Review
- MINIREVIEW] Stress responses in Streptococcus species and their effects on the host
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Cuong Thach Nguyen , Sang-Sang Park , Dong-Kwon Rhee
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J. Microbiol. 2015;53(11):741-749. Published online October 28, 2015
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DOI: https://doi.org/10.1007/s12275-015-5432-6
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Abstract
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Streptococci cause a variety of diseases, such as dental caries,
pharyngitis, meningitis, pneumonia, bacteremia, endocarditis,
erysipelas, and necrotizing fasciitis. The natural niche of this
genus of bacteria ranges from the mouth and nasopharynx
to the skin, indicating that the bacteria will inevitably be subjected
to environmental changes during invasion into the host,
where it is exposed to the host immune system. Thus, the
Streptococcus-host interaction determines whether bacteria are
cleared by the host’s defenses or whether they survive after
invasion to cause serious diseases. If this interaction was to
be deciphered, it could aid in the development of novel preventive
and therapeutic agents. Streptococcus species possess
many virulent factors, such as peroxidases and heat-shock
proteins (HSPs), which play key roles in protecting the bacteria
from hostile host environments. This review will discuss
insights into the mechanism(s) by which streptococci adapt
to host environments. Additionally, we will address how streptococcal
infections trigger host stress responses; however,
the mechanism by which bacterial components modulate
host stress responses remains largely unknown.
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Citations
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- A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries
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Advanced Science.2025;[Epub] CrossRef - MoxR effects as an ATPase on anti-stress and pathogenicity of Riemerella anatipestifer
Yang Zhang, Yanhao Zhang, Yushan He, Yarong Hou, Xuedi Li, Xueying Yang, Zutao Zhou, Zili Li
Veterinary Research.2025;[Epub] CrossRef - Skin microbiota in atopic dermatitis: victim or executioner?
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Cell Reports.2025; 44(10): 116374. CrossRef - Identification of ClpB, a molecular chaperone involved in the stress tolerance and virulence of Streptococcus agalactiae
Lan Yang, Zhihao Wu, Tian-Yu Ma, Hui Zeng, Ming Chen, Yong-An Zhang, Yang Zhou
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mSphere.2023;[Epub] CrossRef - Glucose levels affect MgaSpn regulation on the virulence and adaptability of Streptococcus pneumoniae
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.2023;[Epub] CrossRef - Normal bacterial flora of the oral cavity in healthy pet rabbits (Oryctolagus cuniculus)
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Vector-Borne and Zoonotic Diseases.2023; 23(7): 371. CrossRef - sRNA23, a novel small RNA, regulates to the pathogenesis ofStreptococcus suisserotype 2
Quanming Xu, Hong Chen, Wen Sun, Yongyi Zhang, Dewen Zhu, Kul Raj Rai, Ji-Long Chen, Ye Chen
Virulence.2021; 12(1): 3045. CrossRef - Genome-wide association study identifies the virulence-associated marker in Streptococcus suis serotype 2
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Infection, Genetics and Evolution.2021; 92: 104894. CrossRef - Transcriptome analysis unveils survival strategies of Streptococcus parauberis against fish serum
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PLOS ONE.2021; 16(5): e0252200. CrossRef - Pathogenomics of Streptococcus ilei sp. nov., a newly identified pathogen ubiquitous in human microbiome
Dong-Wook Hyun, Jae-Yun Lee, Min-Soo Kim, Na-Ri Shin, Tae Woong Whon, Kyung Hyun Kim, Pil Soo Kim, Euon Jung Tak, Mi-Ja Jung, June Young Lee, Hyun Sik Kim, Woorim Kang, Hojun Sung, Che Ok Jeon, Jin-Woo Bae
Journal of Microbiology.2021; 59(8): 792. CrossRef - Oral bacteria affect the gut microbiome and intestinal immunity
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Pathogens and Disease.2020;[Epub] CrossRef - Survival of Group A Streptococcus (GAS) is Enhanced Under Desiccated Culture Conditions
