Invasive aspergillosis has emerged as one of the most common
life-threatening fungal disease of humans. The emergence
of antifungal resistant pathogens represents a current
and increasing threat to society. In turn, new strategies to
combat fungal infection are urgently required. Fungal adaptations
to stresses experienced within the human host are a
prerequisite for the survival and virulence strategies of the
pathogen. Here, we review the latest information on the
signalling pathways in Aspergillus fumigatus that contribute
to stress adaptations and virulence, while highlighting their
potential as targets for the development of novel combinational
antifungal therapies.
Citations
Citations to this article as recorded by
The Expanding Mycovirome of Aspergilli Josephine L. Battersby, David A. Stevens, Robert H. A. Coutts, Vladimír Havlíček, Joe L. Hsu, Gabriele Sass, Ioly Kotta-Loizou Journal of Fungi.2024; 10(8): 585. CrossRef
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Kayleigh Earle, Clara Valero, Daniel P. Conn, George Vere, Peter C. Cook, Michael J. Bromley, Paul Bowyer, Sara Gago Virulence.2023;[Epub] CrossRef
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Flavonoids Modulate the Accumulation of Toxins From Aspergillus flavus in Maize Kernels Lina Castano-Duque, Matthew K. Gilbert, Brian M. Mack, Matthew D. Lebar, Carol H. Carter-Wientjes, Christine M. Sickler, Jeffrey W. Cary, Kanniah Rajasekaran Frontiers in Plant Science.2021;[Epub] CrossRef
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Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance Patrícia Alves de Castro, Ana Cristina Colabardini, Adriana Oliveira Manfiolli, Jéssica Chiaratto, Lilian Pereira Silva, Eliciane Cevolani Mattos, Giuseppe Palmisano, Fausto Almeida, Gabriela Felix Persinoti, Laure Nicolas Annick Ries, Laura Mellado, Mari PLOS Genetics.2019; 15(12): e1008551. CrossRef
How Environmental Fungi Cause a Range of Clinical Outcomes in Susceptible Hosts Steven T. Denham, Morgan A. Wambaugh, Jessica C.S. Brown Journal of Molecular Biology.2019; 431(16): 2982. CrossRef
Aspergillus fumigatus High Osmolarity Glycerol Mitogen Activated Protein Kinases SakA and MpkC Physically Interact During Osmotic and Cell Wall Stresses Adriana Oliveira Manfiolli, Eliciane Cevolani Mattos, Leandro José de Assis, Lilian Pereira Silva, Mevlüt Ulaş, Neil Andrew Brown, Rafael Silva-Rocha, Özgür Bayram, Gustavo H. Goldman Frontiers in Microbiology.2019;[Epub] CrossRef
Characterizing the Pathogenic, Genomic, and Chemical Traits of
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Aspergillus fumigatus
Matthew E. Mead, Sonja L. Knowles, Huzefa A. Raja, Sarah R. Beattie, Caitlin H. Kowalski, Jacob L. Steenwyk, Lilian P. Silva, Jessica Chiaratto, Laure N. A. Ries, Gustavo H. Goldman, Robert A. Cramer, Nicholas H. Oberlies, Antonis Rokas, Aaron P. Mitchell mSphere.2019;[Epub] CrossRef
Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin Scientific Reports.2019;[Epub] CrossRef
Overview of selected virulence attributes in Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, and Exophiala dermatitidis Hazal Boral, Banu Metin, Aylin Döğen, Seyedmojtaba Seyedmousavi, Macit Ilkit Fungal Genetics and Biology.2018; 111: 92. CrossRef
Heavy Metal-Induced Expression of PcaA Provides Cadmium Tolerance to Aspergillus fumigatus and Supports Its Virulence in the Galleria mellonella Model Fruzsina Bakti, Christoph Sasse, Thorsten Heinekamp, István Pócsi, Gerhard H. Braus Frontiers in Microbiology.2018;[Epub] CrossRef
Predicted Glycerol 3-Phosphate Dehydrogenase Homologs and the Glycerol Kinase GlcA Coordinately Adapt to Various Carbon Sources and Osmotic Stress in Aspergillus fumigatus
Chi Zhang, Xiuhua Meng, Huiyu Gu, Zhihua Ma, Ling Lu G3 Genes|Genomes|Genetics.2018; 8(7): 2291. CrossRef
