Sensitivity of Candida albicans to Killer Toxins From Debaryomyces hansenii Ana Morales-Menchén, Federico Navarro-García, José P. Guirao-Abad, Elvira Román, Daniel Prieto, Ioana V. Coman, Jesús Pla, Rebeca Alonso-Monge Frontiers in Cellular and Infection Microbiology.2018;[Epub] CrossRef
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Fungal interactions with the human host: exploring the spectrum of symbiosis Rebecca A Hall, Mairi C Noverr Current Opinion in Microbiology.2017; 40: 58. CrossRef
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NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans
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