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Current Microbiology.2020; 77(8): 1518. CrossRef - Oral Probiotics Alleviate Intestinal Dysbacteriosis for People Receiving Bowel Preparation
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Frontiers in Medicine.2020;[Epub] CrossRef - Identification of an Autorepressing Two-Component Signaling System That Modulates Virulence in Streptococcus suis Serotype 2
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Infection and Immunity.2019;[Epub] CrossRef - Galleria mellonella as an experimental model to study human oral pathogens
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Microbial Pathogenesis.2019; 129: 284. CrossRef - Streptococcus pneumoniae two-component regulatory systems: The interplay of the pneumococcus with its environment
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Infection and Immunity.2018;[Epub] CrossRef - Stress Suppressor Screening Leads to Detection of Regulation of Cyclic di-AMP Homeostasis by a Trk Family Effector Protein in Streptococcus pneumoniae
Tiffany M. Zarrella, Dennis W. Metzger, Guangchun Bai, Ann M. Stock
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PLOS ONE.2017; 12(11): e0187728. CrossRef - Relationship between dental caries and metabolic syndrome among 13 998 middle‐aged urban Chinese
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Research Support, Non-U.S. Gov't
- Heat- and Cold-Shock Responses in Fusarium graminearum 3 Acetyl- and 15 Acetyl-Deoxynivalenol Chemotypes
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Vladimir Vujanovic , Yit Kheng Goh , Prasad Daida
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J. Microbiol. 2012;50(1):97-102. Published online February 27, 2012
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DOI: https://doi.org/10.1007/s12275-012-1381-5
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210
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Abstract
PDF
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Fusarium graminearum Schwabe is the primary cause of
Fusarium head blight (FHB) in North America. Chemically
distinct F. graminearum sub-populations can be identified
based on the type or composition of deoxynivalenol (DON)
mycotoxin derivatives, including 3-acetyl (3-ADON) and
15-acetyl (15-ADON). The evaluation of randomly selected
3-ADON and 15-ADON isolates, collected from spring
wheat throughout Canada, was performed using thin layer
chromatography (TLC), high-performance liquid chromatography
(HPLC), ice-nucleation activity (INA), and heat and
cold tolerance tests conducted within a temperature range
of -70°C to 65°C. The results indicated that the 3-ADON
sub-population, which is responsible for the highest disease
severity and has rapidly displaced the 15-ADON sub-population,
produces more DON and zearalenone (ZEA) than
the 15-ADON sub-population when exposed to heat and
cold. Following exposures (1 and 2 h) to extremely high or
low temperatures, 3-ADON isolates exhibited faster mycelial
growth than 15-ADON isolates. In addition, the warmest
temperature at which INA activity occurred was in 3-ADON
(-3.6°C) vs. 15-ADON (-5.1°C). Taken together, these features
suggest that the newly emerging 3-ADON sub-population
is more resilient than the resident 15-ADON sub-population.
Overall, the differences between the two sub-populations
could provide new insights into FHB epidemiology and if
validated under field conditions, may provide important
information for predicting future FHB epidemics.
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- Assessment of the concentrations of ochratoxin A, zearalenone, and deoxynivalenol during cracker production
Amin Mousavi Khaneghah, Parisa Mostashari, Carlos A.F. Oliveira, Fernanda M. Vanin, Saber Amiri, Anderson S. Sant'Ana
Journal of Food Composition and Analysis.2023; 115: 104950. CrossRef - Identification of type B trichothecenes and zearalenone in Chilean cereals by planar chromatography coupled to mass spectroscopy
Diego Jorquera-Pereira, Jessy Pavón-Pérez, Gisela Ríos-Gajardo
Food Additives & Contaminants: Part A.2021; 38(10): 1778. CrossRef - Building on a foundation: advances in epidemiology, resistance breeding, and forecasting research for reducing the impact of fusarium head blight in wheat and barley