Heterogeneity in Pathogenicity-related Properties and Stress Tolerance in Aspergillus fumigatus Clinical Isolates Daisuke Hagiwara, Hiroki Takahashi, Hiroshi Takagi, Akira Watanabe, Katsuhiko Kamei Medical Mycology Journal.2018; 59(4): E63. CrossRef
Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion Vivien Kurucz, Thomas Krüger, Károly Antal, Anna-Maria Dietl, Hubertus Haas, István Pócsi, Olaf Kniemeyer, Tamás Emri BMC Genomics.2018;[Epub] CrossRef
Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control Neil Andrew Brown, Sanne Schrevens, Patrick van Dijck, Gustavo Henrique Goldman Nature Microbiology.2018; 3(4): 402. CrossRef
Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion Alex Hopke, Alistair J.P. Brown, Rebecca A. Hall, Robert T. Wheeler Trends in Microbiology.2018; 26(4): 284. CrossRef
A cytosine methyltransferase ortholog dmtA is involved in the sensitivity of Aspergillus flavus to environmental stresses Qing-Qing Zhi, Jie-Ying Li, Qiu-Yun Liu, Zhu-Mei He Fungal Biology.2017; 121(5): 501. CrossRef
The putative flavin carrier family FlcA-C is important forAspergillus fumigatusvirulence Patrícia A. de Castro, Jéssica Chiaratto, Enyara Rezende Morais, Thaila Fernanda dos Reis, Thomas K. Mitchell, Neil A. Brown, Gustavo H. Goldman Virulence.2017; 8(6): 797. CrossRef
Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks inAspergillus nidulans Erzsébet Orosz, Károly Antal, Zoltán Gazdag, Zsuzsa Szabó, Kap-Hoon Han, Jae-Hyuk Yu, István Pócsi, Tamás Emri International Journal of Genomics.2017; 2017: 1. CrossRef
Genome-wide transcriptome analysis ofAspergillus fumigatusexposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakAHOG1and MpkC dependent Lilian Pereira Silva, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Mario Henrique Paziani, Márcia Regina Von Zeska Kress, Diego M. Riaño-Pachón, Daisuke Hagiwara, Laure N. A. Ries, Neil Andrew Brown, Gustavo H. Goldman Cellular Microbiology.2017; 19(4): e12681. CrossRef
Aspergillus fumigatus morphology and dynamic host interactions Frank L. van de Veerdonk, Mark S. Gresnigt, Luigina Romani, Mihai G. Netea, Jean-Paul Latgé Nature Reviews Microbiology.2017; 15(11): 661. CrossRef
Human fungal pathogens: Why should we learn? Jeong-Yoon Kim Journal of Microbiology.2016; 54(3): 145. CrossRef
Mitogen activated protein kinases SakAHOG1 and MpkC collaborate for Aspergillus fumigatus virulence Ariane Cristina Mendes de Oliveira Bruder Nascimento, Thaila Fernanda dos Reis, Patrícia Alves de Castro, Juliana I. Hori, Vinícius Leite Pedro Bom, Leandro José de Assis, Leandra Naira Zambelli Ramalho, Marina Campos Rocha, Iran Malavazi, Neil Andrew Bro Molecular Microbiology.2016; 100(5): 841. CrossRef
Proteomic analysis of Aspergillus fumigatus – clinical implications Nicola M. Moloney, Rebecca A. Owens, Sean Doyle Expert Review of Proteomics.2016; 13(7): 635. CrossRef
Aspergillus fumigatusMADS-Box Transcription FactorrlmAIs Required for Regulation of the Cell Wall Integrity and Virulence Marina Campos Rocha, João Henrique Tadini Marilhano Fabri, Krissia Franco de Godoy, Patrícia Alves de Castro, Juliana Issa Hori, Anderson Ferreira da Cunha, Mark Arentshorst, Arthur F J Ram, Cees A M J J van den Hondel, Gustavo Henrique Goldman, Iran Mala G3 Genes|Genomes|Genetics.2016; 6(9): 2983. CrossRef
Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison Pedro Pais, Catarina Costa, Mafalda Cavalheiro, Daniela Romão, Miguel C. Teixeira Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef
How to invade a susceptible host: cellular aspects of aspergillosis Sven Krappmann Current Opinion in Microbiology.2016; 34: 136. CrossRef
Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi Daisuke Hagiwara, Akira Watanabe, Katsuhiko Kamei, Gustavo H. Goldman Frontiers in Microbiology.2016;[Epub] CrossRef
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