MSK
Search
- Page Path
- HOME > Search
Review
- [MINIREVIEW] Phylogenetic comparison of Epstein-Barr virus genomes
- Su Jin Choi , Seok Won Jung , Sora Huh , Hyosun Cho , Hyojeung Kang
- J. Microbiol. 2018;56(8):525-533. Published online June 14, 2018
- DOI: https://doi.org/10.1007/s12275-018-8039-x
- 62 View
- 0 Download
- 11 Crossref
-
Abstract
- Technologies used for genome analysis and whole genome sequencing are useful for us to understand genomic characterization and divergence. The Epstein-Barr virus (EBV) is an oncogenic virus that causes diverse diseases such as Burkitt’s lymphoma (BL), nasopharyngeal carcinoma (NPC), Hodgkin’s lymphoma (HL), and gastric carcinoma (GC). EBV genomes found in these diseases can be classified either by phases of EBV latency (type-I, -II, and -III latency) or types of EBNA2 sequence difference (type-I EBV, type-II EBV or EBV-1, EBV-2). EBV from EBV-transformed lymphoblastoid cell line (LCL) establishes type-III latency, EBV from NPC establishes type-II latency, and EBV from GC establishes type-I latency. However, other important factors play key roles in classifying numerous EBV strains because EBV genomes are highly diverse and not phylogenetically related to types of EBV-associated diseases. Herein, we first reviewed previous studies to describe molecular characteristics of EBV genomes. Then, using comparative and phylogenetic analyses, we phylogenetically analyzed molecular variations of EBV genomes and proteins. The review of previous studies and our phylogenetic analysis showed that EBV genomes and proteins were highly diverse regardless of types of EBV-associated diseases. Other factors should be considered in determining EBV taxonomy. This review will be helpful to understand complicated phylogenetic relationships of EBV genomes.
-
Citations
Citations to this article as recorded by
- Mechanistic Understanding of EBV+Lymphoproliferative Disease Development After Transplantation
Philippe L. Furlano, Georg A. Böhmig, Elisabeth Puchhammer-Stöckl, Hannes Vietzen
Transplantation.2024; 108(9): 1867. CrossRef - Aquaporin-3 is down-regulated by LMP1 in nasopharyngeal carcinoma cells to regulate cell migration and affect EBV latent infection
Jing Li, Duo Shi, Zhiyuan Gong, Wen Liu, Yan Zhang, Bing Luo
Virus Genes.2024; 60(5): 488. CrossRef - Characterization of a new CCCTC-binding factor binding site as a dual regulator of Epstein-Barr virus latent infection
Sun Hee Lee, Kyoung-Dong Kim, Miyeon Cho, Sora Huh, Seong Ho An, Donghyun Seo, Kyuhyun Kang, Minhee Lee, Hideki Tanizawa, Inuk Jung, Hyosun Cho, Hyojeung Kang, JJ Miranda
PLOS Pathogens.2023; 19(1): e1011078. CrossRef - Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma
Eddy O. Agwati, Cliff I. Oduor, Cyrus Ayieko, John Michael Ong’echa, Ann M. Moormann, Jeffrey A. Bailey
Virology Journal.2022;[Epub] CrossRef - Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments
Oren Shechter, Daniel G. Sausen, Elisa S. Gallo, Harel Dahari, Ronen Borenstein
International Journal of Molecular Sciences.2022; 23(22): 14389. CrossRef - Current approach and novel perspectives in nasopharyngeal carcinoma: the role of targeting proteasome dysregulation as a molecular landmark in nasopharyngeal cancer
Ramon Yarza, Mateo Bover, Maria Teresa Agulló-Ortuño, Lara Carmen Iglesias-Docampo
Journal of Experimental & Clinical Cancer Research.2021;[Epub] CrossRef - Interplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cancer
Francisco Aguayo, Enrique Boccardo, Alejandro Corvalán, Gloria M. Calaf, Rancés Blanco
Infectious Agents and Cancer.2021;[Epub] CrossRef - Stress-Induced Epstein-Barr Virus Reactivation
Daniel Sausen, Maimoona Bhutta, Elisa Gallo, Harel Dahari, Ronen Borenstein
Biomolecules.2021; 11(9): 1380. CrossRef - Epstein‐Barr virus strain variation and cancer
Teru Kanda, Misako Yajima, Kazufumi Ikuta
Cancer Science.2019; 110(4): 1132. CrossRef - A reliable Epstein-Barr Virus classification based on phylogenomic and population analyses
Louise Zanella, Ismael Riquelme, Kurt Buchegger, Michel Abanto, Carmen Ili, Priscilla Brebi
Scientific Reports.2019;[Epub] CrossRef - Novel Synthetic DNA Immunogens Targeting Latent Expressed Antigens of Epstein–Barr Virus Elicit Potent Cellular Responses and Inhibit Tumor Growth
Krzysztof Wojtak, Alfredo Perales-Puchalt, David B. Weiner
Vaccines.2019; 7(2): 44. CrossRef
- Mechanistic Understanding of EBV+Lymphoproliferative Disease Development After Transplantation
First
Prev
TOP