W.G. Dilantha Fernando, Abbot O. Oghenekaro, James R. Tucker, Ana Badea
Canadian Journal of Plant Pathology.2021; 43(4): 495. CrossRef - Early transcriptomic response of the mycoparasite Sphaerodes mycoparasitica to the mycotoxigenic Fusarium graminearum 3-ADON, the cause of Fusarium head blight
Seon Hwa Kim, Vladimir Vujanovic
Bioresources and Bioprocessing.2021;[Epub] CrossRef - Tri5gene expression analysis during postharvest storage of wheat grain from field plots treated with a triazole and a strobilurin fungicide
Carlos Bolanos-Carriel, Stephen N. Wegulo, P. Stephen Baenziger, Kent M. Eskridge, Deanna Funnell-Harris, Niki Mcmaster, David G. Schmale, Heather E. Hallen-Adams
Canadian Journal of Plant Pathology.2020; 42(4): 547. CrossRef - Recent population changes of Fusarium head blight pathogens: drivers and implications
Esteban Valverde-Bogantes, Andreia Bianchini, Joshua R. Herr, Devin J. Rose, Stephen N. Wegulo, Heather E. Hallen-Adams
Canadian Journal of Plant Pathology.2020; 42(3): 315. CrossRef - Amylose-Free (“waxy”) Wheat Colonization by Fusarium spp. and Response to Fusarium Head Blight
Deanna L. Funnell-Harris, Robert A. Graybosch, Patrick M. O’Neill, Zachary T. Duray, Stephen N. Wegulo
Plant Disease.2019; 103(5): 972. CrossRef - Fusarium graminearum Chemotype–Spring Wheat Genotype Interaction Effects in Type I and II Resistance Response Assays
Mitra Serajazari, Kerin Hudson, Mina Kaviani, Alireza Navabi
Phytopathology®.2019; 109(4): 643. CrossRef - The effects of climate change associated abiotic stresses on maize phytochemical defenses
Martha M. Vaughan, Anna Block, Shawn A. Christensen, Leon Hartwell Allen, Eric A. Schmelz
Phytochemistry Reviews.2018; 17(1): 37. CrossRef - Trichothecene genotypes, chemotypes and zearalenone production by Fusarium graminearum species complex strains causing Fusarium head blight in Argentina during an epidemic and non-epidemic season
Nadia Yerkovich, Juan Manuel Palazzini, Michael Sulyok, Sofía Noemí Chulze
Tropical Plant Pathology.2017; 42(3): 190. CrossRef - Biodegradation and biodetoxification of Fusarium mycotoxins by Sphaerodes mycoparasitica
Seon Hwa Kim, Vladimir Vujanovic
AMB Express.2017;[Epub] CrossRef - Simultaneous determination of the levels of deoxynivalenol, 3-acetyldeoxynivalenol, and nivalenol in grain and feed samples from South Korea using a high-performance liquid chromatography–photodiode array detector
Dong-Ho Kim, Sung-Yong Hong, Mi-Hyeon Jeon, Jae-Min An, Sung-Youn Kim, Hyo-Young Kim, Bo Ryun Yoon, Soo Hyun Chung
Applied Biological Chemistry.2016; 59(6): 881. CrossRef - Population Subdivision of Fusarium graminearum from Barley and Wheat in the Upper Midwestern United States at the Turn of the Century
Junmin Liang, Lotus Lofgren, Zhanhong Ma, Todd J. Ward, H. Corby Kistler
Phytopathology®.2015; 105(11): 1466. CrossRef - Diversity of Fusarium head blight populations and trichothecene toxin types reveals regional differences in pathogen composition and temporal dynamics
Amy C. Kelly, Randall M. Clear, Kerry O’Donnell, Susan McCormick, T. Kelly Turkington, Andy Tekauz, Jeannie Gilbert, H. Corby Kistler, Mark Busman, Todd J. Ward
Fungal Genetics and Biology.2015; 82: 22. CrossRef - Mycotoxins that affect the North American agri-food sector: state of the art and directions for the future
J.D. Miller, A.W. Schaafsma, D. Bhatnagar, G. Bondy, I. Carbone, L.J. Harris, G. Harrison, G.P. Munkvold, I.P. Oswald, J.J. Pestka, L. Sharpe, M.W. Sumarah, S.A. Tittlemier, T. Zhou
World Mycotoxin Journal.2014; 7(1): 63. CrossRef - Quantitative volatile compound profiles in fungal cultures of three differentFusarium graminearumchemotypes
Maciej Buśko, Tomasz Kulik, Anna Ostrowska, Tomasz Góral, Juliusz Perkowski
FEMS Microbiology Letters.2014; 359(1): 85. CrossRef - Genetic approaches to chemotype determination in type B-trichothecene producing Fusaria
Matias Pasquali, Quirico Migheli
International Journal of Food Microbiology.2014; 189: 164. CrossRef - Determination of deoxynivalenol (DON) and its derivatives: Current status of analytical methods
Ran Ran, Canhua Wang, Zheng Han, Aibo Wu, Dabing Zhang, Jianxin Shi
Food Control.2013; 34(1): 138. CrossRef