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- Genipin as a novel chemical activator of EBV lytic cycle
- Myoungki Son , Minjung Lee , Eunhyun Ryu , Aree Moon , Choon-Sik Jeong , Yong Woo Jung , Gyu Hwan Park , Gi-Ho Sung , Hyosun Cho , Hyojeung Kang
- J. Microbiol. 2015;53(2):155-165. Published online January 28, 2015
- DOI: https://doi.org/10.1007/s12275-015-4672-9
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- 29 Crossref
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Abstract
-
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus
that causes acute infection and establishes life-long latency.
EBV causes several human cancers, including Burkitt's lymphoma,
nasopharyngeal and gastric carcinoma. Antiviral
agents can be categorized as virucides, antiviral chemotherapeutic
agents, and immunomodulators. Most antiviral agents
affect actively replicating viruses, but not their latent forms.
Novel antiviral agents must be active on both the replicating
and the latent forms of the virus. Gardenia jasminoides is an
evergreen flowering plant belonging to the Rubiaceae family
and is most commonly found growing wild in Vietnam,
Southern China, Taiwan, Japan, Myanmar, and India. Genipin
is an aglycone derived from an iridoid glycoside called geniposide,
which is present in large quantities in the fruit of
G. jasminoides. In this study, genipin was evaluated for its
role as an antitumor and antiviral agent that produces inhibitory
effects against EBV and EBV associated gastric carcinoma
(EBVaGC). In SNU719 cells, one of EBVaGCs, genipin
caused significant cytotoxicity (70 μM), induced methylation
on EBV C promoter and tumor suppressor gene
BCL7A, arrested cell-cycle progress (S phases), upregulated
EBV latent/lytic genes in a dose-dependent manner, stimulated
EBV progeny production, activated EBV F promoter
for EBV lytic activation, and suppressed EBV infection. These
results
indicated that genipin could be a promising candidate for antiviral and antitumor agents against EBV and EBVaGC. -
Citations
Citations to this article as recorded by
- Research Progress of EB Virus-Associated Gastric Cancer
婷婷 宋
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